BR112018011636A2 - configurações geométricas para sistemas de residência gástrico - Google Patents
configurações geométricas para sistemas de residência gástricoInfo
- Publication number
- BR112018011636A2 BR112018011636A2 BR112018011636-0A BR112018011636A BR112018011636A2 BR 112018011636 A2 BR112018011636 A2 BR 112018011636A2 BR 112018011636 A BR112018011636 A BR 112018011636A BR 112018011636 A2 BR112018011636 A2 BR 112018011636A2
- Authority
- BR
- Brazil
- Prior art keywords
- geometric configurations
- gastric residence
- residence systems
- systems
- residence
- Prior art date
Links
- 230000002496 gastric effect Effects 0.000 title abstract 2
- 210000002784 stomach Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/08—Processes
- C08G18/10—Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
- C08G18/12—Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step using two or more compounds having active hydrogen in the first polymerisation step
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
- C08G18/40—High-molecular-weight compounds
- C08G18/42—Polycondensates having carboxylic or carbonic ester groups in the main chain
- C08G18/4202—Two or more polyesters of different physical or chemical nature
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
- C08G18/40—High-molecular-weight compounds
- C08G18/42—Polycondensates having carboxylic or carbonic ester groups in the main chain
- C08G18/4266—Polycondensates having carboxylic or carbonic ester groups in the main chain prepared from hydroxycarboxylic acids and/or lactones
- C08G18/4269—Lactones
- C08G18/4277—Caprolactone and/or substituted caprolactone
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
- C08G18/72—Polyisocyanates or polyisothiocyanates
- C08G18/73—Polyisocyanates or polyisothiocyanates acyclic
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
- C08L83/04—Polysiloxanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Botany (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Surgical Instruments (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
a invenção proporciona sistemas de residência gástrico com configurações e dimensões geométricas que permitem maior vida útil durante o armazenamento prolongado e propriedades ótimas de permanência quando os sistemas estão implantados no estômago de um paciente.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562264811P | 2015-12-08 | 2015-12-08 | |
US62/264,811 | 2015-12-08 | ||
PCT/US2016/065453 WO2017100367A1 (en) | 2015-12-08 | 2016-12-07 | Geometric configurations for gastric residence systems |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112018011636A2 true BR112018011636A2 (pt) | 2018-11-27 |
BR112018011636B1 BR112018011636B1 (pt) | 2024-03-12 |
Family
ID=59013250
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018011636-0A BR112018011636B1 (pt) | 2015-12-08 | 2016-12-07 | Sistema de residência gástrico para liberação sustentada de um agente terapêutico |
Country Status (14)
Country | Link |
---|---|
US (1) | US11992552B2 (pt) |
EP (2) | EP4302817A3 (pt) |
JP (1) | JP7030052B2 (pt) |
KR (1) | KR20180090881A (pt) |
CN (1) | CN108697649A (pt) |
AU (1) | AU2016366192B2 (pt) |
BR (1) | BR112018011636B1 (pt) |
CA (1) | CA3007633A1 (pt) |
ES (1) | ES2963058T3 (pt) |
HK (1) | HK1259225A1 (pt) |
IL (1) | IL259838B2 (pt) |
MX (1) | MX2018006912A (pt) |
SG (1) | SG11201804384UA (pt) |
WO (1) | WO2017100367A1 (pt) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2015274456B2 (en) | 2014-06-11 | 2020-03-26 | Massachusetts Institute Of Technology | Self-assembled residence devices and related methods |
US20170266112A1 (en) | 2014-06-11 | 2017-09-21 | Massachusetts Institute Of Technology | Residence structures and related methods |
JP2018515476A (ja) | 2015-05-01 | 2018-06-14 | マサチューセッツ インスティテュート オブ テクノロジー | 誘発性形状記憶誘導デバイス |
CA3002916A1 (en) | 2015-10-23 | 2017-04-27 | Lyndra, Inc. | Gastric residence systems for sustained release of therapeutic agents and methods of use thereof |
SG11201804384UA (en) | 2015-12-08 | 2018-06-28 | Lyndra Inc | Geometric configurations for gastric residence systems |
AU2017336154B2 (en) | 2016-09-30 | 2023-11-09 | Lyndra Therapeutics, Inc. | Gastric residence systems for sustained delivery of adamantane-class drugs |
EP3624778A4 (en) | 2017-05-17 | 2021-03-10 | Massachusetts Institute of Technology | SELF-FIRING ARTICLES |
US11541015B2 (en) | 2017-05-17 | 2023-01-03 | Massachusetts Institute Of Technology | Self-righting systems, methods, and related components |
WO2019060458A1 (en) * | 2017-09-20 | 2019-03-28 | Lyndra, Inc. | ENCAPSULATION OF GASTRIC SYSTEMS |
CA3100710A1 (en) | 2018-05-17 | 2019-11-21 | Massachusetts Institute Of Technology | Systems for electrical stimulation |
US11771829B2 (en) | 2019-02-01 | 2023-10-03 | Massachusetts Institute Of Technology | Systems and methods for liquid injection |
WO2021092484A1 (en) * | 2019-11-08 | 2021-05-14 | Lyndra, Inc. | Gastric residence systems having arms with controlled stiffness for improved gastric residence |
EP4054538A4 (en) * | 2019-11-08 | 2024-02-07 | Lyndra Therapeutics Inc | INDINDING GASTRIC SYSTEMS WITH FILAMENT FOR IMPROVED GASTRIC STAY |
EP4054545A4 (en) * | 2019-11-08 | 2024-02-14 | Lyndra Therapeutics Inc | GASTRIC STAY SYSTEMS FOR THE ADMINISTRATION OF ACTIVE AGENTS |
CN115003336A (zh) * | 2019-11-08 | 2022-09-02 | 林德拉治疗公司 | 用于胃驻留系统的聚合物连接体 |
US11541216B2 (en) | 2019-11-21 | 2023-01-03 | Massachusetts Institute Of Technology | Methods for manufacturing tissue interfacing components |
DE102019132938A1 (de) * | 2019-12-04 | 2021-06-10 | Cortronik GmbH | Verfahren zur Herstellung einer intraluminalen Endoprothese mit einer biodegradierbaren Hülle |
CA3216743A1 (en) * | 2021-05-05 | 2022-11-10 | Estelle BEGUIN | Gastric residence systems comprising methadone |
WO2023234868A1 (en) * | 2022-06-03 | 2023-12-07 | The Chloroplast Pte. Ltd | A gastric residence article for oral administration |
WO2024031023A2 (en) * | 2022-08-03 | 2024-02-08 | Lyndra Therapeutics, Inc. | Metal cores for gastric residence systems |
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2016
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US20190262265A1 (en) | 2019-08-29 |
SG11201804384UA (en) | 2018-06-28 |
MX2018006912A (es) | 2018-08-16 |
BR112018011636B1 (pt) | 2024-03-12 |
RU2018124706A3 (pt) | 2020-06-08 |
EP3386488A1 (en) | 2018-10-17 |
IL259838A (en) | 2018-07-31 |
RU2018124706A (ru) | 2020-01-14 |
AU2016366192B2 (en) | 2022-08-04 |
CA3007633A1 (en) | 2017-06-15 |
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