IL87947A - Forms of protection of its anti-tumor methylating agents and process for their preparation - Google Patents

Forms of protection of its anti-tumor methylating agents and process for their preparation

Info

Publication number
IL87947A
IL87947A IL8794788A IL8794788A IL87947A IL 87947 A IL87947 A IL 87947A IL 8794788 A IL8794788 A IL 8794788A IL 8794788 A IL8794788 A IL 8794788A IL 87947 A IL87947 A IL 87947A
Authority
IL
Israel
Prior art keywords
formula
compound
hereinbefore defined
divalent
reacting
Prior art date
Application number
IL8794788A
Other languages
English (en)
Hebrew (he)
Other versions
IL87947A0 (en
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of IL87947A0 publication Critical patent/IL87947A0/xx
Publication of IL87947A publication Critical patent/IL87947A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
    • A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
IL8794788A 1987-10-30 1988-10-06 Forms of protection of its anti-tumor methylating agents and process for their preparation IL87947A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11494087A 1987-10-30 1987-10-30

Publications (2)

Publication Number Publication Date
IL87947A0 IL87947A0 (en) 1989-03-31
IL87947A true IL87947A (en) 1995-05-26

Family

ID=22358378

Family Applications (2)

Application Number Title Priority Date Filing Date
IL8794788A IL87947A (en) 1987-10-30 1988-10-06 Forms of protection of its anti-tumor methylating agents and process for their preparation
IL8794688A IL87946A (en) 1987-10-30 1988-10-06 Converted Disulfides Antimicrobials and Analog Antibacterials of Components 1A, 2A, 3A, 4A, 1B, 2B, G and C of Complex LL-88233

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL8794688A IL87946A (en) 1987-10-30 1988-10-06 Converted Disulfides Antimicrobials and Analog Antibacterials of Components 1A, 2A, 3A, 4A, 1B, 2B, G and C of Complex LL-88233

Country Status (19)

Country Link
EP (2) EP0313874B1 (de)
JP (2) JP2820256B2 (de)
KR (2) KR970011385B1 (de)
AR (1) AR246083A1 (de)
AT (2) ATE104309T1 (de)
AU (2) AU612714B2 (de)
BR (1) BR1100939A (de)
CA (1) CA1321582C (de)
DE (2) DE3851682T2 (de)
DK (2) DK602488A (de)
ES (2) ES2061586T3 (de)
FI (2) FI91262C (de)
HK (2) HK131897A (de)
IE (2) IE65053B1 (de)
IL (2) IL87947A (de)
NO (2) NO173506C (de)
NZ (2) NZ226727A (de)
PT (2) PT88882B (de)
ZA (2) ZA888123B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5079233A (en) * 1987-01-30 1992-01-07 American Cyanamid Company N-acyl derivatives of the LL-E33288 antitumor antibiotics, composition and methods for using the same
US5606040A (en) * 1987-10-30 1997-02-25 American Cyanamid Company Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group
IL115770A (en) * 1989-04-14 1999-03-12 American Cyanamid Co Substituted disulfides of formula q-sp-ss-w their preparation and use for inhibiting the growth of tumours and for treating bacterial infections
GB9007384D0 (en) * 1990-04-02 1990-05-30 Duncan Ruth Coupling between polymers and other organic molecular entities utilising thiol-specific reactive groups
US5712374A (en) * 1995-06-07 1998-01-27 American Cyanamid Company Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
US5714586A (en) * 1995-06-07 1998-02-03 American Cyanamid Company Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
NZ512122A (en) 1998-11-27 2003-12-19 Darwin Discovery Ltd Compositions and methods for increasing bone mineralization
US20040009535A1 (en) 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
NZ511705A (en) * 2001-05-14 2004-03-26 Horticulture & Food Res Inst Methods and rapid immunoassay device for detecting progesterone and other steroids
CA2529623A1 (en) 2003-06-16 2005-02-17 Celltech R & D, Inc. Antibodies specific for sclerostin and methods for increasing bone mineralization
US8841092B2 (en) * 2006-08-30 2014-09-23 Wisconsin Alumni Research Foundation Reversible natural product glycosyltransferase-catalyzed reactions, compounds and related methods
KR100979928B1 (ko) * 2008-07-16 2010-09-03 한주학 수직축형 부력풍차
SI3066074T1 (sl) * 2013-11-04 2020-03-31 Pfizer Inc. Intermediati in postopki za sintetizacijo derivatov kaliheamicina
US11993625B2 (en) * 2017-01-24 2024-05-28 Pfizer, Inc. Calicheamicin derivatives and antibody drug conjugates thereof
SG11202108655TA (en) * 2019-02-15 2021-09-29 Univ Southern California Lym-1 and lym-2 antibody compositions and improved car constructs
WO2022085762A1 (ja) * 2020-10-22 2022-04-28 富士フイルム株式会社 皮膚感作性測定試薬、化合物、及び皮膚感作性の測定方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2430943A1 (fr) * 1978-07-13 1980-02-08 Toyo Jozo Kk Nouveaux derives disulfures
EP0040506B1 (de) * 1980-05-21 1986-08-20 Teijin Limited Reaktives Polymer und Verfahren zu seiner Herstellung
US4530835A (en) * 1983-07-08 1985-07-23 Warner-Lambert Company CL-1577 Antibiotic compounds and their production
CA1314245C (en) * 1984-05-23 1993-03-09 Franz Jansen Process for the preparation of conjugates in which a monovalent carboxylic ionophore is associated by means of a covalent bond with a macromolecule, which are useful as immunotoxin potentiators
DE3588213T2 (de) * 1984-11-16 1999-09-30 American Cyanamid Co., Wayne Antitumorale Antibiotika (Komplex LL-E-33288)
EP0330874A3 (de) * 1988-02-29 1989-10-18 American Cyanamid Company Antibakterielle und Antitumor-Mittel LL-E33288 epsilon-I und LL-E33288-epsilon-Br, deren Herstellungen und Zwischenprodukte
EP0342341A3 (de) * 1988-05-17 1991-07-24 American Cyanamid Company Verfahren zur Herstellung von Antitumor-Antibiotika LL-E33288 Gamma 2

