HK1073101A1 - New crystalline and amorphous form of a triazolo(4,5-d)pyrimidine compound - Google Patents

New crystalline and amorphous form of a triazolo(4,5-d)pyrimidine compound

Info

Publication number
HK1073101A1
HK1073101A1 HK05105060.9A HK05105060A HK1073101A1 HK 1073101 A1 HK1073101 A1 HK 1073101A1 HK 05105060 A HK05105060 A HK 05105060A HK 1073101 A1 HK1073101 A1 HK 1073101A1
Authority
HK
Hong Kong
Prior art keywords
triazolo
amorphous form
pyrimidine compound
new crystalline
crystalline
Prior art date
Application number
HK05105060.9A
Inventor
Martin Bohlin
Steve Cosgrove
Bo Lassen
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9892841&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1073101(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Priority to HK05105060.9A priority Critical patent/HK1073101A1/en
Publication of HK1073101A1 publication Critical patent/HK1073101A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Surgery (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The invention provides new forms of a chemical compound, processes for their preparation, their use as medicaments, and compositions containing them.
HK05105060.9A 2000-06-02 2005-06-16 New crystalline and amorphous form of a triazolo(4,5-d)pyrimidine compound HK1073101A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
HK05105060.9A HK1073101A1 (en) 2000-06-02 2005-06-16 New crystalline and amorphous form of a triazolo(4,5-d)pyrimidine compound

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0013407.2A GB0013407D0 (en) 2000-06-02 2000-06-02 Forms of a chemical compound
HK03104536.0A HK1052347B (en) 2000-06-02 2003-06-24 New crystalline form of a triazolo(4,5-d)pyrimidine compound
HK05105060.9A HK1073101A1 (en) 2000-06-02 2005-06-16 New crystalline and amorphous form of a triazolo(4,5-d)pyrimidine compound

Publications (1)

Publication Number Publication Date
HK1073101A1 true HK1073101A1 (en) 2005-09-23

Family

ID=9892841

Family Applications (2)

Application Number Title Priority Date Filing Date
HK03104536.0A HK1052347B (en) 2000-06-02 2003-06-24 New crystalline form of a triazolo(4,5-d)pyrimidine compound
HK05105060.9A HK1073101A1 (en) 2000-06-02 2005-06-16 New crystalline and amorphous form of a triazolo(4,5-d)pyrimidine compound

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK03104536.0A HK1052347B (en) 2000-06-02 2003-06-24 New crystalline form of a triazolo(4,5-d)pyrimidine compound

Country Status (36)

