IL88899A - 1-phenyl substituted isoquinoline derivatives, their preparation and pharmaceutical compositions containing them - Google Patents

1-phenyl substituted isoquinoline derivatives, their preparation and pharmaceutical compositions containing them

Info

Publication number
IL88899A
IL88899A IL8889989A IL8889989A IL88899A IL 88899 A IL88899 A IL 88899A IL 8889989 A IL8889989 A IL 8889989A IL 8889989 A IL8889989 A IL 8889989A IL 88899 A IL88899 A IL 88899A
Authority
IL
Israel
Prior art keywords
dimethoxy
phenyl
isoquinoline
formula
hydrogen
Prior art date
Application number
IL8889989A
Other languages
English (en)
Other versions
IL88899A0 (en
Inventor
Klaus Hasspacher
Reto Naef
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of IL88899A0 publication Critical patent/IL88899A0/xx
Publication of IL88899A publication Critical patent/IL88899A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL8889989A 1988-01-08 1989-01-06 1-phenyl substituted isoquinoline derivatives, their preparation and pharmaceutical compositions containing them IL88899A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888800397A GB8800397D0 (en) 1988-01-08 1988-01-08 Improvements in/relating to organic compounds

Publications (2)

Publication Number Publication Date
IL88899A0 IL88899A0 (en) 1989-08-15
IL88899A true IL88899A (en) 1994-07-31

Family

ID=10629678

Family Applications (1)

Application Number Title Priority Date Filing Date
IL8889989A IL88899A (en) 1988-01-08 1989-01-06 1-phenyl substituted isoquinoline derivatives, their preparation and pharmaceutical compositions containing them

Country Status (28)

Country Link
US (1) US4980359A (de)
JP (1) JPH0649686B2 (de)
KR (1) KR0142686B1 (de)
AT (1) AT394365B (de)
AU (1) AU622429B2 (de)
BE (1) BE1002730A3 (de)
CA (1) CA1332944C (de)
CH (1) CH678727A5 (de)
DE (1) DE3900233C2 (de)
DK (1) DK5789A (de)
ES (1) ES2010071A6 (de)
FI (1) FI90865C (de)
FR (1) FR2625743B1 (de)
GB (2) GB8800397D0 (de)
GR (1) GR1002750B (de)
HU (1) HU205083B (de)
IE (1) IE61914B1 (de)
IL (1) IL88899A (de)
IT (1) IT1229523B (de)
LU (1) LU87423A1 (de)
MY (1) MY103963A (de)
NL (1) NL8900029A (de)
NZ (1) NZ227561A (de)
PH (1) PH25640A (de)
PL (1) PL156099B1 (de)
PT (1) PT89405B (de)
SE (1) SE501548C2 (de)
ZA (1) ZA89133B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2723674A (en) * 1951-11-28 1955-11-15 Charles E Harris Telephone cableman's tent
US3007541A (en) * 1959-02-24 1961-11-07 Jr John B Mast Temporary covering and support structure therefor
GB8807922D0 (en) * 1988-04-05 1988-05-05 Fujisawa Pharmaceutical Co Isoquinoline compound & process for preparation thereof
US4956371A (en) * 1989-09-19 1990-09-11 Euroceltique, S.A. Substituted isoquinolines and methods of using same
GB8921304D0 (en) * 1989-09-20 1989-11-08 Wyeth John & Brother Ltd New method of treatment and heterocyclic compounds used therein
GB9027055D0 (en) * 1990-12-13 1991-02-06 Sandoz Ltd Organic compounds
KR930703259A (ko) * 1990-12-17 1993-11-29 알베르투스 빌헬무스 요아네스 쩨스트라텐 살균성 이소퀴놀린 유도체
CA2093577C (en) * 1992-05-07 2006-01-03 Michael Klaus Alkyl or alkoxy substituted s-heterocyclic retinoids
US5350423A (en) * 1992-09-23 1994-09-27 Burlington Industries Inc. Fabric finishing procedure
GB9322828D0 (en) * 1993-11-05 1993-12-22 Sandoz Ltd Organic compounds
US5783184A (en) * 1994-12-23 1998-07-21 Smithkline Beecham Corporation Method for treatment and diagnosis of IL-5 mediated disorders
JP2001523083A (ja) * 1994-12-23 2001-11-20 スミスクライン・ビーチャム・コーポレイション Ｉｌ−５により媒介される疾病の治療に有用な組み換えｉｌ−５アンタゴニスト
US7399837B2 (en) * 1995-12-22 2008-07-15 Smithkline Beecham Corporation Recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders
US5683892A (en) * 1994-12-23 1997-11-04 Smithkline Beecham Corporation DNA encoding recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders
GB9622386D0 (en) * 1996-10-28 1997-01-08 Sandoz Ltd Organic compounds
RU2174123C2 (ru) * 1996-10-28 2001-09-27 Новартис Аг Производные 8-арил-1,7-нафтиридина и фармацевтическая композиция, обладающая противовоспалительной активностью
IT1296985B1 (it) * 1997-12-19 1999-08-03 Zambon Spa Derivati benzazinici inibitori della fosfodiesterasi 4
ATE356810T1 (de) * 1999-01-15 2007-04-15 Altana Pharma Ag Polysubstituted 6-phenylphenanthridines mit pde- iv hemmender wirkung
PL200923B1 (pl) 1999-08-21 2009-02-27 Nycomed Gmbh Lek zawierający inhibitor PDE w połączeniu z agonistą receptoraß₂ -adrenergicznego oraz zastosowanie połączenia roflumilastu i salmeterolu
RU2213735C2 (ru) * 2001-09-24 2003-10-10 ГУ Институт технической химии Уральского отделения РАН Способ получения 1-замещенных 3,3-диметил-3,4-дигидроизохинолинов
AR037517A1 (es) * 2001-11-05 2004-11-17 Novartis Ag Derivados de naftiridinas, un proceso para su preparacion, composicion farmaceutica y el uso de los mismos para la preparacion de un medicamento para el tratamiento de una enfermedad inflamatoria
JP2006522151A (ja) 2003-04-01 2006-09-28 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ 不妊症におけるホスホジエステラーゼ阻害剤
WO2008134724A2 (en) * 2007-04-30 2008-11-06 Smithkline Beecham Corporation Methods for administering anti-il-5 antibodies
KR20100134702A (ko) 2008-03-28 2010-12-23 글락소스미스클라인 엘엘씨 치료 방법
AU2009303389B2 (en) 2008-10-17 2014-10-16 Wisconsin Alumni Research Foundation Method of making biologically active alpha-beta peptides
CN110913887A (zh) 2017-06-06 2020-03-24 葛兰素史克有限责任公司 用于儿科患者的生物药物组合物和方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB645139A (en) * 1946-10-22 1950-10-25 Servita Gyogyszeryar Es Vegyip Improved process for the production of isoquinoline derivatives
DE1184344B (de) * 1962-06-16 1964-12-31 Orgamol Sa Verfahren zur Herstellung von Isochinolinderivaten
US3878215A (en) * 1971-12-01 1975-04-15 Sandoz Ag 2-Alkyl-3-substituted-4-aryl isoquinolines
DE2401453A1 (de) * 1973-01-16 1974-07-18 John James Voorhees Pharmazeutische zusammensetzung zur behandlung von hautproliferationserkrankungen
US4018927A (en) * 1973-12-17 1977-04-19 The Regents Of The University Of Michigan Treatment of proliferating skin diseases with papaverine alkaloids
FI750205A7 (de) * 1974-02-05 1975-08-06 Sandoz Ag
DE2811361A1 (de) * 1978-03-16 1979-09-27 Hoechst Ag Neue isochinolinaldehyde und verfahren zu ihrer herstellung
DE3244594A1 (de) * 1982-12-02 1984-06-07 Hoechst Ag, 6230 Frankfurt 1-phenylisochinolinderivate und verfahren zu ihrer herstellung, diese verbindung enthaltende pharmazeutische praeparate und deren anwendung
HU196758B (en) * 1986-05-21 1989-01-30 Gyogyszerkutato Intezet Process for production of 3-hidroxi-methil-quinolines and medical compositions containing them
CA1330560C (en) * 1986-05-21 1994-07-05 Maurits E. A. Vandewalle Di- and tetrahydroisoquinoline derivatives

