IL150215A0 - Di-or oligomer of a dimer, trimer, quatromer or pentamer of recombinant fusion proteins - Google Patents
Di-or oligomer of a dimer, trimer, quatromer or pentamer of recombinant fusion proteinsInfo
- Publication number
- IL150215A0 IL150215A0 IL15021500A IL15021500A IL150215A0 IL 150215 A0 IL150215 A0 IL 150215A0 IL 15021500 A IL15021500 A IL 15021500A IL 15021500 A IL15021500 A IL 15021500A IL 150215 A0 IL150215 A0 IL 150215A0
- Authority
- IL
- Israel
- Prior art keywords
- fragment
- protein
- fusion proteins
- recombinant fusion
- collectin
- Prior art date
Links
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 title abstract 3
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 title abstract 3
- 239000000539 dimer Substances 0.000 title abstract 3
- 239000013638 trimer Substances 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 6
- 108090000623 proteins and genes Proteins 0.000 abstract 6
- 239000012634 fragment Substances 0.000 abstract 5
- 102000037865 fusion proteins Human genes 0.000 abstract 5
- 108020001507 fusion proteins Proteins 0.000 abstract 5
- 102000004405 Collectins Human genes 0.000 abstract 2
- 108090000909 Collectins Proteins 0.000 abstract 2
- 238000006471 dimerization reaction Methods 0.000 abstract 2
- 238000006384 oligomerization reaction Methods 0.000 abstract 2
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 230000002424 anti-apoptotic effect Effects 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000000078 anti-malarial effect Effects 0.000 abstract 1
- 230000000842 anti-protozoal effect Effects 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 239000003430 antimalarial agent Substances 0.000 abstract 1
- 239000003904 antiprotozoal agent Substances 0.000 abstract 1
- 230000001640 apoptogenic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002124 endocrine Effects 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 230000002519 immonomodulatory effect Effects 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 230000011664 signaling Effects 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/472—Complement proteins, e.g. anaphylatoxin, C3a, C5a
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C07K2319/41—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a Myc-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C07K2319/43—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a FLAG-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153 or CD154
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19963859A DE19963859A1 (de) | 1999-12-30 | 1999-12-30 | Bi- oder Oligomer eines Di-, Tri-, Quattro- oder Pentamers von rekombinanten Fusionsproteinen |
PCT/EP2000/013032 WO2001049866A1 (de) | 1999-12-30 | 2000-12-20 | Bi- oder oligomer eines di-, tri-, quattro- oder pentamers von rekombinanten fusionsproteinen |
Publications (1)
Publication Number | Publication Date |
---|---|
IL150215A0 true IL150215A0 (en) | 2002-12-01 |
Family
ID=7935052
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL15021500A IL150215A0 (en) | 1999-12-30 | 2000-12-20 | Di-or oligomer of a dimer, trimer, quatromer or pentamer of recombinant fusion proteins |
