IL154305A0 - INHIBITION OF alpha4 MEDIATED CELL ADHESION - Google Patents
INHIBITION OF alpha4 MEDIATED CELL ADHESIONInfo
- Publication number
- IL154305A0 IL154305A0 IL15430501A IL15430501A IL154305A0 IL 154305 A0 IL154305 A0 IL 154305A0 IL 15430501 A IL15430501 A IL 15430501A IL 15430501 A IL15430501 A IL 15430501A IL 154305 A0 IL154305 A0 IL 154305A0
- Authority
- IL
- Israel
- Prior art keywords
- inhibition
- cell adhesion
- mediated cell
- alpha4
- alpha4 mediated
- Prior art date
Links
- 230000021164 cell adhesion Effects 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
- 230000001404 mediated effect Effects 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Virology (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Molecular Biology (AREA)
- Psychology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22912800P | 2000-08-31 | 2000-08-31 | |
PCT/US2001/026594 WO2002018320A2 (en) | 2000-08-31 | 2001-08-27 | INHIBITORS OF α4 MEDIATED CELL ADHESION |
Publications (1)
Publication Number | Publication Date |
---|---|
IL154305A0 true IL154305A0 (en) | 2003-09-17 |
Family
ID=22859926
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL15430501A IL154305A0 (en) | 2000-08-31 | 2001-08-27 | INHIBITION OF alpha4 MEDIATED CELL ADHESION |
IL154305A IL154305A (en) | 2000-08-31 | 2003-02-05 | Phenylalanine derivatives, medicinal preparations contain them and methods for their preparation |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL154305A IL154305A (en) | 2000-08-31 | 2003-02-05 | Phenylalanine derivatives, medicinal preparations contain them and methods for their preparation |
Country Status (28)
Country | Link |
---|---|
US (6) | US7026501B2 (is) |
EP (1) | EP1315694B1 (is) |
JP (1) | JP3899022B2 (is) |
KR (1) | KR100528049B1 (is) |
CN (1) | CN1229334C (is) |
AR (1) | AR034556A1 (is) |
AT (1) | ATE292615T1 (is) |
AU (2) | AU8677801A (is) |
BR (1) | BR0113629A (is) |
CA (1) | CA2418054C (is) |
CZ (1) | CZ303460B6 (is) |
DE (1) | DE60109943T2 (is) |
DK (1) | DK1315694T3 (is) |
ES (1) | ES2240509T3 (is) |
HK (1) | HK1052684B (is) |
HU (1) | HUP0302693A3 (is) |
IL (2) | IL154305A0 (is) |
MX (1) | MXPA03001837A (is) |
MY (1) | MY129000A (is) |
NO (1) | NO327861B1 (is) |
NZ (1) | NZ524043A (is) |
PL (1) | PL206656B1 (is) |
PT (1) | PT1315694E (is) |
RU (1) | RU2250895C2 (is) |
SI (1) | SI1315694T1 (is) |
TW (1) | TWI224587B (is) |
WO (1) | WO2002018320A2 (is) |
ZA (1) | ZA200301039B (is) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
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PL223152B1 (pl) | 2000-08-18 | 2016-10-31 | Ajinomoto Kk | Pochodne fenyloalaniny, kompozycja farmaceutyczna oraz zastosowanie tych pochodnych |
TWI312347B (en) | 2001-02-08 | 2009-07-21 | Eisai R&D Man Co Ltd | Bicyclic nitrogen-containing condensed ring compounds |
BR0209252A (pt) | 2001-04-27 | 2004-07-20 | Eisai Co Ltd | Pirazolo[1,5-a]piridinas e medicamentos contendo as mesmas |
MY140707A (en) * | 2002-02-28 | 2010-01-15 | Mitsubishi Tanabe Pharma Corp | Process for preparing a phenylalanine derivative and intermediates thereof |
JP2005535710A (ja) * | 2002-08-09 | 2005-11-24 | トランス テック ファーマ,インコーポレイテッド | アリールおよびヘテロアリール化合物ならびに凝固を調節する方法 |
US7176216B2 (en) | 2002-10-22 | 2007-02-13 | Eisai Co., Ltd. | 7-phenylpyrazolopyridine compounds |
