ES2963058T3 - Configuraciones geométricas para sistemas de residencia gástrica - Google Patents

Configuraciones geométricas para sistemas de residencia gástrica Download PDF

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Publication number
ES2963058T3
ES2963058T3 ES16873798T ES16873798T ES2963058T3 ES 2963058 T3 ES2963058 T3 ES 2963058T3 ES 16873798 T ES16873798 T ES 16873798T ES 16873798 T ES16873798 T ES 16873798T ES 2963058 T3 ES2963058 T3 ES 2963058T3
Authority
ES
Spain
Prior art keywords
gastric residence
polymer
elastomer
carrier
residence system
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES16873798T
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English (en)
Spanish (es)
Inventor
Andrew Bellinger
Rosemary Kanasty
Tyler Grant
Colin Gardner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lyndra Therapeutics Inc
Original Assignee
Lyndra Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lyndra Therapeutics Inc filed Critical Lyndra Therapeutics Inc
Application granted granted Critical
Publication of ES2963058T3 publication Critical patent/ES2963058T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00Polymeric products of isocyanates or isothiocyanates
    • C08G18/06Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/08Processes
    • C08G18/10Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
    • C08G18/12Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step using two or more compounds having active hydrogen in the first polymerisation step
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00Polymeric products of isocyanates or isothiocyanates
    • C08G18/06Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40High-molecular-weight compounds
    • C08G18/42Polycondensates having carboxylic or carbonic ester groups in the main chain
    • C08G18/4202Two or more polyesters of different physical or chemical nature
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00Polymeric products of isocyanates or isothiocyanates
    • C08G18/06Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40High-molecular-weight compounds
    • C08G18/42Polycondensates having carboxylic or carbonic ester groups in the main chain
    • C08G18/4266Polycondensates having carboxylic or carbonic ester groups in the main chain prepared from hydroxycarboxylic acids and/or lactones
    • C08G18/4269Lactones
    • C08G18/4277Caprolactone and/or substituted caprolactone
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00Polymeric products of isocyanates or isothiocyanates
    • C08G18/06Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/70Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
    • C08G18/72Polyisocyanates or polyisothiocyanates
    • C08G18/73Polyisocyanates or polyisothiocyanates acyclic
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L83/00Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
    • C08L83/04Polysiloxanes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Botany (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Surgical Instruments (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