Also Published As

Publication number Publication date
MY103963A (en) 1993-10-30
SE8900039L (sv) 1989-07-09
DE3900233A1 (de) 1989-07-20
FR2625743A1 (fr) 1989-07-13
DK5789A (da) 1989-07-09
PH25640A (en) 1991-08-21
NL8900029A (nl) 1989-08-01
FI90865C (fi) 1994-04-11
FR2625743B1 (fr) 1990-11-09
GB8900102D0 (en) 1989-03-01
SE8900039D0 (sv) 1989-01-05
JPH01213267A (ja) 1989-08-28
AU622429B2 (en) 1992-04-09
GB2213482B (en) 1991-09-11
FI890072A0 (fi) 1989-01-06
HU205083B (en) 1992-03-30
FI890072A7 (fi) 1989-07-09
IL88899A0 (en) 1989-08-15
LU87423A1 (fr) 1989-08-30
PL156099B1 (pl) 1992-02-28
FI90865B (fi) 1993-12-31
US4980359A (en) 1990-12-25
GB2213482A (en) 1989-08-16
DK5789D0 (da) 1989-01-06
IT8947504A0 (it) 1989-01-04
GR1002750B (el) 1997-08-26
AU2779589A (en) 1989-07-20
DE3900233C2 (de) 2000-04-27
AT394365B (de) 1992-03-25
NZ227561A (en) 1991-11-26
CH678727A5 (de) 1991-10-31
ZA89133B (en) 1990-09-26
IE890037L (en) 1989-07-08
SE501548C2 (sv) 1995-03-13
ES2010071A6 (es) 1989-10-16
KR0142686B1 (ko) 1998-07-15
PL277092A1 (en) 1989-09-04
JPH0649686B2 (ja) 1994-06-29
PT89405B (pt) 1993-09-30
ATA3589A (de) 1991-09-15
IT1229523B (it) 1991-09-04
CA1332944C (en) 1994-11-08
GR890100008A (el) 1994-03-31
IE61914B1 (en) 1994-11-30
PT89405A (pt) 1990-02-08
BE1002730A3 (fr) 1991-05-21
KR890011851A (ko) 1989-08-22
GB8800397D0 (en) 1988-02-10
HUT52061A (en) 1990-06-28

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Legal Events

Date Code Title Description
HC Change of name of proprietor(s)
KB Patent renewed
RH1 Patent not in force