IL152777A0 - New crystalline and amorphous form of a triazolo(4,5-d) pyrimidine compound - Google Patents

New crystalline and amorphous form of a triazolo(4,5-d) pyrimidine compound

Info

Publication number
IL152777A0
IL152777A0 IL15277701A IL15277701A IL152777A0 IL 152777 A0 IL152777 A0 IL 152777A0 IL 15277701 A IL15277701 A IL 15277701A IL 15277701 A IL15277701 A IL 15277701A IL 152777 A0 IL152777 A0 IL 152777A0
Authority
IL
Israel
Prior art keywords
triazolo
amorphous form
pyrimidine compound
new crystalline
crystalline
Prior art date
Application number
IL15277701A
Other languages
English (en)
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9892841&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL152777(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of IL152777A0 publication Critical patent/IL152777A0/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Surgery (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL15277701A 2000-06-02 2001-05-31 New crystalline and amorphous form of a triazolo(4,5-d) pyrimidine compound IL152777A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0013407.2A GB0013407D0 (en) 2000-06-02 2000-06-02 Forms of a chemical compound
PCT/SE2001/001239 WO2001092262A1 (en) 2000-06-02 2001-05-31 New crystalline and amorphous form of a triazolo(4,5-d)pyrimidine compound

Publications (1)

Publication Number Publication Date
IL152777A0 true IL152777A0 (en) 2003-06-24

Family

ID=9892841

Family Applications (4)

Application Number Title Priority Date Filing Date
IL15277701A IL152777A0 (en) 2000-06-02 2001-05-31 New crystalline and amorphous form of a triazolo(4,5-d) pyrimidine compound
IL152777A IL152777A (en) 2000-06-02 2002-11-11 Crystalline and amorphous form of a compound of triazolo (D-5,4) pyrimidine
IL187482A IL187482A (en) 2000-06-02 2007-11-19 Crystalline and amorphous form of a compound of triazolo (D-5, 4) pyrimidine
IL202582A IL202582A (en) 2000-06-02 2009-12-07 Crystalline and amorphous forms of a compound of triazolo (D-5, 4) pyrimidine

Family Applications After (3)

Application Number Title Priority Date Filing Date
IL152777A IL152777A (en) 2000-06-02 2002-11-11 Crystalline and amorphous form of a compound of triazolo (D-5,4) pyrimidine
IL187482A IL187482A (en) 2000-06-02 2007-11-19 Crystalline and amorphous form of a compound of triazolo (D-5, 4) pyrimidine
IL202582A IL202582A (en) 2000-06-02 2009-12-07 Crystalline and amorphous forms of a compound of triazolo (D-5, 4) pyrimidine

Country Status (36)

Country Link
US (3) US20030181469A1 (no)
EP (3) EP1493745B2 (no)
JP (3) JP5036947B2 (no)
KR (1) KR100781864B1 (no)
CN (2) CN1247583C (no)
AR (2) AR032335A1 (no)
AT (2) ATE320430T1 (no)
AU (4) AU2001262874B2 (no)
BG (3) BG65837B1 (no)
BR (1) BR0111328A (no)
CA (1) CA2408596C (no)
CY (1) CY1113047T1 (no)
CZ (2) CZ307468B6 (no)
DE (1) DE60117972T2 (no)
DK (2) DK1493745T3 (no)
EE (1) EE05222B1 (no)
ES (2) ES2259031T3 (no)
GB (1) GB0013407D0 (no)
HK (2) HK1052347B (no)
HU (2) HU229374B1 (no)
IL (4) IL152777A0 (no)
IS (2) IS2609B (no)
MX (1) MXPA02011795A (no)
MY (2) MY140674A (no)
NO (3) NO323780B1 (no)
NZ (1) NZ522638A (no)
PH (1) PH12011000127A1 (no)
PL (2) PL359172A1 (no)
PT (2) PT1493745E (no)
RU (3) RU2325391C2 (no)
SG (1) SG135965A1 (no)
SI (2) SI1493745T1 (no)
SK (1) SK287817B6 (no)
UA (1) UA73181C2 (no)
WO (1) WO2001092262A1 (no)
ZA (1) ZA200209324B (no)

Families Citing this family (66)

