IL84833A - Morpholinoethylester of mycophenolic acid and derivatives thereof,their preparation and pharmaceutical compositions containing them - Google Patents

Morpholinoethylester of mycophenolic acid and derivatives thereof,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL84833A
IL84833A IL84833A IL8483387A IL84833A IL 84833 A IL84833 A IL 84833A IL 84833 A IL84833 A IL 84833A IL 8483387 A IL8483387 A IL 8483387A IL 84833 A IL84833 A IL 84833A
Authority
IL
Israel
Prior art keywords
pharmaceutical compositions
morpholinoethylester
derivatives
preparation
compositions containing
Prior art date
Application number
IL84833A
Other languages
English (en)
Other versions
IL84833A0 (en
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21733252&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL84833(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of IL84833A0 publication Critical patent/IL84833A0/xx
Publication of IL84833A publication Critical patent/IL84833A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Furan Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
IL84833A 1987-01-30 1987-12-15 Morpholinoethylester of mycophenolic acid and derivatives thereof,their preparation and pharmaceutical compositions containing them IL84833A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/008,717 US4753935A (en) 1987-01-30 1987-01-30 Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions

Publications (2)

Publication Number Publication Date
IL84833A0 IL84833A0 (en) 1988-06-30
IL84833A true IL84833A (en) 1992-03-29

Family

ID=21733252

Family Applications (1)

Application Number Title Priority Date Filing Date
IL84833A IL84833A (en) 1987-01-30 1987-12-15 Morpholinoethylester of mycophenolic acid and derivatives thereof,their preparation and pharmaceutical compositions containing them

Country Status (26)

