RS49762B - Postupak za dobijanje pirazolo (4,3- d) piramidin-7-ona i njihovih intermedijera - Google Patents

Postupak za dobijanje pirazolo (4,3- d) piramidin-7-ona i njihovih intermedijera

Info

Publication number
RS49762B
RS49762B YUP-489/99A YU48999A RS49762B RS 49762 B RS49762 B RS 49762B YU 48999 A YU48999 A YU 48999A RS 49762 B RS49762 B RS 49762B
Authority
RS
Serbia
Prior art keywords
preparation
pyramidin
pyrazolo
intermediates
ones
Prior art date
Application number
YUP-489/99A
Other languages
English (en)
Inventor
Peter James Dunn
Philip Charles LEVETT
Original Assignee
Pfizer Ireland Pharmaceuticals,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10840421&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RS49762(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Ireland Pharmaceuticals, filed Critical Pfizer Ireland Pharmaceuticals,
Publication of YU48999A publication Critical patent/YU48999A/sh
Publication of RS49762B publication Critical patent/RS49762B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Postupak za dobijanje jedinjenja formule (IA) i (IB) naznačen time, što obuhvata reakciju jedinjenja formule (IIA) i (IIB) u prisustvu –OR, gde je R u slučaju formiranja jedinjenja (IA), CH2CH3, i R u slučaju formiranja jedinjenja (IB) je CH2CH2CH3, gde X je odlazeća grupa odabrana iz grupe koju čine: opciono supstituisan arilsulfoniloksi, C1-C4alkilsulfoniloksi, nitro ili halo supstituisan benzensulfoniloksi C1-C4 perfluoroalkilsulfoniloksi, opciono supstituisan aroiloksi, C1-C4perfluoralkanoiloksi, C1-C4alkonoiloksi, halo; diazonium; metoksi, oksonium, perhloriloksi, kvaternariamonijum C1-C4alkilsulfoniloksi, halosulfoniloksi, halonium i diarilsulfonilamino. Prijava sadrži još 21 zahtev.
YUP-489/99A 1998-10-12 1999-09-27 Postupak za dobijanje pirazolo (4,3- d) piramidin-7-ona i njihovih intermedijera RS49762B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9822238.3A GB9822238D0 (en) 1998-10-12 1998-10-12 Process for preparation of pyrazolo[4,3-D]pyrimidin-7-ones and intermediates thereof

Publications (2)

Publication Number Publication Date
YU48999A YU48999A (sh) 2002-06-19
RS49762B true RS49762B (sr) 2008-04-04

Family

ID=10840421

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-489/99A RS49762B (sr) 1998-10-12 1999-09-27 Postupak za dobijanje pirazolo (4,3- d) piramidin-7-ona i njihovih intermedijera

Country Status (49)

