HUP0302693A2 - Az alfa4-integrinek által közvetített sejttapadás inhibitoraiként hatásos új fenil-alanin származékok, eljárás elõállításukra és ilyen hatóanyagot tartalmazó gyógyászati készítmények - Google Patents

Az alfa4-integrinek által közvetített sejttapadás inhibitoraiként hatásos új fenil-alanin származékok, eljárás elõállításukra és ilyen hatóanyagot tartalmazó gyógyászati készítmények

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Publication number
HUP0302693A2
HUP0302693A2 HU0302693A HUP0302693A HUP0302693A2 HU P0302693 A2 HUP0302693 A2 HU P0302693A2 HU 0302693 A HU0302693 A HU 0302693A HU P0302693 A HUP0302693 A HU P0302693A HU P0302693 A2 HUP0302693 A2 HU P0302693A2
Authority
HU
Hungary
Prior art keywords
phenylalanin
alpha4
derivatives
preparation
integrin inhibitors
Prior art date
Application number
HU0302693A
Other languages
English (en)
Inventor
Takayuki Kawaguchi
Toshiyuki Kume
Sumihiro Nomura
Ila Sircar
Mikiko Tsukimoto
Original Assignee
Tanabe Seiyaku Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co., Ltd. filed Critical Tanabe Seiyaku Co., Ltd.
Publication of HUP0302693A2 publication Critical patent/HUP0302693A2/hu
Publication of HUP0302693A3 publication Critical patent/HUP0302693A3/hu

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    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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Abstract

A találmány tárgyát az (I) általános képletű fenil-alanin-származékvagy gyógyászatilag elfogadható sója képezi, ahol X1 jelentésehalogénatom, X2 jelentése halogénatom, Q jelentése egy -CH2- vagy egy-(CH2)2 képletű csoport, Y jelentése 1-6 szénatomos alkilcsoport, -CO2R jelentése adott esetben észterezett karboxilcsoport. A találmánykiterjed a vegyületek alkalmazására és előállítási eljárásukra is. Ó
HU0302693A 2000-08-31 2001-08-27 Phenylalanin-derivatives, integrin inhibitors of alpha4, their use and process for their preparation HUP0302693A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22912800P 2000-08-31 2000-08-31
PCT/US2001/026594 WO2002018320A2 (en) 2000-08-31 2001-08-27 INHIBITORS OF α4 MEDIATED CELL ADHESION

Publications (2)

Publication Number Publication Date
HUP0302693A2 true HUP0302693A2 (hu) 2003-12-29
HUP0302693A3 HUP0302693A3 (en) 2005-05-30

Family

ID=22859926

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0302693A HUP0302693A3 (en) 2000-08-31 2001-08-27 Phenylalanin-derivatives, integrin inhibitors of alpha4, their use and process for their preparation

Country Status (28)

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US (6) US7026501B2 (hu)
EP (1) EP1315694B1 (hu)
JP (1) JP3899022B2 (hu)
KR (1) KR100528049B1 (hu)
CN (1) CN1229334C (hu)
AR (1) AR034556A1 (hu)
AT (1) ATE292615T1 (hu)
AU (2) AU8677801A (hu)
BR (1) BR0113629A (hu)
CA (1) CA2418054C (hu)
CZ (1) CZ303460B6 (hu)
DE (1) DE60109943T2 (hu)
DK (1) DK1315694T3 (hu)
ES (1) ES2240509T3 (hu)
HK (1) HK1052684B (hu)
HU (1) HUP0302693A3 (hu)
IL (2) IL154305A0 (hu)
MX (1) MXPA03001837A (hu)
MY (1) MY129000A (hu)
NO (1) NO327861B1 (hu)
NZ (1) NZ524043A (hu)
PL (1) PL206656B1 (hu)
PT (1) PT1315694E (hu)
RU (1) RU2250895C2 (hu)
SI (1) SI1315694T1 (hu)
TW (1) TWI224587B (hu)
WO (1) WO2002018320A2 (hu)
ZA (1) ZA200301039B (hu)

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