ATE146454T1 - 1,2,3,4-tetrahydronaphthalin-, chroman- und thiochroman-derivate als antithrombotika - Google Patents

1,2,3,4-tetrahydronaphthalin-, chroman- und thiochroman-derivate als antithrombotika

Info

Publication number
ATE146454T1
ATE146454T1 AT94402299T AT94402299T ATE146454T1 AT E146454 T1 ATE146454 T1 AT E146454T1 AT 94402299 T AT94402299 T AT 94402299T AT 94402299 T AT94402299 T AT 94402299T AT E146454 T1 ATE146454 T1 AT E146454T1
Authority
AT
Austria
Prior art keywords
substituted
unsubstituted
group
tetrahydronaphthaline
chromane
Prior art date
Application number
AT94402299T
Other languages
English (en)
Inventor
Gilbert Lavielle
Thierry Dubuffet
Olivier Muller
Michel Laubie
Tony Verbeuren
Serge Simonet
Jean-Jacques Descombes
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Application granted granted Critical
Publication of ATE146454T1 publication Critical patent/ATE146454T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D335/00Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06Benzothiopyrans; Hydrogenated benzothiopyrans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/20Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55Acids; Esters
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrane Compounds (AREA)
AT94402299T 1993-10-15 1994-10-13 1,2,3,4-tetrahydronaphthalin-, chroman- und thiochroman-derivate als antithrombotika ATE146454T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9312237A FR2711139B1 (fr) 1993-10-15 1993-10-15 Nouveaux dérivés de 1,2,3,4-tétrahydronaphtalène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number Publication Date
ATE146454T1 true ATE146454T1 (de) 1997-01-15

Family

ID=9451827

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94402299T ATE146454T1 (de) 1993-10-15 1994-10-13 1,2,3,4-tetrahydronaphthalin-, chroman- und thiochroman-derivate als antithrombotika

Country Status (15)

Country Link
US (1) US5472979A (de)
EP (1) EP0648741B1 (de)
JP (1) JP2859138B2 (de)
AT (1) ATE146454T1 (de)
AU (1) AU676377B2 (de)
CA (1) CA2118102C (de)
CY (1) CY2141B1 (de)
DE (1) DE69401190T2 (de)
DK (1) DK0648741T3 (de)
ES (1) ES2098109T3 (de)
FR (1) FR2711139B1 (de)
GR (1) GR3022637T3 (de)
HK (1) HK64397A (de)
NZ (1) NZ264703A (de)
ZA (1) ZA948082B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9509156D0 (en) * 1995-05-05 1995-06-28 Sandoz Ltd Organic compounds
DE19647000A1 (de) * 1996-11-14 1998-05-20 Hoechst Ag 3-Amido-chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
FR2760235B1 (fr) * 1997-02-28 1999-04-09 Adir Nouveaux derives de benzenesulfonylamine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2803848B1 (fr) * 2000-01-19 2002-02-15 Adir Nouveaux derives de benzenesulfonamide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JP4490543B2 (ja) * 2000-03-07 2010-06-30 日本曹達株式会社 α−アミノケトン類の製造方法
FR2838057B1 (fr) * 2002-04-05 2005-07-08 Servier Lab Nouvelle association d'un antithrombotique et d'aspirine
FR2857593B1 (fr) * 2003-07-18 2005-10-14 Servier Lab Composition pharmaceutique orodispersible d'un compose antithrombotique
FR2860436B1 (fr) * 2003-10-03 2006-01-20 Servier Lab Nouvelle association d'un anti-atherothrombotique et d'un antiagregant plaquettaire
FR2899473B1 (fr) 2006-04-07 2008-06-13 Servier Lab Utilisation d'un compose anti-atherothrombotique pour l'obtention de medicaments destines au traitement des troubles vasculaires
FR2920772B1 (fr) 2007-09-11 2009-10-23 Servier Lab Association entre un anti-atherothrombotique et un inhibiteur de l'enzyme de conversion de l'angiotensine
EP2098511A1 (de) 2008-03-07 2009-09-09 Solvias AG Verfahren zur Herstellung von Verbindungen mit einer Hydronaphtalinstruktur mit einem asymmetrisch substituierten Benzolring
US20130190370A1 (en) * 2010-07-29 2013-07-25 The Trustees Of The University Of Pennsylvania Novel Tetrahydronaphalene Antagonists to the Thromboxane A2 (TP) Receptor
CN103102292B (zh) * 2011-11-14 2015-05-20 上海医药工业研究院 一种快速无污染由伯醇氧化为醛的方法
WO2014165633A1 (en) * 2013-04-04 2014-10-09 The Trustees Of The University Of Pennsylavania Cycloakyl-dione derivatives and methods of their use
CN108707115B (zh) * 2018-07-17 2020-09-01 成都道合尔医药技术有限公司 一种丙烯酸衍生物的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH22076A (en) * 1983-08-25 1988-05-20 Daiichi Seiyaku Co Benzocycloalkane derivative
DE3623941A1 (de) * 1986-07-16 1988-01-28 Bayer Ag Substituierte amino-5,6,7,8-tetrahydronaphthyl-oxyessigsaeuren, verfahren zu deren herstellung sowie die verwendung als arzneimittel
US5206428A (en) * 1989-11-16 1993-04-27 Tanabe Seiyaku Co., Ltd. Tetrahydronaphthalene derivatives and preparation thereof
JPH05178814A (ja) * 1991-05-14 1993-07-20 Tanabe Seiyaku Co Ltd 医薬組成物

Also Published As

Publication number Publication date
CY2141B1 (en) 2002-06-21
HK64397A (en) 1997-05-23
CA2118102A1 (fr) 1995-04-16
JPH07188155A (ja) 1995-07-25
NZ264703A (en) 1995-09-26
DE69401190D1 (de) 1997-01-30
US5472979A (en) 1995-12-05
GR3022637T3 (en) 1997-05-31
AU676377B2 (en) 1997-03-06
FR2711139B1 (fr) 1995-12-01
ZA948082B (en) 1995-06-05
DK0648741T3 (da) 1997-06-09
EP0648741A1 (de) 1995-04-19
ES2098109T3 (es) 1997-04-16
JP2859138B2 (ja) 1999-02-17
AU7582094A (en) 1995-05-11
DE69401190T2 (de) 1997-07-03
FR2711139A1 (fr) 1995-04-21
EP0648741B1 (de) 1996-12-18
CA2118102C (fr) 2000-11-07

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Legal Events

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UEP Publication of translation of european patent specification