YU76401A - 1-amino triazolo(4,3-a)hinazolin-5-oni i/ili - 5-tioni koji inhibiraju fosfodiesteraze iv - Google Patents
1-amino triazolo(4,3-a)hinazolin-5-oni i/ili - 5-tioni koji inhibiraju fosfodiesteraze ivInfo
- Publication number
- YU76401A YU76401A YU76401A YUP76401A YU76401A YU 76401 A YU76401 A YU 76401A YU 76401 A YU76401 A YU 76401A YU P76401 A YUP76401 A YU P76401A YU 76401 A YU76401 A YU 76401A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- phosphodieterase
- thiones
- quinazoline
- inhibiting
- ones
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Addiction (AREA)
- Dermatology (AREA)
- Pregnancy & Childbirth (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Gynecology & Obstetrics (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Pronalazak se odnosi na triazolo (4,3-a) hinozolin-5-one i/ili -5-tione formule I ili II; gde (I) i (II) su izomeri položaja grupe R na azot 3 ili 4. Opcionalno, pronalazak se odnosi na racemske oblike, izomere i njihove farmaceutski prihvatljive soli. Pronalazak se dalje odnosi na postupak njihove proizvodnje i na preparate koji sadrže pomenute derivate. Jedinjenja deluju kao inhibitori fosfodiesteraze IV (PDE-4).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9905398A FR2792938B1 (fr) | 1999-04-28 | 1999-04-28 | NOUVELLES 1-AMINO TRIAZOLO [4,3-a] QUINAZOLINE-5-ONES INHIBITRICES DE PHOSPHODIESTERASES IV |
Publications (1)
Publication Number | Publication Date |
---|---|
YU76401A true YU76401A (sh) | 2004-07-15 |
Family
ID=9544983
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU76401A YU76401A (sh) | 1999-04-28 | 2000-04-28 | 1-amino triazolo(4,3-a)hinazolin-5-oni i/ili - 5-tioni koji inhibiraju fosfodiesteraze iv |
Country Status (34)
Country | Link |
---|---|
US (1) | US6828315B1 (sh) |
EP (1) | EP1177195B1 (sh) |
JP (1) | JP2002543199A (sh) |
KR (1) | KR20020008166A (sh) |
CN (1) | CN1352644A (sh) |
AP (1) | AP2001002309A0 (sh) |
AT (1) | ATE234840T1 (sh) |
AU (1) | AU4411500A (sh) |
BG (1) | BG106026A (sh) |
BR (1) | BR0010072A (sh) |
CA (1) | CA2388658A1 (sh) |
DE (1) | DE60001735T2 (sh) |
DK (1) | DK1177195T3 (sh) |
DZ (1) | DZ3154A1 (sh) |
EA (1) | EA004373B1 (sh) |
EE (1) | EE200100566A (sh) |
ES (1) | ES2194779T3 (sh) |
FR (1) | FR2792938B1 (sh) |
HK (1) | HK1044938B (sh) |
HR (1) | HRP20010794B1 (sh) |
HU (1) | HUP0202656A3 (sh) |
IL (1) | IL146178A0 (sh) |
IS (1) | IS6114A (sh) |
MA (1) | MA27343A1 (sh) |
MX (1) | MXPA01010888A (sh) |
NO (1) | NO20015235L (sh) |
OA (1) | OA11875A (sh) |
PL (1) | PL351951A1 (sh) |
PT (1) | PT1177195E (sh) |
SK (1) | SK15322001A3 (sh) |
TR (1) | TR200103099T2 (sh) |
WO (1) | WO2000066584A1 (sh) |
YU (1) | YU76401A (sh) |
ZA (1) | ZA200108847B (sh) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1188438A1 (en) * | 2000-09-15 | 2002-03-20 | Warner-Lambert Company | Pharmaceutical composition for preventing or treating a disease associated with an excess of Il-12 production |