Also Published As

Publication number Publication date
DK602588D0 (da) 1988-10-28
NO173506C (no) 1993-12-22
AU2448988A (en) 1989-05-04
ES2061586T3 (es) 1994-12-16
FI95204B (fi) 1995-09-29
FI95204C (fi) 1996-01-10
NZ226726A (en) 1991-08-27
AU618763B2 (en) 1992-01-09
IL87946A0 (en) 1989-03-31
FI91262C (fi) 1994-06-10
EP0313874A2 (de) 1989-05-03
KR890006244A (ko) 1989-06-12
DK602488A (da) 1989-05-01
NO176480B (no) 1995-01-02
IL87947A0 (en) 1989-03-31
IE883261L (en) 1989-04-30
CA1321582C (en) 1993-08-24
FI884983A0 (fi) 1988-10-28
HK131997A (en) 1997-10-03
PT88881B (pt) 1993-01-29
AU612714B2 (en) 1991-07-18
BR1100939A (pt) 1999-08-31
ATE104309T1 (de) 1994-04-15
IE883262L (en) 1989-04-30
KR970011385B1 (ko) 1997-07-10
NZ226727A (en) 1991-12-23
AR246083A1 (es) 1994-03-30
AU2449488A (en) 1989-05-04
IE65989B1 (en) 1995-11-29
HK131897A (en) 1997-10-03
IE65053B1 (en) 1995-10-04
NO884834L (no) 1989-05-02
JP2720933B2 (ja) 1998-03-04
DE3851682T2 (de) 1995-05-04
JP2820256B2 (ja) 1998-11-05
DE3851682D1 (de) 1994-11-03
FI884984A0 (fi) 1988-10-28
DE3889063T2 (de) 1994-12-01
DK602488D0 (da) 1988-10-28
JPH01193282A (ja) 1989-08-03
DE3889063D1 (de) 1994-05-19
ES2059464T3 (es) 1994-11-16
NO173506B (no) 1993-09-13
IL87946A (en) 1995-06-29
ZA888123B (en) 1989-07-26
EP0313874A3 (en) 1990-05-09
ZA888127B (en) 1989-07-26
EP0313874B1 (de) 1994-04-13
FI884983A (fi) 1989-05-01
NO176480C (no) 1995-04-12
KR890006245A (ko) 1989-06-12
FI91262B (fi) 1994-02-28
JPH0296599A (ja) 1990-04-09
DK174739B1 (da) 2003-10-13
EP0313873B1 (de) 1994-09-28
FI884984A (fi) 1989-05-01
DK602588A (da) 1989-05-01
PT88882B (pt) 1993-01-29
NO884833L (no) 1989-05-02
NO884834D0 (no) 1988-10-28
EP0313873A1 (de) 1989-05-03
KR0133130B1 (ko) 1998-04-17
ATE112172T1 (de) 1994-10-15
NO884833D0 (no) 1988-10-28

Similar Documents

Publication Publication Date Title
US5053394A (en) Targeted forms of methyltrithio antitumor agents
US5770701A (en) Process for preparing targeted forms of methyltrithio antitumor agents
RU2753416C2 (ru) Новые конъюгаты аманитина
JP3234980B2 (ja) 新規な二官能性化合物を含むコンジュゲートの製法
EP0313873B1 (de) Targetformer von Antitumor-Methyltrithioagenzien
IL118565A (en) Method for preparing conjugate / subject conjugate of monomeric calicamycin
EP0317957A2 (de) Wirkstoff - monoklonale Antikörper - Konjugate
RO112618B1 (ro) Medicamente conjugate continand tioeteri, procedeu de preparare a acestora, compus intermediar si compozitie farmaceutica pe baza de acesti compusi
HU210147B (en) Process for producing antibody-drug conjugates and pharmaceutical compositions containing them
EP0392384B1 (de) Targetformen von Antitumor-Methyltrithioagenzien
JP3273608B2 (ja) 治療薬の部位特異的インビボ活性化
CA1341315C (en) Targeted forms of methyltrithio antitumor agents
Goerlach et al. In vitro antitumor activity of 2'-deoxy-5-fluorouridine-monoclonal antibody conjugates
CA2014459C (en) Targeted forms of methyltrithio antitumor agents
KR0159767B1 (ko) 메틸-트리티오기를 갖는 화합물로 부터 제조된 항종양항균 물질인 치환 디설파이드, 그의 목적 형태및 그의 제조 방법

Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
KB Patent renewed
EXTN Extension order renewed