DE60326869D1 (de) | 2002-10-22 | 2009-05-07 | Eisai R&D Man Co Ltd | 7-phenylpyrazolopyridinverbindungen |
US7208601B2 (en) | 2003-08-08 | 2007-04-24 | Mjalli Adnan M M | Aryl and heteroaryl compounds, compositions, and methods of use |
CA2531796A1 (en) | 2003-08-08 | 2005-02-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions, and methods of use |
WO2005014532A1 (en) * | 2003-08-08 | 2005-02-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions and methods of use |
CN1917881B (zh) * | 2003-12-22 | 2014-11-26 | 味之素株式会社 | 新型苯基丙氨酸衍生物 |
MY140489A (en) | 2003-12-26 | 2009-12-31 | Eisai R&D Man Co Ltd | 1,2-di (cyclic) substituted benzene compounds |
US7419666B1 (en) | 2004-02-23 | 2008-09-02 | Massachusetts Eye And Ear Infirmary | Treatment of ocular disorders |
JP4966017B2 (ja) | 2004-12-20 | 2012-07-04 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 1−シクロプロピルメチル−4−[2−(3,3,5,5−テトラメチルシクロヘキシル)フェニル]ピペラジンの塩および結晶 |
US7410971B2 (en) | 2004-12-24 | 2008-08-12 | Eisai R&D Management Co., Ltd. | 1,2-di(cyclic)substituted benzene compounds |
EA013080B1 (ru) | 2005-06-09 | 2010-02-26 | Юсб Фарма С.А. | 2,6-хинолинильные производные, способы их получения и их применение |
US20090137601A1 (en) * | 2005-11-23 | 2009-05-28 | Astrazeneca Ab | L-Phenylalanine Derivatives |
IL172896A0 (en) * | 2005-12-29 | 2006-06-11 | Yeda Res & Dev | Cxcr4 inhibition |
CA2635531C (en) * | 2005-12-29 | 2014-06-17 | Lexicon Pharmaceutical Inc. | Multicyclic amino acid derivatives and methods of their use |
US7855291B2 (en) | 2005-12-29 | 2010-12-21 | Lexicon Pharmaceuticals, Inc. | Process for the preparation of substituted phenylalanines |
US7897763B2 (en) | 2005-12-29 | 2011-03-01 | Lexicon Pharmaceuticals, Inc. | Process for the preparation of substituted phenylalanines |
WO2007092471A2 (en) * | 2006-02-03 | 2007-08-16 | The Regents Of The University Of California | Methods for inhibition of lymphangiogenesis and tumor metastasis |
US20090203663A1 (en) * | 2006-02-09 | 2009-08-13 | Astrazeneca Ab | Chemical compounds |
PL2676967T3 (pl) | 2006-02-28 | 2019-12-31 | Biogen Ma Inc. | Metody leczenia chorób zapalnych i autoimmunologicznych za pomocą natalizumabu |
CA2641160A1 (en) * | 2006-02-28 | 2007-09-07 | Elan Pharmaceuticals, Inc. | Methods of treating inflammatory and autoimmune diseases with alpha-4 inhibitory compounds |
EA016626B1 (ru) | 2006-03-03 | 2012-06-29 | Элан Фамэсьютикэлс, Инк. | Способ лечения натализумабом воспалительного и/или аутоиммунного заболевания (варианты) |
EP3318260B1 (en) | 2007-08-24 | 2020-09-23 | Lexicon Pharmaceuticals, Inc. | Methods of preparing 4-phenyl-6-(2,2,2- trifluoro-1-phenylethoxy) pyrimidine-based compounds |
PT2266990E (pt) | 2008-04-15 | 2012-12-27 | Eisai R&D Man Co Ltd | Composto de 3-fenilpirazolo[5,1-b]tiazole |
AR078521A1 (es) | 2009-10-08 | 2011-11-16 | Eisai R&D Man Co Ltd | Compuesto pirazolotiazol |
MX2012004707A (es) * | 2009-10-21 | 2012-06-08 | Glaxo Group Ltd | Proceso para la preparacion de un derivado de fenilalanina. |
DK3339865T5 (da) | 2010-01-11 | 2023-03-20 | Biogen Ma Inc | Assay for jc-virus-antistoffer |
US11287423B2 (en) | 2010-01-11 | 2022-03-29 | Biogen Ma Inc. | Assay for JC virus antibodies |
US20150010563A1 (en) * | 2012-02-21 | 2015-01-08 | Massachusetts Eye & Ear Infirmary | Methods for Treating Corneal and Conjunctival Inflammation and Inflammatory Disorders |