ES16873798T 2015-12-08 2016-12-07 Configuraciones geométricas para sistemas de residencia gástrica Active ES2963058T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562264811P 2015-12-08 2015-12-08
PCT/US2016/065453 WO2017100367A1 (en) 2015-12-08 2016-12-07 Geometric configurations for gastric residence systems

Publications (1)

Publication Number Publication Date
ES2963058T3 true ES2963058T3 (es) 2024-03-25

Family

ID=59013250

Family Applications (1)

Application Number Title Priority Date Filing Date
ES16873798T Active ES2963058T3 (es) 2015-12-08 2016-12-07 Configuraciones geométricas para sistemas de residencia gástrica

Country Status (14)

Country Link
US (2) US11992552B2 (enExample)
EP (2) EP4302817A3 (enExample)
JP (1) JP7030052B2 (enExample)
KR (1) KR102796240B1 (enExample)
CN (2) CN120827528A (enExample)
AU (1) AU2016366192B2 (enExample)
BR (1) BR112018011636B1 (enExample)
CA (1) CA3007633A1 (enExample)
ES (1) ES2963058T3 (enExample)
IL (1) IL259838B2 (enExample)
MX (1) MX2018006912A (enExample)
SG (1) SG11201804384UA (enExample)
WO (1) WO2017100367A1 (enExample)
ZA (1) ZA202407197B (enExample)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6666858B2 (ja) 2014-06-11 2020-03-18 マサチューセッツ インスティテュート オブ テクノロジー 滞留構造体および関連方法
US20170266112A1 (en) 2014-06-11 2017-09-21 Massachusetts Institute Of Technology Residence structures and related methods
WO2016178971A1 (en) 2015-05-01 2016-11-10 Massachusetts Institute Of Technology Triggerable shape memory induction devices
CN118975972A (zh) * 2015-10-23 2024-11-19 林德拉治疗公司 用于治疗剂缓释的胃驻留系统及其使用方法
BR112018011636B1 (pt) 2015-12-08 2024-03-12 Lyndra Therapeutics, Inc Sistema de residência gástrico para liberação sustentada de um agente terapêutico
CN119925721A (zh) 2016-05-27 2025-05-06 林德拉治疗公司 用于胃驻留系统的材料结构
CN110022861B (zh) 2016-09-30 2024-06-28 林德拉治疗公司 用于金刚烷类药物缓释的胃驻留系统
IL301683B2 (en) 2017-05-17 2025-02-01 Massachusetts Inst Technology Self-healing systems and related components and methods
US11541015B2 (en) 2017-05-17 2023-01-03 Massachusetts Institute Of Technology Self-righting systems, methods, and related components
AU2018279853B2 (en) 2017-06-09 2024-07-04 Lyndra Therapeutics, Inc. Gastric residence systems with release rate-modulating films
ES3009743T3 (en) 2017-09-20 2025-03-31 Lyndra Therapeutics Inc Encapsulation of gastric residence systems
EP3716850A1 (en) * 2017-11-28 2020-10-07 Massachusetts Institute of Technology Gastric resident electronics
EP3793667A1 (en) 2018-05-17 2021-03-24 Massachusetts Institute of Technology Systems for electrical stimulation
US12142158B2 (en) 2018-12-03 2024-11-12 Lyndra Therapeutics, Inc. Stomach simulating device
US11771829B2 (en) 2019-02-01 2023-10-03 Massachusetts Institute Of Technology Systems and methods for liquid injection
EP3941445A4 (en) 2019-03-20 2023-08-02 Lyndra Therapeutics, Inc. CAPSULES AND CAPSULE COATINGS FOR GASOLINE DOSAGE FORMS
AU2020379040A1 (en) * 2019-11-08 2022-06-09 Lyndra Therapeutics, Inc. Gastric residence systems having a filament for improved gastric residence
EP4054545A4 (en) * 2019-11-08 2024-02-14 Lyndra Therapeutics, Inc. GASTRIC STAY SYSTEMS FOR THE ADMINISTRATION OF ACTIVE AGENTS
WO2021092487A1 (en) * 2019-11-08 2021-05-14 Lyndra, Inc. Polymeric linkers for a gastric residence system