Country Link
US (3) US20030181469A1 (en)
EP (3) EP1493745B2 (en)
JP (3) JP5036947B2 (en)
KR (1) KR100781864B1 (en)
CN (2) CN1817883B (en)
AR (2) AR032335A1 (en)
AT (2) ATE320430T1 (en)
AU (4) AU6287401A (en)
BG (3) BG65837B1 (en)
BR (1) BR0111328A (en)
CA (1) CA2408596C (en)
CY (1) CY1113047T1 (en)
CZ (2) CZ304347B6 (en)
DE (1) DE60117972T2 (en)
DK (2) DK1289992T3 (en)
EE (1) EE05222B1 (en)
ES (2) ES2259031T3 (en)
GB (1) GB0013407D0 (en)
HK (2) HK1052347B (en)
HU (2) HU230471B1 (en)
IL (4) IL152777A0 (en)
IS (2) IS2609B (en)
MX (1) MXPA02011795A (en)
MY (2) MY148652A (en)
NO (3) NO323780B1 (en)
NZ (1) NZ522638A (en)
PH (1) PH12011000127A1 (en)
PL (2) PL359172A1 (en)
PT (2) PT1289992E (en)
RU (3) RU2325391C2 (en)
SG (1) SG135965A1 (en)
SI (2) SI1493745T1 (en)
SK (1) SK287817B6 (en)
UA (1) UA73181C2 (en)
WO (1) WO2001092262A1 (en)
ZA (1) ZA200209324B (en)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI229674B (en) 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
GB0013488D0 (en) * 2000-06-02 2000-07-26 Astrazeneca Ab Chemical compound
GB0013407D0 (en) * 2000-06-02 2000-07-26 Astrazeneca Ab Forms of a chemical compound
JP4298212B2 (en) * 2002-03-29 2009-07-15 大日本印刷株式会社 Method for producing high melting point type epinastine hydrochloride
US20080045548A1 (en) * 2006-08-21 2008-02-21 Astrazeneca Ab Pharmaceutical Compositions
TWI482772B (en) * 2006-08-21 2015-05-01 Astrazeneca Ab Compositions, suitable for oral administration, comprising a triazolo(4,5-d)pyrimidin derivate
JP2010508350A (en) * 2006-10-31 2010-03-18 ヤンセン ファーマシューティカ エヌ．ベー． Triazolopyrimidine derivatives as ADPP2Y12 receptor antagonists
CN103071154A (en) * 2007-04-13 2013-05-01 千年药品公司 Combination anticoagulant therapy with a compound that acts as a factor XA inhibitor
TWI496776B (en) * 2007-11-15 2015-08-21 Astrazeneca Ab A process for preparing a diastereomerically pure dibenzoyl-l-tartrate salt of (3ar, 4s, 6r, 6as)-6-amino-2, 2-dimethyltetrahydro-3ah-cyclopenta(d)(1, 3)-dioxol-4-ol
UA100864C2 (en) * 2007-12-03 2013-02-11 Астразенека Аб Method for the for the treatment or prevention of abdominal aortic aneurysms
KR101669297B1 (en) 2008-09-09 2016-10-25 아스트라제네카 아베 A process for preparing [1s-[1-alpha,2-alpha,3-beta(1s*,2r*),5-beta]]-3-[7-[2-(3,4-difluorophenyl)-cyclopropylamino]-5-(propylthio)-3h-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol and its intermediates
US8802850B2 (en) 2009-07-27 2014-08-12 Auspex Pharmaceuticals, Inc. Cyclopropyl modulators of P2Y12 receptor
WO2011067571A1 (en) * 2009-12-03 2011-06-09 Astrazeneca Ab Co - crystals of a triazolo [4,5 - d] pyrimidine platelet aggregation inhibitor
WO2011076749A2 (en) 2009-12-23 2011-06-30 Ratiopharm Gmbh Solid pharmaceutical dosage form
CZ2011229A3 (en) 2011-04-19 2012-08-15 Zentiva, K.S. Optically active salts of (3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta-[d][1,3]dioxol-4-ole and process for their preparation
CN103764149A (en) 2011-06-01 2014-04-30 阿斯利康(瑞典)有限公司 Novel ticagrelor co-crystal
CN104039792A (en) * 2011-11-30 2014-09-10 阿特维斯集团公司 Novel crystalline form of ticagrelor and process for the preparation thereof
US9233966B2 (en) 2012-04-05 2016-01-12 Dr. Reddy's Laboratories Limited Preparation of ticagrelor
WO2014000719A1 (en) * 2012-06-29 2014-01-03 Zentiva, K.S. Novel pharmaceutical solid forms of (1s,2s,3r,5s)-3-[7-[(1r,2s)-2-(3,4difluorophenyl)cyclopropylamino]-5-(propylthio)-3h-[1,2,3]triazolo[4,5-d]pyrimidin-3yl]-5-(2-hydroxyethoxy)cyclopentane-l,2-diol
CA2877541C (en) 2012-07-04 2020-06-30 Lek Pharmaceuticals D.D. Ticagrelor adducts with divalent metal salts
CZ2012705A3 (en) * 2012-10-16 2014-04-23 Zentiva, K.S. Solid oral pharmaceutical formulation containing ticagrelor
CN103772393B (en) * 2012-10-18 2017-08-04 博瑞生物医药（苏州）股份有限公司 Crystal formation of Ticagrelor and preparation method thereof
WO2014083139A1 (en) * 2012-11-29 2014-06-05 Actavis Group Ptc Ehf Novel amorphous form of ticagrelor
CN103848836B (en) * 2012-12-07 2016-08-03 天津市汉康医药生物技术有限公司 Ticagrelor times semihydrate and preparation method thereof
WO2014118808A2 (en) * 2013-02-04 2014-08-07 Hetero Research Foundation Ticagrelor solid dispersion
CZ307217B6 (en) 2013-03-14 2018-04-04 Zentiva, K.S. An improved manufacturing process and new intermediates for synthesis of ticagrelor
WO2014155389A2 (en) * 2013-03-25 2014-10-02 Glenmark Pharmaceuticals Limited; Glenmark Generics Limited Process for preparation of ticagrelor
CN104098570A (en) * 2013-04-07 2014-10-15 杭州领业医药科技有限公司 Crystal form of Ticagrelor Brilinta and preparation method and purpose thereof
