IL259838B2 - Geometric configurations for stomach stay systems, methods for their preparation and their uses - Google Patents
Geometric configurations for stomach stay systems, methods for their preparation and their usesInfo
- Publication number
- IL259838B2 IL259838B2 IL259838A IL25983818A IL259838B2 IL 259838 B2 IL259838 B2 IL 259838B2 IL 259838 A IL259838 A IL 259838A IL 25983818 A IL25983818 A IL 25983818A IL 259838 B2 IL259838 B2 IL 259838B2
- Authority
- IL
- Israel
- Prior art keywords
- gastric residence
- residence system
- elastomer
- polymer
- elastomer component
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
- A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/08—Processes
- C08G18/10—Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
- C08G18/12—Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step using two or more compounds having active hydrogen in the first polymerisation step
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
- C08G18/40—High-molecular-weight compounds
- C08G18/42—Polycondensates having carboxylic or carbonic ester groups in the main chain
- C08G18/4202—Two or more polyesters of different physical or chemical nature
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
- C08G18/40—High-molecular-weight compounds
- C08G18/42—Polycondensates having carboxylic or carbonic ester groups in the main chain
- C08G18/4266—Polycondensates having carboxylic or carbonic ester groups in the main chain prepared from hydroxycarboxylic acids and/or lactones
- C08G18/4269—Lactones
- C08G18/4277—Caprolactone and/or substituted caprolactone
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
- C08G18/72—Polyisocyanates or polyisothiocyanates
- C08G18/73—Polyisocyanates or polyisothiocyanates acyclic
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
- C08L83/04—Polysiloxanes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Botany (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Surgical Instruments (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562264811P | 2015-12-08 | 2015-12-08 | |
| PCT/US2016/065453 WO2017100367A1 (en) | 2015-12-08 | 2016-12-07 | Geometric configurations for gastric residence systems |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IL259838A IL259838A (en) | 2018-07-31 |
| IL259838B IL259838B (en) | 2022-10-01 |
| IL259838B2 true IL259838B2 (en) | 2023-02-01 |
Family
ID=59013250
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL259838A IL259838B2 (en) | 2015-12-08 | 2018-06-05 | Geometric configurations for stomach stay systems, methods for their preparation and their uses |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11992552B2 (enExample) |
| EP (2) | EP4302817A3 (enExample) |
| JP (1) | JP7030052B2 (enExample) |
| KR (1) | KR102796240B1 (enExample) |
| CN (2) | CN108697649A (enExample) |
| AU (1) | AU2016366192B2 (enExample) |
| BR (1) | BR112018011636B1 (enExample) |
| CA (2) | CA3306219A1 (enExample) |
| ES (1) | ES2963058T3 (enExample) |
| IL (1) | IL259838B2 (enExample) |
| MX (1) | MX2018006912A (enExample) |
| SG (1) | SG11201804384UA (enExample) |
| WO (1) | WO2017100367A1 (enExample) |
| ZA (1) | ZA202407197B (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2016016406A (es) | 2014-06-11 | 2017-10-12 | Massachusetts Inst Technology | Estructuras de permanencia, y métodos relacionados. |
| US20170266112A1 (en) | 2014-06-11 | 2017-09-21 | Massachusetts Institute Of Technology | Residence structures and related methods |
| WO2016178971A1 (en) | 2015-05-01 | 2016-11-10 | Massachusetts Institute Of Technology | Triggerable shape memory induction devices |
| AU2016342374B2 (en) | 2015-10-23 | 2022-08-04 | Nortiva Bio, Inc. | Gastric residence systems for sustained release of therapeutic agents and methods of use thereof |
| KR102796240B1 (ko) | 2015-12-08 | 2025-04-16 | 린드라 테라퓨틱스 인코퍼레이티드 | 위 체류 시스템을 위한 기하 구성형태 |
