PT1015586E - Homologos de ligandos do receptor tirosina-quinase tie - Google Patents

Homologos de ligandos do receptor tirosina-quinase tie

Info

Publication number
PT1015586E
PT1015586E PT98946988T PT98946988T PT1015586E PT 1015586 E PT1015586 E PT 1015586E PT 98946988 T PT98946988 T PT 98946988T PT 98946988 T PT98946988 T PT 98946988T PT 1015586 E PT1015586 E PT 1015586E
Authority
PT
Portugal
Prior art keywords
tirosin
kinase
receptor ligands
nucleic acid
tie receptor
Prior art date
Application number
PT98946988T
Other languages
English (en)
Inventor
Sherman Fong
Ferrara Napoleone
Audrey Goddard
Paul J Godowski
Austin L Gurney
Hillan Kenneth
Williams P Mickey
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of PT1015586E publication Critical patent/PT1015586E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Dermatology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PT98946988T 1997-09-19 1998-09-14 Homologos de ligandos do receptor tirosina-quinase tie PT1015586E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/934,494 US6030831A (en) 1997-09-19 1997-09-19 Tie ligand homologues

Publications (1)

Publication Number Publication Date
PT1015586E true PT1015586E (pt) 2006-07-31

Family

ID=25465645

Family Applications (2)

Application Number Title Priority Date Filing Date
PT98946988T PT1015586E (pt) 1997-09-19 1998-09-14 Homologos de ligandos do receptor tirosina-quinase tie
PT04012203T PT1482040E (pt) 1997-09-19 1998-09-14 Homologos nl3 de ligandos do receptor tirosina-quinase tie

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT04012203T PT1482040E (pt) 1997-09-19 1998-09-14 Homologos nl3 de ligandos do receptor tirosina-quinase tie

Country Status (16)

Country Link
US (3) US6030831A (pt)
EP (3) EP1482040B1 (pt)
JP (3) JP3668795B2 (pt)
KR (3) KR100467185B1 (pt)
AT (3) ATE318905T1 (pt)
AU (1) AU744285B2 (pt)
CA (1) CA2304810C (pt)
CY (1) CY1105248T1 (pt)
DE (3) DE69834852T2 (pt)
DK (3) DK1482040T3 (pt)
ES (2) ES2268538T3 (pt)
IL (3) IL134647A0 (pt)
NZ (1) NZ502945A (pt)
PT (2) PT1015586E (pt)
WO (1) WO1999015654A2 (pt)
ZA (1) ZA988392B (pt)

