IL152924A - חומצות –5 (–4אתיל – 1 – פיפרזינילסולפוניל) בנזואיות מותמרות בעמדה 2 - Google Patents

חומצות –5 (–4אתיל – 1 – פיפרזינילסולפוניל) בנזואיות מותמרות בעמדה 2

Info

Publication number
IL152924A
IL152924A IL15292499A IL15292499A IL152924A IL 152924 A IL152924 A IL 152924A IL 15292499 A IL15292499 A IL 15292499A IL 15292499 A IL15292499 A IL 15292499A IL 152924 A IL152924 A IL 152924A
Authority
IL
Israel
Prior art keywords
compound
reaction
ethyl
title compound
methyl
Prior art date
Application number
IL15292499A
Other languages
English (en)
Original Assignee
Pfizer Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10840421&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL152924(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Res & Dev filed Critical Pfizer Res & Dev
Publication of IL152924A publication Critical patent/IL152924A/he

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL15292499A 1998-10-12 1999-10-07 חומצות –5 (–4אתיל – 1 – פיפרזינילסולפוניל) בנזואיות מותמרות בעמדה 2 IL152924A (he)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9822238.3A GB9822238D0 (en) 1998-10-12 1998-10-12 Process for preparation of pyrazolo[4,3-D]pyrimidin-7-ones and intermediates thereof
IL13227399A IL132273A (he) 1998-10-12 1999-10-07 -5[(-4מתיל--1פיפרזינילסולפוניל)- -2 בנאזמידומותמר] - -1 מתיל--3פרופיל - h1 - פירזול - -5 קרבוקסאמידים, הכנתם ותהליך להכנת סילדנפיל מהם

Publications (1)

Publication Number Publication Date
IL152924A true IL152924A (he) 2004-02-19

Family

ID=10840421

Family Applications (11)

Application Number Title Priority Date Filing Date
IL13227399A IL132273A (he) 1998-10-12 1999-10-07 -5[(-4מתיל--1פיפרזינילסולפוניל)- -2 בנאזמידומותמר] - -1 מתיל--3פרופיל - h1 - פירזול - -5 קרבוקסאמידים, הכנתם ותהליך להכנת סילדנפיל מהם
IL15292399A IL152923A (he) 1998-10-12 1999-10-07 חומצות –5(–4מתיל––1 פיפרזינילסולפוניל) בנזואיות מותמרות בעמדה 2
IL15292799A IL152927A (he) 1998-10-12 1999-10-07 1-[3-(7,6 דיהידרו-1-מתיל-7-אוקסו-3-פרופיל-1H‏-פיראזולו [3,4-d‏] פירימידין-5-איל)-(פניל מותמר בעמדה 4) סולפוניל]-4-מתיל פיפראזינים
IL15292699A IL152926A (he) 1998-10-12 1999-10-07 תהליך להכנת –1אתיל––4 [–3{3 אתיל–6, –7דיהידרו – 7 – אוקסו – 2 – (פירידילמתיל) H2 – פיראזולו [4, 3 – [d פירימידין – 5 – איל] פרופוקסיסולפוניל} – פיפראזין ותוצרי ביניים –4 [2 מותמר––5 (–4אתיל––1 פיפראזינילסולפוניל) – בנזאמידו] – 5 – אתיל––1 (–2 פירידילמתיל) – H1 – פיראזול – 3 – קרבוקסאמיד עבורו
IL152928A IL152928A (he) 1998-10-12 1999-10-07 1 – אתיל – 4 – [3 – [ 3 – אתיל – 6, 7 – דיהידרו – 7 אוקסו – 2 – (2 – פירידילמתיל) – 2H – פיראזולו [4, 3 – d] פירמידין – 5 – איל] (4 – פניל מותמר) סולפוניל] פיפראזינים
IL15292499A IL152924A (he) 1998-10-12 1999-10-07 חומצות –5 (–4אתיל – 1 – פיפרזינילסולפוניל) בנזואיות מותמרות בעמדה 2
IL15292802A IL152928A0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo [4,3-d] pyrimidin-7-ones and intermediates thereof
IL15292302A IL152923A0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo[4,3-d] pyrimidin-7-ones and intermediates thereof
IL15292602A IL152926A0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo[4,3-d] pyrimidin-7-ones and intermediates thereof
IL15292702A IL152927A0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo [4,3-d] pyrimidin-7-ones and intermediates thereof
IL15292402A IL152924A0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo[4,3-d] pyrimidin-7-ones and intermediates thereof