EP3004334A4 (en) | 2013-05-28 | 2016-12-21 | Biogen Ma Inc | METHODS OF EVALUATION RISK OF DEVELOPMENT OF PML |
WO2018085552A1 (en) * | 2016-11-02 | 2018-05-11 | Saint Louis University | Integrin antagonists |
EP3873897A1 (en) | 2018-10-30 | 2021-09-08 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
JP7189369B2 (ja) | 2018-10-30 | 2022-12-13 | ギリアード サイエンシーズ, インコーポレイテッド | アルファ4β7インテグリンの阻害のための化合物 |
CN112969687A (zh) | 2018-10-30 | 2021-06-15 | 吉利德科学公司 | 作为α4β7整合素抑制剂的喹啉衍生物 |
CN112969700A (zh) | 2018-10-30 | 2021-06-15 | 吉利德科学公司 | 作为α4β7整合素抑制剂的咪唑并吡啶衍生物 |
WO2021030438A1 (en) | 2019-08-14 | 2021-02-18 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
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JPH09504302A (ja) | 1993-11-01 | 1997-04-28 | 日本チバガイギー株式会社 | エンドセリン・レセプター・アンタゴニスト |
BR9507220A (pt) | 1994-03-28 | 1997-09-09 | Japat Ltd | Antagonistas de receptores de endotelina |
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2001
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- 2001-08-27 HU HU0302693A patent/HUP0302693A3/hu unknown
- 2001-08-27 AU AU8677801A patent/AU8677801A/xx active Pending
- 2001-08-27 DE DE60109943T patent/DE60109943T2/de not_active Expired - Lifetime
- 2001-08-27 ES ES01966246T patent/ES2240509T3/es not_active Expired - Lifetime
- 2001-08-27 CN CNB018149871A patent/CN1229334C/zh not_active Expired - Fee Related
- 2001-08-27 JP JP2002523438A patent/JP3899022B2/ja not_active Expired - Fee Related
- 2001-08-27 CZ CZ20030487A patent/CZ303460B6/cs not_active IP Right Cessation
- 2001-08-27 CA CA 2418054 patent/CA2418054C/en not_active Expired - Fee Related
- 2001-08-27 BR BR0113629-1A patent/BR0113629A/pt active Search and Examination
- 2001-08-27 AT AT01966246T patent/ATE292615T1/de active
- 2001-08-27 DK DK01966246T patent/DK1315694T3/da active
- 2001-08-27 SI SI200130351T patent/SI1315694T1/xx unknown
- 2001-08-27 US US10/333,985 patent/US7026501B2/en not_active Expired - Fee Related
- 2001-08-27 AU AU2001286778A patent/AU2001286778B2/en not_active Ceased
- 2001-08-27 KR KR10-2003-7001993A patent/KR100528049B1/ko not_active IP Right Cessation
- 2001-08-27 EP EP01966246A patent/EP1315694B1/en not_active Expired - Lifetime
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- 2001-08-27 NZ NZ524043A patent/NZ524043A/en not_active IP Right Cessation
- 2001-08-27 ZA ZA200301039A patent/ZA200301039B/xx unknown
- 2001-08-27 MX MXPA03001837A patent/MXPA03001837A/es active IP Right Grant
- 2001-08-27 WO PCT/US2001/026594 patent/WO2002018320A2/en active IP Right Grant
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- 2001-08-27 IL IL15430501A patent/IL154305A0/xx unknown
- 2001-08-31 AR ARP010104172A patent/AR034556A1/es active IP Right Grant
- 2001-08-31 TW TW090121581A patent/TWI224587B/zh not_active IP Right Cessation
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2003
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- 2003-02-25 NO NO20030885A patent/NO327861B1/no not_active IP Right Cessation
- 2003-07-11 HK HK03105043.3A patent/HK1052684B/zh not_active IP Right Cessation
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2005
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2008
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2010
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2013
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