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US20030092002A1 (en) * 1997-09-17 2003-05-15 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US7169906B2 (en) 1997-09-17 2007-01-30 Genentech, Inc. PRO211 polypeptides
US6974689B1 (en) 1997-09-18 2005-12-13 Genentech, Inc. Nucleic acid encoding PRO211 polypeptides
US6030831A (en) * 1997-09-19 2000-02-29 Genetech, Inc. Tie ligand homologues
AU1931599A (en) * 1997-12-19 1999-07-12 Zymogenetics Inc. Angiopoietin homolog, dna encoding it, and method of making it
US6706869B1 (en) * 1998-02-11 2004-03-16 Wyeth Map kinase phosphatases and polynucleotides encoding them
US20030099994A1 (en) * 1998-03-02 2003-05-29 Millennium Pharamceuticals, Inc. Novel FDRG protein and nucleic acid molecules and uses therefor
JP2002516067A (ja) * 1998-03-02 2002-06-04 ミレニアム・フアーマシユーチカルズ・インコーポレーテツド 新規ｆｄｒｇタンパク質および核酸分子、ならびにそのための用途
WO1999055869A1 (en) * 1998-04-27 1999-11-04 Zymogenetics, Inc. Novel polypeptide growth factors and materials and methods for making them
SV1999000069A (es) * 1998-06-02 2000-04-11 Lilly Co Eli Angiopoyetina relacionada con secuencia del gen 3 en la cicatrizacion de la cara ref. x-12261
WO1999067382A2 (en) * 1998-06-24 1999-12-29 Compugen Ltd. Angiopoietin-like growth factor sequences
US7488590B2 (en) * 1998-10-23 2009-02-10 Amgen Inc. Modified peptides as therapeutic agents
DE69940964D1 (de) * 1998-12-22 2009-07-16 Genentech Inc Verfahren und Zusammensetzungen zur Hemmung des neoplastischen Zellenwachstums
PT1632499E (pt) * 1999-03-08 2007-09-11 Genentech Inc Dispositivo de detecção de impacto para automóveis.
KR20010104373A (ko) * 1999-03-08 2001-11-24 제넨테크, 인크. 혈관신생 및 심혈관형성의 촉진 또는 억제 방법
IL145941A (en) 1999-04-28 2007-08-19 Univ Texas Preparations and methods for the treatment of cancer by selective inhibition of VEGF
US6703020B1 (en) 1999-04-28 2004-03-09 Board Of Regents, The University Of Texas System Antibody conjugate methods for selectively inhibiting VEGF
WO2001002429A2 (en) * 1999-07-02 2001-01-11 Bayer Aktiengesellschaft Angiopoietin-6 and uses thereof
AU6605900A (en) * 1999-07-16 2001-02-05 Hyseq, Inc. Novel angiopoietin materials and methods
US7001766B2 (en) * 1999-07-20 2006-02-21 Curagen Corporation Nucleic acid sequences encoding human angiopoietin-like polypeptides
AU4011300A (en) * 1999-07-20 2001-02-05 Genentech Inc. Compositions and methods for the treatment of immune related diseases
EP1196576A2 (en) * 1999-07-20 2002-04-17 Curagen Corporation Secreted polypeptides and corresponding polynucleotides
EP1484401A1 (en) * 1999-07-20 2004-12-08 Curagen Corporation Secreted polypeptides and corresponding polynucleotides
CA2390676A1 (en) * 1999-12-09 2001-06-14 Sankyo Company, Limited Method of testing remedy or preventive for hyperlipemia
AU2001244509A1 (en) * 2000-03-30 2001-10-08 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of treatment of conditions involving obstruction of blood flow
US20030096364A1 (en) * 2000-09-05 2003-05-22 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
EP1341771A2 (en) * 2000-11-29 2003-09-10 Glaxo Group Limited Benzimidazole derivatives useful as tie-2 and/or vegfr-2 inhibitors
US7205275B2 (en) * 2001-10-11 2007-04-17 Amgen Inc. Methods of treatment using specific binding agents of human angiopoietin-2
US7658924B2 (en) * 2001-10-11 2010-02-09 Amgen Inc. Angiopoietin-2 specific binding agents
US7521053B2 (en) * 2001-10-11 2009-04-21 Amgen Inc. Angiopoietin-2 specific binding agents
US7138370B2 (en) * 2001-10-11 2006-11-21 Amgen Inc. Specific binding agents of human angiopoietin-2
AU2002365261A1 (en) * 2001-10-18 2003-09-02 The Children's Hospital Of Philadelphia Methods and materials for the recruitment of endothelial cells
US20050123925A1 (en) * 2002-11-15 2005-06-09 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
US20040067882A1 (en) * 2001-10-22 2004-04-08 Alsobrook John P. Therapeutic polypeptides, nucleic acids encoding same, and methods of use
AU2002348286B2 (en) * 2001-11-16 2008-04-03 Genentech, Inc. Composition comprising and method of using angiopoietin-like protein 3 Angptl3
WO2003048185A2 (en) * 2001-11-30 2003-06-12 Genvec, Inc. Angiopioetin related factors
US20090181092A1 (en) * 2004-07-16 2009-07-16 Spinal Restoration, Inc. Methods for Treating Joints and Discs with a Carrier Matrix and Cells
US8604185B2 (en) 2004-07-20 2013-12-10 Genentech, Inc. Inhibitors of angiopoietin-like 4 protein, combinations, and their use
GB0423554D0 (en) * 2004-10-22 2004-11-24 Cancer Rec Tech Ltd Therapeutic compounds
US20080119367A1 (en) * 2004-12-17 2008-05-22 Mayo Foundation For Medical Education And Research Prognosis of Renal Cell Carcinoma
GB0428082D0 (en) * 2004-12-22 2005-01-26 Welcome Trust The Ltd Therapeutic compounds
AU2007245495A1 (en) 2006-04-26 2007-11-08 Astex Therapeutics Limited Imidazo[4, 5-b]pyridin-2-one and oxazolo[4, 5-b]pyridin-2-one compounds and analogs thereof as cancer therapeutic compounds
MX2009006082A (es) * 2006-12-08 2009-08-18 Lexicon Pharmaceuticals Inc Anticuerpos monoclonales contra la proteina 3 similar a angiopoyetina (angptl3).
UA105763C2 (uk) * 2007-12-19 2014-06-25 Кансер Рісерч Текнолоджі Лімітед 8-ЗАМІЩЕНІ ПІРИДО[2,3-b]ПІРАЗИНИ ТА ЇХ ЗАСТОСУВАННЯ
JO2913B1 (en) 2008-02-20 2015-09-15 امجين إنك, Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses
GB0807609D0 (en) * 2008-04-25 2008-06-04 Cancer Rec Tech Ltd Therapeutic compounds and their use
DK2531502T3 (da) 2010-02-01 2014-05-19 Cancer Rec Tech Ltd 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea og associerede forbindelser og ders anvendelse i terapi
AR087329A1 (es) 2011-06-17 2014-03-19 Regeneron Pharma Anticuerpos humanos contra proteina 3 de tipo angiopoietina humana
UY35368A (es) 2013-03-08 2014-10-31 Irm Llc Péptidos y composiciones para el tratamiento de daño articular
US9301971B2 (en) 2013-03-08 2016-04-05 Novartis Ag Peptides and compositions for treatment of joint damage
GB201320732D0 (en) 2013-11-25 2014-01-08 Cancer Rec Tech Ltd Methods of chemical synthesis
GB201320729D0 (en) 2013-11-25 2014-01-08 Cancer Rec Tech Ltd Therapeutic compounds and their use
MA40512A (fr) 2014-08-07 2021-03-24 Novartis Ag Anticorps de l'angiopoïétine-like 4 et procédés d'utilisation correspondants
US9988443B2 (en) 2014-08-07 2018-06-05 Novartis Ag Angiopoetin-like 4 (ANGPTL4) antibodies and methods of use
TW202027794A (zh) 2018-10-03 2020-08-01 瑞士商諾華公司 血管生成素樣３多肽之持續遞送

