ZA200301039B - Inhibitors of alpha4 mediated cell adhesion. - Google Patents
Inhibitors of alpha4 mediated cell adhesion.Info
- Publication number
- ZA200301039B ZA200301039B ZA200301039A ZA200301039A ZA200301039B ZA 200301039 B ZA200301039 B ZA 200301039B ZA 200301039 A ZA200301039 A ZA 200301039A ZA 200301039 A ZA200301039 A ZA 200301039A ZA 200301039 B ZA200301039 B ZA 200301039B
- Authority
- ZA
- South Africa
- Prior art keywords
- inhibitors
- cell adhesion
- mediated cell
- alpha4
- alpha4 mediated
- Prior art date
Links
- 230000021164 cell adhesion Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000001404 mediated effect Effects 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Tropical Medicine & Parasitology (AREA)
- Transplantation (AREA)
- Endocrinology (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Psychology (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22912800P | 2000-08-31 | 2000-08-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200301039B true ZA200301039B (en) | 2004-02-09 |
Family
ID=22859926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200301039A ZA200301039B (en) | 2000-08-31 | 2001-08-27 | Inhibitors of alpha4 mediated cell adhesion. |
Country Status (28)
| Country | Link |
|---|---|
| US (6) | US7026501B2 (hu) |
| EP (1) | EP1315694B1 (hu) |
| JP (1) | JP3899022B2 (hu) |
| KR (1) | KR100528049B1 (hu) |
| CN (1) | CN1229334C (hu) |
| AR (1) | AR034556A1 (hu) |
| AT (1) | ATE292615T1 (hu) |
| AU (2) | AU2001286778B2 (hu) |
| BR (1) | BR0113629A (hu) |
| CA (1) | CA2418054C (hu) |
| CZ (1) | CZ303460B6 (hu) |
| DE (1) | DE60109943T2 (hu) |
| DK (1) | DK1315694T3 (hu) |
| ES (1) | ES2240509T3 (hu) |
| HK (1) | HK1052684B (hu) |
| HU (1) | HUP0302693A3 (hu) |
| IL (2) | IL154305A0 (hu) |
| MX (1) | MXPA03001837A (hu) |
| MY (1) | MY129000A (hu) |
| NO (1) | NO327861B1 (hu) |
| NZ (1) | NZ524043A (hu) |
| PL (1) | PL206656B1 (hu) |
| PT (1) | PT1315694E (hu) |
| RU (1) | RU2250895C2 (hu) |
| SI (1) | SI1315694T1 (hu) |
| TW (1) | TWI224587B (hu) |
| WO (1) | WO2002018320A2 (hu) |
| ZA (1) | ZA200301039B (hu) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1325480C (zh) | 2000-08-18 | 2007-07-11 | 味之素株式会社 | 苯基丙氨酸衍生物 |
| TWI312347B (en) | 2001-02-08 | 2009-07-21 | Eisai R&D Man Co Ltd | Bicyclic nitrogen-containing condensed ring compounds |
| ES2366082T3 (es) | 2001-04-27 | 2011-10-17 | EISAI R&D MANAGEMENT CO., LTD. | Pirazolo 1,5-a piridinas y medicinas que las contienen. |
| MY140707A (en) * | 2002-02-28 | 2010-01-15 | Mitsubishi Tanabe Pharma Corp | Process for preparing a phenylalanine derivative and intermediates thereof |
| US7122580B2 (en) | 2002-08-09 | 2006-10-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds and methods to modulate coagulation |
| RU2327699C2 (ru) | 2002-10-22 | 2008-06-27 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Соединения 7-фенилпиразолопиридина |
| US7176216B2 (en) | 2002-10-22 | 2007-02-13 | Eisai Co., Ltd. | 7-phenylpyrazolopyridine compounds |
| WO2005014533A2 (en) * | 2003-08-08 | 2005-02-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions, and methods of use |
| US7208601B2 (en) | 2003-08-08 | 2007-04-24 | Mjalli Adnan M M | Aryl and heteroaryl compounds, compositions, and methods of use |
| WO2005014534A1 (en) * | 2003-08-08 | 2005-02-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions, and methods of use |
| RU2390520C2 (ru) | 2003-12-22 | 2010-05-27 | Адзиномото Ко., Инк. | Новые производные фенилаланина |
