IL202288A - Rsv-specific antibody or functional part thereof, nucleic acids encoding it, vectors, host cells, method for producing such antibody, compositions comprising the same and use thereof for treating rsv-related disorders - Google Patents
Rsv-specific antibody or functional part thereof, nucleic acids encoding it, vectors, host cells, method for producing such antibody, compositions comprising the same and use thereof for treating rsv-related disordersInfo
- Publication number
- IL202288A IL202288A IL202288A IL20228809A IL202288A IL 202288 A IL202288 A IL 202288A IL 202288 A IL202288 A IL 202288A IL 20228809 A IL20228809 A IL 20228809A IL 202288 A IL202288 A IL 202288A
- Authority
- IL
- Israel
- Prior art keywords
- rsv
- antibody
- vectors
- producing
- nucleic acids
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—RNA viruses
- C07K16/11—Paramyxoviridae (F); Pneumoviridae (F), e.g. respiratory syncytial virus [RSV]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Vascular Medicine (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07109472A EP1997830A1 (en) | 2007-06-01 | 2007-06-01 | RSV specific binding molecules and means for producing them |
| PCT/NL2008/050333 WO2008147196A2 (en) | 2007-06-01 | 2008-05-30 | Rsv-specific binding molecules and means for producing them |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL202288A0 IL202288A0 (en) | 2010-06-16 |
| IL202288A true IL202288A (en) | 2016-10-31 |
Family
ID=38578633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL202288A IL202288A (en) | 2007-06-01 | 2009-11-23 | Rsv-specific antibody or functional part thereof, nucleic acids encoding it, vectors, host cells, method for producing such antibody, compositions comprising the same and use thereof for treating rsv-related disorders |
Country Status (22)
| Country | Link |
|---|---|
| US (5) | US8562996B2 (enExample) |
| EP (3) | EP1997830A1 (enExample) |
| JP (4) | JP5450395B2 (enExample) |
| KR (2) | KR101652652B1 (enExample) |
| CN (2) | CN101778866B (enExample) |
| AU (1) | AU2008257801B8 (enExample) |
| BR (1) | BRPI0812878C1 (enExample) |
| CA (2) | CA2950515A1 (enExample) |
| CY (1) | CY1117767T1 (enExample) |
| DK (1) | DK2170952T3 (enExample) |
| ES (1) | ES2575129T3 (enExample) |
| HR (1) | HRP20160632T1 (enExample) |
| HU (1) | HUE029225T2 (enExample) |
| IL (1) | IL202288A (enExample) |
| MX (2) | MX350375B (enExample) |
| NZ (3) | NZ621824A (enExample) |
| PL (1) | PL2170952T3 (enExample) |
| PT (1) | PT2170952E (enExample) |
| RU (2) | RU2527067C2 (enExample) |
| SI (1) | SI2170952T1 (enExample) |
| WO (1) | WO2008147196A2 (enExample) |
| ZA (1) | ZA200908320B (enExample) |
Families Citing this family (66)
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| JP4336498B2 (ja) | 2000-12-12 | 2009-09-30 | メディミューン,エルエルシー | 延長した半減期を有する分子ならびにその組成物および用途 |
| DK1974017T4 (da) | 2005-12-09 | 2023-09-25 | Academisch Medisch Centrum Bij De Univ Van Amsterdam | Midler og fremgangsmåder til at påvirke stabiliteten af antistof producerende celler |
| WO2007067032A1 (en) | 2005-12-09 | 2007-06-14 | Academisch Medisch Cemtrum Bij De Universiteit Van Amsterdam | Means and methods for influencing the stability of cells |
| EP1997830A1 (en) | 2007-06-01 | 2008-12-03 | AIMM Therapeutics B.V. | RSV specific binding molecules and means for producing them |
| EP2201040A1 (en) | 2007-09-24 | 2010-06-30 | Vanderbilt University | Monoclonal antibodies to respiratory syncytial virus and uses thereof |
| US8775090B2 (en) | 2008-12-12 | 2014-07-08 | Medimmune, Llc | Crystals and structure of a human IgG Fc variant with enhanced FcRn binding |
| DK2454283T3 (en) | 2009-07-15 | 2018-05-07 | Aimm Therapeutics Bv | METHODS AND PROCEDURES FOR MANUFACTURING HIGH EFFICIENCY ANTIBODIES |
| AU2015200208B2 (en) * | 2009-07-15 | 2016-10-20 | Kling Biotherapeutics B.V. | Means and methods for producing high affinity antibodies |
| CN104628850B (zh) * | 2009-10-06 | 2020-07-28 | 医学免疫有限公司 | Rsv-特异性结合分子 |
| US8568726B2 (en) | 2009-10-06 | 2013-10-29 | Medimmune Limited | RSV specific binding molecule |
| AU2009353693B2 (en) * | 2009-10-06 | 2016-07-21 | Medimmune Ltd | RSV-specific binding molecule |
| EP2591000B1 (en) * | 2010-07-09 | 2017-05-17 | Janssen Vaccines & Prevention B.V. | Anti-human respiratory syncytial virus (rsv) antibodies and methods of use |
| ES2626671T3 (es) * | 2010-12-02 | 2017-07-25 | Aimm Therapeutics B.V. | Medios y métodos para producir anticuerpos de alta afinidad |
| JP6067575B2 (ja) | 2010-12-17 | 2017-01-25 | ニューリミューン ホールディング エイジー | ヒト抗sod1抗体 |
| RU2624046C2 (ru) * | 2011-11-07 | 2017-06-30 | Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретэри, Департмент Оф Хелт Энд Хьюман Сервисиз | Gp41-нейтрализующие антитела и их применение |
| EP2780366A2 (en) | 2011-11-17 | 2014-09-24 | AIMM Therapeutics B.V. | Rsv g protein specific antibodies |
| CA2865856C (en) * | 2012-03-20 | 2023-03-14 | Humabs Biomed Sa | Antibodies that neutralize rsv, mpv and pvm and uses thereof |
| US10017739B2 (en) | 2012-09-06 | 2018-07-10 | Duke University | Methods of expanding and assessing B cells and using expanded B cells to treat disease |
| ES2778899T3 (es) * | 2013-02-01 | 2020-08-12 | Medimmune Llc | Epítopos de proteína F del virus sincitial respiratorio |
| PT2970398T (pt) | 2013-03-13 | 2024-06-07 | The Us Secretary Department Ofhealth And Human Servic | Proteínas f de pré-fusão do vsr e sua utilização |
| US9738689B2 (en) | 2013-03-13 | 2017-08-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Prefusion RSV F proteins and their use |
| TWI659968B (zh) | 2013-03-14 | 2019-05-21 | 再生元醫藥公司 | 針對呼吸道融合病毒f蛋白質的人類抗體及其使用方法 |
| US9060975B2 (en) | 2013-03-14 | 2015-06-23 | Mucosis Bv | Heat-stable respiratory syncytial virus F protein oligomers and their use in immunological compositions |
| CN105722856B (zh) * | 2013-03-15 | 2019-04-16 | 厦门大学 | Rsv融合蛋白的表位以及识别其的抗体 |
| US10047145B2 (en) | 2013-07-24 | 2018-08-14 | Humabs Biomed Sa | Antibodies that potently neutralize RSV and uses thereof |
| WO2015037992A1 (en) | 2013-09-11 | 2015-03-19 | Aimm Therapeutics B.V. | Parechovirus specific antibodies |
| KR20240042192A (ko) | 2013-12-17 | 2024-04-01 | 크링 바이오테라퓨틱스 비.브이. | 골수 증식성 또는 림프 증식성 질환에 대응하는 수단 및 방법 |
