IL65922A - Preparation of apovincaminic acid esters,certain novel optically active trans-derivatives thereof and pharmaceutical compositions containing them - Google Patents
Preparation of apovincaminic acid esters,certain novel optically active trans-derivatives thereof and pharmaceutical compositions containing themInfo
- Publication number
- IL65922A IL65922A IL65922A IL6592282A IL65922A IL 65922 A IL65922 A IL 65922A IL 65922 A IL65922 A IL 65922A IL 6592282 A IL6592282 A IL 6592282A IL 65922 A IL65922 A IL 65922A
- Authority
- IL
- Israel
- Prior art keywords
- derivatives
- preparation
- pharmaceutical compositions
- acid esters
- optically active
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL72955A IL72955A0 (en) | 1981-06-12 | 1984-09-14 | Racemic cis and trans hydroxy-iminooctahydroindolo(2,3-a)-quinolizine derivatives,the corresponding optically active derivatives and acid addition salts,their preparation and pharmaceutical compositions containing them |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU811753A HU186891B (en) | 1981-06-12 | 1981-06-12 | Process for producing esters of apovincaminic acid |
Publications (2)
Publication Number | Publication Date |
---|---|
IL65922A0 IL65922A0 (en) | 1982-08-31 |
IL65922A true IL65922A (en) | 1985-07-31 |
Family
ID=10956018
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL65922A IL65922A (en) | 1981-06-12 | 1982-05-31 | Preparation of apovincaminic acid esters,certain novel optically active trans-derivatives thereof and pharmaceutical compositions containing them |
Country Status (24)
Country | Link |
---|---|
US (1) | US4474960A (sv) |
JP (2) | JPS5843971A (sv) |
AT (1) | AT382619B (sv) |
AU (2) | AU551445B2 (sv) |
BE (1) | BE893492A (sv) |
CA (1) | CA1258071A (sv) |
CH (2) | CH656128A5 (sv) |
DE (1) | DE3222096A1 (sv) |
DK (1) | DK152651C (sv) |
ES (3) | ES8400433A1 (sv) |
FI (1) | FI71142C (sv) |
FR (2) | FR2507605B1 (sv) |
GB (2) | GB2102415B (sv) |
GE (1) | GEP19970819B (sv) |
GR (1) | GR76494B (sv) |
HU (1) | HU186891B (sv) |
IL (1) | IL65922A (sv) |
IT (1) | IT1200961B (sv) |
NL (1) | NL192452C (sv) |
NO (1) | NO821954L (sv) |
PT (1) | PT75042B (sv) |
SE (2) | SE450383B (sv) |
SU (2) | SU1258326A3 (sv) |
ZA (1) | ZA823873B (sv) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU182411B (en) * | 1981-11-03 | 1984-01-30 | Richter Gedeon Vegyeszet | Process for preparing eburnamonine derivatives |
HU191454B (en) * | 1984-10-05 | 1987-02-27 | Richter Gedeon Vegyeszeti Gyar Rt.,Hu | Process for producing amides of oktahydro-indolo/2,3-a/quinolyzin-1-yl-alkanecarboxylic acids and pharmaceutically acceptable acid additional salts thereof |
HU198207B (en) * | 1985-04-19 | 1989-08-28 | Richter Gedeon Vegyeszet | Process for production of derivatives of eburnamenin and medical compositions containing them |
JPH0438474Y2 (sv) * | 1986-04-30 | 1992-09-09 | ||
JPS63164190U (sv) * | 1987-02-18 | 1988-10-26 | ||
US5122607A (en) * | 1989-06-21 | 1992-06-16 | Richter Gedeon Vegyesczeti Gyar Rt. | Racemic and optically active octahydro-indolo(2,3-a) tetrahydropyranyl (2,3-c) quinolizine diester derivatives and process for preparing the same |
HU214600B (hu) * | 1995-12-22 | 1998-04-28 | Richter Gedeon Vegyészeti Gyár Rt. | Transz-apovinkaminsav-észter-származékok, az azokat tartalmazó gyógyszerkészítmények és eljárás ezek előállítására |
ES2429132T3 (es) * | 2001-08-31 | 2013-11-13 | The Rockefeller University | Atividad de fosfodiesterasa y regulación de la señalización mediada por fosfodiesterasa 1-B en el cerebro |
WO2011016861A2 (en) | 2009-08-05 | 2011-02-10 | Intra-Cellular Therapies, Inc. | Novel regulatory proteins and inhibitors |