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TWI229674B (en) 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
GB0013488D0 (en) * 2000-06-02 2000-07-26 Astrazeneca Ab Chemical compound
GB0013407D0 (en) * 2000-06-02 2000-07-26 Astrazeneca Ab Forms of a chemical compound
JP4298212B2 (ja) * 2002-03-29 2009-07-15 大日本印刷株式会社 塩酸エピナスチン高融点型結晶の製造法
TWI482772B (zh) * 2006-08-21 2015-05-01 Astrazeneca Ab 適合口服且包含三唑并[4,5-d]嘧啶衍生物之組合物
WO2008024044A1 (en) * 2006-08-21 2008-02-28 Astrazeneca Ab Compositions, suitable for oral administration, comprising a triazolo [4, 5] pyrimidin derivate
JP2010508350A (ja) * 2006-10-31 2010-03-18 ヤンセン ファーマシューティカ エヌ．ベー． Ａｄｐｐ２ｙ１２レセプターアンタゴニストとしてのトリアゾロピリミジン誘導体
BRPI0809655B8 (pt) * 2007-04-13 2021-05-25 Millennium Pharm Inc uso de um composto e um agente terapêutico,composição farmacêutica,e,kit
TWI496776B (zh) * 2007-11-15 2015-08-21 Astrazeneca Ab 製備(3aR,4S,6R,6aS)-6-胺基-2,2-二甲基四氫-3aH-環戊并[d][1,3]二氧雜環戊烯-4-醇之純非對映異構性之二苯甲醯-L-酒石酸鹽之方法
UA100864C2 (uk) 2007-12-03 2013-02-11 Астразенека Аб Спосіб лікування або запобігання аневризмі черевної аорти
US8563755B2 (en) 2008-09-09 2013-10-22 Astrazeneca Ab Process for preparing [1S-[1-α, 2-α, 3-β(1S*,2R*) 5-β]]-3-[7-[2-(3,4-difluorophenyl)-cyclopropylamino]-5-(propylthio)-3H-1,2,3-triazolo [4,5-d] pyrimidin-3-yl]-5-(2-hydroxyethoxy) cyclopentane-1,2-diol and to its intermediates
WO2011017108A2 (en) 2009-07-27 2011-02-10 Auspex Pharmaceuticals, Inc. Cyclopropyl modulators of p2y12 receptor
WO2011067571A1 (en) * 2009-12-03 2011-06-09 Astrazeneca Ab Co - crystals of a triazolo [4,5 - d] pyrimidine platelet aggregation inhibitor
ES2550033T3 (es) 2009-12-23 2015-11-04 Ratiopharm Gmbh Forma de dosificación farmacéutica sólida de ticagrelor
CZ2011229A3 (cs) * 2011-04-19 2012-08-15 Zentiva, K.S. Opticky aktivní soli (3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyklopenta-[d][1,3]dioxol-4-olu a zpusob jejich prípravy
CA2836394A1 (en) * 2011-06-01 2012-12-06 Astrazeneca Ab Novel ticagrelor co - crystal
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CN104640864B (zh) 2012-07-04 2016-11-16 力奇制药公司 替格瑞洛与二价金属盐的加合物
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CN103772393B (zh) * 2012-10-18 2017-08-04 博瑞生物医药（苏州）股份有限公司 替卡格雷的晶型及其制备方法
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CN104098572A (zh) * 2013-04-08 2014-10-15 博瑞生物医药技术(苏州)有限公司 替卡格雷共晶型
CN107573333B (zh) * 2013-04-10 2019-10-18 江苏恒瑞医药股份有限公司 替格瑞洛的中间体及其制备方法和替格瑞洛的制备方法
WO2014170026A1 (en) 2013-04-18 2014-10-23 Zentiva, K.S. Stabilized amorphous ticagrelor
EP2813216A1 (en) 2013-06-10 2014-12-17 Zentiva, a.s. Stabilized amorphous ticagrelor
US20160120869A1 (en) 2013-05-29 2016-05-05 Ratiopharm Gmbh Solid pharmaceutical dosage form
CN106496235A (zh) * 2013-06-03 2017-03-15 杭州领业医药科技有限公司 结晶形态的三唑[4,5‑d]嘧啶化合物及其制备方法和用途
WO2014195861A2 (en) * 2013-06-04 2014-12-11 Dr. Reddy’S Laboratories Limited Preparation of ticagrelor
EP2816043A1 (en) 2013-06-21 2014-12-24 LEK Pharmaceuticals d.d. Spherical ticagrelor particles
WO2015001489A1 (en) * 2013-07-01 2015-01-08 Ranbaxy Laboratories Limited Pharmaceutical compositions of ticagrelor