WO2021092484A1 (en) * 2019-11-08 2021-05-14 Lyndra, Inc. Gastric residence systems having arms with controlled stiffness for improved gastric residence
US11541216B2 (en) 2019-11-21 2023-01-03 Massachusetts Institute Of Technology Methods for manufacturing tissue interfacing components
DE102019132938A1 (de) * 2019-12-04 2021-06-10 Cortronik GmbH Verfahren zur Herstellung einer intraluminalen Endoprothese mit einer biodegradierbaren Hülle
US11446114B2 (en) * 2020-01-21 2022-09-20 Med-Genesis, Llc Biopsy marker with anchoring capabilities
JP2023536456A (ja) 2020-07-29 2023-08-25 ザ・セカント・グループ・エルエルシー 架橋ポリ(セバシン酸グリセロール)を含む構造を含む形状誘導型制御放出および保持
US20240335400A1 (en) * 2021-05-05 2024-10-10 Lyndra Therapeutics, Inc. Gastric residence systems comprising methadone
WO2023234868A1 (en) * 2022-06-03 2023-12-07 The Chloroplast Pte. Ltd A gastric residence article for oral administration
EP4565274A2 (en) * 2022-08-03 2025-06-11 Lyndra Therapeutics, Inc. Metal cores for gastric residence systems
US20240398701A1 (en) * 2023-06-02 2024-12-05 Lyndra Therapeutics, Inc. Manufacturing methods for gastric residence systems
WO2025042350A1 (en) * 2023-08-24 2025-02-27 Junion Therapeutics (Xiamen) Co., Ltd. A gastric residence article for oral administration
WO2025153071A1 (en) * 2024-01-18 2025-07-24 Junion Therapeutics (Xiamen) Co., Ltd. Gastric residence article for oral administration

Family Cites Families (155)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1957564A (en) * 1932-11-23 1934-05-08 Aubra T West Expanding capsule body
US3154461A (en) 1960-03-07 1964-10-27 Minnesota Mining & Mfg Matte-finish polymeric film and method of forming the same
US3531368A (en) 1966-01-07 1970-09-29 Toray Industries Synthetic filaments and the like
US3716614A (en) 1969-05-12 1973-02-13 Toray Industries Process of manufacturing collagen fiber-like synthetic superfine filament bundles
AU449029B2 (en) * 1969-08-28 1974-04-17 Commonwealth Scientific And Industrial Research Organisation Device for administration to ruminants
JPS5512411B2 (enExample) 1974-03-12 1980-04-02
US4304767A (en) 1980-05-15 1981-12-08 Sri International Polymers of di- (and higher functionality) ketene acetals and polyols
DK154078C (da) 1981-02-06 1989-05-22 Ucb Sa Analogifremgangsmaade til fremstilling af 2-(2-(4-(diphenyl-methyl)-1-piperazinyl)ethoxy)-acetamider eller syreadditionssalte heraf
US4451260A (en) 1982-03-26 1984-05-29 Minnesota Mining And Manufacturing Company Sustained release oral medicinal delivery device
US4676507A (en) 1985-05-06 1987-06-30 Patterson Bruce D Puzzles forming platonic solids
US4735804A (en) 1985-05-10 1988-04-05 Merck & Co., Inc. Drug delivery device which can be retained in the stomach for a controlled period of time
JPS6226215A (ja) 1985-05-10 1987-02-04 メルク エンド カムパニ− インコ−ポレ−テツド 一定に制御した時間内胃中に保持できる薬剤移送装置
DE3680024D1 (de) * 1985-05-10 1991-08-08 Merck & Co Inc Abgabesystem fuer arzneimittel, das waehrend einer kontrollierten zeitspanne im magen zurueckgehalten werden kann.
US4767627A (en) * 1985-05-29 1988-08-30 Merck & Co., Inc. Drug delivery device which can be retained in the stomach for a controlled period of time