IL150215A IL150215A (en) | 1999-12-30 | 2002-06-13 | Recombinant dehydrated protein in the form of di or oligomer, dimmer, trimmer, quatrumer or pentamer |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL150215A IL150215A (en) | 1999-12-30 | 2002-06-13 | Recombinant dehydrated protein in the form of di or oligomer, dimmer, trimmer, quatrumer or pentamer |
Country Status (19)
Country | Link |
---|---|
US (6) | US7385032B2 (pl) |
EP (2) | EP1985706A3 (pl) |
JP (1) | JP5031165B2 (pl) |
KR (1) | KR100767980B1 (pl) |
CN (1) | CN100385002C (pl) |
AT (1) | ATE397076T1 (pl) |
AU (1) | AU783833B2 (pl) |
BR (1) | BRPI0017054B1 (pl) |
CA (1) | CA2395632C (pl) |
CY (1) | CY1108195T1 (pl) |
DE (2) | DE19963859A1 (pl) |
DK (1) | DK1246925T3 (pl) |
ES (1) | ES2307550T3 (pl) |
HU (1) | HU229204B1 (pl) |
IL (2) | IL150215A0 (pl) |
PL (1) | PL204277B1 (pl) |
PT (1) | PT1246925E (pl) |
WO (1) | WO2001049866A1 (pl) |
ZA (1) | ZA200205069B (pl) |
Families Citing this family (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7300774B1 (en) | 1999-12-09 | 2007-11-27 | The Regents Of The University Of California | Multimeric fusion proteins of the TNF superfamily ligands |
US20030095967A1 (en) * | 1999-01-25 | 2003-05-22 | Mackay Fabienne | BAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders |
US20050100548A1 (en) * | 2001-07-24 | 2005-05-12 | Biogen Idec Ma Inc. | BAFF, inhibitors thereof and their use in the modulation of B-cell response |
SK782002A3 (en) * | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
DE19963859A1 (de) * | 1999-12-30 | 2001-07-12 | Apotech Res & Dev Ltd | Bi- oder Oligomer eines Di-, Tri-, Quattro- oder Pentamers von rekombinanten Fusionsproteinen |
CA2410525A1 (en) * | 2000-05-26 | 2001-11-29 | Mochida Pharmaceuticals Co., Ltd. | Fas ligand-fused proteins |
GB0015426D0 (en) * | 2000-06-24 | 2000-08-16 | Univ Southampton | Method for generating soluble highly multimeric proteins |
CA2435000C (en) * | 2001-01-18 | 2014-03-25 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Oligomeric complexes of chimeric proteins with enhanced immunogenic potential |
DE10122140A1 (de) * | 2001-05-08 | 2002-11-28 | Apotech Res & Dev Ltd | Rekombinante Fusionsproteine und deren Trimere |
BR0214621A (pt) * | 2001-11-30 | 2004-10-13 | Ca Nat Research Council | Moléculas de automontagem |
AU2002333502A1 (en) | 2002-02-10 | 2003-09-04 | Apoxis Sa | Fusion constructs containing active sections of tnf ligands |
WO2003072713A2 (en) * | 2002-02-21 | 2003-09-04 | Biogen Idec Ma Inc. | Use of bcma as an immunoregulatory agent |
WO2003095489A1 (en) * | 2002-05-08 | 2003-11-20 | Apoxis S.A. | Hexamers of receptors, members of the tnf receptor family, their use in therapy and pharmaceutical compositions comprising the same |
FR2840307B1 (fr) * | 2002-05-30 | 2006-07-07 | Centre Nat Rech Scient | Nouvelles molecules multimeriques, leur procede de preparation, et leur utilisation pour la preparation de medicaments |
DE10247755B4 (de) * | 2002-10-14 | 2006-01-19 | Pfizenmaier, Klaus, Prof. Dr. | Selektive, lokale Aktivierung von Mitgliedern der TNF-Rezeptorfamilie durch systemisch inaktive nicht-Antikörper-TNF-Liganden-Fusionsproteine |
AU2003277828B2 (en) * | 2002-10-29 | 2009-06-04 | Anaphore, Inc. | Trimeric binding proteins for trimeric cytokines |
SI1606318T1 (sl) * | 2003-03-26 | 2009-12-31 | Apogenix Gmbh | Izboljšani Fc fuzijski proteini |
DK2298347T3 (en) | 2003-05-06 | 2016-01-11 | Biogen Hemophilia Inc | COAGULATION FACTOR CHEMICAL PROTEINS FOR TREATING A HEMOSTATIC DISORDER |