Country Link
US (3) US6207829B1 (sr)
EP (1) EP0994115B1 (sr)
JP (1) JP3721021B2 (sr)
KR (1) KR100380954B1 (sr)
CN (2) CN1473831A (sr)
AP (1) AP1233A (sr)
AR (1) AR019244A1 (sr)
AT (1) ATE290003T1 (sr)
AU (1) AU756463B2 (sr)
BG (1) BG63205B1 (sr)
BR (1) BR9905092A (sr)
CA (1) CA2285733C (sr)
CO (1) CO5150214A1 (sr)
CR (1) CR6118A (sr)
CU (1) CU22928A3 (sr)
CZ (1) CZ296816B6 (sr)
DE (1) DE69923906T2 (sr)
DK (1) DK0994115T3 (sr)
DZ (1) DZ2912A1 (sr)
EA (1) EA003774B1 (sr)
EE (1) EE04192B1 (sr)
EG (1) EG22630A (sr)
ES (1) ES2237049T3 (sr)
GB (1) GB9822238D0 (sr)
GE (1) GEP20022700B (sr)
GT (1) GT199900172A (sr)
HK (1) HK1027559A1 (sr)
HR (1) HRP990318B1 (sr)
HU (1) HU226162B1 (sr)
ID (1) ID23351A (sr)
IL (11) IL152927A (sr)
IS (1) IS1951B (sr)
MA (1) MA25007A1 (sr)
MY (1) MY124620A (sr)
NO (1) NO313700B1 (sr)
OA (1) OA11165A (sr)
PE (1) PE20001086A1 (sr)
PL (1) PL198150B1 (sr)
PT (1) PT994115E (sr)
RS (1) RS49762B (sr)
SG (1) SG118060A1 (sr)
SI (1) SI0994115T1 (sr)
SK (1) SK285215B6 (sr)
TN (1) TNSN99189A1 (sr)
TR (1) TR199902541A2 (sr)
TW (1) TW589314B (sr)
UA (1) UA66787C2 (sr)
UY (1) UY25750A1 (sr)
ZA (1) ZA996412B (sr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5204800A (en) * 1999-06-21 2001-01-09 Biochemical Pharmaceutical Factory of Zhuhai Sez, The Process for preparing sildenafil, and troche which comprises sildenafil and apomorphine
YU93902A (sh) * 2000-06-22 2005-11-28 Pfizer Products Inc. Postupak za pripremanje pirazolopirimidinona
US6667398B2 (en) 2000-06-22 2003-12-23 Pfizer Inc Process for the preparation of pyrazolopyrimidinones
YU51701A (sh) * 2000-07-28 2003-12-31 Pfizer Inc. Postupak za dobijanje jedinjenja pirazola/4,3-d/ pirimidin-7-ona i njihovih derivata
EP1176142A1 (en) * 2000-07-28 2002-01-30 Pfizer Inc. Process for the preparation of pyrazoles
US6407259B1 (en) 2000-07-28 2002-06-18 Pfizer Inc. Process for the preparation of pyrazoles
PE20020394A1 (es) 2000-08-18 2002-06-21 Agouron Pharma Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2
EP1458679B1 (en) 2001-12-20 2010-01-20 Merck Serono SA Pyrrolidine derivatives as prostaglandin modulators
CA2470427C (en) * 2001-12-21 2012-07-10 Cytokinetics, Incorporated Compositions and methods for treating heart failure
EP1719772A1 (en) 2002-05-31 2006-11-08 Schering Corporation Process for preparing xanthine phosphodiesterase v inhibitors and precursors thereof
WO2004072079A1 (en) * 2003-02-11 2004-08-26 Pfizer Limited Hydrated and anhydrous sildenafil hemi-citrate compound
ES2378620T3 (es) * 2003-03-27 2012-04-16 Cytokinetics, Inc. Sulfonamidas para el tratamiento de insuficiencia cardiaca congestiva, sus composiciones y usos.
CN100360531C (zh) * 2003-12-18 2008-01-09 中国人民解放军军事医学科学院放射与辐射医学研究所 用于预防或治疗阳萎和性冷淡的新吡唑并嘧啶类化合物
US20070010525A1 (en) * 2005-06-27 2007-01-11 Meyer Jackson Method and compositions for modulating neuropeptide hormone secretion
NL2000291C2 (nl) * 2005-11-10 2009-02-17 Pfizer Prod Inc 1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H- pyrazool(4,3-d)pyrimidine-5-yl)piperidine-4-carbonzuur en zouten daarvan.
EP2024369A4 (en) * 2006-06-05 2010-10-27 Matrix Lab Ltd NEW PROCESS FOR THE PREPARATION OF SILDENAFIL CITRATE
CZ308056B6 (cs) * 2015-07-20 2019-11-27 Ustav Experimentalni Botaniky Av Cr V V I 5-Substituované-7-[4-(substituované)benzyl]amino-3-isopropylpyrazolo[4,3-d]pyrimidiny, jejich použití jako antirevmatika, a farmaceutické přípravky
WO2017168174A1 (en) 2016-04-02 2017-10-05 N4 Pharma Uk Limited New pharmaceutical forms of sildenafil
CN107759603B (zh) * 2016-08-18 2020-09-01 四川科伦药物研究院有限公司 一种杂环化合物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3992441A (en) * 1972-12-26 1976-11-16 Pfizer Inc. Sulfamylbenzoic acids
GB9013750D0 (en) * 1990-06-20 1990-08-08 Pfizer Ltd Therapeutic agents
GB9612514D0 (en) * 1996-06-14 1996-08-14 Pfizer Ltd Novel process
WO1998049166A1 (en) * 1997-04-25 1998-11-05 Pfizer Limited PYRAZOLOPYRIMIDINONES WHICH INHIBIT TYPE 5 CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE PHOSPHODIESTERASE (cGMP PDE5) FOR THE TREATMENT OF SEXUAL DYSFUNCTION