EP1199074A1 (en) * | 2000-09-15 | 2002-04-24 | Warner-Lambert Company | Pharmaceutical composition for preventing or treating a disease associated with an excess of il-12 production |
PA8539501A1 (es) * | 2001-02-14 | 2002-09-30 | Warner Lambert Co | Compuestos triazolo como inhibidores de mmp |
KR20040007596A (ko) * | 2001-05-23 | 2004-01-24 | 다나베 세이야꾸 가부시키가이샤 | 골절 치료 촉진용 조성물 |
EP1285922A1 (en) * | 2001-08-13 | 2003-02-26 | Warner-Lambert Company | 1-Alkyl or 1-cycloalkyltriazolo[4,3-a]quinazolin-5-ones as phosphodiesterase inhibitors |
FR2832711B1 (fr) * | 2001-11-26 | 2004-01-30 | Warner Lambert Co | Derives de triazolo [4,3-a] pyrido [2,3-d] pyrimidin-5-ones, compositions les contenant, procede de preparation et utilisation |
DE10229778A1 (de) * | 2002-07-03 | 2004-01-29 | Bayer Ag | Neue Verwendung von Imidazotriazinonen |
JP4700965B2 (ja) * | 2002-11-06 | 2011-06-15 | あすか製薬株式会社 | ピラゾロナフチリジン誘導体 |
PL378245A1 (pl) * | 2003-01-09 | 2006-03-20 | Astellas Pharma Inc. | Pochodne pirolopirydazyny |
MXPA06012279A (es) * | 2004-04-23 | 2007-01-31 | Celgene Corp | Metodos de uso y composiciones que comprenden moduladores de pde4 para el tratamiento y manejo de la hipertension pulmonar. |
EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
EP2275095A3 (en) | 2005-08-26 | 2011-08-17 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
US7985756B2 (en) | 2005-10-21 | 2011-07-26 | Braincells Inc. | Modulation of neurogenesis by PDE inhibition |
EP1942879A1 (en) | 2005-10-31 | 2008-07-16 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
MX2008014320A (es) | 2006-05-09 | 2009-03-25 | Braincells Inc | Neurogenesis mediada por el receptor de 5-hidroxitriptamina. |
JP2009536669A (ja) | 2006-05-09 | 2009-10-15 | ブレインセルス,インコーポレイティド | アンジオテンシン調節による神経新生 |
JP2010502722A (ja) | 2006-09-08 | 2010-01-28 | ブレインセルス,インコーポレイティド | 4−アシルアミノピリジン誘導体を含む組み合わせ |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
JP2010505811A (ja) | 2006-10-04 | 2010-02-25 | ファイザー・プロダクツ・インク | カルシウム受容体アンタゴニストとしてのピリド[4,3−d]ピリミジン−4(3H)−オン誘導体 |
WO2009013286A1 (en) * | 2007-07-24 | 2009-01-29 | Novartis Ag | Organic compounds |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
EP2804603A1 (en) | 2012-01-10 | 2014-11-26 | President and Fellows of Harvard College | Beta-cell replication promoting compounds and methods of their use |
CN103224498B (zh) * | 2013-05-07 | 2015-10-28 | 陈定奔 | 两种唑并喹唑啉酮稠杂环的新合成方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3865824A (en) * | 1972-03-07 | 1975-02-11 | Icn Pharmaceuticals | 2-Aryl-7-substituted pyrazolo {8 1,5{i a{b {9 1,3,5-triazines |
US3850932A (en) * | 1973-06-28 | 1974-11-26 | Sandoz Ag | 5-(2-carboxy and 2-carboalkoxy-phenylamino)-1,2,4-triazolo-quinazolines |
IL66835A (en) * | 1981-09-24 | 1988-05-31 | Roussel Uclaf | 1,4-disubstituted(1,2,4)triazolo(4,3-alpha)quinazolin-5(4h)-one derivatives and their salts,their preparation and pharmaceutical compositions containing them |
