IL166587A0 - Process for preparing nitrooxyderivatives of napr oxen - Google Patents

Process for preparing nitrooxyderivatives of napr oxen

Info

Publication number
IL166587A0
IL166587A0 IL16658705A IL16658705A IL166587A0 IL 166587 A0 IL166587 A0 IL 166587A0 IL 16658705 A IL16658705 A IL 16658705A IL 16658705 A IL16658705 A IL 16658705A IL 166587 A0 IL166587 A0 IL 166587A0
Authority
IL
Israel
Prior art keywords
preparing
nitrooxyderivatives
napr
oxen
compound
Prior art date
Application number
IL16658705A
Other languages
English (en)
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox Sa filed Critical Nicox Sa
Publication of IL166587A0 publication Critical patent/IL166587A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/02—Preparation of esters of nitric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/10—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with ester groups or with a carbon-halogen bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
IL16658705A 2002-08-29 2005-01-31 Process for preparing nitrooxyderivatives of napr oxen IL166587A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT001861A ITMI20021861A1 (it) 2002-08-29 2002-08-29 Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione.
PCT/EP2003/008698 WO2004020384A1 (en) 2002-08-29 2003-08-06 Process for preparing nitrooxyderivatives of naproxen

Publications (1)

Publication Number Publication Date
IL166587A0 true IL166587A0 (en) 2006-01-15

Family

ID=31972201

Family Applications (1)

Application Number Title Priority Date Filing Date
IL16658705A IL166587A0 (en) 2002-08-29 2005-01-31 Process for preparing nitrooxyderivatives of napr oxen

Country Status (20)