Family Applications Before (5)

Application Number Title Priority Date Filing Date
IL13227399A IL132273A (he) 1998-10-12 1999-10-07 -5[(-4מתיל--1פיפרזינילסולפוניל)- -2 בנאזמידומותמר] - -1 מתיל--3פרופיל - h1 - פירזול - -5 קרבוקסאמידים, הכנתם ותהליך להכנת סילדנפיל מהם
IL15292399A IL152923A (he) 1998-10-12 1999-10-07 חומצות –5(–4מתיל––1 פיפרזינילסולפוניל) בנזואיות מותמרות בעמדה 2
IL15292799A IL152927A (he) 1998-10-12 1999-10-07 1-[3-(7,6 דיהידרו-1-מתיל-7-אוקסו-3-פרופיל-1H‏-פיראזולו [3,4-d‏] פירימידין-5-איל)-(פניל מותמר בעמדה 4) סולפוניל]-4-מתיל פיפראזינים
IL15292699A IL152926A (he) 1998-10-12 1999-10-07 תהליך להכנת –1אתיל––4 [–3{3 אתיל–6, –7דיהידרו – 7 – אוקסו – 2 – (פירידילמתיל) H2 – פיראזולו [4, 3 – [d פירימידין – 5 – איל] פרופוקסיסולפוניל} – פיפראזין ותוצרי ביניים –4 [2 מותמר––5 (–4אתיל––1 פיפראזינילסולפוניל) – בנזאמידו] – 5 – אתיל––1 (–2 פירידילמתיל) – H1 – פיראזול – 3 – קרבוקסאמיד עבורו
IL152928A IL152928A (he) 1998-10-12 1999-10-07 1 – אתיל – 4 – [3 – [ 3 – אתיל – 6, 7 – דיהידרו – 7 אוקסו – 2 – (2 – פירידילמתיל) – 2H – פיראזולו [4, 3 – d] פירמידין – 5 – איל] (4 – פניל מותמר) סולפוניל] פיפראזינים

Family Applications After (5)

Application Number Title Priority Date Filing Date
IL15292802A IL152928A0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo [4,3-d] pyrimidin-7-ones and intermediates thereof
IL15292302A IL152923A0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo[4,3-d] pyrimidin-7-ones and intermediates thereof
IL15292602A IL152926A0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo[4,3-d] pyrimidin-7-ones and intermediates thereof
IL15292702A IL152927A0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo [4,3-d] pyrimidin-7-ones and intermediates thereof
IL15292402A IL152924A0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo[4,3-d] pyrimidin-7-ones and intermediates thereof

Country Status (49)

Country Link
US (3) US6207829B1 (he)
EP (1) EP0994115B1 (he)
JP (1) JP3721021B2 (he)
KR (1) KR100380954B1 (he)
CN (2) CN1207295C (he)
AP (1) AP1233A (he)
AR (1) AR019244A1 (he)
AT (1) ATE290003T1 (he)
AU (1) AU756463B2 (he)
BG (1) BG63205B1 (he)
BR (1) BR9905092A (he)
CA (1) CA2285733C (he)
CO (1) CO5150214A1 (he)
CR (1) CR6118A (he)
CU (1) CU22928A3 (he)
CZ (1) CZ296816B6 (he)
DE (1) DE69923906T2 (he)
DK (1) DK0994115T3 (he)
DZ (1) DZ2912A1 (he)
EA (1) EA003774B1 (he)
EE (1) EE04192B1 (he)
EG (1) EG22630A (he)
ES (1) ES2237049T3 (he)
GB (1) GB9822238D0 (he)
GE (1) GEP20022700B (he)
GT (1) GT199900172A (he)
HK (1) HK1027559A1 (he)
HR (1) HRP990318B1 (he)
HU (1) HU226162B1 (he)
ID (1) ID23351A (he)
IL (11) IL132273A (he)
IS (1) IS1951B (he)
MA (1) MA25007A1 (he)
MY (1) MY124620A (he)
NO (1) NO313700B1 (he)
OA (1) OA11165A (he)
PE (1) PE20001086A1 (he)
PL (1) PL198150B1 (he)
PT (1) PT994115E (he)
RS (1) RS49762B (he)
SG (1) SG118060A1 (he)
SI (1) SI0994115T1 (he)
SK (1) SK285215B6 (he)
TN (1) TNSN99189A1 (he)
TR (1) TR199902541A2 (he)
TW (1) TW589314B (he)
UA (1) UA66787C2 (he)
UY (1) UY25750A1 (he)
ZA (1) ZA996412B (he)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5204800A (en) * 1999-06-21 2001-01-09 Biochemical Pharmaceutical Factory of Zhuhai Sez, The Process for preparing sildenafil, and troche which comprises sildenafil and apomorphine
AU6259701A (en) * 2000-06-22 2002-01-02 Dunn Peter James Process for the preparation of pyrazolopyrimidinones
US6667398B2 (en) 2000-06-22 2003-12-23 Pfizer Inc Process for the preparation of pyrazolopyrimidinones
EP1176142A1 (en) * 2000-07-28 2002-01-30 Pfizer Inc. Process for the preparation of pyrazoles
US6407259B1 (en) 2000-07-28 2002-06-18 Pfizer Inc. Process for the preparation of pyrazoles
YU51701A (sh) * 2000-07-28 2003-12-31 Pfizer Inc. Postupak za dobijanje jedinjenja pirazola/4,3-d/ pirimidin-7-ona i njihovih derivata
PE20020394A1 (es) 2000-08-18 2002-06-21 Agouron Pharma Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2
ATE455758T1 (de) 2001-12-20 2010-02-15 Merck Serono Sa Pyrrolidin-derivatie als prostaglandin- modulatoren
WO2003059258A2 (en) * 2001-12-21 2003-07-24 Cytokinetics, Inc. Compositions and methods for treating heart failure
SI1509525T1 (sl) 2002-05-31 2006-12-31 Schering Corp Postopek priprave inhibitorjev ksantinske fosfodiesteraze V in njihovih prekurzorjev
WO2004072079A1 (en) * 2003-02-11 2004-08-26 Pfizer Limited Hydrated and anhydrous sildenafil hemi-citrate compound
ES2378620T3 (es) * 2003-03-27 2012-04-16 Cytokinetics, Inc. Sulfonamidas para el tratamiento de insuficiencia cardiaca congestiva, sus composiciones y usos.
CN100360531C (zh) * 2003-12-18 2008-01-09 中国人民解放军军事医学科学院放射与辐射医学研究所 用于预防或治疗阳萎和性冷淡的新吡唑并嘧啶类化合物
US20070010525A1 (en) * 2005-06-27 2007-01-11 Meyer Jackson Method and compositions for modulating neuropeptide hormone secretion
NL2000291C2 (nl) * 2005-11-10 2009-02-17 Pfizer Prod Inc 1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H- pyrazool(4,3-d)pyrimidine-5-yl)piperidine-4-carbonzuur en zouten daarvan.
EP2024369A4 (en) * 2006-06-05 2010-10-27 Matrix Lab Ltd NEW PROCESS FOR THE PREPARATION OF SILDENAFIL CITRATE
CZ308056B6 (cs) * 2015-07-20 2019-11-27 Ustav Experimentalni Botaniky Av Cr V V I 5-Substituované-7-[4-(substituované)benzyl]amino-3-isopropylpyrazolo[4,3-d]pyrimidiny, jejich použití jako antirevmatika, a farmaceutické přípravky
WO2017168174A1 (en) 2016-04-02 2017-10-05 N4 Pharma Uk Limited New pharmaceutical forms of sildenafil
CN107759603B (zh) * 2016-08-18 2020-09-01 四川科伦药物研究院有限公司 一种杂环化合物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3992441A (en) * 1972-12-26 1976-11-16 Pfizer Inc. Sulfamylbenzoic acids
GB9013750D0 (en) * 1990-06-20 1990-08-08 Pfizer Ltd Therapeutic agents
GB9612514D0 (en) * 1996-06-14 1996-08-14 Pfizer Ltd Novel process
SK285991B6 (sk) * 1997-04-25 2008-01-07 Pfizer Inc. Pyrazolopyrimidinóny, spôsob a medziprodukty na ich výrobu, ich použitie a farmaceutické a veterinárne kompozície na ich báze

