IL41034A - 6-aza-3h-1,4-benzodiazepines and 6-aza-1,2-dihydro-3h-1,4-benzodiazepines their preparation and pharmaceutical compositions containing them - Google Patents
6-aza-3h-1,4-benzodiazepines and 6-aza-1,2-dihydro-3h-1,4-benzodiazepines their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL41034A IL41034A IL41034A IL4103472A IL41034A IL 41034 A IL41034 A IL 41034A IL 41034 A IL41034 A IL 41034A IL 4103472 A IL4103472 A IL 4103472A IL 41034 A IL41034 A IL 41034A
- Authority
- IL
- Israel
- Prior art keywords
- alkyl
- carbon
- compound according
- compound
- benzodiazepines
- Prior art date
Links
- RHUHLVLFKDUQLC-UHFFFAOYSA-N 2,3-dihydro-1h-pyrido[3,2-e][1,4]diazepine Chemical class N1CCN=CC2=NC=CC=C21 RHUHLVLFKDUQLC-UHFFFAOYSA-N 0.000 title 1
- BTQDZLVHRYXJDK-UHFFFAOYSA-N 3h-pyrido[3,2-e][1,4]diazepine Chemical class C1=NCC=NC2=CC=CN=C21 BTQDZLVHRYXJDK-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 11
- 125000000217 alkyl group Chemical group 0.000 claims 10
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 9
- 229910052799 carbon Inorganic materials 0.000 claims 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 3
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 239000011737 fluorine Substances 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 125000004423 acyloxy group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000000278 alkyl amino alkyl group Chemical group 0.000 claims 1
- 125000001589 carboacyl group Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- -1 salts compound Chemical class 0.000 claims 1
- 229940125725 tranquilizer Drugs 0.000 claims 1
- 239000003204 tranquilizing agent Substances 0.000 claims 1
- 230000002936 tranquilizing effect Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/57—Nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL44720A IL44720A (en) | 1972-12-08 | 1974-04-26 | 5-phenyl-6-aza-7-amino-1,2-dihydro-3h1,4-benzodiazepin-2-one derivatives,their preparation and pharmaceutical compositions containing them |
| IL44888A IL44888A (en) | 1972-12-08 | 1974-05-23 | 6-aza-3h-1,4-benzodiazepines,their preparation and pharmacceutical compositions containing them |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT1060471A AT333284B (de) | 1971-12-09 | 1971-12-09 | Verfahren zur herstellung von neuen 6-aza-3h-1,4-benzodiazepinen, deren optischen isomeren und deren salzen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL41034A0 IL41034A0 (en) | 1973-02-28 |
| IL41034A true IL41034A (en) | 1976-10-31 |
Family
ID=3623479
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL41034A IL41034A (en) | 1971-12-09 | 1972-12-08 | 6-aza-3h-1,4-benzodiazepines and 6-aza-1,2-dihydro-3h-1,4-benzodiazepines their preparation and pharmaceutical compositions containing them |
Country Status (26)
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2364636C2 (de) * | 1973-12-24 | 1982-11-04 | Degussa Ag, 6000 Frankfurt | Verfahren zur Herstellung von 2-Benzoyl-6-chlor-3-nitro-pyridinen |
| EP0032516B1 (en) * | 1980-01-16 | 1984-05-02 | Lacer, S.A. | New 2-halo-pyridines, their production and pharmaceutical compositions |
| JPS60132610A (ja) * | 1983-12-20 | 1985-07-15 | Japan Organo Co Ltd | 汚泥脱水装置 |