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SV1999000069A (es) * 1998-06-02 2000-04-11 Lilly Co Eli Angiopoyetina relacionada con secuencia del gen 3 en la cicatrizacion de la cara ref. x-12261
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Also Published As

Publication number Publication date
EP1015586B1 (en) 2006-03-01
EP1015586A2 (en) 2000-07-05
KR20010024143A (ko) 2001-03-26
AU744285B2 (en) 2002-02-21
JP4239018B2 (ja) 2009-03-18
NZ502945A (en) 2001-11-30
KR100467185B1 (ko) 2005-01-24
DK1482040T3 (da) 2006-10-02
DE69833670T2 (de) 2006-09-21
JP3668795B2 (ja) 2005-07-06
CY1105248T1 (el) 2010-03-03
ATE329028T1 (de) 2006-06-15
ES2268538T3 (es) 2007-03-16
WO1999015654A2 (en) 1999-04-01
ATE435912T1 (de) 2009-07-15
KR20040097230A (ko) 2004-11-17
EP1482040A3 (en) 2004-12-08
DE69833670D1 (de) 2006-04-27
US6030831A (en) 2000-02-29
ZA988392B (en) 2000-03-22
IL187847A (en) 2011-06-30
DK1015586T3 (da) 2006-07-03
JP2005185284A (ja) 2005-07-14
CA2304810C (en) 2011-05-10
DE69840966D1 (de) 2009-08-20
DK1482041T3 (da) 2009-11-02
JP2001517438A (ja) 2001-10-09
EP1482041A1 (en) 2004-12-01
CA2304810A1 (en) 1999-04-01
EP1482040A2 (en) 2004-12-01
JP2005176848A (ja) 2005-07-07
IL187847A0 (en) 2008-03-20
ATE318905T1 (de) 2006-03-15
DE69834852D1 (de) 2006-07-20
US6074873A (en) 2000-06-13
WO1999015654A3 (en) 1999-10-21
EP1482041B1 (en) 2009-07-08
KR100472262B1 (ko) 2005-03-07
KR100467186B1 (ko) 2005-01-24
US6348351B1 (en) 2002-02-19
IL177638A0 (en) 2006-12-31
PT1482040E (pt) 2006-10-31
ES2260848T3 (es) 2006-11-01
KR20040097229A (ko) 2004-11-17
DE69834852T2 (de) 2007-05-24
EP1482040B1 (en) 2006-06-07
IL134647A0 (en) 2001-04-30
AU9388198A (en) 1999-04-12

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