HK1044768A1 - 晶狀1-甲基碳青霉烯化合物 - Google Patents

晶狀1-甲基碳青霉烯化合物

Info

Publication number
HK1044768A1
HK1044768A1 HK02106273.3A HK02106273A HK1044768A1 HK 1044768 A1 HK1044768 A1 HK 1044768A1 HK 02106273 A HK02106273 A HK 02106273A HK 1044768 A1 HK1044768 A1 HK 1044768A1
Authority
HK
Hong Kong
Prior art keywords
crystalline
methylcarbapenem compounds
methylcarbapenem
compounds
Prior art date
Application number
HK02106273.3A
Other languages
English (en)
Inventor
Kawamoto Isao
Shimoji Yasuo
Fukuhara Hiroshi
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of HK1044768A1 publication Critical patent/HK1044768A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK02106273.3A 1999-07-06 2002-08-26 晶狀1-甲基碳青霉烯化合物 HK1044768A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP19136899 1999-07-06
PCT/JP2000/004496 WO2001002401A1 (fr) 1999-07-06 2000-07-06 Composes de 1-methylcarbapenem cristallin

Publications (1)

Publication Number Publication Date
HK1044768A1 true HK1044768A1 (zh) 2002-11-01

Family

ID=16273433

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02106273.3A HK1044768A1 (zh) 1999-07-06 2002-08-26 晶狀1-甲基碳青霉烯化合物

Country Status (21)

Country Link
US (3) US20020128254A1 (zh)
EP (1) EP1193269A4 (zh)
JP (1) JP3476420B2 (zh)
KR (1) KR100750552B1 (zh)
CN (2) CN100360530C (zh)
AU (1) AU758190B2 (zh)
BR (1) BR0012253A (zh)
CA (1) CA2378483C (zh)
CZ (1) CZ20014731A3 (zh)
HK (1) HK1044768A1 (zh)
HU (1) HUP0202255A3 (zh)
IL (2) IL147214A0 (zh)
MX (1) MXPA02000061A (zh)
NO (1) NO327786B1 (zh)
NZ (1) NZ516310A (zh)
PL (1) PL352296A1 (zh)
RU (2) RU2214411C2 (zh)
TR (2) TR200200100T2 (zh)
TW (1) TWI250160B (zh)
WO (1) WO2001002401A1 (zh)
ZA (1) ZA200110413B (zh)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2219172C2 (ru) * 1999-04-06 2003-12-20 Санкио Компани, Лимитед α-ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ КАРБОНОВЫХ КИСЛОТ
US7041660B2 (en) * 1999-07-06 2006-05-09 Sankyo Company, Limited Crystalline 1-methylcarbapenem derivatives
EP1447406B1 (en) * 1999-09-30 2006-08-09 Otsuka Kagaku Kabushiki Kaisha 3-Cephem derivative crystal
EP2263654B1 (en) 2000-06-21 2012-10-10 Cubist Pharmaceuticals, Inc. Compositions for improving the oral absorption of antimicrobial agents
KR100451672B1 (ko) * 2001-06-05 2004-10-08 한미약품 주식회사 결정성 세프디니르 산부가염, 이의 제조방법 및 이를이용한 세프디니르의 제조방법
WO2003016312A1 (fr) * 2001-08-13 2003-02-27 Eisai Co., Ltd. Procede de preparation d'antibiotiques a base de carbapenem
ES2368997T3 (es) * 2001-09-26 2011-11-24 Merck Sharp & Dohme Corp. Procedimiento de fabricación de compuestos de carbapenem.
HRP20040264B1 (en) * 2001-09-26 2012-07-31 Merck@Sharp@@@Dohme@Corp Process for making carbapenem compounds
ITMI20012364A1 (it) * 2001-11-09 2003-05-09 Antibioticos Spa Processo di sintesi della cefixima via alchil-o arilsolfonati
JP2005097278A (ja) * 2003-08-25 2005-04-14 Sankyo Co Ltd １−メチルカルバペネム化合物の結晶
CA2644316A1 (en) 2003-08-25 2005-03-03 Sankyo Company Limited Crystal of 1-methyl carbapenem compound
JP2008501657A (ja) * 2004-06-02 2008-01-24 サンド・アクチエンゲゼルシヤフト 結晶形態のメロペネム中間体
EP1862456A4 (en) * 2005-03-22 2010-01-27 Daiichi Sankyo Co Ltd PROCESS FOR PREPARING A CARBAPENE DERIVATIVE WITH 1-ALKYLPYRROLIDINE STRUCTURE
EP1877041A2 (en) 2005-04-29 2008-01-16 Cubist Pharmaceuticals, Inc. Therapeutic compositions
WO2006121151A1 (ja) * 2005-05-13 2006-11-16 Daiichi Sankyo Company, Limited １－メチルカルバペネム化合物の結晶
CN101328179B (zh) * 2007-06-15 2011-01-12 山东轩竹医药科技有限公司 含有氧代氮杂环的巯基吡咯烷培南衍生物
CN101412717B (zh) * 2007-10-19 2011-01-12 山东轩竹医药科技有限公司 含有胍基烷酰胺基杂环的碳青霉烯衍生物
JPWO2009091031A1 (ja) * 2008-01-17 2011-05-26 大日本住友製薬株式会社 アデニン化合物の製造方法
CN102918041A (zh) * 2010-05-21 2013-02-06 山东轩竹医药科技有限公司 碳青霉烯衍生物或其水合物的晶型及其制备方法与用途
US8822445B2 (en) * 2010-06-03 2014-09-02 Xuanzhu Pharma Co., Ltd. Crystalline form of carbapenem derivative or its hydrates and preparation methods and uses thereof
CN108752241B (zh) * 2013-01-15 2021-03-12 默克专利股份公司 用于治疗关节病的酰基胍类