US4758436A (en) 1985-05-29 1988-07-19 Merck & Co., Inc. Drug delivery device which can be retained in the stomach for a controlled period of time
EP0253554A3 (en) 1986-07-15 1988-07-20 Pfizer Inc. Controlled release drug-containing fibers
CA1314742C (en) 1986-12-12 1993-03-23 Hiromu Terada Optical fiber array
IL87710A (en) 1987-09-18 1992-06-21 Ciba Geigy Ag Covered floating retard form for controlled release in gastric juice
US5002772A (en) 1988-05-31 1991-03-26 Pfizer Inc. Gastric retention system for controlled drug release
NZ228382A (en) 1989-03-17 1992-08-26 Carter Holt Harvey Plastic Pro Drug administering coil-like device for insertion in body cavity of animal
US5007790A (en) 1989-04-11 1991-04-16 Depomed Systems, Inc. Sustained-release oral drug dosage form
NZ234227A (en) 1989-06-30 1991-08-27 Smithkline Beecham Corp Delayed release dosage form
JPH03163011A (ja) 1989-08-31 1991-07-15 Yamanouchi Pharmaceut Co Ltd 胃内滞留デバイス
US5047464A (en) 1989-09-20 1991-09-10 Merck & Co., Inc. Bioerodible thermoset elastomers
US5121329A (en) 1989-10-30 1992-06-09 Stratasys, Inc. Apparatus and method for creating three-dimensional objects
JP2648897B2 (ja) 1991-07-01 1997-09-03 塩野義製薬株式会社 ピリミジン誘導体
US5939467A (en) 1992-06-26 1999-08-17 The Procter & Gamble Company Biodegradable polymeric compositions and products thereof
US5369142A (en) 1993-01-15 1994-11-29 The Ohio State University Water soluble polymers containing amino acid residues for dental restoratives
WO1995003558A1 (en) 1993-07-19 1995-02-02 Reflexite Corporation Retroreflective structure
DE4406424A1 (de) 1994-02-28 1995-08-31 Bayer Ag Expandierbare Arzneiformen
US5837276A (en) 1994-09-02 1998-11-17 Delab Apparatus for the delivery of elongate solid drug compositions
US6962579B2 (en) 1995-03-23 2005-11-08 Advanced Animal Technology Limited Substance delivery device
DE69628344T2 (de) 1995-03-23 2004-04-01 Advanced Animal Technology Ltd. Vorrichtung zur Verabreichung einer Substanz
DE19539361A1 (de) 1995-10-23 1997-04-24 Basf Ag Verfahren zur Herstellung von mehrschichtigen, festen Arzneiformen zur oralen oder rektalen Verabreichung
US5840332A (en) 1996-01-18 1998-11-24 Perio Products Ltd. Gastrointestinal drug delivery system
WO1997038969A1 (en) 1996-04-12 1997-10-23 Japan Atomic Energy Research Institute pH-SENSITIVE POLYMERS
US5762637A (en) * 1996-08-27 1998-06-09 Scimed Life Systems, Inc. Insert molded catheter tip
AU8699298A (en) 1997-08-11 1999-03-01 Alza Corporation Prolonged release active agent dosage form adapted for gastric retention
DE19850309A1 (de) 1998-10-30 2000-05-04 Lohmann Therapie Syst Lts Expandierbares gastroretensives Therapiesystem mit verlängerter Magenverweildauer
IL133196A0 (en) 1999-11-29 2001-03-19 Yissum Res Dev Co Gastroretentive controlled release pharmaceutical dosage forms
GB0001621D0 (en) 2000-01-26 2000-03-15 Astrazeneca Ab Pharmaceutical compositions
ES2257412T3 (es) 2000-05-18 2006-08-01 Therics, Inc. Encapsulacion de un nucleo toxico en una region no toxica en una forma de dosificacion oral.
US20020022048A1 (en) * 2000-05-26 2002-02-21 Bromberg Lev E. Composite wafer for controlled drug delivery
US6488962B1 (en) 2000-06-20 2002-12-03 Depomed, Inc. Tablet shapes to enhance gastric retention of swellable controlled-release oral dosage forms
US8158143B2 (en) 2000-07-14 2012-04-17 Helmholtz-Zentrum Geesthacht Zentrum Fuer Material- Und Kuestenforschung Gmbh Systems for releasing active ingredients, based on biodegradable or biocompatible polymers with a shape memory effect
US7803392B2 (en) 2000-12-27 2010-09-28 University Of Kentucky Research Foundation pH-Sensitive mucoadhesive film-forming gels and wax-film composites suitable for topical and mucosal delivery of molecules
US6627206B2 (en) 2001-07-25 2003-09-30 Greg A. Lloyd Method and apparatus for treating obesity and for delivering time-released medicaments
US20040219186A1 (en) 2001-08-16 2004-11-04 Ayres James W. Expandable gastric retention device
EP1416914A1 (en) 2001-08-16 2004-05-12 The State of Oregon acting by and through The State Board of Higher Education on behalf of Oregon State University Expandable gastric retention device
US20050165136A1 (en) 2002-01-23 2005-07-28 Uab Research Foundation Glass-ionomer cements containing amino acids
AU2003234159A1 (en) 2002-04-22 2003-11-03 Purdue Research Foundation Hydrogels having enhanced elasticity and mechanical strength properties
DE10224352A1 (de) 2002-06-01 2003-12-11 Mueller Schulte Detlef Thermosensitive Polymerträger mit veränderbarer physikalischer Struktur für die biochemische Analytik, Diagnostik und Therapie
GB0214013D0 (en) 2002-06-18 2002-07-31 Euro Celtique Sa Pharmaceutical product
MY142179A (en) 2002-07-25 2010-10-15 Glaxo Group Ltd Multicomponent pharmaceutical dosage form
CA2501345A1 (en) 2002-10-11 2004-04-22 Depomed Development, Ltd. Gastro-retentive levodopa delivery form
EP1594475A1 (en) 2003-02-19 2005-11-16 Mnemoscience GmbH Self-expanding device for the gastrointestinal or urogenital area
JP4497833B2 (ja) 2003-04-21 2010-07-07 富士フイルム株式会社 ポジ型平版印刷版原版
US7662864B2 (en) 2003-06-04 2010-02-16 Rutgers, The State University Of New Jersey Solution polymerization processes to prepare a polymer that degrades to release a physiologically active agent
EP1633281A1 (de) 2003-06-13 2006-03-15 Mnemoscience GmbH Stents
EP1638533A1 (en) 2003-06-18 2006-03-29 John Michael Newton Controlled release devices with lumens
US20090259236A2 (en) 2003-07-28 2009-10-15 Baronova, Inc. Gastric retaining devices and methods
US8048169B2 (en) 2003-07-28 2011-11-01 Baronova, Inc. Pyloric valve obstructing devices and methods
DE10350556A1 (de) 2003-10-29 2005-06-02 Clariant Gmbh Wasserbasierende Pigmentpräparationen
US6825308B1 (en) 2003-10-29 2004-11-30 Council Of Scientific And Industrial Research Copolymers and preparation thereof
AU2004296404A1 (en) 2003-12-09 2005-06-23 Spherics, Inc. Bioadhesive polymers with catechol functionality
WO2005065660A2 (en) 2003-12-31 2005-07-21 Alpharma, Inc. Ziprasidone formulations
US20080089933A1 (en) 2006-10-16 2008-04-17 Amir Alon Device and method for reducing calorie intake
AR048033A1 (es) 2004-03-12 2006-03-22 Smithkline Beecham Plc Composicion farmaceutica para moldear componentes que comprende copolimero de poli(met)acrilato, cubierta, conector o espaciador de capsula moldeado por inyeccion que tiene la composicion farmaceutica y forma de dosificacion farmaceutica de multicomponentes a partir de dicha composicion
