NO20020030L - Krystallinske 1-metylkarbapenemforbindelser - Google Patents

Krystallinske 1-metylkarbapenemforbindelser

Info

Publication number
NO20020030L
NO20020030L NO20020030A NO20020030A NO20020030L NO 20020030 L NO20020030 L NO 20020030L NO 20020030 A NO20020030 A NO 20020030A NO 20020030 A NO20020030 A NO 20020030A NO 20020030 L NO20020030 L NO 20020030L
Authority
NO
Norway
Prior art keywords
crystalline
methylcarbapenem compounds
methylcarbapenem
compounds
Prior art date
Application number
NO20020030A
Other languages
English (en)
Other versions
NO20020030D0 (no
NO327786B1 (no
Inventor
Isao Kawamoto
Yasuo Shimoji
Hiroshi Fukuhara
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of NO20020030D0 publication Critical patent/NO20020030D0/no
Publication of NO20020030L publication Critical patent/NO20020030L/no
Publication of NO327786B1 publication Critical patent/NO327786B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
NO20020030A 1999-07-06 2002-01-04 Krystallinske 1-metylkarbapenemforbindelser NO327786B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP19136899 1999-07-06
PCT/JP2000/004496 WO2001002401A1 (fr) 1999-07-06 2000-07-06 Composes de 1-methylcarbapenem cristallin

Publications (3)

Publication Number Publication Date
NO20020030D0 NO20020030D0 (no) 2002-01-04
NO20020030L true NO20020030L (no) 2002-03-05
NO327786B1 NO327786B1 (no) 2009-09-21

Family

ID=16273433

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20020030A NO327786B1 (no) 1999-07-06 2002-01-04 Krystallinske 1-metylkarbapenemforbindelser

Country Status (21)

Country Link
US (3) US20020128254A1 (no)
EP (1) EP1193269A4 (no)
JP (1) JP3476420B2 (no)
KR (1) KR100750552B1 (no)
CN (2) CN100360530C (no)
AU (1) AU758190B2 (no)
BR (1) BR0012253A (no)
CA (1) CA2378483C (no)
CZ (1) CZ20014731A3 (no)
HK (1) HK1044768A1 (no)
HU (1) HUP0202255A3 (no)
IL (2) IL147214A0 (no)
MX (1) MXPA02000061A (no)
NO (1) NO327786B1 (no)
NZ (1) NZ516310A (no)
PL (1) PL352296A1 (no)
RU (2) RU2214411C2 (no)
TR (2) TR200200100T2 (no)
TW (1) TWI250160B (no)
WO (1) WO2001002401A1 (no)
ZA (1) ZA200110413B (no)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL145732A0 (en) * 1999-04-06 2002-07-25 Sankyo Co α-SUBSTITUTED CARBOXYLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
US7041660B2 (en) * 1999-07-06 2006-05-09 Sankyo Company, Limited Crystalline 1-methylcarbapenem derivatives
KR100494825B1 (ko) * 1999-09-30 2005-06-14 오쯔까 가가꾸 가부시키가이샤 3-세펨 유도체 결정 및 그 제조 방법
UA82824C2 (uk) 2000-06-21 2008-05-26 К'Юбіст Фармасьютікалз, Інк. Композиція і спосіб поліпшення перорального всмоктування протимікробних засобів
KR100451672B1 (ko) * 2001-06-05 2004-10-08 한미약품 주식회사 결정성 세프디니르 산부가염, 이의 제조방법 및 이를이용한 세프디니르의 제조방법
WO2003016312A1 (fr) * 2001-08-13 2003-02-27 Eisai Co., Ltd. Procede de preparation d'antibiotiques a base de carbapenem
BRPI0212411B8 (pt) 2001-09-26 2021-07-27 Merck & Co Inc ' processos para reduzir os níveis de solventes orgânicos em um sólido de carbapenem, e para fabricar um hidrato cristalino'
HRP20040264B1 (en) * 2001-09-26 2012-07-31 Merck@Sharp@@@Dohme@Corp Process for making carbapenem compounds
ITMI20012364A1 (it) * 2001-11-09 2003-05-09 Antibioticos Spa Processo di sintesi della cefixima via alchil-o arilsolfonati
JP2005097278A (ja) * 2003-08-25 2005-04-14 Sankyo Co Ltd １−メチルカルバペネム化合物の結晶
CA2536886C (en) 2003-08-25 2009-10-27 Sankyo Company Limited Crystal of 1-methyl carbapenem compound
JP2008501657A (ja) * 2004-06-02 2008-01-24 サンド・アクチエンゲゼルシヤフト 結晶形態のメロペネム中間体
CA2602097A1 (en) * 2005-03-22 2006-09-28 Daiichi Sankyo Company, Limited Process for producing carbapenem derivatives having 1-alkylpyrrolidine structure
CA2606386C (en) 2005-04-29 2014-06-10 Cubist Pharmaceuticals, Inc. Therapeutic compositions
TW200639176A (en) * 2005-05-13 2006-11-16 Sankyo Co Crystal of 1-methyl carbapenem compound
CN101328179B (zh) * 2007-06-15 2011-01-12 山东轩竹医药科技有限公司 含有氧代氮杂环的巯基吡咯烷培南衍生物
CN101412717B (zh) * 2007-10-19 2011-01-12 山东轩竹医药科技有限公司 含有胍基烷酰胺基杂环的碳青霉烯衍生物
US20110054168A1 (en) * 2008-01-17 2011-03-03 Ayumu Kurimoto Method for preparing adenine compound
WO2011143935A1 (zh) * 2010-05-21 2011-11-24 山东轩竹医药科技有限公司 碳青霉烯衍生物或其水合物的晶型及其制备方法与用途
CN103025733B (zh) * 2010-06-03 2015-11-25 山东轩竹医药科技有限公司 碳青霉烯类衍生物或其水合物的晶型及其制备方法与用途
ES2785313T3 (es) * 2013-01-15 2020-10-06 Merck Patent Gmbh Acilguanidinas para el tratamiento de la artrosis