WO2018069312A1 (en) * | 2016-10-11 | 2018-04-19 | Deutsches Zentrum Für Neurodegenerative Erkrankungen E. V. (Dzne) | Treatment of synucleinopathies |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3770724A (en) * | 1970-03-31 | 1973-11-06 | Roussel Uclaf | Process for preparing pentacyclic alkaloids |
HU163143B (sv) * | 1971-05-07 | 1973-06-28 | ||
US4033969A (en) * | 1972-06-19 | 1977-07-05 | Agence Nationale De Valorisation De La Recherche (Anvar) | Vincamine derivatives |
US4033960A (en) * | 1973-07-31 | 1977-07-05 | Bayer Aktiengesellschaft | 2-Mercaptoquinoxaline-di-N-oxide products and a method for their preparation |
AU499923B2 (en) * | 1975-06-27 | 1979-05-03 | Richter Gedeon Vegyeszeti Gyar N | Indoloquinolizine derivatives & their production |
FR2389625B1 (sv) * | 1977-05-06 | 1980-04-18 | Roussel Uclaf | |
FR2459799A1 (fr) * | 1979-06-22 | 1981-01-16 | Synthelabo | Synthese de la ()-vincamine |
AU532001B2 (en) * | 1978-11-20 | 1983-09-15 | Sumitomo Chemical Company, Limited | Polycyclic indole derivatives |
JPS55100383A (en) * | 1979-01-25 | 1980-07-31 | Sumitomo Chem Co Ltd | Preparation of novel nitrogen-containing polycyclic compound |
HU181495B (en) * | 1979-05-31 | 1983-07-28 | Richter Gedeon Vegyeszet | Process for producing hydroxy-imino-eburnane derivatives |
HU180927B (en) * | 1979-07-13 | 1983-05-30 | Richter Gedeon Vegyeszet | Process for producing 1k-hydroximino-e-homoe-eburane de rivatives |
FR2468605A1 (fr) * | 1979-10-30 | 1981-05-08 | Richter Gedeon Vegyeszet | Procede de preparation d'ester de l'acide apovincaminique |
HU182380B (en) * | 1981-09-30 | 1983-12-28 | Richter Gedeon Vegyeszet | Process for producing esters of vincaminic acid |
-
1981
- 1981-06-12 HU HU811753A patent/HU186891B/hu not_active IP Right Cessation
-
1982
- 1982-05-31 IL IL65922A patent/IL65922A/xx not_active IP Right Cessation
- 1982-06-02 FI FI821963A patent/FI71142C/fi not_active IP Right Cessation
- 1982-06-02 ZA ZA823873A patent/ZA823873B/xx unknown
- 1982-06-08 GR GR68366A patent/GR76494B/el unknown
- 1982-06-09 SE SE8203580A patent/SE450383B/sv not_active IP Right Cessation
- 1982-06-09 PT PT75042A patent/PT75042B/pt not_active IP Right Cessation
- 1982-06-10 CH CH3597/82A patent/CH656128A5/de not_active IP Right Cessation
- 1982-06-10 CH CH5868/84A patent/CH659474A5/de not_active IP Right Cessation
- 1982-06-10 FR FR8210103A patent/FR2507605B1/fr not_active Expired
- 1982-06-11 AU AU84798/82A patent/AU551445B2/en not_active Ceased
- 1982-06-11 NL NL8202396A patent/NL192452C/nl not_active IP Right Cessation
- 1982-06-11 ES ES513016A patent/ES8400433A1/es not_active Expired
- 1982-06-11 AT AT0227182A patent/AT382619B/de not_active IP Right Cessation
- 1982-06-11 GB GB08217030A patent/GB2102415B/en not_active Expired
- 1982-06-11 NO NO821954A patent/NO821954L/no unknown
- 1982-06-11 SU SU3452054A patent/SU1258326A3/ru active
- 1982-06-11 DE DE19823222096 patent/DE3222096A1/de not_active Withdrawn
- 1982-06-11 US US06/387,676 patent/US4474960A/en not_active Expired - Lifetime
- 1982-06-11 BE BE0/208331A patent/BE893492A/fr not_active IP Right Cessation
- 1982-06-11 DK DK262982A patent/DK152651C/da not_active IP Right Cessation
- 1982-06-11 IT IT67752/82A patent/IT1200961B/it active
- 1982-06-12 JP JP57099997A patent/JPS5843971A/ja active Pending
- 1982-12-14 FR FR8220957A patent/FR2515653B1/fr not_active Expired
-
1983
- 1983-02-22 SU SU833557652A patent/SU1376947A3/ru active
- 1983-06-11 CA CA000405030A patent/CA1258071A/en not_active Expired
- 1983-06-16 ES ES523345A patent/ES523345A0/es active Granted
-
1984
- 1984-11-30 ES ES538125A patent/ES8604581A1/es not_active Expired
-
1985
- 1985-01-07 GB GB08500325A patent/GB2151629B/en not_active Expired
-
1986
- 1986-03-13 AU AU54712/86A patent/AU568790B2/en not_active Ceased
-
1987
- 1987-01-02 SE SE8700015A patent/SE461654B/sv not_active IP Right Cessation