| JPS6219221A (ja) * | 1985-07-16 | 1987-01-28 | Chiyoda Chem Eng & Constr Co Ltd | 原液中の微細粒子を除去する濾過方法と濾過装置 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3314941A (en) * | 1964-06-23 | 1967-04-18 | American Cyanamid Co | Novel substituted pyridodiazepins |
| US3523939A (en) * | 1967-07-03 | 1970-08-11 | Hoffmann La Roche | 5-(2,6-disubstituted phenyl)-1,4-benzodiazepines and methods for their preparation |
-
1971
- 1971-12-09 AT AT1060471A patent/AT333284B/de not_active IP Right Cessation
- 1971-12-09 AT AT902174A patent/AT332877B/de active
- 1971-12-09 AT AT902274A patent/AT332878B/de active
-
1972
- 1972-11-29 ES ES409089A patent/ES409089A1/es not_active Expired
- 1972-11-29 ES ES409090A patent/ES409090A1/es not_active Expired
- 1972-11-30 FI FI3390/72A patent/FI54710C/fi active
- 1972-11-30 ZA ZA728497A patent/ZA728497B/xx unknown
- 1972-12-05 DE DE2259471A patent/DE2259471C2/de not_active Expired
- 1972-12-05 SE SE7215858A patent/SE404803B/xx unknown
- 1972-12-06 FR FR7243359A patent/FR2162482B1/fr not_active Expired
- 1972-12-06 HU HUDE799A patent/HU169468B/hu unknown
- 1972-12-06 EG EG502/72A patent/EG10918A/xx active
- 1972-12-07 IT IT7254583Q patent/IT1035053B/it active
- 1972-12-07 RO RO7281196A patent/RO65263A/ro unknown
- 1972-12-07 RO RO7281197A patent/RO67345A/ro unknown
- 1972-12-07 RO RO7200073075A patent/RO62312A/ro unknown
- 1972-12-07 PL PL1972175581A patent/PL91876B1/pl unknown
- 1972-12-07 PL PL1972175582A patent/PL91828B1/pl unknown
- 1972-12-07 PL PL1972159365A patent/PL89682B1/pl unknown
- 1972-12-07 RO RO7281195A patent/RO65264A/ro unknown
- 1972-12-07 NL NLAANVRAGE7216621,A patent/NL171986C/xx not_active IP Right Cessation
- 1972-12-08 GB GB5688372A patent/GB1400755A/en not_active Expired
- 1972-12-08 CS CS728424A patent/CS212736B2/cs unknown
- 1972-12-08 IL IL41034A patent/IL41034A/en unknown
- 1972-12-08 DK DK615172AA patent/DK138425B/da not_active IP Right Cessation
- 1972-12-08 YU YU03059/72A patent/YU305972A/xx unknown
- 1972-12-08 SU SU1855103A patent/SU468423A3/ru active
- 1972-12-08 NO NO4536/72A patent/NO137094C/no unknown
- 1972-12-08 BE BE792541A patent/BE792541A/xx not_active IP Right Cessation
- 1972-12-09 JP JP12387872A patent/JPS569509B2/ja not_active Expired
- 1972-12-11 CH CH1794972A patent/CH594665A5/xx not_active IP Right Cessation
- 1972-12-11 DD DD167428A patent/DD105448A5/xx unknown
- 1972-12-11 CH CH1526076A patent/CH603645A5/xx not_active IP Right Cessation
- 1972-12-11 CH CH1506576A patent/CH605946A5/xx not_active IP Right Cessation
- 1972-12-11 AU AU49931/72A patent/AU473253B2/en not_active Expired
- 1972-12-11 CH CH1506676A patent/CH603644A5/xx not_active IP Right Cessation
-
1973
- 1973-09-10 AR AR250008A patent/AR201201A1/es active
-
1974
- 1974-03-20 AR AR252867A patent/AR200309A1/es active
- 1974-07-08 SU SU742041603A patent/SU674675A3/ru active
- 1974-07-08 SU SU7402042686A patent/SU564809A3/ru active
- 1974-10-15 SU SU7402067128A patent/SU574156A3/ru active
- 1974-10-31 AR AR256352A patent/AR203311A1/es active
- 1974-11-11 AT AT902074A patent/AT338798B/de not_active IP Right Cessation
-
1980
- 1980-04-15 JP JP5022280A patent/JPS55147282A/ja active Granted
- 1980-04-15 JP JP5022180A patent/JPS5625180A/ja active Granted
- 1980-04-15 JP JP5022380A patent/JPS5625181A/ja active Granted
-
1981
- 1981-05-07 YU YU01168/81A patent/YU116881A/xx unknown
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