TWI353991B (en) * | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
US20050143297A1 (en) * | 2003-05-26 | 2005-06-30 | Jean-Pierre Rosat | Method for the administration of ligands, agonists of ligands of the TNF family with reduced toxicity |
EP1481686A1 (en) * | 2003-05-26 | 2004-12-01 | Apoxis SA | Use of multimeric ligands of the TNF family with reduced toxicity for treating cell proliferative diseases |
US20050287118A1 (en) * | 2003-11-26 | 2005-12-29 | Epitomics, Inc. | Bacterial plasmid with immunological adjuvant function and uses thereof |
DE102004014983A1 (de) * | 2004-03-26 | 2005-10-20 | Univ Stuttgart | Rekombinante Polypeptide der Mitglieder der TNF Ligandenfamilie und deren Verwendung |
AU2005291298B2 (en) * | 2004-10-01 | 2012-01-19 | Apoxis Sa | Method for ex-vivo purging in autologous transplantation |
FR2879202B1 (fr) | 2004-12-15 | 2007-02-23 | Centre Nat Rech Scient Cnrse | Nouveaux ligands multimeriques de cd40, leur procede de preparation et leur utilisation pour la preparation de medicaments |
WO2006077232A2 (en) * | 2005-01-20 | 2006-07-27 | Apoxis Sa | Multimeric soluble fas ligand for eliminating alloreactive t lymphocyte in allogenic harmatopoietic stem-cell transplantation transplantation |
CA2621083C (en) | 2005-08-30 | 2017-04-11 | University Of Miami | Immunomodulating tumor necrosis factor receptor 25 (tnfr25) agonists, antagonists and immunotoxins |
EP1979488A4 (en) * | 2006-01-09 | 2009-05-27 | Univ California | IMMUNOSTIMULATORY COMBINATIONS OF TNFRSF, TLR, NLR, RHR, PURINERGIC RECEPTOR AND CYTOKINE RECEPTOR AGONISTS USED FOR VACCINES AND ANTI-TUMOR IMMUNOTHERAPY |
WO2007117339A2 (en) * | 2006-01-11 | 2007-10-18 | The United States Of America As Respresented By The Secretary Of The Navy | Adhesin-enterotoxin chimera based immunogenic composition against entertoxigenic escherichia coli |
CA2860950C (en) | 2007-07-10 | 2017-08-01 | Apogenix Gmbh | Tnf superfamily collectin fusion proteins |
SI2310509T1 (sl) | 2008-07-21 | 2015-07-31 | Apogenix Gmbh | TNFSF enoverižne molekule |
AU2009308707A1 (en) * | 2008-10-31 | 2010-05-06 | Biogen Idec Ma Inc. | LIGHT targeting molecules and uses thereof |
ES2593049T3 (es) | 2009-01-09 | 2016-12-05 | Apogenix Ag | Proteínas de fusión que forman trímeros |
WO2010102518A1 (zh) * | 2009-03-13 | 2010-09-16 | 北京表源生物技术有限公司 | 一种融合蛋白多聚体 |
CN102612525A (zh) | 2009-06-09 | 2012-07-25 | 儿童医院医疗中心 | 抗原-诺罗病毒p-结构域单体和二聚体,抗原-诺罗病毒p-粒子分子,及其制备和应用方法 |
KR20120089259A (ko) | 2009-08-03 | 2012-08-09 | 유니버시티 오브 마이애미 | T 조절 세포의 생체 내 확장 방법 |
US10822396B2 (en) | 2009-12-15 | 2020-11-03 | MuHyeon CHOE | Repeat-chain for the production of dimer, multimer, multimer complex and super-complex |
EP2518078B1 (en) * | 2009-12-15 | 2020-05-20 | Choe, Muhyeon | Method for manufacturing dimers and multimers by increasing the production of bond bridges in a complex of multiple monomers and repeating chains of an affinity domain of a type specifically binding to protein monomers |
US8932575B2 (en) | 2010-09-21 | 2015-01-13 | University Of Miami | Compositions and methods for inducing migration by dendritic cells and an immune response |
WO2012040266A2 (en) * | 2010-09-24 | 2012-03-29 | University Of Miami | Gene-based adjuvants and compositions thereof to increase antibody production in response to gene-based vaccines |
