HRP20040264B1 - Process for making carbapenem compounds - Google Patents

Process for making carbapenem compounds

Info

Publication number
HRP20040264B1
HRP20040264B1 HRP20040264AA HRP20040264A HRP20040264B1 HR P20040264 B1 HRP20040264 B1 HR P20040264B1 HR P20040264A A HRP20040264A A HR P20040264AA HR P20040264 A HRP20040264 A HR P20040264A HR P20040264 B1 HRP20040264 B1 HR P20040264B1
Authority
HR
Croatia
Prior art keywords
carbapenem
organic solvent
solid
heteroaryl
formula
Prior art date
Application number
HRP20040264AA
Other languages
Croatian (hr)
Inventor
Raymond@Cvetovich
Robert@Wenslow
M@@John@Willams
Daniel@Sidler
Louis@Crocker
Hsien@Hsin@Tung
Brian@K@@Johnson
Joseph@II@Kukura
Ulf@Dolling
Original Assignee
Merck@Sharp@@@Dohme@Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2002/029879 external-priority patent/WO2003027067A2/en
Application filed by Merck@Sharp@@@Dohme@Corp filed Critical Merck@Sharp@@@Dohme@Corp
Publication of HRP20040264A2 publication Critical patent/HRP20040264A2/en
Publication of HRP20040264B1 publication Critical patent/HRP20040264B1/en

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Postupak redukcije razine organskih otapala u kristaliničnom karbapenemu formule I ili njegovoj soli naznačen time da su R i R isti ili različiti i odabrani od H alkil aril i heteroaril a spomenuti alkil aril i heteroaril su opcionalno supstituirani a koji se sastoji od slijedećih koraka a ispiranje karbapenem krutine koja sadrži organsko otapalo s organskim otapalom koje sadrži vodu da se dobije isprana karbapenem krutina koja sadrži ostatke organskog otapala ib otparavanje ostataka organskog otapala u ispranoj karbapenem krutini koristeći vakuum i ili struju inertnog plina na temperaturi od °C do °C da se dobije karbapenem krutina formule I koja sadržava farmaceutski prihvatljive razine farmaceutskih otapala gdjeje sadržaj vode u krutini karbapenema korigiran za ostatak organskog otapala održavan na do za vrijeme postupka Patent sadrži još patentnih zahtjevaA process for reducing the level of organic solvents in a crystalline carbapenem of formula I or its salt characterized in that R and R are the same or different and selected from H alkyl aryl and heteroaryl and said alkyl aryl and heteroaryl are optionally substituted and which consists of the following steps and carbapenem washing organic solvent-containing solid with water-containing organic solvent to obtain a carbapenem-washed solid containing organic solvent residues and evaporating the organic solvent residues in the carbapenem-washed solid using vacuum and or an inert gas stream at a temperature of °C to °C to obtain the carbapenem a solid of formula I containing pharmaceutically acceptable levels of pharmaceutical solvents where the water content of the carbapenem solid is corrected for the remainder of the organic solvent maintained at up to during the process The patent contains further patent claims

HRP20040264AA 2001-09-26 2004-03-17 Process for making carbapenem compounds HRP20040264B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35213001P 2001-09-26 2001-09-26
PCT/US2002/029879 WO2003027067A2 (en) 2001-09-26 2002-09-20 Process for making carbapenem compounds

Publications (2)

Publication Number Publication Date
HRP20040264A2 HRP20040264A2 (en) 2004-10-31
HRP20040264B1 true HRP20040264B1 (en) 2012-07-31

Family

ID=33130307

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20040264AA HRP20040264B1 (en) 2001-09-26 2004-03-17 Process for making carbapenem compounds

Country Status (1)

Country Link
HR (1) HRP20040264B1 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020128254A1 (en) * 1999-07-06 2002-09-12 Sankyo Company, Limited Crystalline 1-methylcarbapenem derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020128254A1 (en) * 1999-07-06 2002-09-12 Sankyo Company, Limited Crystalline 1-methylcarbapenem derivatives

Also Published As

Publication number Publication date
HRP20040264A2 (en) 2004-10-31

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Legal Events

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A1OB Publication of a patent application
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PNAN Change of the applicant name, address/residence

Owner name: MERCK SHARP & DOHME CORP., US

B1PR Patent granted
PNAN Change of the applicant name, address/residence

Owner name: MERCK SHARP & DOHME CORP., US

Owner name: SCHERING CORPORATION, US

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