JPS6028979A (ja) * | 1983-07-14 | 1985-02-14 | Dai Ichi Seiyaku Co Ltd | イミダゾキナゾリン類化合物 |
CA2223624C (en) * | 1995-06-06 | 2001-02-20 | Pfizer Inc. | Tricyclic 5,6-dihydro-9h-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-.alpha.]pyridines |
ES2137113B1 (es) * | 1997-07-29 | 2000-09-16 | Almirall Prodesfarma Sa | Nuevos derivados de triazolo-piridazinas heterociclicos. |
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1999
- 1999-04-28 FR FR9905398A patent/FR2792938B1/fr not_active Expired - Lifetime
-
2000
- 2000-04-28 AP APAP/P/2001/002309A patent/AP2001002309A0/en unknown
- 2000-04-28 DE DE60001735T patent/DE60001735T2/de not_active Expired - Fee Related
- 2000-04-28 KR KR1020017013825A patent/KR20020008166A/ko not_active Application Discontinuation
- 2000-04-28 AU AU44115/00A patent/AU4411500A/en not_active Abandoned
- 2000-04-28 DK DK00967407T patent/DK1177195T3/da active
- 2000-04-28 US US09/980,540 patent/US6828315B1/en not_active Expired - Fee Related
- 2000-04-28 EP EP00967407A patent/EP1177195B1/fr not_active Expired - Lifetime
- 2000-04-28 CA CA002388658A patent/CA2388658A1/en not_active Abandoned
- 2000-04-28 CN CN00808153A patent/CN1352644A/zh active Pending
- 2000-04-28 IL IL14617800A patent/IL146178A0/xx unknown
- 2000-04-28 BR BR0010072-2A patent/BR0010072A/pt not_active IP Right Cessation
- 2000-04-28 YU YU76401A patent/YU76401A/sh unknown
- 2000-04-28 MX MXPA01010888A patent/MXPA01010888A/es active IP Right Grant
- 2000-04-28 WO PCT/FR2000/001174 patent/WO2000066584A1/fr active Search and Examination
- 2000-04-28 HU HU0202656A patent/HUP0202656A3/hu unknown
- 2000-04-28 PT PT00967407T patent/PT1177195E/pt unknown
- 2000-04-28 JP JP2000615614A patent/JP2002543199A/ja active Pending
- 2000-04-28 DZ DZ003154A patent/DZ3154A1/xx active
- 2000-04-28 SK SK1532-2001A patent/SK15322001A3/sk unknown
- 2000-04-28 EE EEP200100566A patent/EE200100566A/xx unknown
- 2000-04-28 OA OA1200100282A patent/OA11875A/fr unknown
- 2000-04-28 AT AT00967407T patent/ATE234840T1/de not_active IP Right Cessation
- 2000-04-28 EA EA200100994A patent/EA004373B1/ru not_active IP Right Cessation
- 2000-04-28 PL PL00351951A patent/PL351951A1/xx not_active Application Discontinuation
- 2000-04-28 ES ES00967407T patent/ES2194779T3/es not_active Expired - Lifetime
- 2000-04-28 TR TR2001/03099T patent/TR200103099T2/xx unknown
-
2001
- 2001-10-18 BG BG106026A patent/BG106026A/bg unknown
- 2001-10-19 IS IS6114A patent/IS6114A/is unknown
- 2001-10-23 MA MA26381A patent/MA27343A1/fr unknown
- 2001-10-26 NO NO20015235A patent/NO20015235L/no not_active Application Discontinuation
- 2001-10-26 HR HR20010794A patent/HRP20010794B1/xx not_active IP Right Cessation
- 2001-10-26 ZA ZA200108847A patent/ZA200108847B/xx unknown
-
2002
- 2002-08-05 HK HK02105712.4A patent/HK1044938B/zh not_active IP Right Cessation
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