WO2006033679A2 (en) 2004-05-25 2006-03-30 Chimeracore, Inc. Self-assembling nanoparticle drug delivery system
DE102004047076A1 (de) 2004-09-28 2006-04-06 Zimmer Ag Verfahren zur Herstellung von Polyestern
IL166183A0 (en) 2005-01-06 2006-01-15 Yissum Res Dev Co Novel diagnostic and imaging techniques of the gi tract
US20060182788A1 (en) 2005-01-27 2006-08-17 Parminder Singh Hydrophilic biocompatible adhesive formulations and uses
ES2540929T3 (es) 2005-02-01 2015-07-14 Emisphere Technologies, Inc. Sistema de administración de retención gástrica y liberación controlada
US7785291B2 (en) * 2005-03-01 2010-08-31 Tulip Medical Ltd. Bioerodible self-deployable intragastric implants
JP2006323082A (ja) 2005-05-18 2006-11-30 Canon Inc 現像剤補給容器
US8021384B2 (en) 2005-07-26 2011-09-20 Ram Weiss Extending intrabody capsule
WO2007018138A1 (ja) 2005-08-05 2007-02-15 Shiga Prefecture ポリマーブレンドを含んでなる液中物質移動材料
US20070048383A1 (en) 2005-08-25 2007-03-01 Helmus Michael N Self-assembled endovascular structures
EP1957052A2 (en) 2005-10-25 2008-08-20 Pharmascience Inc. A gastric retention drug delivery system
EP1945189A4 (en) 2005-11-03 2012-08-15 Sun Pharmaceutical Ind Ltd CONTROLLED RELEASE COATED TABLETS CHARACTERIZED BY PROLONGED GASTRIC RETENTION
US7674396B2 (en) 2005-11-08 2010-03-09 Plensat Llc Method and system for treatment of eating disorders
US8298574B2 (en) 2006-01-18 2012-10-30 Intec Pharma Ltd. Method and apparatus for forming delivery devices for oral intake of an agent
CA2642479C (en) 2006-02-15 2014-08-19 Intec Pharma Ltd. A gastro-retentive system for the delivery of macromolecules
WO2007106415A2 (en) 2006-03-10 2007-09-20 Massachusetts Institute Of Technology Triggered self-assembly conjugates and nanosystems
US7691151B2 (en) 2006-03-31 2010-04-06 Spiration, Inc. Articulable Anchor
US20070264307A1 (en) 2006-05-15 2007-11-15 Medtronic Vascular, Inc. Biodegradable Modified Caprolactone Polymers for Fabricating and Coating Medical Devices
EP1886665A1 (en) 2006-08-01 2008-02-13 Boehringer Ingelheim Pharma GmbH & Co. KG Gastro retentive delivery system
BRPI0716481A2 (pt) 2006-09-04 2014-03-18 Panacea Biotec Ltd Tecnologia de liberação flutuante programável
US20080075766A1 (en) * 2006-09-25 2008-03-27 Shun-Por Li Multi-core dosage form having transparent outer coating
AU2007338631A1 (en) 2006-12-22 2008-07-03 Combinatorx, Incorporated Pharmaceutical compositions for treatment of parkinson's disease and related disorders
WO2008111077A2 (en) 2007-03-13 2008-09-18 Technion Research & Development Foundation Ltd. Self-assembled polyhedral multimeric chemical structures
US8507778B2 (en) 2007-03-13 2013-08-13 Arthur J. Olson Self-assembled polyhedra
US20080249156A1 (en) 2007-04-09 2008-10-09 Palepu Nageswara R Combinations of statins and anti-obesity agent and glitazones
WO2008148083A1 (en) 2007-05-25 2008-12-04 Gorham Enterprises Llc Bariatric magnetic apparatus and method of manufacturing thereof
CA2687979C (en) 2007-05-25 2017-07-04 Tolmar Therapeutics, Inc. Sustained delivery formulations of risperidone compounds
US8038659B2 (en) 2007-10-17 2011-10-18 The Invention Science Fund I, Llc Disintegrating digestive tract interaction system
US8637455B2 (en) 2007-10-22 2014-01-28 Affinergy, Llc Compositions and methods for delivery of glycopeptide antibiotics to medical device surfaces
US8974814B2 (en) 2007-11-12 2015-03-10 California Institute Of Technology Layered drug delivery polymer monofilament fibers
EP2262367A4 (en) 2008-03-08 2011-04-20 Theraquest Biosciences Inc PHARMACEUTICAL ORAL COMPOSITIONS OF BUPRENORPHINE AND METHOD FOR THEIR USE
AU2009223061B2 (en) 2008-03-11 2014-10-09 Depomed Inc. Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic
US20130273135A1 (en) 2008-03-25 2013-10-17 University Of Utah Research Foundation Controlled Release Combination Biomaterials
ES2606395T3 (es) 2008-04-18 2017-03-23 Intec Pharma Ltd. Administración de fármacos gastrorretentivos para carbidopa/levodopa
US9066877B2 (en) 2008-04-28 2015-06-30 Eat Little Inc. Bezoar-forming units for weight control
US20100256342A1 (en) 2008-08-12 2010-10-07 Francis Raymond Salemme Protein nodes for controlled nanoscale assembly
JP2012500230A (ja) 2008-08-18 2012-01-05 北京天衡▲薬▼物研究院 胃内滞留薬物放出システム及びその製造方法と使用
US20110268666A1 (en) 2008-09-29 2011-11-03 Yissum Research Development Company of the Research University of Jerusalem, Ltd. Novel gastroretentive delivery system
JP5559798B2 (ja) 2008-10-10 2014-07-23 レヴァ メディカル、 インコーポレイテッド 拡張可能スライドとロックステント
PL2378883T3 (pl) 2008-12-04 2016-06-30 Intec Pharma Ltd SYSTEM DOSTARCZANIA LEKU ZATRZYMYWANEGO W ŻOŁĄDKU dLA ZALEPLONU
CA2746989A1 (en) 2008-12-27 2010-07-01 Chandra S. Duggirala Devices for treating obesity and methods of using those devices
CN102414116B (zh) 2009-02-26 2015-01-21 加利福尼亚大学董事会 用于制备尺寸可控的纳米颗粒的超分子方法
US8414559B2 (en) 2009-05-07 2013-04-09 Rainbow Medical Ltd. Gastroretentive duodenal pill
EP3103502A1 (en) * 2009-05-15 2016-12-14 Intersect ENT, Inc. Expandable devices and methods therefor
DE102009028076A1 (de) 2009-07-29 2011-02-03 Evonik Röhm Gmbh Beschichtungsmittel zum Tauchbeschichten von Kapselhälften
US20110052700A1 (en) 2009-08-31 2011-03-03 Depomed, Inc. Gastric retentive pharmaceutical compositions for immediate and extended release of levosulpiride
WO2011032087A2 (en) 2009-09-11 2011-03-17 Replication Medical Inc. Swellable polymeric device for dietary regulation
US20120321706A1 (en) 2009-10-19 2012-12-20 Intec Pharma Ltd. Novel gastroretentive dosage forms of poorly soluble drugs
US9421169B2 (en) 2009-11-20 2016-08-23 Covidien Lp Oral dosage forms for delivery of therapeutic agents
CN101711752B (zh) 2009-11-26 2011-09-21 中国科学院上海药物研究所 一种苯并异噁唑类衍生物的控释制剂及其制备方法
WO2011139796A2 (en) 2010-04-27 2011-11-10 The Johns Hopkins University Self-folding sub-centimeter structures
CA2801620A1 (en) 2010-07-06 2012-01-12 Gruenenthal Gmbh Novel gastro-retentive dosage forms comprising a gaba analog and an opioid
PL3517101T3 (pl) * 2010-08-05 2021-02-22 Taris Biomedical Llc Wszczepiane urządzenia do podawania leków w miejscach moczowo-płciowych
US20120165792A1 (en) 2010-12-22 2012-06-28 Ethicon Endo-Surgery, Inc. Pill Catchers
US20120165793A1 (en) 2010-12-22 2012-06-28 Ethicon Endo-Surgery, Inc. Pill Catchers
US20120165794A1 (en) 2010-12-22 2012-06-28 Ethicon Endo-Surgery, Inc. Pill Catchers
WO2012106714A1 (en) 2011-02-04 2012-08-09 Taris Biomedical, Inc. Implantable device for controlled release of low solubility drug