Country Link
US (7) US4753935A (de)
EP (1) EP0281713B1 (de)
JP (1) JPS63188672A (de)
KR (1) KR940003758B1 (de)
AT (1) ATE68180T1 (de)
AU (1) AU599728B2 (de)
CA (1) CA1333285C (de)
DE (2) DE19675020I2 (de)
DK (1) DK166675B1 (de)
ES (1) ES2038190T3 (de)
FI (1) FI85141C (de)
GE (1) GEP20094816B (de)
GR (1) GR3002866T3 (de)
HK (1) HK125893A (de)
HU (2) HU201927B (de)
IE (1) IE60750B1 (de)
IL (1) IL84833A (de)
LU (1) LU88795I2 (de)
LV (1) LV5748B4 (de)
MX (1) MX9203163A (de)
NL (1) NL960019I2 (de)
NO (2) NO171680C (de)
NZ (1) NZ222922A (de)
PH (1) PH23819A (de)
PT (1) PT86343B (de)
ZA (1) ZA879414B (de)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
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US5177072A (en) * 1987-01-30 1993-01-05 Syntex (U.S.A.) Inc. Treatment of autoimmune inflammatory, and psoriatic diseases with heterocyclic aminoalkyl esters of mycophenolic acid and derivatives
AU632796B2 (en) * 1989-02-23 1993-01-14 University Of North Carolina At Chapel Hill, The Etoposide analogues
US5219851A (en) * 1991-03-05 1993-06-15 Warner-Lambert Company Tetrahydroisoquinoline-type renin inhibiting peptides
US5247083A (en) * 1992-07-10 1993-09-21 Syntex (U.S.A.) Inc. Direct esterification of mycophenolic acid
WO1994012184A1 (en) * 1992-11-24 1994-06-09 Syntex (U.S.A.) Inc. Use of mycophenolic acid, mycophenolate mofetil or derivate thereof to inhibit stenosis
US5455045A (en) * 1993-05-13 1995-10-03 Syntex (U.S.A.) Inc. High dose formulations
ATE185698T1 (de) * 1993-06-25 1999-11-15 Main Camp Marketing Pty Ltd Therapeutisches agens
NZ273801A (en) * 1993-09-15 1997-10-24 Syntex Inc Crystalline anhydrous mycophenolate mofetil complexed as a salt with chloride, sulphate, phosphate, or acetate anion; intravenous formulations
CZ301771B6 (cs) * 1993-10-01 2010-06-16 Syntex (U.S.A.) Llc. Farmaceutický prostredek ve forme suchého granulátu obsahující mofetil mykofenolát nebo kyselinu mykofenolovou a zpusob jeho prípravy
US5444072A (en) * 1994-02-18 1995-08-22 Syntex (U.S.A.) Inc. 6-substituted mycophenolic acid and derivatives
US5525602A (en) * 1994-02-18 1996-06-11 Syntex (U.S.A.) Inc. Method of using 4-amino 6-substituted mycophenolic acid and derivatives
US5493030A (en) * 1994-02-18 1996-02-20 Syntex (U.S.A.) Inc. 5-substituted derivatives of mycophenolic acid
US5512568A (en) * 1994-02-18 1996-04-30 Syntex (U.S.A.) Inc. Method of using 4-amino derivatives of 5-substituted mycophenolic acid
US5380879A (en) * 1994-02-18 1995-01-10 Syntex (U.S.A.) Inc. Derivatives of mycophenolic acid
US6225073B1 (en) * 1994-07-07 2001-05-01 Dade Behring Marburg Gmbh Immunoassay for mycophenolic acid
ID18663A (id) * 1996-04-12 1998-04-30 Novartis Ag Komposisi farmasi berlapis enterik
US6420403B1 (en) 1998-10-29 2002-07-16 Edwin J. Iwanowicz Inhibitors of IMPDH enzyme
JP2002528499A (ja) 1998-10-29 2002-09-03 ブリストル−マイヤーズ スクイブ カンパニー Ｉｍｐｄｈ酵素のインヒビターであるアミノ核誘導化合物
US6596747B2 (en) 1998-10-29 2003-07-22 Bristol-Myers Squibb Company Compounds derived from an amine nucleus and pharmaceutical compositions comprising same
EP1127054A4 (de) 1998-10-29 2006-11-02 Bristol Myers Squibb Co Inhibitoern des impdh-enzyms
IN188985B (de) 1998-12-09 2002-11-30 Biocon Ltd
US6514979B1 (en) 1999-03-03 2003-02-04 University Of Maryland Biotechnology Institute Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor
US6107052A (en) * 1999-06-09 2000-08-22 Roche Diagnostics Corporation Enzymatic measurement of mycophenolic acid
AU5553801A (en) * 2000-04-24 2001-11-07 Bristol Myers Squibb Co Heterocycles that are inhibitors of impdh enzyme
US6471980B2 (en) 2000-12-22 2002-10-29 Avantec Vascular Corporation Intravascular delivery of mycophenolic acid
US7179791B2 (en) * 2001-01-11 2007-02-20 Duke University Inhibiting GS-FDH to modulate NO bioactivity
GB0124953D0 (en) * 2001-10-17 2001-12-05 Novartis Ag Organic Compounds
TW200301698A (en) * 2001-12-21 2003-07-16 Bristol Myers Squibb Co Acridone inhibitors of IMPDH enzyme
EP1490090A4 (de) 2002-02-22 2006-09-20 New River Pharmaceuticals Inc Wirkstoff-abgabesystem und verfahren zum schutz und zur verabreichung von wirkstoffen
AU2003261354A1 (en) * 2002-08-02 2004-02-23 The Regents Of The University Of California New uses for inhibitors of inosine monophosphate dehydrogenase
TWI221414B (en) * 2003-02-21 2004-10-01 Chunghwa Chemical Synthesis & Method of making mycophenolate mofetil using transesterification
GB0307553D0 (en) * 2003-04-01 2003-05-07 Novartis Ag Organic compounds
AU2003231924A1 (en) * 2003-04-07 2004-11-01 Biocon Limited Microwave synthesis of mycophenolate
CN100562314C (zh) * 2003-05-14 2009-11-25 帝斯曼知识产权资产管理有限公司 苯并呋喃酮衍生物用于治疗和预防糖尿病的用途
US20050187170A1 (en) * 2003-06-16 2005-08-25 Biocryst Pharmaceuticals, Inc. Enhancing the efficiency of RNA polymerase inhibitors by using inosine monophosphate dehydrogenase inhibitors
WO2005023791A2 (en) * 2003-09-11 2005-03-17 Sandoz Ag Process for the production of mycophenolate mofetil
EP1662906A1 (de) * 2003-09-23 2006-06-07 DSM IP Assets B.V. Zusammensetzungen für die behandlung und vorbeugung von diabetes mellitus
WO2005033089A1 (en) * 2003-10-07 2005-04-14 Biocon Limited Salt of 6-(1, 3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid with n, n-dimethyl-imidodicarbonimidic diamide