| MY140489A (en) | 2003-12-26 | 2009-12-31 | Eisai R&D Man Co Ltd | 1,2-di (cyclic) substituted benzene compounds |
| US7419666B1 (en) | 2004-02-23 | 2008-09-02 | Massachusetts Eye And Ear Infirmary | Treatment of ocular disorders |
| CN101068798B (zh) | 2004-12-20 | 2010-05-12 | 卫材R&D管理有限公司 | 1-环丙基甲基-4-[2-(3,3,5,5-四甲基环己基)苯基]哌嗪的盐及结晶 |
| US7410971B2 (en) | 2004-12-24 | 2008-08-12 | Eisai R&D Management Co., Ltd. | 1,2-di(cyclic)substituted benzene compounds |
| CA2610800A1 (en) | 2005-06-09 | 2006-12-14 | Ucb Pharma, S.A. | 2,6 quinolinyl derivatives, processes for preparing them and their use as medicament |
| JP2009516729A (ja) * | 2005-11-23 | 2009-04-23 | アストラゼネカ アクチボラグ | Ｌ−フェニルアラニン誘導体 |
| IL172896A0 (en) * | 2005-12-29 | 2006-06-11 | Yeda Res & Dev | Cxcr4 inhibition |
| PT1984344E (pt) * | 2005-12-29 | 2012-12-21 | Lexicon Pharmaceuticals Inc | Derivados de aminoácidos multicíclicos e métodos para a sua utilização |
| US7897763B2 (en) | 2005-12-29 | 2011-03-01 | Lexicon Pharmaceuticals, Inc. | Process for the preparation of substituted phenylalanines |
| US7855291B2 (en) | 2005-12-29 | 2010-12-21 | Lexicon Pharmaceuticals, Inc. | Process for the preparation of substituted phenylalanines |
| WO2007092471A2 (en) * | 2006-02-03 | 2007-08-16 | The Regents Of The University Of California | Methods for inhibition of lymphangiogenesis and tumor metastasis |
| WO2007091046A1 (en) * | 2006-02-09 | 2007-08-16 | Astrazeneca Ab | Chemical compounds |
| US20070207141A1 (en) * | 2006-02-28 | 2007-09-06 | Ivan Lieberburg | Methods of treating inflammatory and autoimmune diseases with natalizumab |
| CA2641160A1 (en) | 2006-02-28 | 2007-09-07 | Elan Pharmaceuticals, Inc. | Methods of treating inflammatory and autoimmune diseases with alpha-4 inhibitory compounds |
| JP5504390B2 (ja) | 2006-03-03 | 2014-05-28 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | ナタリズマブを用いて炎症性疾患及び自己免疫疾患を治療する方法 |
| JP5553752B2 (ja) * | 2007-08-24 | 2014-07-16 | レクシコン ファーマシューティカルズ インコーポレイテッド | ４−フェニル−６−（２，２，２−トリフルオロ−１−フェニルエトキシ）ピリミジン系化合物を調製する方法 |
| PT2266990E (pt) | 2008-04-15 | 2012-12-27 | Eisai R&D Man Co Ltd | Composto de 3-fenilpirazolo[5,1-b]tiazole |
| AR078521A1 (es) | 2009-10-08 | 2011-11-16 | Eisai R&D Man Co Ltd | Compuesto pirazolotiazol |
| KR20120107461A (ko) * | 2009-10-21 | 2012-10-02 | 미츠비시 다나베 파마 코포레이션 | 페닐알라닌 유도체의 제조방법 |
| US11287423B2 (en) | 2010-01-11 | 2022-03-29 | Biogen Ma Inc. | Assay for JC virus antibodies |
| PL2524060T3 (pl) | 2010-01-11 | 2018-05-30 | Biogen Ma Inc. | Test wykrywający przeciwciała przeciwko wirusowi jc |
| US20150010563A1 (en) * | 2012-02-21 | 2015-01-08 | Massachusetts Eye & Ear Infirmary | Methods for Treating Corneal and Conjunctival Inflammation and Inflammatory Disorders |
| EP3004334A4 (en) | 2013-05-28 | 2016-12-21 | Biogen Ma Inc | METHODS OF EVALUATION RISK OF DEVELOPMENT OF PML |
| WO2018085552A1 (en) * | 2016-11-02 | 2018-05-11 | Saint Louis University | Integrin antagonists |
| US11224600B2 (en) | 2018-10-30 | 2022-01-18 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
| CA3114240C (en) | 2018-10-30 | 2023-09-05 | Gilead Sciences, Inc. | Imidazopyridine derivatives as alpha4beta7 integrin inhibitors |
| WO2020092401A1 (en) | 2018-10-30 | 2020-05-07 | Gilead Sciences, Inc. | COMPOUNDS FOR INHIBITION OF ALPHA 4β7 INTEGRIN |
| EP3873884A1 (en) | 2018-10-30 | 2021-09-08 | Gilead Sciences, Inc. | Quinoline derivatives as alpha4beta7 integrin inhibitors |