US20130017264A1 (en) 2011-07-15 2013-01-17 Piramal Life Sciences Limited Alginate tube drug delivery system and method therefor
JP2014533975A (ja) 2011-09-26 2014-12-18 ノースイースタン・ユニバーシティ カスタマイズ可能な埋め込みセンサ
US20150265536A1 (en) 2011-12-09 2015-09-24 Purdue Pharma L.P. Pharmaceutical dosage forms comprising poly(epsilon-caprolactone) and polyethylene oxide
US8979887B2 (en) 2012-02-24 2015-03-17 Elwha Llc Devices, systems, and methods to control stomach volume
AU2013290875A1 (en) 2012-07-16 2015-02-05 APET Holding B.V. Gastro-retentive drug delivery system
US9307966B2 (en) 2012-08-15 2016-04-12 St. Jude Medical Puerto Rico Llc Vascular closure device anchor
IN2015DN01023A (enExample) 2012-08-16 2015-06-26 Teva Pharma
US10441760B2 (en) 2013-03-01 2019-10-15 The Johns Hopkins University Self-actuating chemomechanical devices for delivery and extended release of therapeutic agents in the gastrointestinal tract
CN103654903A (zh) 2013-11-27 2014-03-26 西安交通大学 一种用于人体消化道吻合的磁性可降解装置
CA2932574C (en) 2013-12-05 2023-03-07 Tulip Medical Ltd. Retentive devices and systems for in-situ release of pharmaceutical active agents
US20170051099A1 (en) 2014-04-29 2017-02-23 The Brigham And Women's Hospital, Inc. Polymeric materials for bio-applications
CN106456550A (zh) 2014-05-26 2017-02-22 格吕伦塔尔有限公司 避免乙醇剂量倾泻的多颗粒
CN106535878B (zh) 2014-06-02 2022-11-01 科莱西奥生物科技有限公司 可张开的胃内滞留剂型
JP6666858B2 (ja) 2014-06-11 2020-03-18 マサチューセッツ インスティテュート オブ テクノロジー 滞留構造体および関連方法
US20170266112A1 (en) 2014-06-11 2017-09-21 Massachusetts Institute Of Technology Residence structures and related methods
WO2016178971A1 (en) 2015-05-01 2016-11-10 Massachusetts Institute Of Technology Triggerable shape memory induction devices
CN118975972A (zh) 2015-10-23 2024-11-19 林德拉治疗公司 用于治疗剂缓释的胃驻留系统及其使用方法
EP3383365A1 (en) 2015-12-01 2018-10-10 Clexio Biosciences Ltd. Gastric retentive devices
JP2018537201A (ja) 2015-12-02 2018-12-20 クレキシオ バイオサイエンシーズ エルティーディー. 胃保持型投与形態を調整する装置および方法
BR112018011636B1 (pt) 2015-12-08 2024-03-12 Lyndra Therapeutics, Inc Sistema de residência gástrico para liberação sustentada de um agente terapêutico
EP3246050A1 (de) 2016-05-17 2017-11-22 BSN medical GmbH Wund- oder hautauflage
CN119925721A (zh) 2016-05-27 2025-05-06 林德拉治疗公司 用于胃驻留系统的材料结构
CN110022861B (zh) 2016-09-30 2024-06-28 林德拉治疗公司 用于金刚烷类药物缓释的胃驻留系统
WO2018089684A1 (en) 2016-11-09 2018-05-17 Massachusetts Institute Of Technology Triggerable hydrogel compositions and related methods
IL266377B2 (en) 2016-12-02 2023-10-01 Clexio Biosciences Ltd Gastric residence system
AU2018279853B2 (en) 2017-06-09 2024-07-04 Lyndra Therapeutics, Inc. Gastric residence systems with release rate-modulating films
ES3009743T3 (en) 2017-09-20 2025-03-31 Lyndra Therapeutics Inc Encapsulation of gastric residence systems
WO2019111132A1 (en) 2017-12-04 2019-06-13 Clexio Biosciences Ltd. Long acting gastric residence system
US20190365645A1 (en) 2018-05-31 2019-12-05 Massachusetts Institute Of Technology Drug delivery articles for gram-level dosing
WO2020102648A1 (en) 2018-11-15 2020-05-22 Massachusetts Institute Of Technology Millineedle systems for esophageal drug delivery

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