IL166546A0 - Further novel forms of interfering ran molecules - Google Patents
Further novel forms of interfering ran moleculesInfo
- Publication number
- IL166546A0 IL166546A0 IL16654603A IL16654603A IL166546A0 IL 166546 A0 IL166546 A0 IL 166546A0 IL 16654603 A IL16654603 A IL 16654603A IL 16654603 A IL16654603 A IL 16654603A IL 166546 A0 IL166546 A0 IL 166546A0
- Authority
- IL
- Israel
- Prior art keywords
- ran
- interfering
- molecules
- stretch
- further novel
- Prior art date
Links
Classifications
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A61K31/713—Double-stranded nucleic acids or oligonucleotides
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/11—Protein-serine/threonine kinases (2.7.11)
- C12Y207/11001—Non-specific serine/threonine protein kinase (2.7.11.1), i.e. casein kinase or checkpoint kinase
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- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
- C12Y301/03048—Protein-tyrosine-phosphatase (3.1.3.48)
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/14—Type of nucleic acid interfering N.A.
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/317—Chemical structure of the backbone with an inverted bond, e.g. a cap structure
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- C12N2310/31—Chemical structure of the backbone
- C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
- C12N2310/3183—Diol linkers, e.g. glycols or propanediols
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- C12N2310/321—2'-O-R Modification
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- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/343—Spatial arrangement of the modifications having patterns, e.g. ==--==--==--
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- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
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- C12N2310/3521—Methyl
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Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02017601A EP1389637B1 (en) | 2002-08-05 | 2002-08-05 | Blunt-ended interfering RNA molecules |
US40254102P | 2002-08-12 | 2002-08-12 | |
EP03008383 | 2003-04-10 | ||
PCT/EP2003/008666 WO2004015107A2 (en) | 2002-08-05 | 2003-08-05 | Further novel forms of interfering rna molecules |
Publications (1)
Publication Number | Publication Date |
---|---|
IL166546A0 true IL166546A0 (en) | 2006-01-15 |
Family
ID=31720998
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL16654603A IL166546A0 (en) | 2002-08-05 | 2003-08-05 | Further novel forms of interfering ran molecules |
IL16654605A IL166546A (en) | 2002-08-05 | 2005-01-27 | Double-stranded ribonucleic acid, preparations containing it, is used in drug preparation and in vitro method to inhibit the expression of a target gene |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL16654605A IL166546A (en) | 2002-08-05 | 2005-01-27 | Double-stranded ribonucleic acid, preparations containing it, is used in drug preparation and in vitro method to inhibit the expression of a target gene |
Country Status (19)
Country | Link |
---|---|
US (15) | US7452987B2 (zh) |
EP (6) | EP1527176B2 (zh) |
JP (4) | JP5490655B2 (zh) |
KR (1) | KR101201664B1 (zh) |
CN (1) | CN100543137C (zh) |
AT (1) | ATE350473T2 (zh) |
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