Also Published As

Publication number Publication date
HU226162B1 (en) 2008-05-28
IL152923A0 (en) 2003-06-24
IL152927A (en) 2004-06-01
IL132273A0 (en) 2001-03-19
SI0994115T1 (sr) 2005-08-31
HU9903469D0 (en) 1999-12-28
SG118060A1 (en) 2006-01-27
CA2285733C (en) 2004-08-24
CR6118A (es) 2005-09-16
GEP20022700B (en) 2002-05-27
NO313700B1 (no) 2002-11-18
IS5209A (is) 2000-04-13
IL152926A (en) 2004-02-19
SK138599A3 (en) 2000-05-16
GT199900172A (es) 2001-03-28
US20010009962A1 (en) 2001-07-26
IL152928A (en) 2007-07-04
JP2000119273A (ja) 2000-04-25
CU22928A3 (es) 2004-02-20
IL152927A0 (en) 2003-06-24
HUP9903469A3 (en) 2000-10-30
PL198150B1 (pl) 2008-05-30
CN1473831A (zh) 2004-02-11
ES2237049T3 (es) 2005-07-16
TNSN99189A1 (fr) 2005-11-10
SK285215B6 (sk) 2006-09-07
CZ353299A3 (cs) 2000-05-17
IL152924A (en) 2004-02-19
BR9905092A (pt) 2000-08-08
MA25007A1 (fr) 2000-07-01
ZA996412B (en) 2001-04-11
EP0994115A2 (en) 2000-04-19
JP3721021B2 (ja) 2005-11-30
MY124620A (en) 2006-06-30
EA199900822A3 (ru) 2000-08-28
EP0994115A3 (en) 2000-05-24
CO5150214A1 (es) 2002-04-29
IL152923A (en) 2004-02-08
PL335959A1 (en) 2000-04-25
IS1951B (is) 2004-10-13
PT994115E (pt) 2005-06-30
UA66787C2 (en) 2004-06-15
DZ2912A1 (fr) 2004-03-01
US20030069422A1 (en) 2003-04-10
CN1255497A (zh) 2000-06-07
YU48999A (sh) 2002-06-19
AU5358199A (en) 2000-04-13
IL132273A (en) 2004-06-20
EA199900822A2 (ru) 2000-04-24
EE04192B1 (et) 2003-12-15
EA003774B1 (ru) 2003-08-28
ID23351A (id) 2000-04-13
AR019244A1 (es) 2001-12-26
US6207829B1 (en) 2001-03-27
BG63205B1 (bg) 2001-06-29
TW589314B (en) 2004-06-01
KR100380954B1 (ko) 2003-04-21
EP0994115B1 (en) 2005-03-02
CA2285733A1 (en) 2000-04-12
NO994943D0 (no) 1999-10-11
OA11165A (en) 2003-04-22
IL152926A0 (en) 2003-06-24
CZ296816B6 (cs) 2006-06-14
EG22630A (en) 2003-05-31
HUP9903469A2 (hu) 2000-08-28
IL152928A0 (en) 2003-06-24
NO994943L (no) 2000-04-13
AU756463B2 (en) 2003-01-16
HRP990318A2 (en) 2000-06-30
HK1027559A1 (en) 2001-01-19
TR199902541A2 (xx) 2000-07-21
GB9822238D0 (en) 1998-12-09
PE20001086A1 (es) 2000-10-18
CN1207295C (zh) 2005-06-22
KR20000028987A (ko) 2000-05-25
AP1233A (en) 2003-12-18
HRP990318B1 (en) 2004-06-30
IL152924A0 (en) 2003-06-24
AP9901672A0 (en) 1999-12-31
EE9900507A (et) 2000-06-15
BG103794A (en) 2000-09-29
DE69923906T2 (de) 2006-04-06
DK0994115T3 (da) 2005-06-20
ATE290003T1 (de) 2005-03-15
UY25750A1 (es) 2001-08-27
DE69923906D1 (de) 2005-04-07

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