ATE518865T1 - Meropenem-zwischenprodukt in kristalliner form - Google Patents

Meropenem-zwischenprodukt in kristalliner form

Info

Publication number
ATE518865T1
ATE518865T1 AT05753188T AT05753188T ATE518865T1 AT E518865 T1 ATE518865 T1 AT E518865T1 AT 05753188 T AT05753188 T AT 05753188T AT 05753188 T AT05753188 T AT 05753188T AT E518865 T1 ATE518865 T1 AT E518865T1
Authority
AT
Austria
Prior art keywords
crystalline form
intermediate product
meropenem
meropenem intermediate
compound
Prior art date
Application number
AT05753188T
Other languages
English (en)
Inventor
Peter Nadenik
Ole Storm
Peter Kremminger
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Application granted granted Critical
Publication of ATE518865T1 publication Critical patent/ATE518865T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT05753188T 2004-06-02 2005-06-01 Meropenem-zwischenprodukt in kristalliner form ATE518865T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT9442004 2004-06-02
PCT/EP2005/005909 WO2005118586A1 (en) 2004-06-02 2005-06-01 Meropenem intermediate in crystalline form

Publications (1)

Publication Number Publication Date
ATE518865T1 true ATE518865T1 (de) 2011-08-15

Family

ID=34970809

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05753188T ATE518865T1 (de) 2004-06-02 2005-06-01 Meropenem-zwischenprodukt in kristalliner form

Country Status (7)

Country Link
US (1) US20070249827A1 (de)
EP (1) EP1776365B1 (de)
JP (1) JP2008501657A (de)
CN (1) CN1960992B (de)
AT (1) ATE518865T1 (de)
ES (1) ES2370829T3 (de)
WO (1) WO2005118586A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006035300A2 (en) * 2004-09-30 2006-04-06 Ranbaxy Laboratories Limited A process for the preparation of meropenem
US8148520B2 (en) 2005-09-15 2012-04-03 Orchid Chemicals And Pharmaceuticals Limited Process for the preparation of beta-lactam antibiotic meropenem trihydrate
KR100781821B1 (ko) * 2006-02-16 2007-12-03 문순구 카르바페넴계 화합물의 제조방법
CN101410398B (zh) * 2006-03-28 2013-01-23 株式会社钟化 碳青霉素烯化合物的改良制备方法
JP2009143808A (ja) * 2006-03-28 2009-07-02 Kaneka Corp メロペネム中間体の単離方法
US20090216010A1 (en) * 2008-02-22 2009-08-27 Wei-Hong Tseng Crystalline carbapenem compound and produced method thereof
IT1390756B1 (it) * 2008-07-04 2011-09-23 Acs Dobfar Spa Processo per la sintesi di carbapenem mediante l'uso di nickel raney
US8097719B2 (en) * 2008-07-15 2012-01-17 Genesen Labs Meropenem intermediate in novel crystalline form and a method of manufacture of meropenem
CA2815167A1 (en) 2010-10-22 2012-04-26 Ranbaxy Laboratories Limited A process for the preparation of pure meropenem trihydrate
CN102633800B (zh) * 2011-02-14 2014-03-12 深圳市海滨制药有限公司 美罗培南中间体的晶体及其制备方法和应用
CN111039945B (zh) * 2019-12-30 2021-04-20 山东安弘制药有限公司 一种保护美罗培南的纯化方法