| JP7491996B2 (ja) | 2019-08-14 | 2024-05-28 | ギリアード サイエンシーズ， インコーポレイテッド | α４β７インテグリンの阻害のための化合物 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK148576A (da) | 1975-04-18 | 1976-10-19 | Boehringer Mannheim Gmbh | Fenylalkankarbonsyrederivater og fremgangsmade til deres fremstilling |
| RU2126418C1 (ru) | 1993-11-01 | 1999-02-20 | Циба-Гейги Джапан Димитед | Антагонисты рецепторов эндотелина |
| US5703106A (en) | 1994-03-28 | 1997-12-30 | Japat Ltd. | Antagonists of endothelin receptors |
| US6306840B1 (en) | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
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-
2001
- 2001-08-21 MY MYPI20013917A patent/MY129000A/en unknown
- 2001-08-27 KR KR10-2003-7001993A patent/KR100528049B1/ko not_active IP Right Cessation
- 2001-08-27 CZ CZ20030487A patent/CZ303460B6/cs not_active IP Right Cessation
- 2001-08-27 BR BR0113629-1A patent/BR0113629A/pt active Search and Examination
- 2001-08-27 PT PT01966246T patent/PT1315694E/pt unknown
- 2001-08-27 DK DK01966246T patent/DK1315694T3/da active
- 2001-08-27 CA CA 2418054 patent/CA2418054C/en not_active Expired - Fee Related
- 2001-08-27 MX MXPA03001837A patent/MXPA03001837A/es active IP Right Grant
- 2001-08-27 WO PCT/US2001/026594 patent/WO2002018320A2/en active IP Right Grant
- 2001-08-27 SI SI200130351T patent/SI1315694T1/xx unknown
- 2001-08-27 CN CNB018149871A patent/CN1229334C/zh not_active Expired - Fee Related
- 2001-08-27 AU AU2001286778A patent/AU2001286778B2/en not_active Ceased
- 2001-08-27 PL PL365668A patent/PL206656B1/pl unknown
- 2001-08-27 US US10/333,985 patent/US7026501B2/en not_active Expired - Fee Related
- 2001-08-27 DE DE60109943T patent/DE60109943T2/de not_active Expired - Lifetime
- 2001-08-27 EP EP01966246A patent/EP1315694B1/en not_active Expired - Lifetime
- 2001-08-27 IL IL15430501A patent/IL154305A0/xx unknown
- 2001-08-27 RU RU2003105885/04A patent/RU2250895C2/ru not_active IP Right Cessation
- 2001-08-27 ES ES01966246T patent/ES2240509T3/es not_active Expired - Lifetime
- 2001-08-27 ZA ZA200301039A patent/ZA200301039B/xx unknown
- 2001-08-27 AT AT01966246T patent/ATE292615T1/de active
- 2001-08-27 NZ NZ524043A patent/NZ524043A/en not_active IP Right Cessation
- 2001-08-27 JP JP2002523438A patent/JP3899022B2/ja not_active Expired - Fee Related
- 2001-08-27 AU AU8677801A patent/AU8677801A/xx active Pending
- 2001-08-27 HU HU0302693A patent/HUP0302693A3/hu unknown
- 2001-08-31 AR ARP010104172A patent/AR034556A1/es active IP Right Grant
- 2001-08-31 TW TW090121581A patent/TWI224587B/zh not_active IP Right Cessation
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2003
- 2003-02-05 IL IL154305A patent/IL154305A/en not_active IP Right Cessation
- 2003-02-25 NO NO20030885A patent/NO327861B1/no not_active IP Right Cessation
- 2003-07-11 HK HK03105043.3A patent/HK1052684B/zh not_active IP Right Cessation
-
2005
- 2005-07-13 US US11/179,729 patent/US7456217B2/en not_active Expired - Fee Related
-
2008
- 2008-10-07 US US12/247,129 patent/US7671090B2/en not_active Expired - Fee Related
-
2010
- 2010-01-07 US US12/683,648 patent/US7872151B2/en not_active Expired - Fee Related
- 2010-12-08 US US12/962,707 patent/US8501809B2/en not_active Expired - Fee Related
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2013
- 2013-07-03 US US13/934,405 patent/US20130289109A1/en not_active Abandoned
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