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EP1675841A1 (de) * 2004-04-27 2006-07-05 Teva Gyógyszergyár Zártköruen Muködo Részvenytarsaság Verfahren zur herstellung von mykophenolatmofetil und anderen estern von mykophenolsäure
EP1768662A2 (de) 2004-06-24 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Immunstimulatoren kleiner moleküle und assays für deren nachweis
ATE461182T1 (de) * 2004-07-20 2010-04-15 Teva Gyogyszergyar Zartkoeruen Kristallines mycophenolat-natrium
WO2006017896A1 (en) * 2004-08-16 2006-02-23 The University Of Queensland Metabolism-modulating agents and uses therefor
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WO2006086500A2 (en) * 2005-02-08 2006-08-17 Aspreva Pharmaceuticals Sa Compositions and methods for treating vascular, autoimmune and inflammatory diseases
US20060235009A1 (en) * 2005-02-08 2006-10-19 Richard Glickman Treatment of vascular, autoimmune and inflammatory diseases using low dosages of IMPDH inhibitors
US20080281111A1 (en) * 2005-04-26 2008-11-13 Sandor Molnar Process for preparation of mycophenolate mofetil and other esters of mycophenolic acid
CN100402516C (zh) * 2005-10-18 2008-07-16 深圳市东阳光实业发展有限公司 一种霉酚酸莫啡酯的制备方法
KR20080094788A (ko) * 2006-02-13 2008-10-24 노파르티스 아게 고복용량의 미코페놀산(엠피에이)
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US20080161324A1 (en) * 2006-09-14 2008-07-03 Johansen Lisa M Compositions and methods for treatment of viral diseases
US20080188653A1 (en) 2007-02-04 2008-08-07 Formosa Laboratories, Inc. Process for Preparation of Mycophenolate Mofetil
CN100484930C (zh) * 2007-03-16 2009-05-06 重庆大新药业股份有限公司 一种吗替麦考酚酯的制备方法
WO2009000834A1 (en) * 2007-06-27 2008-12-31 Dsm Ip Assets B.V. Method for the purification of mycophenolate mofetil
WO2009010503A1 (en) * 2007-07-18 2009-01-22 Dsm Ip Assets B.V. Mycophenolic acid recycling in a method for the preparation of mycophenolate mofetil
US20090076000A1 (en) * 2007-09-15 2009-03-19 Protia, Llc Deuterium-enriched mycophenolate mofetil
TW200932240A (en) 2007-10-25 2009-08-01 Astellas Pharma Inc Pharmaceutical composition containing lipophilic substance which inhibits IL-2 production
WO2009084008A1 (en) * 2007-12-28 2009-07-09 Cadila Healthcare Limited Process for preparing mycophenolate mofetil
KR100975520B1 (ko) * 2008-02-01 2010-08-12 종근당바이오 주식회사 마이코페놀레이트 모페틸의 개선된 제조방법
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
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US8716263B2 (en) 2008-12-23 2014-05-06 Gilead Pharmasset Llc Synthesis of purine nucleosides
CN102753563A (zh) * 2008-12-23 2012-10-24 吉利德制药有限责任公司 核苷类似物
FI124873B (fi) 2009-10-06 2015-02-27 Maricap Oy Menetelmä ja laitteisto pneumaattisessa materiaalinsiirtojärjestelmässä
FI20096026L (fi) 2009-10-06 2011-04-07 Maricap Oy Menetelmä ja laitteisto pneumaattisessa materiaalinsiirtojärjestelmässä
EA026341B9 (ru) 2010-03-31 2021-12-27 ГАЙЛИД ФАРМАССЕТ ЭлЭлСи Кристаллическая форма нуклеозидфосфорамидата
GB201100786D0 (en) 2011-01-18 2011-03-02 Ems Sa Pharmaceutical compositions of immunosuppressants
CN102952105A (zh) * 2011-08-26 2013-03-06 中国科学院上海药物研究所 一类霉酚酸衍生物、其制备方法和用途
WO2013041205A1 (de) 2011-09-19 2013-03-28 Pyxirion Pharma Gmbh Neue therapeutische konzepte zur behandlung von gefässerkrankungen
US8669281B1 (en) 2013-03-14 2014-03-11 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
ES2955137T3 (es) 2013-03-14 2023-11-28 Alkermes Pharma Ireland Ltd Profármacos de fumaratos y su uso en el tratamiento de diversas enfermedades
WO2015013422A1 (en) * 2013-07-23 2015-01-29 University Of Tennessee Research Foundation Immunosuppressive compounds and therapeutics
EP3093662B1 (de) * 2014-01-10 2019-05-15 Fujifilm Corporation Vorhersageverfahren und vorhersagevorrichtung für wirksame dosis/sensitivität von 5-hydroxy-1h-imidazol-4-carboxamid, xanthosin-monophosphat-mengenmessverfahren und behandlungsmittel und behandlungsverfahren für myelodysplastisches syndrom
CA2940845C (en) 2014-02-24 2019-09-24 Alkermes Pharma Ireland Limited Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases
US12011429B2 (en) 2016-06-02 2024-06-18 Steven Baranowitz Prevention and treatment of viral infections
CA3026241A1 (en) 2016-06-02 2017-12-07 Steven Baranowitz Prevention and treatment of viral infections
US10603299B2 (en) 2016-06-02 2020-03-31 Steven Baranowitz Prevention and treatment of viral infections
US11918684B2 (en) 2017-03-13 2024-03-05 Liqmeds Worldwide Limited Pharmaceutical composition of oral suspension of immunosuppressive agents
US10835489B2 (en) * 2018-03-09 2020-11-17 University Of Saskatchewan Modified release formulations of mycophenolate mofetil
EP3836898A2 (de) 2018-08-18 2021-06-23 FTF Pharma Private Limited Pharmazeutische suspension zur oralen verabreichung
CN110526885A (zh) * 2019-08-20 2019-12-03 上海英诺富成生物科技有限公司 麦考酚酸的前体药物及其制备方法
CN113549040B (zh) * 2020-04-23 2024-08-06 鲁南制药集团股份有限公司 一种吗替麦考酚酯杂质d的制备方法
CN112121173B (zh) * 2020-08-22 2022-05-06 浙江大学 脂肪酸修饰的免疫抑制剂mmf及fk506纳米制剂及其制备方法和应用
IL305524A (en) 2021-03-03 2023-10-01 Sana Biotechnology Inc Immunosuppressive therapies for use with cardiomyocyte cell therapies, and associated methods and compositions

