IL47860A - 5,9 -disubstituted 2-tetrahydrofuryl-6,7-benzomorphans andns containing them - Google Patents

5,9 -disubstituted 2-tetrahydrofuryl-6,7-benzomorphans andns containing them

Info

Publication number
IL47860A
IL47860A IL47860A IL4786075A IL47860A IL 47860 A IL47860 A IL 47860A IL 47860 A IL47860 A IL 47860A IL 4786075 A IL4786075 A IL 4786075A IL 47860 A IL47860 A IL 47860A
Authority
IL
Israel
Prior art keywords
andns
benzomorphans
tetrahydrofuryl
disubstituted
benzomorphans andns
Prior art date
Application number
IL47860A
Other languages
English (en)
Other versions
IL47860A0 (en
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Publication of IL47860A0 publication Critical patent/IL47860A0/xx
Publication of IL47860A publication Critical patent/IL47860A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL47860A 1974-08-05 1975-08-04 5,9 -disubstituted 2-tetrahydrofuryl-6,7-benzomorphans andns containing them IL47860A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2437610A DE2437610A1 (de) 1974-08-05 1974-08-05 Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung

Publications (2)

Publication Number Publication Date
IL47860A0 IL47860A0 (en) 1975-11-25
IL47860A true IL47860A (en) 1979-01-31

Family

ID=5922448

Family Applications (1)

Application Number Title Priority Date Filing Date
IL47860A IL47860A (en) 1974-08-05 1975-08-04 5,9 -disubstituted 2-tetrahydrofuryl-6,7-benzomorphans andns containing them

Country Status (27)

Country Link
US (1) US3982005A (ro)
JP (1) JPS60358B2 (ro)
AT (1) AT348140B (ro)
BE (1) BE832099R (ro)
BG (3) BG25089A3 (ro)
CA (1) CA1049008A (ro)
CH (7) CH613963A5 (ro)
CS (1) CS189717B2 (ro)
DD (1) DD122685A5 (ro)
DE (1) DE2437610A1 (ro)
DK (1) DK138992C (ro)
ES (6) ES452768A1 (ro)
FI (1) FI63229C (ro)
FR (1) FR2320096A2 (ro)
GB (1) GB1513950A (ro)
HU (1) HU177952B (ro)
IE (1) IE42216B1 (ro)
IL (1) IL47860A (ro)
LU (1) LU73138A1 (ro)
NL (1) NL7509249A (ro)
NO (1) NO143460C (ro)
PH (1) PH13687A (ro)
PL (3) PL99838B1 (ro)
RO (3) RO67390A (ro)
SE (1) SE425392B (ro)
SU (3) SU591147A3 (ro)
ZA (1) ZA754997B (ro)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4087532A (en) * 1974-03-09 1978-05-02 Boehringer Ingelheim Gmbh Analgesically useful 2-tetrahydrofurfuryl-5-lower alkyl-2-oxy-6,7-benzomorphans and salts thereof
GB1575009A (en) * 1976-06-21 1980-09-17 Acf Chemiefarma Nv 6,7-benzomorphan derivatives
DE2716687A1 (de) * 1977-04-15 1978-10-19 Boehringer Sohn Ingelheim 2'-hydroxy-2-(5-isoxazolylmethyl)-6,7benzomorphane, deren saeureadditionssalze und diese enthaltende arzneimittel
NL7804509A (nl) * 1978-04-26 1979-10-30 Acf Chemiefarma Nv Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan.
DE2828039A1 (de) * 1978-06-26 1980-01-10 Boehringer Sohn Ingelheim 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung
JPS5636521A (en) * 1979-08-31 1981-04-09 Shin Etsu Chem Co Ltd Production of alkenyloxy group-containing organopolysiloxane
ES2395081T3 (es) 2007-07-26 2013-02-08 Vitae Pharmaceuticals, Inc. Síntesis de inhibidores de la 11beta-hidroxiesteroide deshidrogenasa de tipo 1
EP2220048B1 (en) 2007-11-16 2017-01-25 Boehringer Ingelheim International GmbH Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
WO2009075835A1 (en) 2007-12-11 2009-06-18 Vitae Pharmaceutical, Inc CYCLIC UREA INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE 1
TW200934490A (en) 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
CA2712500A1 (en) 2008-01-24 2009-07-30 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2009102460A2 (en) 2008-02-15 2009-08-20 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8569292B2 (en) 2008-05-01 2013-10-29 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
JP5538365B2 (ja) 2008-05-01 2014-07-02 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤
EP2300461B1 (en) 2008-05-01 2013-04-17 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8765780B2 (en) 2008-05-13 2014-07-01 Boehringer Ingelheim International Gmbh Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use
RU2539979C2 (ru) 2008-07-25 2015-01-27 Вайтаи Фармасьютиклз, Инк. Циклические ингибиторы 11бета-гидроксистероид-дегидрогеназы 1
JP5777030B2 (ja) 2008-07-25 2015-09-09 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング １１β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤
UA109255C2 (ru) 2009-04-30 2015-08-10 Берінгер Інгельхайм Інтернешнл Гмбх Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1
EP2440537A1 (en) 2009-06-11 2012-04-18 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
TWI531571B (zh) 2009-11-06 2016-05-01 維它藥物公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜芳基羰基衍生物
WO2011159760A1 (en) 2010-06-16 2011-12-22 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
TWI537258B (zh) 2010-11-05 2016-06-11 百靈佳殷格翰國際股份有限公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
EP2744783A1 (en) 2011-08-17 2014-06-25 Boehringer Ingelheim International GmbH Indenopyridine derivatives
US20240002606A1 (en) 2020-11-26 2024-01-04 Shin-Etsu Chemical Co., Ltd. Room temperature curable organopolysiloxane composition, article, hydrolyzable organosilane compound and method for producing same
KR20240052040A (ko) 2021-09-03 2024-04-22 신에쓰 가가꾸 고교 가부시끼가이샤 오르가노폴리실록산 화합물, 실온 경화성 오르가노폴리실록산 조성물 및 물품