CN104098572A (en) * 2013-04-08 2014-10-15 博瑞生物医药技术(苏州)有限公司 Eutectic form of Ticagrelor Brilinta
CN104098553B (en) * 2013-04-10 2017-11-28 江苏恒瑞医药股份有限公司 The preparation method of intermediate of ticagrelor and preparation method thereof and ticagrelor
EP2813216A1 (en) 2013-06-10 2014-12-17 Zentiva, a.s. Stabilized amorphous ticagrelor
WO2014170026A1 (en) 2013-04-18 2014-10-23 Zentiva, K.S. Stabilized amorphous ticagrelor
CA2913326A1 (en) 2013-05-29 2014-12-04 Ratiopharm Gmbh Solid pharmaceutical dosage form
CN104211704B (en) * 2013-06-03 2017-08-25 杭州领业医药科技有限公司 Triazole [4,5 d] pyrimidine compound of crystal habit and its production and use
EP3004113A2 (en) * 2013-06-04 2016-04-13 Dr. Reddy's Laboratories Ltd. Preparation of ticagrelor
EP2816043A1 (en) 2013-06-21 2014-12-24 LEK Pharmaceuticals d.d. Spherical ticagrelor particles
WO2015001489A1 (en) * 2013-07-01 2015-01-08 Ranbaxy Laboratories Limited Pharmaceutical compositions of ticagrelor
CN104341423B (en) * 2013-08-02 2017-03-01 上海京新生物医药有限公司 Monohydrate of ticagrelor and preparation method thereof and the application in pharmacy
CN104370912A (en) * 2013-08-13 2015-02-25 开原亨泰制药股份有限公司 Ticagrelor polycrystal and preparation method thereof
IN2013CH04023A (en) * 2013-09-10 2015-08-07 Laurus Labs Pvt Ltd
CZ2013866A3 (en) 2013-11-08 2015-05-20 Zentiva, K.S. Novel crystalline form of ticagrelor synthesis intermediate and process for preparing thereof
CN104650085A (en) * 2013-11-22 2015-05-27 天津市汉康医药生物技术有限公司 Ticagrelor sesquihydrate compound
CN103601726B (en) * 2013-12-02 2016-09-28 浙江大学 Two kinds of ticagrelor pharmaceutical co-crystals and preparation method thereof
CN104710425B (en) * 2013-12-16 2019-06-14 石药集团中奇制药技术（石家庄）有限公司 A kind of ticagrelor newly crystallizes and preparation method thereof
CN104650091B (en) * 2014-01-24 2016-10-05 福州乾正药业有限公司 The micronization of ticagrelor and crystal formation thereof, and preparation method and medicinal application
CN104940204A (en) * 2014-03-27 2015-09-30 广东东阳光药业有限公司 Ticagrelor solid preparation and preparation method thereof
WO2015162537A1 (en) * 2014-04-23 2015-10-29 Glenmark Pharmaceuticals Limited; Glenmark Generics Limited Process for preparation of ticagrelor
WO2015162630A1 (en) 2014-04-25 2015-10-29 Anlon Chemical Research Organization Novel processes for preparing triazolo [4,5-d]- pyrimidines, including ticagrelor, vianew intermediates and new route of synthesis.
CN105315282B (en) * 2014-07-15 2018-09-21 博瑞生物医药（苏州）股份有限公司 It is a kind of to prepare the unformed method of Ticagrelor
WO2016016907A1 (en) * 2014-08-01 2016-02-04 Msn Laboratories Private Limited Novel polymorphs of (1s,2s,3r,5s)-3-[7-{[(1r,2s)-2-(3,4-difluorophenyl) cyclopropyl]amino}-5-(propylthio)-3h-[1,2,3]-triazolo[4,5-d]pyrimidin-3-yi]-5-(2-hydroxvethoxy) cyclopentane-1,2-diol
WO2016024225A1 (en) * 2014-08-11 2016-02-18 Sun Pharmaceutical Industries Limited Stable amorphous ticagrelor and a process for its preparation
CN104193747B (en) * 2014-08-12 2016-05-11 许彩霞 The unbodied preparation of ADZ6140
WO2016116942A1 (en) 2015-01-20 2016-07-28 Anlon Chemical Research Organization Novel pharmaceutical compounds comprising ticagrelor with salts of aspirin
CN105968113B (en) * 2015-03-12 2019-06-07 四川海思科制药有限公司 A kind of triazolopyrimidine derivative and its application
WO2017072790A1 (en) * 2015-10-26 2017-05-04 Avra Laboratories Pvt. Ltd. An improved process for synthesis of ticagrelor
US20190002471A1 (en) * 2016-01-05 2019-01-03 Amneal Pharmaceuticals Company Gmbh Crystalline Form Of Ticagrelor
MA44720A (en) * 2016-04-21 2019-02-27 Astrazeneca Ab ORAL DISINTEGRATION TABLETS
US10905691B2 (en) 2016-09-09 2021-02-02 Université de Liège Use of triazolo(4,5-d)pyrimidine derivatives for prevention and treatment of bacterial infection
ES2731658T3 (en) * 2016-09-09 2019-11-18 Univ Liege Triazolo (4,5-d) pyrimidine derivatives for use in the prevention and treatment of bacterial infection
KR101916956B1 (en) 2016-12-13 2018-11-08 보령제약 주식회사 Novel Solid form of Ticagrelor and methods of preparing therof
WO2018178997A1 (en) 2017-03-31 2018-10-04 Natco Pharma Limited Novel crystalline form of ticagrelor
WO2019127294A1 (en) * 2017-12-29 2019-07-04 浙江天宇药业股份有限公司 Ticagrelor purification method
WO2019170244A1 (en) 2018-03-08 2019-09-12 Pharmaceutical Oriented Services Ltd. Ticagrelor—containing tablet formulation
EA202190328A1 (en) 2018-07-27 2021-07-01 КРКА, д.д., НОВО МЕСТО PHARMACEUTICAL COMPOSITION CONTAINING TICAGRELOR
CN110194771A (en) * 2019-05-08 2019-09-03 北京济美堂医药研究有限公司 A kind of preparation method of the medicinal II crystal form of ticagrelor
CN114634489B (en) * 2022-04-19 2023-07-04 奎马特里克斯有限公司 Crystalline forms