| US12109305B2 (en) | 2016-05-27 | 2024-10-08 | Lyndra Therapeutics, Inc. | Materials architecture for gastric residence systems |
| EP3518902A4 (en) | 2016-09-30 | 2020-07-08 | Lyndra, Inc. | GASTRIC RESIDENCE SYSTEMS FOR LONG-TERM ADMINISTRATION OF ADAMANTANE CLASS MEDICINES |
| US11541015B2 (en) | 2017-05-17 | 2023-01-03 | Massachusetts Institute Of Technology | Self-righting systems, methods, and related components |
| US11207272B2 (en) | 2017-05-17 | 2021-12-28 | Massachusetts Institute Of Technology | Tissue anchoring articles |
| TWI811221B (zh) | 2017-06-09 | 2023-08-11 | 美商萊恩卓治療公司 | 具有釋放速率調節膜之胃的滯留系統 |
| JP7288435B2 (ja) * | 2017-09-20 | 2023-06-07 | リンドラ セラピューティクス， インコーポレイティド | 胃内滞留システムのカプセル封入 |
| JP7394775B2 (ja) * | 2017-11-28 | 2023-12-08 | マサチューセッツ インスティテュート オブ テクノロジー | 胃滞在電子機器 |
| US11202903B2 (en) | 2018-05-17 | 2021-12-21 | Massachusetts Institute Of Technology | Systems for electrical stimulation |
| WO2020117855A1 (en) | 2018-12-03 | 2020-06-11 | Lyndra, Inc. | Stomach simulating device |
| US11771829B2 (en) | 2019-02-01 | 2023-10-03 | Massachusetts Institute Of Technology | Systems and methods for liquid injection |
| CN113840596A (zh) | 2019-03-20 | 2021-12-24 | 林德拉治疗公司 | 用于胃滞留剂型的衣层 |
| IL286512B2 (en) | 2019-03-20 | 2026-03-01 | Lyndra Therapeutics Inc | Capsules and capsule coatings for stomach-retaining dosage forms |
| CA3160665A1 (en) * | 2019-11-08 | 2021-05-14 | Lyndra Therapeutics, Inc. | Gastric residence systems for administration of active agents |
| EP4054538A4 (en) * | 2019-11-08 | 2024-02-07 | Lyndra Therapeutics, Inc. | STOMACH RESIDENCE SYSTEMS WITH A FILAMENT FOR IMPROVED STOMACH RESIDENCE |
| IL292848A (en) * | 2019-11-08 | 2022-07-01 | Lyndra Therapeutics Inc | Polymeric links for the gastric retention system |
| WO2021092484A1 (en) * | 2019-11-08 | 2021-05-14 | Lyndra, Inc. | Gastric residence systems having arms with controlled stiffness for improved gastric residence |
| US11541216B2 (en) | 2019-11-21 | 2023-01-03 | Massachusetts Institute Of Technology | Methods for manufacturing tissue interfacing components |
| DE102019132938A1 (de) * | 2019-12-04 | 2021-06-10 | Cortronik GmbH | Verfahren zur Herstellung einer intraluminalen Endoprothese mit einer biodegradierbaren Hülle |
| US11446114B2 (en) * | 2020-01-21 | 2022-09-20 | Med-Genesis, Llc | Biopsy marker with anchoring capabilities |
| CN116234540A (zh) | 2020-07-29 | 2023-06-06 | 赛康特集团有限责任公司 | 具有包括交联聚(癸二酸甘油酯)的结构的形状引导控释和滞留 |
| AU2022270208A1 (en) * | 2021-05-05 | 2023-12-07 | Lyndra Therapeutics, Inc. | Gastric residence systems comprising methadone |
| WO2023234868A1 (en) * | 2022-06-03 | 2023-12-07 | The Chloroplast Pte. Ltd | A gastric residence article for oral administration |
| EP4565274A2 (en) * | 2022-08-03 | 2025-06-11 | Lyndra Therapeutics, Inc. | Metal cores for gastric residence systems |
| WO2024249946A2 (en) * | 2023-06-02 | 2024-12-05 | Lyndra Therapeutics, Inc. | Manufacturing methods for gastric residence systems |
| CN121752250A (zh) * | 2023-08-24 | 2026-03-27 | 厦门君德医药科技有限公司 | 一种口服胃滞留物 |
| WO2025153071A1 (en) * | 2024-01-18 | 2025-07-24 | Junion Therapeutics (Xiamen) Co., Ltd. | Gastric residence article for oral administration |
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| EP0415671A2 (en) * | 1989-08-31 | 1991-03-06 | Yamanouchi Pharmaceutical Co. Ltd. | Gastric retention device |
| US20110040318A1 (en) * | 2005-03-01 | 2011-02-17 | Tulip Medical Ltd. | Bioerodible self-deployable intragastric implants |
| US20140052171A1 (en) * | 2012-08-15 | 2014-02-20 | St. Jude Medical Puerto Rico Llc | Vascular closure device anchor |
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| EP3386488A1 (en) | 2018-10-17 |
| CA3007633A1 (en) | 2017-06-15 |
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| KR20180090881A (ko) | 2018-08-13 |
| HK1259225A1 (en) | 2019-11-29 |
| BR112018011636B1 (pt) | 2024-03-12 |
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