ES8501772A1 - Procedimiento de preparacion de nuevos derivados de la nitrosourea - Google Patents

Procedimiento de preparacion de nuevos derivados de la nitrosourea

Info

Publication number
ES8501772A1
ES8501772A1 ES527353A ES527353A ES8501772A1 ES 8501772 A1 ES8501772 A1 ES 8501772A1 ES 527353 A ES527353 A ES 527353A ES 527353 A ES527353 A ES 527353A ES 8501772 A1 ES8501772 A1 ES 8501772A1
Authority
ES
Spain
Prior art keywords
pharmaceutical compositions
preparation
compositions containing
alkyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES527353A
Other languages
English (en)
Other versions
ES527353A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Publication of ES8501772A1 publication Critical patent/ES8501772A1/es
Publication of ES527353A0 publication Critical patent/ES527353A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE NITROSOUREA, EN FORMA RACEMICA O DE ISOMEROS OPTICOS, DE FORMULA (I), EN LA QUE R1, R2 Y R3 PUEDEN SER VARIOS TIPOS DE RADICALES.CONSISTE EN LA REACCION DE CONDENSACION DE UN DERIVADOB AB-AMINOFOSFONADO, DE FORMULA (II), EN LA QUE R1, R2 Y R3 TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), CON UN EXCESO DE BBB-CLOROETILISICIANATO, EN AGUA O CLOROFORMADO, EN PRESENCIA DE UNA BASE, A TEMPERATURA ENTRE 0JC Y 10JC; SEGUIDA DE NITROSACION DEL PRODUCTO FORMADO.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE INFECCIONES BACTERIANAS Y DEL CANCER.
ES527353A 1982-11-17 1983-11-17 Procedimiento de preparacion de nuevos derivados de la nitrosourea Granted ES527353A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8219199A FR2536075B1 (fr) 1982-11-17 1982-11-17 Nouveaux derives de la nitrosouree, leur procede de preparation et les compositions pharmaceutiques les renfermant

Publications (2)

Publication Number Publication Date
ES8501772A1 true ES8501772A1 (es) 1984-12-01
ES527353A0 ES527353A0 (es) 1984-12-01

Family

ID=9279241

Family Applications (1)

Application Number Title Priority Date Filing Date
ES527353A Granted ES527353A0 (es) 1982-11-17 1983-11-17 Procedimiento de preparacion de nuevos derivados de la nitrosourea

Country Status (19)

Country Link
US (1) US4567169A (es)
EP (1) EP0117959B1 (es)
JP (1) JPS59106497A (es)
AT (1) ATE21905T1 (es)
AU (1) AU557139B2 (es)
CA (1) CA1204442A (es)
DE (1) DE3365900D1 (es)
DK (1) DK169340B1 (es)
ES (1) ES527353A0 (es)
FR (1) FR2536075B1 (es)
IE (1) IE56259B1 (es)
IL (1) IL70253A (es)
MA (1) MA19952A1 (es)
NO (1) NO163409C (es)
NZ (1) NZ206293A (es)
OA (1) OA07589A (es)
PT (1) PT77666B (es)
SU (1) SU1303024A3 (es)
ZA (1) ZA838558B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2567129B1 (fr) * 1984-07-06 1986-12-05 Adir Nouveaux derives de l'oxaazaphosphorine, leur procede de preparation et les compositions pharmaceutiques les renfermant
IT1246778B (it) * 1991-04-12 1994-11-26 Boehringer Mannheim Italia Nitrosocarbamoil derivati di acidi gem-difosfonici, un processo per la loro preparazione e composizioni farmaceutiche che li contengono
US5298499A (en) * 1991-07-05 1994-03-29 Research Triangle Institute S-2-(substituted ethylamino)ethyl phosphorothioates
AU7737896A (en) * 1995-11-20 1997-06-11 Sepracor, Inc. Antineoplastic methods and compositions employing (+)-fotemustine
WO1997018819A1 (en) * 1995-11-20 1997-05-29 Sepracor, Inc. Antineoplastic methods and compositions employing optically pure (-)-fotemustine
US20040072889A1 (en) * 1997-04-21 2004-04-15 Pharmacia Corporation Method of using a COX-2 inhibitor and an alkylating-type antineoplastic agent as a combination therapy in the treatment of neoplasia
CN100365002C (zh) * 2004-06-02 2008-01-30 上海医药科技发展有限公司 注射用福莫司汀制备工艺
AT501496B1 (de) * 2005-02-21 2007-03-15 Iep Gmbh Verfahren zur enantioselektiven enzymatischen reduktion von ketoverbindungen
CN102311456A (zh) * 2011-07-08 2012-01-11 山东睿鹰先锋制药有限公司 一种福莫司汀原料药的合成方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3920733A (en) * 1973-08-06 1975-11-18 Monsanto Co Ureidoalkylphosphonic acids

Also Published As

Publication number Publication date
IL70253A0 (en) 1984-02-29
NO834214L (no) 1984-05-18
EP0117959B1 (fr) 1986-09-03
AU2143683A (en) 1984-05-24
PT77666B (fr) 1986-05-12
IE56259B1 (en) 1991-06-05
NO163409B (no) 1990-02-12
OA07589A (fr) 1985-03-31
SU1303024A3 (ru) 1987-04-07
DK524283D0 (da) 1983-11-16
AU557139B2 (en) 1986-12-04
IL70253A (en) 1986-10-31
EP0117959A3 (en) 1984-11-14
PT77666A (fr) 1983-12-01
US4567169A (en) 1986-01-28
JPS6411637B2 (es) 1989-02-27
ZA838558B (en) 1984-07-25
CA1204442A (fr) 1986-05-13
EP0117959A2 (fr) 1984-09-12
DK524283A (da) 1984-05-18
DK169340B1 (da) 1994-10-10
ATE21905T1 (de) 1986-09-15
FR2536075A1 (fr) 1984-05-18
JPS59106497A (ja) 1984-06-20
ES527353A0 (es) 1984-12-01
IE832680L (en) 1984-05-17
NZ206293A (en) 1987-02-20
NO163409C (no) 1990-05-23
FR2536075B1 (fr) 1985-07-05
DE3365900D1 (en) 1986-10-09
MA19952A1 (fr) 1984-07-01

Similar Documents

Publication Publication Date Title
ES8705393A1 (es) Un procedimiento para preparar un derivado de pirazol (como divisional de la solicitud de patente de invencion n 543.046, presentada el 10.5.85)
IL65501A (en) 1-alkyl-2-aminotetralin derivatives,process for their preparation and pharmaceutical compositions containing them
ES8501772A1 (es) Procedimiento de preparacion de nuevos derivados de la nitrosourea
ES8200680A1 (es) Un procedimiento para la preparacion de fenil-quinolicidinas
DE3374005D1 (en) 1-methyl-5-nitro-imidazoline derivatives and therapeutic compositions which contain them as active principle
ES8600224A1 (es) Procedimiento de preparacion de nuevos derivados carbamiloxibenzoles
ES487631A1 (es) Procedimiento para la obtencion de hexahidro-1,4-oxazepinas
ES8802311A1 (es) Procedimiento de preparacion de derivados del triazol y de sus sales de adicion con los acidos apropiados
ES2001893A6 (es) Procedimiento para la obtencion de derivados de metilendioxifenantreno
ES477257A1 (es) Un procedimiento para preprarar derivados de isoquinoleina.
DE3269505D1 (en) Substituted 1-benzoyl-2-phenylimino-imidazolidines, their acid addition salts, process for their preparation and pharmaceutical compositions containing them
ES485828A1 (es) Procedimiento para la preparacion de piridazinas substitui- das
ES8201150A1 (es) Procedimiento para la preparacion de acidos 5-sulfamoilorta-nilicos
ES8403471A1 (es) Un procedimiento para preparar nuevos compuestos de cromanona.