-
1991
- 1991-09-26 JP JP3317577A patent/JPH0714932B2/ja not_active Expired - Lifetime
-
1993
- 1993-07-07 GE GEAP1993974A patent/GEP19970819B/en unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL59407A (en) | Di-n-propylacetic acid diesters of glycerol,their preparation and pharmaceutical compositions containing them | |
IL56991A (en) | 4-halo-3-oxoandrost-4-ene-17 beta-thiocarboxylic acid esters,their preparation and pharmaceutical compositions containing them | |
IL64573A (en) | Derivatives of formylphenoxyalkanoic acids and formylphenoxymethylbenzoic acids,their preparation and pharmaceutical formulations containing them | |
SG6885G (en) | 2-hydroxy-5-phenylazobenzoic acid derivatives and pharmaceutical compositions containing them | |
AU588968B2 (en) | Pyrrolidineamide derivative of acylamino acid and pharmaceutical composition containing the same | |
IL79025A0 (en) | Quinolonecarboxylic acid esters,their preparation and pharmaceutical compositions containing them | |
IL73427A (en) | 5-substituted-3-(hetero)aralkyl-oxazolidine-2-carboxylic acid esters,their preparation and pharmaceutical compositions containing them | |
JPS56154417A (en) | Use of 3,3'-azobis -(6-hydroxybenzoic acid) as drug and pharmaceutical composition containing it | |
IL65922A (en) | Preparation of apovincaminic acid esters,certain novel optically active trans-derivatives thereof and pharmaceutical compositions containing them | |
GB2191483B (en) | New retinoic acid esters of antibiotics , process for the preparation thereof and pharmaceutical and cosmetic compositions containing them | |
AU537560B2 (en) | Phenyl-alkanoic acid derivatives and their preparation and pharmaceutical compositions containing them | |
JPS57183736A (en) | Novel derivative of phenylaliphatic carboxylic acid, manufacture, use as drug and composition containing same | |
PT82339A (en) | Process for the preparation of novel androstane-17beta-carboxylic acid esters and of pharmaceutical compositions containing the same | |
IL79181A0 (en) | 3-(substituted)propenylaminothiazolylcephalosporanic acids and esters thereof,their preparation and pharmaceutical compositions containing them | |
IL84877A0 (en) | Pharmaceutical compositions containing 13-cis-retinoic acid | |
IL59514A (en) | 6beta-iodo-substituted penicillanic acid and esters,their preparation and pharmaceutical compositions containing them | |
GB2081708B (en) | Novel derivatives of (1-benzyl-1h-indazol-3-yl) oxyacetic acid and pharmaceutical composition containing it | |
PT86776A (pt) | Process for the preparation of piperazinecarboxylic acid and pharmaceutical compositions containing it | |
DE2967551D1 (en) | 5(6)-(2-amino-5-thiazoloyl)benzimidazole-2-carbamic acid esters and their salts, their preparation and use, and pharmaceutical compositions containing them | |
IL65396A0 (en) | Esters of mercapto acyl-carnitines,process for their preparation and pharmaceutical compositions containing same | |
PT72899B (en) | Monohydrated isopthalic acid picolylamide process of preparation and pharmaceutical use thereof | |
PT76949B (en) | Process for the preparation of racemic and optically active apovincaminic acid derivatives and pharmaceutical compositions containing them | |
IL70606A (en) | Esters of 2-carbamoyloxymethyl-6-hydroxyethyl-2-penem-3-carboxylic acid,their preparation and pharmaceutical compositions containing them | |
PT76951B (en) | Process for the preparation of racemic or optically active eburnane-oxime derivatives and pharmaceutical compositions containing them | |
IL64808A (en) | Apovincaminol esters of 3,4,5-trimethoxybenzoic acid,their preparation and pharmaceutical compositions containing them |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
KB | Patent renewed | ||
RH | Patent void |