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE582575A (ro) * 1958-09-22
US3700734A (en) * 1969-01-23 1972-10-24 Merck & Co Inc 2{40 -hydroxy-2,3,5-trimethyl-6,7-benzomorphan
DE2105743C3 (de) * 1971-02-08 1979-11-29 Boehringer Sohn Ingelheim 2-(Furylmethyl)- a -5,9-dialkyl -6,7benzomorphane, Verfahren zu ihrer Herstellung und deren Verwendung
CS166804B2 (ro) * 1971-02-08 1976-03-29 Boehringer Sohn Ingelheim
DE2200596A1 (de) * 1972-01-07 1973-07-12 Boehringer Sohn Ingelheim N-(furyl-methyl)-2'-hydroxy-5-phenyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung
DE2217420C3 (de) * 1972-04-12 1981-03-12 C.H. Boehringer Sohn, 6507 Ingelheim N-Thienylmethyl-Heterocyclen, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zubereitungen
DE2229695A1 (de) * 1972-06-19 1974-01-31 Boehringer Sohn Ingelheim 2-(heteroaryl-methyl)-5,9 beta-dialkyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung

Also Published As

Publication number Publication date
BG25089A3 (en) 1978-07-12
CS189717B2 (en) 1979-04-30
PL99816B1 (pl) 1978-08-31
NO143460C (no) 1981-02-18
AT348140B (de) 1979-01-25
CH616420A5 (ro) 1980-03-31
FI63229B (fi) 1983-01-31
BG25090A3 (en) 1978-07-12
DK138992C (da) 1979-04-30
CH615680A5 (ro) 1980-02-15
RO72736A (ro) 1982-09-09
ES452764A1 (es) 1977-10-16
ES452768A1 (es) 1977-10-01
CA1049008A (en) 1979-02-20
IE42216L (en) 1976-02-05
JPS60358B2 (ja) 1985-01-07
IL47860A0 (en) 1975-11-25
FI752211A (ro) 1976-02-06
SU591147A3 (ru) 1978-01-30
FR2320096B2 (ro) 1978-09-01
BG25088A3 (en) 1978-07-12
ES452763A1 (es) 1977-10-01
ZA754997B (en) 1977-04-27
LU73138A1 (ro) 1977-04-13
SU587859A3 (ru) 1978-01-05
RO72735A (ro) 1982-09-09
NO143460B (no) 1980-11-10
NO752731L (ro) 1976-02-06
AU8364675A (en) 1977-02-10
ES452767A1 (es) 1977-10-01
ES452765A1 (es) 1977-10-16
CH615678A5 (ro) 1980-02-15
PL99819B1 (pl) 1978-08-31
CH613963A5 (ro) 1979-10-31
DD122685A5 (ro) 1976-10-20
FI63229C (fi) 1983-05-10
PH13687A (en) 1980-09-01
RO67390A (ro) 1981-06-30
CH615679A5 (ro) 1980-02-15
GB1513950A (en) 1978-06-14
JPS5139673A (en) 1976-04-02
CH615677A5 (ro) 1980-02-15
NL7509249A (nl) 1976-02-09
SU587858A3 (ru) 1978-01-05
ATA523775A (de) 1978-06-15
SE425392B (sv) 1982-09-27
FR2320096A2 (fr) 1977-03-04
DE2437610A1 (de) 1976-02-26
BE832099R (fr) 1976-02-04
SE7508789L (sv) 1976-02-10
HU177952B (en) 1982-02-28
CH616421A5 (ro) 1980-03-31
US3982005A (en) 1976-09-21
IE42216B1 (en) 1980-07-02
PL99838B1 (pl) 1978-08-31
ES452766A1 (es) 1977-10-01
DK352875A (da) 1976-02-06
DK138992B (da) 1978-11-27

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