EP2681245B1 (en) | 2011-03-03 | 2018-05-09 | Zymeworks Inc. | Multivalent heteromultimer scaffold design and constructs |
NZ700025A (en) * | 2012-02-15 | 2018-07-27 | Biocon Ltd | A process for detection and optional quantification of an analyte |
US9562077B2 (en) | 2012-07-11 | 2017-02-07 | Children's Hospital Medical Center | Protein complex system for increased immunogenicity and functionality, and methods making and use |
CN104768571B (zh) | 2012-07-13 | 2018-11-09 | 酵活有限公司 | 多价异多聚体支架设计和构建体 |
KR102565827B1 (ko) | 2013-01-09 | 2023-08-11 | 유니버시티 오브 마이애미 | TL1A-Ig 융합 단백질을 사용한 T 조절 세포의 조절을 위한 조성물 및 방법 |
WO2014145355A1 (en) | 2013-03-15 | 2014-09-18 | Stone Geoffrey W | Composition comprised of antigen linked to a tnf superfamily ligand |
AU2014228938B2 (en) | 2013-03-15 | 2019-05-02 | Bioverativ Therapeutics Inc. | Factor IX polypeptide formulations |
WO2014179494A1 (en) | 2013-04-30 | 2014-11-06 | Colorado State University Research Foundation | Sensors and assays for ubiquitin or ubiquitin-like proteins |
EP3015860A4 (en) * | 2013-05-30 | 2017-03-29 | Muhyeon Choe | Super-complex formed by cross-binding between complexes of repeating chain and monomer, and use thereof |
US9321803B2 (en) | 2013-07-12 | 2016-04-26 | Children's Hospital Medical Center | Compositions and methods for inhibiting norovirus infection |
CN104299540A (zh) * | 2013-07-15 | 2015-01-21 | 驰众信息技术(上海)有限公司 | 广告互动播放系统及其广告机终端 |
NO2776305T3 (pl) | 2014-04-23 | 2018-01-27 | ||
JP2014218510A (ja) * | 2014-08-11 | 2014-11-20 | アポゲニクスゲゼルシャフト ミット ベシュレンクテルハフツングApogenix GmbH | 三量体形成融合タンパク質 |
CN104356233B (zh) * | 2014-10-11 | 2017-09-29 | 中国科学院微生物研究所 | 一种人热休克蛋白gp96的scFv抗体及其制备方法与应用 |
WO2016112983A1 (en) | 2015-01-15 | 2016-07-21 | Biontech Ag | Cytokine fusion proteins |
JP7179464B2 (ja) | 2015-01-20 | 2022-11-29 | アイジーエム バイオサイエンシズ インコーポレイテッド | 腫瘍壊死因子 (tnf) スーパーファミリー受容体結合分子およびその使用 |
MA41460A (fr) | 2015-02-03 | 2017-12-12 | Oncomed Pharm Inc | Agents de liaison à la tnfrsf et leurs utilisations |
RU2745801C2 (ru) | 2015-05-04 | 2021-04-01 | Аподжиникс Аг | Одноцепочечные белки-агонисты рецептора cd40 |
RU2018108236A (ru) * | 2015-08-12 | 2019-09-12 | Медиммьюн Лимитед | Слитые белки на основе gitrl и пути их применения |
CA3002587A1 (en) | 2015-10-23 | 2017-04-27 | Apogenix Ag | Single-chain light receptor agonist proteins |
JP6917368B2 (ja) | 2015-10-23 | 2021-08-11 | アポジェニックス アーゲー | 一本鎖cd27受容体アゴニストタンパク質 |
JP6959229B2 (ja) | 2015-10-23 | 2021-11-02 | アポジェニックス アーゲー | 一本鎖gitr受容体アゴニストタンパク質 |
CA3003511A1 (en) | 2015-10-28 | 2017-05-04 | Apogenix Ag | Single-chain tl1a receptor agonist proteins |
EP3231813A1 (en) | 2016-03-29 | 2017-10-18 | F. Hoffmann-La Roche AG | Trimeric costimulatory tnf family ligand-containing antigen binding molecules |
WO2017172853A1 (en) | 2016-03-30 | 2017-10-05 | Ab Biosciences, Inc. | Recombinant intravenous immunoglobulin (rivig) compositions and methods for their production and use |
CA3033105A1 (en) * | 2016-08-11 | 2018-02-15 | The Council Of The Queensland Institute Of Medical Research | Immune-modulating compounds |
WO2018115305A1 (en) * | 2016-12-22 | 2018-06-28 | Leibniz-Institut für Pflanzengenetik Und Kulturpflanzenforschung (IPK) | Oligomeric vaccines from plants by s-tag-s-protein fusions |
US11833198B2 (en) | 2017-03-28 | 2023-12-05 | Children's Hospital Medical Center | Norovirus S particle based vaccines and methods of making and using same |