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5561134A (en) * 1990-09-25 1996-10-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
WO1997003084A1 (en) 1995-07-11 1997-01-30 Astra Pharmaceuticals Ltd. New inhibitors of platelet aggregation
ATE213245T1 (en) * 1996-12-20 2002-02-15 TRIAZOLO(4,5-D)PYRIMIDINYL DERIVATIVES AND THEIR USE AS MEDICATIONS
AR017014A1 (en) * 1997-07-22 2001-08-22 Astrazeneca Ab TRIAZOL COMPOUNDS [4,5-D] PYRIMIDINE, PHARMACEUTICAL COMPOSITIONS, USE OF THE SAME TO PREPARE MEDICATIONS AND PROCESSES FOR THE PREPARATION OF SUCH COMPOUNDS
WO1999005150A1 (en) * 1997-07-25 1999-02-04 Gilead Sciences, Inc. Nucleotide analog composition and synthesis method
TWI229674B (en) * 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
SE9904129D0 (en) * 1999-11-15 1999-11-15 Astra Pharma Prod Novel compounds
GB0013407D0 (en) * 2000-06-02 2000-07-26 Astrazeneca Ab Forms of a chemical compound
GB0013488D0 (en) * 2000-06-02 2000-07-26 Astrazeneca Ab Chemical compound

