WO2005066173A3 - Processes for the preparation of substituted azetidinone - Google Patents

Processes for the preparation of substituted azetidinone Download PDF

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Publication number
WO2005066173A3
WO2005066173A3 PCT/GB2005/000021 GB2005000021W WO2005066173A3 WO 2005066173 A3 WO2005066173 A3 WO 2005066173A3 GB 2005000021 W GB2005000021 W GB 2005000021W WO 2005066173 A3 WO2005066173 A3 WO 2005066173A3
Authority
WO
WIPO (PCT)
Prior art keywords
processes
preparation
substituted azetidinone
formula
azetidinone
Prior art date
Application number
PCT/GB2005/000021
Other languages
French (fr)
Other versions
WO2005066173A2 (en
Inventor
Michael Anthony Harris
Simon Lancelot Howie
Original Assignee
Glaxo Group Ltd
Michael Anthony Harris
Simon Lancelot Howie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd, Michael Anthony Harris, Simon Lancelot Howie filed Critical Glaxo Group Ltd
Publication of WO2005066173A2 publication Critical patent/WO2005066173A2/en
Publication of WO2005066173A3 publication Critical patent/WO2005066173A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A novel intermediate compound of formula (II) wherein R1 is an oxygen protecting group can be use in an efficient process for making certain carbapenem compounds useful as anti-bacterial agents.
PCT/GB2005/000021 2004-01-08 2005-01-07 Processes for the preparation of substituted azetidinone WO2005066173A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0400329.9A GB0400329D0 (en) 2004-01-08 2004-01-08 Novel processes
GB0400329.9 2004-01-08

Publications (2)

Publication Number Publication Date
WO2005066173A2 WO2005066173A2 (en) 2005-07-21
WO2005066173A3 true WO2005066173A3 (en) 2008-12-31

Family

ID=31503577

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2005/000021 WO2005066173A2 (en) 2004-01-08 2005-01-07 Processes for the preparation of substituted azetidinone

Country Status (2)

Country Link
GB (1) GB0400329D0 (en)
WO (1) WO2005066173A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017060418A1 (en) * 2015-10-07 2017-04-13 Neurovive Pharmaceutical Ab Protected carboxylic acid-based metabolites for the treatment of mitochondria-related diseases

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995011905A1 (en) * 1993-10-29 1995-05-04 Smithkline Beecham Plc 2-(pyrazol-3-yl)carbapenem derivatives
WO1996034869A1 (en) * 1995-05-03 1996-11-07 Smithkline Beecham Plc Esters of carbapenems

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995011905A1 (en) * 1993-10-29 1995-05-04 Smithkline Beecham Plc 2-(pyrazol-3-yl)carbapenem derivatives
WO1996034869A1 (en) * 1995-05-03 1996-11-07 Smithkline Beecham Plc Esters of carbapenems

Also Published As

Publication number Publication date
GB0400329D0 (en) 2004-02-11
WO2005066173A2 (en) 2005-07-21

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