CN104341423B (zh) * 2013-08-02 2017-03-01 上海京新生物医药有限公司 替格瑞洛的一水合物及其制备方法与在制药中的应用
CN104370912A (zh) * 2013-08-13 2015-02-25 开原亨泰制药股份有限公司 替卡格雷多晶型体及其制备方法
WO2015037016A2 (en) * 2013-09-10 2015-03-19 Laurus Labs Private Limited An improved process for the preparation of ticagrelor and intermediates thereof
CZ2013866A3 (cs) 2013-11-08 2015-05-20 Zentiva, K.S. Způsob výroby a nová krystalická forma intermediátu syntézy ticagreloru
CN104650085A (zh) * 2013-11-22 2015-05-27 天津市汉康医药生物技术有限公司 替卡格雷倍半水合物化合物
CN103601726B (zh) * 2013-12-02 2016-09-28 浙江大学 两种替格瑞洛药物共晶及其制备方法
CN104710425B (zh) * 2013-12-16 2019-06-14 石药集团中奇制药技术（石家庄）有限公司 一种替格瑞洛新结晶及其制备方法
CN104650091B (zh) * 2014-01-24 2016-10-05 福州乾正药业有限公司 替格瑞洛的微粉化及其晶型，以及制备方法和药物应用
CN104940204A (zh) * 2014-03-27 2015-09-30 广东东阳光药业有限公司 一种替格瑞洛固体制剂及其制备方法
WO2015162537A1 (en) * 2014-04-23 2015-10-29 Glenmark Pharmaceuticals Limited; Glenmark Generics Limited Process for preparation of ticagrelor
WO2015162630A1 (en) 2014-04-25 2015-10-29 Anlon Chemical Research Organization Novel processes for preparing triazolo [4,5-d]- pyrimidines, including ticagrelor, vianew intermediates and new route of synthesis.
CN105315282B (zh) * 2014-07-15 2018-09-21 博瑞生物医药（苏州）股份有限公司 一种制备替卡格雷无定型的方法
WO2016016907A1 (en) * 2014-08-01 2016-02-04 Msn Laboratories Private Limited Novel polymorphs of (1s,2s,3r,5s)-3-[7-{[(1r,2s)-2-(3,4-difluorophenyl) cyclopropyl]amino}-5-(propylthio)-3h-[1,2,3]-triazolo[4,5-d]pyrimidin-3-yi]-5-(2-hydroxvethoxy) cyclopentane-1,2-diol
US10017515B2 (en) 2014-08-11 2018-07-10 Sun Pharmaceutical Industries Limited Stable amorphous ticagrelor and a process for its preparation
CN104193747B (zh) * 2014-08-12 2016-05-11 许彩霞 替卡格雷无定形的制备
WO2016116942A1 (en) 2015-01-20 2016-07-28 Anlon Chemical Research Organization Novel pharmaceutical compounds comprising ticagrelor with salts of aspirin
CN105968113B (zh) * 2015-03-12 2019-06-07 四川海思科制药有限公司 一种三唑并嘧啶衍生物及其应用
WO2017072790A1 (en) * 2015-10-26 2017-05-04 Avra Laboratories Pvt. Ltd. An improved process for synthesis of ticagrelor
WO2017118633A1 (en) * 2016-01-05 2017-07-13 Amneal Pharmaceuticals Company Gmbh Crystalline form of ticagrelor
CN107595789B (zh) 2016-04-21 2021-01-15 阿斯利康(瑞典)有限公司 口腔崩解片
US10905691B2 (en) 2016-09-09 2021-02-02 Université de Liège Use of triazolo(4,5-d)pyrimidine derivatives for prevention and treatment of bacterial infection
EP3292867B1 (en) * 2016-09-09 2019-05-15 Université de Liège Triazolo(4,5-d)pyrimidine derivatives for use in the prevention and treatment of bacterial infection
KR101916956B1 (ko) 2016-12-13 2018-11-08 보령제약 주식회사 티카그렐러의 신규한 고체 형태 및 이의 제조방법
WO2018178997A1 (en) 2017-03-31 2018-10-04 Natco Pharma Limited Novel crystalline form of ticagrelor
WO2019127294A1 (zh) * 2017-12-29 2019-07-04 浙江天宇药业股份有限公司 一种纯化替格瑞洛的方法
WO2019170244A1 (en) 2018-03-08 2019-09-12 Pharmaceutical Oriented Services Ltd. Ticagrelor—containing tablet formulation
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SE9904129D0 (sv) * 1999-11-15 1999-11-15 Astra Pharma Prod Novel compounds
GB0013407D0 (en) * 2000-06-02 2000-07-26 Astrazeneca Ab Forms of a chemical compound
GB0013488D0 (en) * 2000-06-02 2000-07-26 Astrazeneca Ab Chemical compound