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4260543A (en) 1978-07-03 1981-04-07 Merck & Co., Inc. Crystalline N-formimidoyl thienamycin
US4748238A (en) 1984-03-14 1988-05-31 Merck & Co., Inc. Crystalline 1R,5S,6S,8R-1-methyl-2-(N,N-dimethylcarbamimidoylmethylthio)-6-(1-hydroxyethyl)-1-carbapen-2-em-3-carboxylic acid
US4713451A (en) 1984-04-09 1987-12-15 Merck & Co., Inc. Crystalline dimethyliminothienamycin
IE60588B1 (en) 1986-07-30 1994-07-27 Sumitomo Pharma Carbapenem compound in crystalline form, and its production and use
US4866171A (en) 1987-04-11 1989-09-12 Lederle (Japan), Ltd. (1R,5S,6S)-2-[(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazolium-6-yl)]thio-6-[R-1-hydroxyethyl]-1-methyl-carbapenum-3-carboxylate
TW209220B (zh) * 1991-11-27 1993-07-11 Manyu Seiyaku Kk
ES2131560T3 (es) 1992-11-17 1999-08-01 Sankyo Co Derivado de carbapenem cristalino.
JPH06336483A (ja) * 1993-05-26 1994-12-06 Banyu Pharmaceut Co Ltd アミノアルキルピロリジニルチオカルバペネム誘導体
JPH07291973A (ja) * 1994-04-27 1995-11-07 Banyu Pharmaceut Co Ltd 新規な２−ピロリジニルチオカルバペネム誘導体
JPH09110869A (ja) * 1995-10-23 1997-04-28 Lederle Japan Ltd カルバペネム化合物
NZ324447A (en) * 1995-12-21 1999-08-30 Sankyo Co 1-methyl-carbapenem substituted by a 4-pyrrolidinylthio group and medicaments
JP2955276B2 (ja) * 1997-06-19 1999-10-04 三共株式会社 １−メチルカルバペネム誘導体を含有する抗菌剤

Also Published As

Publication number Publication date
HUP0202255A2 (en) 2002-10-28
RU2003118411A (ru) 2004-12-20
EP1193269A4 (en) 2003-05-28
AU5848700A (en) 2001-01-22
NO327786B1 (no) 2009-09-21
NO20020030D0 (no) 2002-01-04
US20030158174A1 (en) 2003-08-21
CA2378483A1 (en) 2001-01-11
RU2214411C2 (ru) 2003-10-20
MXPA02000061A (es) 2002-07-02
JP2001072681A (ja) 2001-03-21
ZA200110413B (en) 2003-03-19
NZ516310A (en) 2004-05-28
CN1372560A (zh) 2002-10-02
WO2001002401A1 (fr) 2001-01-11
PL352296A1 (en) 2003-08-11
CN101077869A (zh) 2007-11-28
EP1193269A1 (en) 2002-04-03
JP3476420B2 (ja) 2003-12-10
KR100750552B1 (ko) 2007-08-20
US20020128254A1 (en) 2002-09-12
US6924279B2 (en) 2005-08-02
BR0012253A (pt) 2002-03-26
NO20020030L (no) 2002-03-05
IL147214A (en) 2009-12-24
KR20020022761A (ko) 2002-03-27
TR200403436T2 (tr) 2005-03-21
US20030232803A1 (en) 2003-12-18
TWI250160B (en) 2006-03-01
HUP0202255A3 (en) 2003-10-28
IL147214A0 (en) 2002-08-14
AU758190B2 (en) 2003-03-20
CN100360530C (zh) 2008-01-09
CA2378483C (en) 2008-09-16
CZ20014731A3 (cs) 2002-04-17
TR200200100T2 (tr) 2002-05-21

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