Also Published As

Publication number Publication date
EP1493745A1 (en) 2005-01-05
IL202582A0 (en) 2010-06-30
MY140674A (en) 2010-01-15
NZ522638A (en) 2004-06-25
MXPA02011795A (en) 2003-04-10
NO20025756D0 (en) 2002-11-29
EE200200665A (en) 2004-06-15
CN1247583C (en) 2006-03-29
JP2014129423A (en) 2014-07-10
BG66332B1 (en) 2013-06-28
NO333289B1 (en) 2013-04-29
BR0111328A (en) 2003-06-10
NO323780B1 (en) 2007-07-02
RU2010150799A (en) 2012-06-20
EP1493745B1 (en) 2012-04-25
AU2001262874B2 (en) 2007-03-22
US20030181469A1 (en) 2003-09-25
AU2007200958A1 (en) 2007-03-29
EP1493745B2 (en) 2021-05-19
RU2418802C2 (en) 2011-05-20
SK16852002A3 (en) 2003-08-05
EE05222B1 (en) 2009-10-15
IS8825A (en) 2009-06-02
ES2259031T3 (en) 2006-09-16
PT1493745E (en) 2012-06-28
IL152777A0 (en) 2003-06-24
IS2609B (en) 2010-04-15
PL359172A1 (en) 2004-08-23
EP2292622A1 (en) 2011-03-09
PT1289992E (en) 2006-07-31
BG65837B1 (en) 2010-02-26
CY1113047T1 (en) 2016-04-13
AU2007200958B2 (en) 2010-10-07
CN1817883A (en) 2006-08-16
MY148652A (en) 2013-05-15
US20070173518A1 (en) 2007-07-26
BG110440A (en) 2010-03-31
SG135965A1 (en) 2007-10-29
IS6623A (en) 2002-11-15
IS3019B (en) 2020-02-15
HUP1300386A2 (en) 2003-10-28
NO20120595L (en) 2003-01-24
HK1052347B (en) 2006-09-08
US7265124B2 (en) 2007-09-04
JP5036947B2 (en) 2012-09-26
ES2384708T3 (en) 2012-07-11
PH12011000127A1 (en) 2016-08-31
BG107331A (en) 2003-07-31
WO2001092262A1 (en) 2001-12-06
DE60117972T2 (en) 2006-11-23
DE60117972D1 (en) 2006-05-11
GB0013407D0 (en) 2000-07-26
IL187482A (en) 2010-06-16
CZ307468B6 (en) 2018-09-26
NO332306B1 (en) 2012-08-20
JP2012149093A (en) 2012-08-09
HUP0302284A3 (en) 2007-05-29
ATE320430T1 (en) 2006-04-15
EP1289992B1 (en) 2006-03-15
HUP0302284A2 (en) 2003-10-28
NO20071547L (en) 2003-01-24
AU2010257449B2 (en) 2012-03-22
JP2003535092A (en) 2003-11-25
PL392882A1 (en) 2011-03-14
US20070293513A1 (en) 2007-12-20
NO20025756L (en) 2003-01-24
KR100781864B1 (en) 2007-12-05
KR20030007829A (en) 2003-01-23
CZ304347B6 (en) 2014-03-19
BG111017A (en) 2011-12-30
DK1289992T3 (en) 2006-07-03
HU229374B1 (en) 2013-11-28
RU2005127356A (en) 2007-03-10
IL202582A (en) 2012-12-31
CN1817883B (en) 2011-10-05
SI1289992T1 (en) 2006-08-31
JP5684192B2 (en) 2015-03-11
AR068086A2 (en) 2009-11-04
CA2408596C (en) 2010-12-21
EP1289992A1 (en) 2003-03-12
AU2010257449A1 (en) 2011-01-20
SK287817B6 (en) 2011-11-04
CZ20120293A3 (en) 2003-07-16
IL152777A (en) 2008-11-26
RU2325391C2 (en) 2008-05-27
DK1493745T3 (en) 2012-07-16
SI1493745T1 (en) 2012-08-31
ZA200209324B (en) 2004-02-16
AR032335A1 (en) 2003-11-05
ATE555115T1 (en) 2012-05-15
HK1052347A1 (en) 2003-09-11
CN1432018A (en) 2003-07-23
AU6287401A (en) 2001-12-11
CA2408596A1 (en) 2001-12-06
HU230471B1 (en) 2016-07-28
UA73181C2 (en) 2005-06-15

Similar Documents

Publication Publication Date Title
HK1073101A1 (en) New crystalline and amorphous form of a triazolo(4,5-d)pyrimidine compound
UA66801C2 (en) Novel compounds
MY121867A (en) Novel triazolo(4,5-d)pyrimidine compounds.
WO2002048147A3 (en) Pyrazolopyridines
AU2002305143A1 (en) Pyrazolo'1,5-a!pyridine derivatives
WO2003095455A3 (en) Substituted pyrazolopyrimidines
HUP0100328A3 (en) Novel triazolo(4,5-d)pyrimidine compounds, and pharmaceutical compositions containing the compounds
HUP0303487A3 (en) Compositions containing 3,7-diazabicyclo [3,3,1] compounds as anthiarhythmic agents and process for preparation of the compounds
MXPA03008965A (en) Use of substituted imidazo[1,2-a]-pyridine compounds as medicaments.
DE69911785D1 (en) Triazolo [4,5-D] PYRIMIDINE COMPOUNDS
HUP0303486A3 (en) Compositions containing 3,7-diazabicyclo [3,3,1] compounds as anti-arrythmic compounds agents
EP1466914A4 (en) Amorphous substance of tricyclic triazolobenzazepine derivative
AU2002214467A1 (en) Novel compounds
HK1056361A1 (en) Novel compounds
WO2002051845A3 (en) Triazolopyrimidines
AU2002257753A1 (en) Use of substituted imidazo(1,2-A)-pyridine compounds as medicaments
SI1222195T1 (en) Novel thiazolo(4,5-d)pyrimidine compounds

Legal Events

Date Code Title Description
PE Patent expired

Effective date: 20210530