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GB1261060A (en) * 1969-09-09 1972-01-19 Ici Ltd Phthalen-1-one derivatives
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US3868454A (en) * 1972-08-14 1975-02-25 Lilly Co Eli Psoriasis treatment with mycophenolic acid derivatives
US3777020A (en) * 1972-08-14 1973-12-04 Lilly Co Eli Psoriasis treatment with mycophenolic acid
US3880995A (en) * 1973-05-14 1975-04-29 Lilly Co Eli Treatment of arthritis with mycophenolic acid and derivatives
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Also Published As

Publication number Publication date
ATE68180T1 (de) 1991-10-15
HU201927B (en) 1991-01-28
HUT47567A (en) 1989-03-28
HK125893A (en) 1993-11-19
KR940003758B1 (ko) 1994-04-30
LV5748A4 (lv) 1996-10-20
IE873397L (en) 1988-07-30
US4948793A (en) 1990-08-14
FI875502A0 (fi) 1987-12-15
LV5748B4 (lv) 1997-02-20
KR880009016A (ko) 1988-09-13
US4808592A (en) 1989-02-28
IL84833A0 (en) 1988-06-30
US4786637A (en) 1988-11-22
GR3002866T3 (en) 1993-01-25
FI875502L (fi) 1988-07-31
NZ222922A (en) 1990-09-26
DE19675020I2 (de) 2002-11-07
MX9203163A (es) 1992-07-31
US4952579A (en) 1990-08-28
LU88795I2 (fr) 1996-11-05
AU599728B2 (en) 1990-07-26
AU8254087A (en) 1988-08-04
US4753935A (en) 1988-06-28
JPH0571591B2 (de) 1993-10-07
PH23819A (en) 1989-11-23
NO875240D0 (no) 1987-12-15
GEP20094816B (en) 2009-11-10
PT86343B (pt) 1991-02-08
US4992467A (en) 1991-02-12
NL960019I1 (nl) 1996-10-01
NO171680B (no) 1993-01-11
US4868153A (en) 1989-09-19
IE60750B1 (en) 1994-08-10
EP0281713B1 (de) 1991-10-09
ZA879414B (en) 1989-08-30
NL960019I2 (nl) 1997-06-02
FI85141B (fi) 1991-11-29
FI85141C (fi) 1992-03-10
NO1997007I1 (no) 1997-07-01
DK658787D0 (da) 1987-12-15
HU210350A9 (en) 1995-03-28
PT86343A (en) 1988-01-01
DK166675B1 (da) 1993-06-28
NO875240L (no) 1988-08-01
ES2038190T3 (es) 1993-07-16
CA1333285C (en) 1994-11-29
DE3773660D1 (de) 1991-11-14
DK658787A (da) 1988-07-31
JPS63188672A (ja) 1988-08-04
NO171680C (no) 1993-04-21
EP0281713A1 (de) 1988-09-14

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