Also Published As

Publication number Publication date
PL198150B1 (pl) 2008-05-30
NO994943L (no) 2000-04-13
GT199900172A (es) 2001-03-28
US6207829B1 (en) 2001-03-27
SK138599A3 (en) 2000-05-16
IL152928A0 (en) 2003-06-24
CN1255497A (zh) 2000-06-07
OA11165A (en) 2003-04-22
ZA996412B (en) 2001-04-11
HRP990318B1 (en) 2004-06-30
HUP9903469A2 (hu) 2000-08-28
SG118060A1 (en) 2006-01-27
ID23351A (id) 2000-04-13
IL152926A0 (en) 2003-06-24
IL152923A (he) 2004-02-08
DZ2912A1 (fr) 2004-03-01
HU9903469D0 (en) 1999-12-28
IL152927A (he) 2004-06-01
EP0994115A3 (en) 2000-05-24
US20010009962A1 (en) 2001-07-26
IL132273A0 (en) 2001-03-19
DE69923906D1 (de) 2005-04-07
TNSN99189A1 (fr) 2005-11-10
EA003774B1 (ru) 2003-08-28
AU756463B2 (en) 2003-01-16
IS5209A (is) 2000-04-13
EP0994115B1 (en) 2005-03-02
EA199900822A2 (ru) 2000-04-24
EA199900822A3 (ru) 2000-08-28
YU48999A (sh) 2002-06-19
IL152926A (he) 2004-02-19
PT994115E (pt) 2005-06-30
HRP990318A2 (en) 2000-06-30
CN1207295C (zh) 2005-06-22
PL335959A1 (en) 2000-04-25
ATE290003T1 (de) 2005-03-15
KR100380954B1 (ko) 2003-04-21
IL152927A0 (en) 2003-06-24
TW589314B (en) 2004-06-01
AP1233A (en) 2003-12-18
EE9900507A (et) 2000-06-15
EP0994115A2 (en) 2000-04-19
BR9905092A (pt) 2000-08-08
KR20000028987A (ko) 2000-05-25
UY25750A1 (es) 2001-08-27
NO313700B1 (no) 2002-11-18
TR199902541A2 (xx) 2000-07-21
DK0994115T3 (da) 2005-06-20
JP2000119273A (ja) 2000-04-25
CR6118A (es) 2005-09-16
EE04192B1 (et) 2003-12-15
AR019244A1 (es) 2001-12-26
AP9901672A0 (en) 1999-12-31
CN1473831A (zh) 2004-02-11
RS49762B (sr) 2008-04-04
CO5150214A1 (es) 2002-04-29
CZ296816B6 (cs) 2006-06-14
GEP20022700B (en) 2002-05-27
IS1951B (is) 2004-10-13
IL152928A (he) 2007-07-04
AU5358199A (en) 2000-04-13
HU226162B1 (en) 2008-05-28
GB9822238D0 (en) 1998-12-09
MY124620A (en) 2006-06-30
CA2285733C (en) 2004-08-24
ES2237049T3 (es) 2005-07-16
MA25007A1 (fr) 2000-07-01
IL152924A0 (en) 2003-06-24
DE69923906T2 (de) 2006-04-06
CZ353299A3 (cs) 2000-05-17
BG63205B1 (bg) 2001-06-29
UA66787C2 (en) 2004-06-15
CU22928A3 (es) 2004-02-20
IL152923A0 (en) 2003-06-24
JP3721021B2 (ja) 2005-11-30
NO994943D0 (no) 1999-10-11
US20030069422A1 (en) 2003-04-10
SK285215B6 (sk) 2006-09-07
IL132273A (he) 2004-06-20
BG103794A (en) 2000-09-29
SI0994115T1 (he) 2005-08-31
CA2285733A1 (en) 2000-04-12
PE20001086A1 (es) 2000-10-18
HUP9903469A3 (en) 2000-10-30
HK1027559A1 (en) 2001-01-19
EG22630A (en) 2003-05-31

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