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4260543A (en) 1978-07-03 1981-04-07 Merck & Co., Inc. Crystalline N-formimidoyl thienamycin
US4748238A (en) 1984-03-14 1988-05-31 Merck & Co., Inc. Crystalline 1R,5S,6S,8R-1-methyl-2-(N,N-dimethylcarbamimidoylmethylthio)-6-(1-hydroxyethyl)-1-carbapen-2-em-3-carboxylic acid
US4713451A (en) 1984-04-09 1987-12-15 Merck & Co., Inc. Crystalline dimethyliminothienamycin
IE60588B1 (en) 1986-07-30 1994-07-27 Sumitomo Pharma Carbapenem compound in crystalline form, and its production and use
US4866171A (en) 1987-04-11 1989-09-12 Lederle (Japan), Ltd. (1R,5S,6S)-2-[(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazolium-6-yl)]thio-6-[R-1-hydroxyethyl]-1-methyl-carbapenum-3-carboxylate
TW209220B (no) * 1991-11-27 1993-07-11 Manyu Seiyaku Kk
DE69324106T2 (de) 1992-11-17 1999-12-09 Sankyo Co Krystallines Carbapenemderivat
JPH06336483A (ja) * 1993-05-26 1994-12-06 Banyu Pharmaceut Co Ltd アミノアルキルピロリジニルチオカルバペネム誘導体
JPH07291973A (ja) * 1994-04-27 1995-11-07 Banyu Pharmaceut Co Ltd 新規な２−ピロリジニルチオカルバペネム誘導体
JPH09110869A (ja) * 1995-10-23 1997-04-28 Lederle Japan Ltd カルバペネム化合物
NZ324447A (en) * 1995-12-21 1999-08-30 Sankyo Co 1-methyl-carbapenem substituted by a 4-pyrrolidinylthio group and medicaments
JP2955276B2 (ja) * 1997-06-19 1999-10-04 三共株式会社 １−メチルカルバペネム誘導体を含有する抗菌剤

Also Published As

Publication number Publication date
MXPA02000061A (es) 2002-07-02
CN101077869A (zh) 2007-11-28
NO20020030D0 (no) 2002-01-04
EP1193269A1 (en) 2002-04-03
KR20020022761A (ko) 2002-03-27
ZA200110413B (en) 2003-03-19
BR0012253A (pt) 2002-03-26
HUP0202255A3 (en) 2003-10-28
CN100360530C (zh) 2008-01-09
CN1372560A (zh) 2002-10-02
CZ20014731A3 (cs) 2002-04-17
RU2214411C2 (ru) 2003-10-20
PL352296A1 (en) 2003-08-11
US20020128254A1 (en) 2002-09-12
HUP0202255A2 (en) 2002-10-28
JP3476420B2 (ja) 2003-12-10
IL147214A (en) 2009-12-24
US20030158174A1 (en) 2003-08-21
NO327786B1 (no) 2009-09-21
CA2378483A1 (en) 2001-01-11
TWI250160B (en) 2006-03-01
WO2001002401A1 (fr) 2001-01-11
EP1193269A4 (en) 2003-05-28
CA2378483C (en) 2008-09-16
HK1044768A1 (zh) 2002-11-01
KR100750552B1 (ko) 2007-08-20
US20030232803A1 (en) 2003-12-18
RU2003118411A (ru) 2004-12-20
AU758190B2 (en) 2003-03-20
NZ516310A (en) 2004-05-28
TR200403436T2 (tr) 2005-03-21
US6924279B2 (en) 2005-08-02
TR200200100T2 (tr) 2002-05-21
IL147214A0 (en) 2002-08-14
AU5848700A (en) 2001-01-22
JP2001072681A (ja) 2001-03-21

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