Country Link
US (3) US7199258B2 (ko)
EP (2) EP1537070A1 (ko)
JP (2) JP4528123B2 (ko)
KR (1) KR101100064B1 (ko)
CN (1) CN1326830C (ko)
AT (1) ATE449060T1 (ko)
AU (2) AU2003266261A1 (ko)
CA (1) CA2497187C (ko)
CY (1) CY1109769T1 (ko)
DE (1) DE60330152D1 (ko)
DK (1) DK1532098T3 (ko)
ES (1) ES2335656T3 (ko)
IL (1) IL166587A0 (ko)
IT (1) ITMI20021861A1 (ko)
NZ (1) NZ537993A (ko)
PT (1) PT1532098E (ko)
RU (1) RU2315035C2 (ko)
SI (1) SI1532098T1 (ko)
WO (2) WO2004020385A1 (ko)
ZA (1) ZA200500890B (ko)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7163958B2 (en) 2002-07-03 2007-01-16 Nitromed Inc. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
ITMI20021861A1 (it) * 2002-08-29 2004-02-29 Nicox Sa Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione.
ES2327550T3 (es) 2004-11-25 2009-10-30 Nicox S.A. Proceso para preparar nitratos de halogenoalquilo.
WO2009149053A2 (en) * 2008-06-02 2009-12-10 Dr. Reddy's Laboratories Ltd. Naproxcinod process and solid dispersion
ITRM20080325A1 (it) * 2008-06-20 2009-12-21 Nicox Sa Metodo per purificare 4-(nitroosi)butil(2s)-2-(6-metossi-2-naftil) propanoato
US8062653B2 (en) * 2009-02-18 2011-11-22 Bezwada Biomedical, Llc Controlled release of nitric oxide and drugs from functionalized macromers and oligomers
CN101885684B (zh) * 2010-07-01 2013-10-30 南京中医药大学 带有一氧化氮供体的芳香酸前体药物及其制备方法和其应用
TWI417276B (zh) * 2011-03-01 2013-12-01 Everlight Chem Ind Corp ２-（ｓ）-（６-甲氧基-２-萘基）-丙酸之酸酐衍生物、其製法暨及其用途
CA2897571C (en) 2013-01-21 2018-12-18 Apparao Satyam Nitric oxide releasing prodrugs of therapeutic agents containing at least one carboxylic acid group
AU2019369157A1 (en) * 2018-10-25 2021-05-06 Dsm Ip Assets B.V. Aqueous compositions comprising omega nitrooxy-1-alkanols
CN111333560B (zh) * 2020-04-13 2024-01-23 合肥工业大学 一种制备螺环β-内酰胺的方法
CN112321420A (zh) * 2020-11-03 2021-02-05 浙江海翔川南药业有限公司 一种萘普生杂质及其制备方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5279359A (en) * 1975-12-26 1977-07-04 Hitachi Ltd Cleaning material arrestor
US5057427A (en) * 1988-04-07 1991-10-15 Sepracor, Inc. Method for resolution of stereoisomers
JPH05279359A (ja) 1992-02-06 1993-10-26 Kawaken Fine Chem Co Ltd アポビンカミン酸エステルの製造方法
JPH05247015A (ja) * 1992-03-05 1993-09-24 Nippon Iyakuhin Kogyo Kk 新規ピペラジン誘導体
HU218923B (hu) * 1993-10-06 2000-12-28 Nicox S.A. Gyulladásgátló és/vagy fájdalomcsillapító hatású nitrát-észterek, ezeket tartalmazó gyógyszerkészítmények és eljárás a vegyületek előállítására
RU2145595C1 (ru) * 1994-05-10 2000-02-20 Никокс С.А. Нитроксисоединения и фармацевтическая композиция на их основе, имеющие противовоспалительную, анальгетическую и антитромбоцитарную активности
IT1276071B1 (it) * 1995-10-31 1997-10-24 Nicox Ltd Compositi ad attivita' anti-infiammatoria
CA2262788A1 (en) 1996-08-16 1998-02-26 Gustavo Enrique Aldoma Non-ulcerogenic analgesic/anti-inflammatory clonixin derivative
IT1288123B1 (it) * 1996-09-04 1998-09-10 Nicox Sa Uso di nitroderivati per l'incontinenza urinaria
FR2757159B1 (fr) * 1996-12-12 1999-12-17 Hoechst Marion Roussel Inc Nouveaux derives nitres analgesiques, anti-inflammatoires et anti-thrombotiques, leur procede de preparation, leur application comme medicaments
IT1311924B1 (it) * 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
IT1313596B1 (it) * 1999-08-04 2002-09-09 Nicox Sa Processo per la preparazione di nitrossialchil esteri del naproxene
IT1314184B1 (it) * 1999-08-12 2002-12-06 Nicox Sa Composizioni farmaceutiche per la terapia di condizioni di stressossidativo
US6429223B1 (en) * 2000-06-23 2002-08-06 Medinox, Inc. Modified forms of pharmacologically active agents and uses therefor
ITMI20010985A1 (it) * 2001-05-15 2002-11-15 Nicox Sa Farmaci per il morbo di alzheimer
ITMI20011307A1 (it) * 2001-06-21 2002-12-21 Nicox Sa Farmaci per l'epilessia
ITMI20011308A1 (it) * 2001-06-21 2002-12-21 Nicox Sa Farmaci per il dolore cronico
CA2465697C (en) * 2001-11-27 2010-05-11 Astrazeneca Ab Process for the preparation of (s)-naproxen 4-nitrooxybutyl ester
EP1539134A4 (en) * 2002-06-11 2007-04-11 Nitromed Inc SELECTIVE INHIBITORS OF CYCLOOXIGENASE-2 NITROSIS AND / OR NITROSYLES, COMPOSITIONS AND METHODS OF USE
US7163958B2 (en) * 2002-07-03 2007-01-16 Nitromed Inc. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
ITMI20021861A1 (it) * 2002-08-29 2004-02-29 Nicox Sa Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione.
US7199947B2 (en) * 2004-12-28 2007-04-03 Motorola Inc. Miniature digital camera lens