WO2018178074A1 (en) | 2017-03-29 | 2018-10-04 | F. Hoffmann-La Roche Ag | Trimeric antigen binding molecules specific for a costimulatory tnf receptor |
WO2019048936A1 (en) | 2017-09-07 | 2019-03-14 | University Of Oslo | VACCINE MOLECULES |
CN112552415B (zh) * | 2021-02-22 | 2021-06-22 | 北京百普赛斯生物科技股份有限公司 | B淋巴细胞刺激因子十二聚体及其制备方法与应用 |
EP4347665A1 (en) * | 2021-05-27 | 2024-04-10 | Beijing Anxinhuaide Biotech. Co., Ltd. | A super-trail molecule comprising two trail trimers |
WO2024003353A1 (en) | 2022-07-01 | 2024-01-04 | Transgene | Fusion protein comprising a surfactant-protein-d and a member of the tnfsf |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5859330A (en) * | 1989-12-12 | 1999-01-12 | Epitope, Inc. | Regulated expression of heterologous genes in plants and transgenic fruit with a modified ripening phenotype |
US5763733A (en) * | 1994-10-13 | 1998-06-09 | Enzon, Inc. | Antigen-binding fusion proteins |
US5869330A (en) * | 1995-06-05 | 1999-02-09 | Whitehead Institute For Biomedical Research | DNA encoding a novel serum protein produced exclusively in adipocytes |
US6046310A (en) * | 1996-03-13 | 2000-04-04 | Protein Design Labs., Inc. | FAS ligand fusion proteins and their uses |
US6165476A (en) * | 1997-07-10 | 2000-12-26 | Beth Israel Deaconess Medical Center | Fusion proteins with an immunoglobulin hinge region linker |
IL134011A0 (en) * | 1997-07-18 | 2001-04-30 | Zymogenetics Inc | Adipocyte-specific protein homologs |
JP4057127B2 (ja) * | 1998-02-19 | 2008-03-05 | セイコーエプソン株式会社 | アクティブマトリックス基板及びアクティブマトリックス基板の製造方法並びに液晶装置 |
AU765378B2 (en) * | 1998-02-19 | 2003-09-18 | President And Fellows Of Harvard College | Monovalent, multivalent, and multimeric MHC binding domain fusion proteins and conjugates, and uses therefor |
US7300774B1 (en) * | 1999-12-09 | 2007-11-27 | The Regents Of The University Of California | Multimeric fusion proteins of the TNF superfamily ligands |
JP2003501027A (ja) * | 1999-05-27 | 2003-01-14 | ザイモジェネティクス,インコーポレイティド | 脂肪細胞補体関連タンパク質同族体zacrp5 |
MXPA02001417A (es) * | 1999-08-09 | 2002-08-12 | Lexigen Pharm Corp | Complejos multiples de citosina-anticuerpo. |
DE19963859A1 (de) * | 1999-12-30 | 2001-07-12 | Apotech Res & Dev Ltd | Bi- oder Oligomer eines Di-, Tri-, Quattro- oder Pentamers von rekombinanten Fusionsproteinen |
-
1999
- 1999-12-30 DE DE19963859A patent/DE19963859A1/de not_active Withdrawn
-
2000
- 2000-12-20 DK DK00987425T patent/DK1246925T3/da active
- 2000-12-20 EP EP08103225A patent/EP1985706A3/de not_active Withdrawn
- 2000-12-20 JP JP2001550394A patent/JP5031165B2/ja not_active Expired - Fee Related
- 2000-12-20 DE DE50015185T patent/DE50015185D1/de not_active Expired - Lifetime
- 2000-12-20 HU HU0203628A patent/HU229204B1/hu not_active IP Right Cessation
- 2000-12-20 AU AU23673/01A patent/AU783833B2/en not_active Ceased
- 2000-12-20 EP EP00987425A patent/EP1246925B1/de not_active Expired - Lifetime
- 2000-12-20 AT AT00987425T patent/ATE397076T1/de active
- 2000-12-20 ES ES00987425T patent/ES2307550T3/es not_active Expired - Lifetime
- 2000-12-20 WO PCT/EP2000/013032 patent/WO2001049866A1/de active IP Right Grant
- 2000-12-20 CA CA2395632A patent/CA2395632C/en not_active Expired - Lifetime
- 2000-12-20 KR KR1020027008522A patent/KR100767980B1/ko active IP Right Grant
- 2000-12-20 CN CNB008181004A patent/CN100385002C/zh not_active Expired - Fee Related
- 2000-12-20 PL PL358456A patent/PL204277B1/pl unknown
- 2000-12-20 PT PT00987425T patent/PT1246925E/pt unknown
- 2000-12-20 IL IL15021500A patent/IL150215A0/xx active IP Right Grant
- 2000-12-20 BR BRPI0017054A patent/BRPI0017054B1/pt not_active IP Right Cessation
-
2002
- 2002-06-13 IL IL150215A patent/IL150215A/en unknown
- 2002-06-24 ZA ZA200205069A patent/ZA200205069B/xx unknown
- 2002-06-28 US US10/185,425 patent/US7385032B2/en not_active Expired - Lifetime
-
2004
- 2004-06-18 US US10/871,776 patent/US20040235117A1/en not_active Abandoned
-
2008
- 2008-06-02 US US12/131,478 patent/US20090053252A1/en not_active Abandoned
- 2008-07-14 CY CY20081100738T patent/CY1108195T1/el unknown
-
2011
- 2011-03-31 US US13/077,512 patent/US20120009211A1/en not_active Abandoned
-
2013
- 2013-02-11 US US13/764,322 patent/US20130202552A1/en not_active Abandoned
-
2014
- 2014-04-29 US US14/264,402 patent/US20150004129A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL150215A0 (en) | Di-or oligomer of a dimer, trimer, quatromer or pentamer of recombinant fusion proteins | |
Waterfield et al. | Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus | |
NZ502392A (en) | Interleukin-18 binding proteins (IL-18BP) their preparation and use in pharmaceuticals | |
ATE168415T1 (de) | Wasserlösliche peptidanaloguen mit bindungstellen | |
DK1037991T3 (da) | Celleoverfladeglycoproteiner associeret med humane B-cellelumfoner - ULBP, DNA og polypeptider | |
NO20000934L (no) | Adipocyttspesifikke proteinhomologer | |
ATE259419T1 (de) | Humanes cyr61, ein signalmolekül der extrazellulaeren matrix | |
ATE271129T1 (de) | Isoliertes p27 protein und nukleinsäure dafür kodierend | |
CA2318482A1 (en) | Il-18 receptors | |
DE69133281D1 (de) | Rezeptoren der wachstumsfaktoren aus fibroblasten | |
NO20000215L (no) | Adipocyttspesifikke proteinhomologer | |
DE69841140D1 (de) | Interleukin-17 rezeptor-ähnliches protein | |
PT1015586E (pt) | Homologos de ligandos do receptor tirosina-quinase tie | |
Kumagai et al. | Disulfide-bonding between Drosophila laminin β and γ chains is essential for α chain to form αβγ trimer | |
Krautwald et al. | Bacterially expressed murine CSF-1 possesses agonistic activity in its monomeric form | |
WO1990007000A3 (en) | Nucleotides encoding human b1, 4-galactosyltransferase and uses thereof | |
DE68918519T2 (de) | DNA, welche für ein antikoagulierendes Polypeptid kodiert. | |
IL138585A0 (en) | Vertebrate batched -2 protein | |
Spoerri et al. | Colocalization of low-and high-affinity NGF receptors on PC12 cells, C6 glioma cells and dorsal root ganglion neurons. | |
Ji et al. | Macromolecular affinity labeling | |
Alexenko et al. | Mapping of an epitope of human leukocyte alpha interferon A which is recognized by the murine monoclonal antibody NK2. | |
Niimi et al. | Distinct roles of mouse laminin β1 long arm domains for α1β1γ1 trimer formation | |
Marikar et al. | Characterization of concanavalin A-binding neuronal and glial surface glycoproteins from human foetal brain. | |
WO2000073446A3 (en) | Adipocyte complement related protein homolog zacrp6 | |
PT1270590E (pt) | Proteina que melhora a sobrevivencia de celulas bastonete foto-receptoras e acido nucleico que a codifica |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed |