IL302205B2 - Rna-guided transcriptional regulation - Google Patents

Rna-guided transcriptional regulation

Info

Publication number
IL302205B2
IL302205B2 IL302205A IL30220523A IL302205B2 IL 302205 B2 IL302205 B2 IL 302205B2 IL 302205 A IL302205 A IL 302205A IL 30220523 A IL30220523 A IL 30220523A IL 302205 B2 IL302205 B2 IL 302205B2
Authority
IL
Israel
Prior art keywords
cell
dna
rna
protein
nucleic acid
Prior art date
Application number
IL302205A
Other languages
English (en)
Hebrew (he)
Other versions
IL302205B1 (en
IL302205A (en
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Harvard College
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Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52008736&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL302205(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Harvard College filed Critical Harvard College
Publication of IL302205A publication Critical patent/IL302205A/en
Publication of IL302205B1 publication Critical patent/IL302205B1/en
Publication of IL302205B2 publication Critical patent/IL302205B2/en

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3513—Protein; Peptide
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    • C12Y301/00—Hydrolases acting on ester bonds (3.1)

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  • Chemical & Material Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
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  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Lubricants (AREA)
IL302205A 2013-06-04 2014-06-04 Rna-guided transcriptional regulation IL302205B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361830787P 2013-06-04 2013-06-04
PCT/US2014/040868 WO2014197568A2 (en) 2013-06-04 2014-06-04 Rna-guideded transcriptional regulation

Publications (3)

Publication Number Publication Date
IL302205A IL302205A (en) 2023-06-01
IL302205B1 IL302205B1 (en) 2025-04-01
IL302205B2 true IL302205B2 (en) 2025-08-01

Family

ID=52008736

Family Applications (3)

Application Number Title Priority Date Filing Date
IL302205A IL302205B2 (en) 2013-06-04 2014-06-04 Rna-guided transcriptional regulation
IL284773A IL284773B2 (en) 2013-06-04 2014-06-04 RNA-guided transcriptional regulation
IL242959A IL242959B (en) 2013-06-04 2015-12-06 Rna-guided transcriptional regulation

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL284773A IL284773B2 (en) 2013-06-04 2014-06-04 RNA-guided transcriptional regulation
IL242959A IL242959B (en) 2013-06-04 2015-12-06 Rna-guided transcriptional regulation

Country Status (15)

Country Link
US (7) US20140356956A1 (cg-RX-API-DMAC10.html)
EP (4) EP3603679B1 (cg-RX-API-DMAC10.html)
JP (6) JP6621738B2 (cg-RX-API-DMAC10.html)
KR (3) KR102884236B1 (cg-RX-API-DMAC10.html)
CN (2) CN105451778B (cg-RX-API-DMAC10.html)
AU (4) AU2014274939B2 (cg-RX-API-DMAC10.html)
CA (2) CA3176690A1 (cg-RX-API-DMAC10.html)
ES (1) ES2930537T3 (cg-RX-API-DMAC10.html)
IL (3) IL302205B2 (cg-RX-API-DMAC10.html)
MX (3) MX385330B (cg-RX-API-DMAC10.html)
MY (3) MY208492A (cg-RX-API-DMAC10.html)
RU (2) RU2756865C2 (cg-RX-API-DMAC10.html)
SG (3) SG11201509962QA (cg-RX-API-DMAC10.html)
WO (1) WO2014197568A2 (cg-RX-API-DMAC10.html)
ZA (1) ZA201509025B (cg-RX-API-DMAC10.html)

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