Also Published As

Publication number Publication date
WO2004020384A1 (en) 2004-03-11
CA2497187C (en) 2012-09-25
US20070112194A1 (en) 2007-05-17
NZ537993A (en) 2006-11-30
DE60330152D1 (de) 2009-12-31
EP1532098A1 (en) 2005-05-25
JP4528123B2 (ja) 2010-08-18
AU2003266966B2 (en) 2009-08-06
US20100217028A1 (en) 2010-08-26
US20060173005A1 (en) 2006-08-03
ZA200500890B (en) 2006-02-22
CN1678560A (zh) 2005-10-05
US7723382B2 (en) 2010-05-25
KR101100064B1 (ko) 2011-12-29
CY1109769T1 (el) 2014-09-10
ATE449060T1 (de) 2009-12-15
ITMI20021861A1 (it) 2004-02-29
KR20050057057A (ko) 2005-06-16
EP1537070A1 (en) 2005-06-08
WO2004020385A1 (en) 2004-03-11
AU2003266966A1 (en) 2004-03-19
AU2003266261A1 (en) 2004-03-19
PT1532098E (pt) 2010-02-04
ES2335656T3 (es) 2010-03-31
RU2315035C2 (ru) 2008-01-20
EP1532098B1 (en) 2009-11-18
RU2005104419A (ru) 2005-11-20
CA2497187A1 (en) 2004-03-11
JP2005536558A (ja) 2005-12-02
US7199258B2 (en) 2007-04-03
DK1532098T3 (da) 2010-03-15
JP2005536559A (ja) 2005-12-02
SI1532098T1 (sl) 2010-03-31
CN1326830C (zh) 2007-07-18

Similar Documents

Publication Publication Date Title
IL166587A0 (en) Process for preparing nitrooxyderivatives of napr oxen
GB0015876D0 (en) Organic compounds
GB0220581D0 (en) Organic Compound
JO2707B1 (ar) مشتقات ثيوفين جليكوسايد جديدة, طرق تحضيرها, والادوية المحتوية على هذه المركبات واستخدامها
CA2425560A1 (en) Anticholinergics, processes for preparing them and their use as pharmaceutical compositions
NO20053890L (no) Syntese av 4-amino-2-butenolklorider og anvendelse derav for fremstilling av 3-cyanokinoliner
NO20051225L (no) 1,2,4- oksadiazoler som modulatorer av metabotropisk glutamat-reseptor-5
HUP0500457A2 (hu) Polialkilén polimervegyületek, ilyeneket tartalmazó készítmények és azok alkalmazása
MY138051A (en) Compounds and processes
BR0308419A (pt) Derivados de azetidina como antagonistas do receptor ccr-3
HK1075013A1 (en) Crystal modification of a cyclic depsipeptide having improved strength
SE9000871D0 (sv) Derivatives of thieno-triazolo-diazepine, a preparation process of the same and therapeutic compositions containing them
CA2370376A1 (en) Anhydrous mirtazapine crystals and process for the production thereof
ES2019840A6 (es) Procedimiento para preparar nuevos derivados de tieno-triazolo-diazepina.
AU2001250356A1 (en) Method for the production of spirocyclic tetronic acid derivatives
SG146692A1 (en) Melanin concentrating hormone antagonists
KR850001212A (ko) 시너지스틴 유도체의 제조방법
EP0391254A3 (en) Novel thiouracil derivatives pharmaceutical compositions containing them and process for preparing same
YU3099A (sh) Novi derivati eritromicina, postupak za njihovo dobijanje i njihova primena
GB9920959D0 (en) Novel process
NO20001541L (no) Nye substituerte dimeriske forbindelser, fremgangsmÕte for deres fremstilling og farmasøytiske sammensetninger inneholdende dem
MXPA06001115A (es) Un proceso nuevo para la preparacion de imipenem.
YU75703A (sh) Postupak za pripremanje tetrasupstituisanih derivata imidazola i njihove nove kristalne strukure
AU2007601A (en) Method for production of 1,3-disubstituted 2-nitroguanidines

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees