MX2016016406A - Estructuras de permanencia, y métodos relacionados. - Google Patents

Estructuras de permanencia, y métodos relacionados.

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Publication number
MX2016016406A
MX2016016406A MX2016016406A MX2016016406A MX2016016406A MX 2016016406 A MX2016016406 A MX 2016016406A MX 2016016406 A MX2016016406 A MX 2016016406A MX 2016016406 A MX2016016406 A MX 2016016406A MX 2016016406 A MX2016016406 A MX 2016016406A
Authority
MX
Mexico
Prior art keywords
residence
gastric
subject
certain embodiments
degradation
Prior art date
Application number
MX2016016406A
Other languages
English (en)
Inventor
Robert S Langer
A Eckhoff Philip
Bellinger Andrew
Zhang Shiyi
Giovanni Traverso Carlo
Mo Stacy
GRANT Tyler
Jafari Mousa
Liang Glettig Dean
Diciccio Angela
l jr wood Lowell
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54834353&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2016016406(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Publication of MX2016016406A publication Critical patent/MX2016016406A/es

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    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
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    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/42—Polycondensates having carboxylic or carbonic ester groups in the main chain
    • C08G18/4266—Polycondensates having carboxylic or carbonic ester groups in the main chain prepared from hydroxycarboxylic acids and/or lactones
    • C08G18/4269—Lactones
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    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
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    • C08L33/14—Homopolymers or copolymers of esters of esters containing halogen, nitrogen, sulfur, or oxygen atoms in addition to the carboxy oxygen
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Prostheses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

Se proporcionan generalmente estructuras de permanencia, sistemas y métodos relacionados; ciertas modalidades comprenden administrar (por ejemplo, por vía oral) una estructura de permanencia a un sujeto (por ejemplo, un paciente) de modo que la estructura de permanencia sea retenida en un sitio interno del sujeto por una cantidad de tiempo particular (por ejemplo, por lo menos aproximadamente 24 horas) antes de que sea liberada; la estructura de permanencia puede ser, en algunos casos, una estructura de permanencia gástrica; en algunas modalidades, las estructuras y sistemas descritos en la presente comprenden uno o más materiales configurados para la carga de altos niveles de sustancias activas (por ejemplo, un agente terapéutico), sustancia altamente activa y/o estabilidad de estructura en ambientes ácidos, flexibilidad y resistencia mecánica en un orificio interno (por ejemplo, la cavidad gástrica), de fácil paso a través del tracto GI hasta su suministro hacia un orificio interno deseado (por ejemplo, la cavidad gástrica) y/o disolución/degradación rápida en un ambiente fisiológico (por ejemplo, el ambiente intestinal) y/o en respuesta a un estimulante químico (por ejemplo, la ingestión de una solución que induce disolución/degradación rápida); en ciertas modalidades, la estructura tiene un diseño modular, que combina un material configurado para la liberación controlada de agentes terapéuticos, de diagnóstico y/o de intensificación con un material estructural necesario para la permanencia gástrica, pero configurado para la degradación/disolución controlada y/o armonizable para determinar el tiempo al cual la integridad de la forma de retención se pierde para permitir que la estructura salga de la cavidad gástrica; por ejemplo, en ciertas modalidades, la estructura de permanencia comprende un primer componente elástico, un segundo componente configurado para libera una sustancia activa (por ejemplo, un agente terapéutico) y, opcionalmente, un enlazador; en algunas de dichas modalidades, el enlazador puede estar configurado para degradarse, de modo que la estructura de permanencia se rompe y es liberada de sitio interno del sujeto después de una cantidad de tiempo predeterminada.
MX2016016406A 2014-06-11 2015-06-11 Estructuras de permanencia, y métodos relacionados. MX2016016406A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462010992P 2014-06-11 2014-06-11
PCT/US2015/035423 WO2015191920A1 (en) 2014-06-11 2015-06-11 Residence structures and related methods

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MX2016016406A true MX2016016406A (es) 2017-10-12

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MX2016016406A MX2016016406A (es) 2014-06-11 2015-06-11 Estructuras de permanencia, y métodos relacionados.
MX2023005223A MX2023005223A (es) 2014-06-11 2016-12-09 Estructuras de permanencia, y metodos relacionados.

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US (16) US10849853B2 (es)
EP (5) EP3154622B1 (es)
JP (9) JP6666858B2 (es)
KR (2) KR102471095B1 (es)
CN (4) CN106573015B (es)
AU (6) AU2015274456B2 (es)
BR (2) BR112016028957B1 (es)
CA (3) CA2951884A1 (es)
DK (2) DK3155024T4 (es)
ES (2) ES3001020T3 (es)
FI (2) FI3155024T4 (es)
IL (1) IL249435B (es)
MX (2) MX2016016406A (es)
NZ (1) NZ727659A (es)
PL (1) PL3725357T3 (es)
RU (1) RU2766335C2 (es)
SG (2) SG11201610246PA (es)
WO (3) WO2015191922A1 (es)
ZA (1) ZA201608889B (es)

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