| KR102188437B1 (ko) * | 2014-01-15 | 2020-12-08 | 메디뮨 엘엘씨 | Rsv 특이적 항체 및 이의 기능적 부위 |
| WO2015115892A1 (en) | 2014-01-31 | 2015-08-06 | Aimm Therapeutics B.V. | Means and methods for producing stable antibodies |
| EP2974739A1 (en) | 2014-07-15 | 2016-01-20 | Novartis AG | RSVF trimerization domains |
| US9340604B1 (en) | 2014-10-29 | 2016-05-17 | Aridis Pharmaceuticals, Inc. | Human monoclonal antibody specific for the F protein of respiratory syncytial virus (RSV) |
| JP5996707B2 (ja) * | 2015-04-15 | 2016-09-21 | メディミューン リミテド | Rsv特異的結合分子 |
| EP3124042A1 (en) | 2015-07-28 | 2017-02-01 | VIB, vzw | Immunoglobulin single variable domain antibody against rsv prefusion f protein |
| MY192870A (en) | 2015-06-18 | 2022-09-13 | Univ Gent | Immunoglobulin single variable domain antibody against rsv prefusion f protein |
| JP7010704B2 (ja) | 2015-06-24 | 2022-02-10 | クリング・バイオセラピューティックス・べー・フェー | Aml抗原及びその使用 |
| IL302353A (en) * | 2015-08-19 | 2023-06-01 | Pfizer | TFPI inhibitory antibodies and their uses |
| JO3555B1 (ar) | 2015-10-29 | 2020-07-05 | Merck Sharp & Dohme | جسم مضاد يبطل فعالية فيروس الالتهاب الرئوي البشري |
| PE20240817A1 (es) | 2015-12-23 | 2024-04-18 | Pfizer | Mutantes de proteina f de rsv |
| CN115960263A (zh) | 2016-03-29 | 2023-04-14 | 美国政府(由卫生和人类服务部的部长所代表) | 取代修饰的融合前rsv f蛋白及其用途 |
| KR102695416B1 (ko) | 2016-10-21 | 2024-08-13 | 아디맵 엘엘씨 | 항-호흡기 세포융합 바이러스 항체, 그리고 이의 생성 방법 및 사용 방법 |
| EP3529272A2 (en) | 2016-10-21 | 2019-08-28 | Adimab, LLC | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
| CA3040893A1 (en) | 2016-10-21 | 2018-04-26 | Adimab, Llc | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
| WO2018109220A2 (en) | 2016-12-16 | 2018-06-21 | Institute For Research In Biomedicine | Novel recombinant prefusion rsv f proteins and uses thereof |
| TWI911431B (zh) | 2017-03-01 | 2026-01-11 | 英商梅迪繆思有限公司 | 抗rsv單株抗體配製物 |
| JP7541482B2 (ja) | 2018-01-29 | 2024-08-28 | メルク・シャープ・アンド・ドーム・エルエルシー | 安定化rsv fタンパク質およびその使用 |
| US11623004B2 (en) | 2018-03-16 | 2023-04-11 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Compositions and methods for vaccination against respiratory syncytial virus infection |
| JP7614841B2 (ja) | 2018-04-03 | 2025-01-16 | サノフイ | 抗原性呼吸器合胞体ウイルスポリペプチド |
| CN112512566A (zh) | 2018-04-03 | 2021-03-16 | 赛诺菲 | 抗原性爱泼斯坦-巴尔病毒多肽 |
| EP3773698A1 (en) | 2018-04-03 | 2021-02-17 | Sanofi | Ferritin proteins |
| CN113993884A (zh) * | 2019-04-18 | 2022-01-28 | 弗劳恩霍夫应用研究促进协会 | 抑制呼吸道合胞病毒感染的生物及合成分子 |
| US12024553B2 (en) | 2019-04-30 | 2024-07-02 | Medimmune Limited | Dosage regimens for and compositions including anti-RSV antibodies |
| AU2020332350A1 (en) * | 2019-08-21 | 2022-04-07 | Board Of Regents, The University Of Texas System | Immune cells for adoptive cell therapies |
| WO2021247712A1 (en) * | 2020-06-02 | 2021-12-09 | Battelle Memorial Institute | SYSTEMS AND PROCESSES TO SCREEN FOR SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-CoV-2) OF 2019 (COVID-19) |
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| JP7822149B2 (ja) | 2020-10-02 | 2026-03-02 | ファイザー・インク | Rsv fタンパク質生産のための細胞培養工程 |
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