HRP20040264B1 - Process for making carbapenem compounds - Google Patents
Process for making carbapenem compoundsInfo
- Publication number
- HRP20040264B1 HRP20040264B1 HRP20040264AA HRP20040264A HRP20040264B1 HR P20040264 B1 HRP20040264 B1 HR P20040264B1 HR P20040264A A HRP20040264A A HR P20040264AA HR P20040264 A HRP20040264 A HR P20040264A HR P20040264 B1 HRP20040264 B1 HR P20040264B1
- Authority
- HR
- Croatia
- Prior art keywords
- carbapenem
- organic solvent
- solid
- heteroaryl
- formula
- Prior art date
Links
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Postupak redukcije razine organskih otapala u kristaliničnom karbapenemu formule I ili njegovoj soli naznačen time da su R i R isti ili različiti i odabrani od H alkil aril i heteroaril a spomenuti alkil aril i heteroaril su opcionalno supstituirani a koji se sastoji od slijedećih koraka a ispiranje karbapenem krutine koja sadrži organsko otapalo s organskim otapalom koje sadrži vodu da se dobije isprana karbapenem krutina koja sadrži ostatke organskog otapala ib otparavanje ostataka organskog otapala u ispranoj karbapenem krutini koristeći vakuum i ili struju inertnog plina na temperaturi od °C do °C da se dobije karbapenem krutina formule I koja sadržava farmaceutski prihvatljive razine farmaceutskih otapala gdjeje sadržaj vode u krutini karbapenema korigiran za ostatak organskog otapala održavan na do za vrijeme postupka Patent sadrži još patentnih zahtjevaA process for reducing the level of organic solvents in a crystalline carbapenem of formula I or its salt characterized in that R and R are the same or different and selected from H alkyl aryl and heteroaryl and said alkyl aryl and heteroaryl are optionally substituted and which consists of the following steps and carbapenem washing organic solvent-containing solid with water-containing organic solvent to obtain a carbapenem-washed solid containing organic solvent residues and evaporating the organic solvent residues in the carbapenem-washed solid using vacuum and or an inert gas stream at a temperature of °C to °C to obtain the carbapenem a solid of formula I containing pharmaceutically acceptable levels of pharmaceutical solvents where the water content of the carbapenem solid is corrected for the remainder of the organic solvent maintained at up to during the process The patent contains further patent claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35213001P | 2001-09-26 | 2001-09-26 | |
PCT/US2002/029879 WO2003027067A2 (en) | 2001-09-26 | 2002-09-20 | Process for making carbapenem compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
HRP20040264A2 HRP20040264A2 (en) | 2004-10-31 |
HRP20040264B1 true HRP20040264B1 (en) | 2012-07-31 |
Family
ID=33130307
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20040264AA HRP20040264B1 (en) | 2001-09-26 | 2004-03-17 | Process for making carbapenem compounds |
Country Status (1)
Country | Link |
---|---|
HR (1) | HRP20040264B1 (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020128254A1 (en) * | 1999-07-06 | 2002-09-12 | Sankyo Company, Limited | Crystalline 1-methylcarbapenem derivatives |
-
2004
- 2004-03-17 HR HRP20040264AA patent/HRP20040264B1/en not_active IP Right Cessation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020128254A1 (en) * | 1999-07-06 | 2002-09-12 | Sankyo Company, Limited | Crystalline 1-methylcarbapenem derivatives |
Also Published As
Publication number | Publication date |
---|---|
HRP20040264A2 (en) | 2004-10-31 |
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Legal Events
Date | Code | Title | Description |
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A1OB | Publication of a patent application | ||
ARAI | Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application | ||
PNAN | Change of the applicant name, address/residence |
Owner name: MERCK SHARP & DOHME CORP., US |
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B1PR | Patent granted | ||
PNAN | Change of the applicant name, address/residence |
Owner name: MERCK SHARP & DOHME CORP., US Owner name: SCHERING CORPORATION, US |
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ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20190910 Year of fee payment: 18 |
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ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20200907 Year of fee payment: 19 |
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ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20210907 Year of fee payment: 20 |
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PB20 | Patent expired after termination of 20 years |
Effective date: 20220920 |