Also Published As

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RU2325391C2 (ru) 2008-05-27
BG66332B1 (bg) 2013-06-28
AU2001262874B2 (en) 2007-03-22
ATE320430T1 (de) 2006-04-15
CY1113047T1 (el) 2016-04-13
MY140674A (en) 2010-01-15
AU6287401A (en) 2001-12-11
BG110440A (bg) 2010-03-31
NZ522638A (en) 2004-06-25
BG111017A (bg) 2011-12-30
EP1493745A1 (en) 2005-01-05
JP2003535092A (ja) 2003-11-25
NO20025756L (no) 2003-01-24
EP1493745B1 (en) 2012-04-25
CN1432018A (zh) 2003-07-23
DK1493745T3 (da) 2012-07-16
SG135965A1 (en) 2007-10-29
CZ20120293A3 (no) 2003-07-16
RU2418802C2 (ru) 2011-05-20
IL152777A (en) 2008-11-26
HUP0302284A3 (en) 2007-05-29
CN1817883A (zh) 2006-08-16
DK1289992T3 (da) 2006-07-03
NO332306B1 (no) 2012-08-20
NO20025756D0 (no) 2002-11-29
JP2014129423A (ja) 2014-07-10
JP5036947B2 (ja) 2012-09-26
BG65837B1 (bg) 2010-02-26
SI1493745T1 (sl) 2012-08-31
AU2007200958B2 (en) 2010-10-07
BR0111328A (pt) 2003-06-10
NO20071547L (no) 2003-01-24
DE60117972D1 (de) 2006-05-11
US20070173518A1 (en) 2007-07-26
CZ307468B6 (cs) 2018-09-26
HUP0302284A2 (hu) 2003-10-28
KR20030007829A (ko) 2003-01-23
RU2010150799A (ru) 2012-06-20
NO323780B1 (no) 2007-07-02
ZA200209324B (en) 2004-02-16
KR100781864B1 (ko) 2007-12-05
EE200200665A (et) 2004-06-15
AU2010257449B2 (en) 2012-03-22
IL202582A0 (en) 2010-06-30
CA2408596C (en) 2010-12-21
HK1073101A1 (en) 2005-09-23
IS3019B (is) 2020-02-15
IS2609B (is) 2010-04-15
HU230471B1 (hu) 2016-07-28
IL187482A (en) 2010-06-16
EP1493745B2 (en) 2021-05-19
PT1289992E (pt) 2006-07-31
PT1493745E (pt) 2012-06-28
WO2001092262A1 (en) 2001-12-06
CN1817883B (zh) 2011-10-05
PH12011000127A1 (en) 2016-08-31
SK16852002A3 (sk) 2003-08-05
ATE555115T1 (de) 2012-05-15
NO333289B1 (no) 2013-04-29
AR068086A2 (es) 2009-11-04
AR032335A1 (es) 2003-11-05
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EP1289992A1 (en) 2003-03-12
IS8825A (is) 2009-06-02
HU229374B1 (en) 2013-11-28
HK1052347B (zh) 2006-09-08
IL202582A (en) 2012-12-31
CZ304347B6 (cs) 2014-03-19
US20030181469A1 (en) 2003-09-25
EP1289992B1 (en) 2006-03-15
HK1052347A1 (en) 2003-09-11
EP2292622A1 (en) 2011-03-09
GB0013407D0 (en) 2000-07-26
AU2007200958A1 (en) 2007-03-29
IS6623A (is) 2002-11-15
AU2010257449A1 (en) 2011-01-20
RU2005127356A (ru) 2007-03-10
BG107331A (bg) 2003-07-31
JP5684192B2 (ja) 2015-03-11
CN1247583C (zh) 2006-03-29
SI1289992T1 (sl) 2006-08-31
PL359172A1 (en) 2004-08-23
DE60117972T2 (de) 2006-11-23
UA73181C2 (en) 2005-06-15
HUP1300386A2 (en) 2003-10-28
ES2384708T3 (es) 2012-07-11
MY148652A (en) 2013-05-15
MXPA02011795A (es) 2003-04-10
EE05222B1 (et) 2009-10-15
JP2012149093A (ja) 2012-08-09
CA2408596A1 (en) 2001-12-06
ES2259031T3 (es) 2006-09-16
US7265124B2 (en) 2007-09-04
NO20120595L (no) 2003-01-24
PL392882A1 (pl) 2011-03-14
US20070293513A1 (en) 2007-12-20

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