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4260543A (en) * 1978-07-03 1981-04-07 Merck & Co., Inc. Crystalline N-formimidoyl thienamycin
CA1283906C (en) * 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
JPS60104088A (ja) * 1983-11-11 1985-06-08 Sumitomo Chem Co Ltd 新規なβ−ラクタム化合物およびその製造法
JPS6479181A (en) * 1983-11-11 1989-03-24 Sumitomo Pharma Novel beta-lactam compound and production thereof
US4748238A (en) * 1984-03-14 1988-05-31 Merck & Co., Inc. Crystalline 1R,5S,6S,8R-1-methyl-2-(N,N-dimethylcarbamimidoylmethylthio)-6-(1-hydroxyethyl)-1-carbapen-2-em-3-carboxylic acid
US4713451A (en) * 1984-04-09 1987-12-15 Merck & Co., Inc. Crystalline dimethyliminothienamycin
JPS60233076A (ja) * 1984-05-03 1985-11-19 Sumitomo Chem Co Ltd 新規なβ−ラクタム化合物およびその製造法
JP2722318B2 (ja) * 1984-12-27 1998-03-04 住友製薬株式会社 β−ラクタム化合物
NZ214691A (en) * 1984-12-27 1988-08-30 Sumitomo Pharma The preparation of carbapenem derivatives and beta-lactam intermediates
JP2654753B2 (ja) * 1984-12-27 1997-09-17 住友製薬株式会社 β−ラクタム化合物の製造方法
JP2860379B2 (ja) * 1984-12-27 1999-02-24 住友製薬株式会社 β−ラクタム化合物およびその製造方法
US5310897A (en) * 1984-12-27 1994-05-10 Sumitomo Pharmaceuticals Co., Ltd. Beta-lactams and their production
IE60588B1 (en) * 1986-07-30 1994-07-27 Sumitomo Pharma Carbapenem compound in crystalline form, and its production and use
JP2522671B2 (ja) * 1986-07-30 1996-08-07 住友製薬 株式会社 結晶態のカルバペネム化合物、その製造方法およびその化合物を含有する注射用抗菌剤
US4866171A (en) * 1987-04-11 1989-09-12 Lederle (Japan), Ltd. (1R,5S,6S)-2-[(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazolium-6-yl)]thio-6-[R-1-hydroxyethyl]-1-methyl-carbapenum-3-carboxylate
US5371215A (en) * 1991-03-20 1994-12-06 American Cyanamid Company 4-substituted azetidinones as precursors to 2-substituted-3-carboxy carbapenem antibiotics and a method of producing them
US5541317A (en) * 1991-05-31 1996-07-30 Sankyo Company, Limited Azetidinone compounds useful in the preparation of carbapenem antibiotics and process for preparing carbapenem and penem compounds
ATE178066T1 (de) * 1992-11-17 1999-04-15 Sankyo Co Krystallines carbapenemderivat
GB9807354D0 (en) * 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound
US7141593B1 (en) * 1999-06-04 2006-11-28 Abbott Laboratories Pharmaceutical formulations
TWI250160B (en) * 1999-07-06 2006-03-01 Sankyo Co Crystalline 1-methylcarbapenem compound
SK14402003A3 (sk) * 2001-05-22 2004-06-08 Pfizer Products Inc. Kryštalické formy azitromycínu
US6821502B2 (en) * 2002-06-12 2004-11-23 Chevron U.S.A. Inc. Method of making aluminum-containing zeolite with IFR structure
AR047541A1 (es) * 2004-02-13 2006-01-25 Sandoz Ag Fosfato de 5-[[4-[2-metil-2-piridinil-amino-etoxi]fenil]metil]-2,4 tiazolidinadiona (rosiglitazona) y sus formas polimorficas
US7351833B2 (en) * 2004-07-23 2008-04-01 Abbott Laboratories (1S,5S)-3-(5,6-dichloropyridin-3-yl)-3,6-diazabicyclo[3.2.0]heptane benzenesulfonate
US8436176B2 (en) * 2004-12-30 2013-05-07 Medicis Pharmaceutical Corporation Process for preparing 2-methyl-1-(2-methylpropyl)-1H-imidazo[4,5-c][1,5]naphthyridin-4-amine
UA91546C2 (uk) * 2005-05-03 2010-08-10 Бьорінгер Інгельхайм Інтернаціональ Гмбх КРИСТАЛІЧНА ФОРМА 1-ХЛОР-4-(β-D-ГЛЮКОПІРАНОЗ-1-ИЛ)-2-[4-((S)-ТЕТРАГІДРОФУРАН-3-ІЛОКСИ)-БЕНЗИЛ]-БЕНЗОЛУ, СПОСІБ ЇЇ ОДЕРЖАННЯ ТА ЇЇ ЗАСТОСУВАННЯ ПРИ ПРИГОТУВАННІ ЛІКАРСЬКИХ ЗАСОБІВ
MY152185A (en) * 2005-06-10 2014-08-29 Novartis Ag Modified release 1-[(3-hydroxy-adamant-1-ylamino)-acetyl]-pyrrolidine-2(s)-carbonitrile formulation
US20070197781A1 (en) * 2005-07-29 2007-08-23 Neera Tewari Processes for the preparation of carbapenems
AU2006285142B2 (en) * 2005-08-29 2012-06-14 Sanofi-Aventis U.S. Llc Novel crystalline form of a pyridazino [4 , 5-b] indole derivative
TW200804410A (en) * 2005-09-13 2008-01-16 Sicor Inc Pure rocuronium bromide
US8148520B2 (en) * 2005-09-15 2012-04-03 Orchid Chemicals And Pharmaceuticals Limited Process for the preparation of beta-lactam antibiotic meropenem trihydrate
CN101410398B (zh) * 2006-03-28 2013-01-23 株式会社钟化 碳青霉素烯化合物的改良制备方法
CN101528212A (zh) * 2006-09-28 2009-09-09 默克公司 Hdac抑制剂和可螯合的金属化合物的药物组合物以及金属-hdac抑制剂螯合物
US7837978B2 (en) * 2006-10-13 2010-11-23 Chevron U.S.A. Inc. Process for preparing aluminum-containing molecular sieve SSZ-26
PE20081506A1 (es) * 2006-12-12 2008-12-09 Infinity Discovery Inc Formulaciones de ansamicina
JP2010527996A (ja) * 2007-05-22 2010-08-19 ウルティモルフィクス・テクノロジーズ・ベー・フェー テノホビルジソプロキシル−ヘミフマル酸共結晶
TW200944520A (en) * 2008-01-29 2009-11-01 Glaxo Group Ltd Spiro compounds as NPY Y5 receptor antagonists
US8097719B2 (en) * 2008-07-15 2012-01-17 Genesen Labs Meropenem intermediate in novel crystalline form and a method of manufacture of meropenem

Also Published As

Publication number Publication date
JP2008501657A (ja) 2008-01-24
EP1776365A1 (de) 2007-04-25
CN1960992B (zh) 2011-10-19
CN1960992A (zh) 2007-05-09
WO2005118586A1 (en) 2005-12-15
EP1776365B1 (de) 2011-08-03
US20070249827A1 (en) 2007-10-25
ES2370829T3 (es) 2011-12-23

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