DE69834852D1 - NL3 TIE Rezeptortyrosinekinase Ligandhomologe - Google Patents

NL3 TIE Rezeptortyrosinekinase Ligandhomologe

Info

Publication number
DE69834852D1
DE69834852D1 DE69834852T DE69834852T DE69834852D1 DE 69834852 D1 DE69834852 D1 DE 69834852D1 DE 69834852 T DE69834852 T DE 69834852T DE 69834852 T DE69834852 T DE 69834852T DE 69834852 D1 DE69834852 D1 DE 69834852D1
Authority
DE
Germany
Prior art keywords
tyrosine kinase
receptor tyrosine
tie receptor
kinase ligand
ligand homologue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69834852T
Other languages
English (en)
Other versions
DE69834852T2 (de
Inventor
Sherman Fong
Napoleone Ferrara
Audrey Goddard
Paul J Godowski
Austin L Gurney
Kenneth Hillan
P Mickey Williams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of DE69834852D1 publication Critical patent/DE69834852D1/de
Application granted granted Critical
Publication of DE69834852T2 publication Critical patent/DE69834852T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Dermatology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69834852T 1997-09-19 1998-09-14 NL3 TIE Rezeptortyrosinekinase Ligandhomologe Expired - Lifetime DE69834852T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US934494 1997-09-19
US08/934,494 US6030831A (en) 1997-09-19 1997-09-19 Tie ligand homologues

Publications (2)

Publication Number Publication Date
DE69834852D1 true DE69834852D1 (de) 2006-07-20
DE69834852T2 DE69834852T2 (de) 2007-05-24

Family

ID=25465645

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69834852T Expired - Lifetime DE69834852T2 (de) 1997-09-19 1998-09-14 NL3 TIE Rezeptortyrosinekinase Ligandhomologe
DE69833670T Expired - Lifetime DE69833670T2 (de) 1997-09-19 1998-09-14 Homologe des tie-rezeptortyrosinekinase liganden
DE69840966T Expired - Lifetime DE69840966D1 (de) 1997-09-19 1998-09-14 Homolog NL6 des Tie Rezeptor Tyrosinekinase Liganden

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE69833670T Expired - Lifetime DE69833670T2 (de) 1997-09-19 1998-09-14 Homologe des tie-rezeptortyrosinekinase liganden
DE69840966T Expired - Lifetime DE69840966D1 (de) 1997-09-19 1998-09-14 Homolog NL6 des Tie Rezeptor Tyrosinekinase Liganden

Country Status (16)

Country Link
US (3) US6030831A (de)
EP (3) EP1015586B1 (de)
JP (3) JP3668795B2 (de)
KR (3) KR100467186B1 (de)
AT (3) ATE435912T1 (de)
AU (1) AU744285B2 (de)
CA (1) CA2304810C (de)
CY (1) CY1105248T1 (de)
DE (3) DE69834852T2 (de)
DK (3) DK1015586T3 (de)
ES (2) ES2268538T3 (de)
IL (3) IL134647A0 (de)
NZ (1) NZ502945A (de)
PT (2) PT1015586E (de)
WO (1) WO1999015654A2 (de)
ZA (1) ZA988392B (de)

Families Citing this family (56)

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US6057435A (en) * 1997-09-19 2000-05-02 Genentech, Inc. Tie ligand homologues
US7169906B2 (en) 1997-09-17 2007-01-30 Genentech, Inc. PRO211 polypeptides
US20030049676A1 (en) * 1997-09-17 2003-03-13 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US6974689B1 (en) 1997-09-18 2005-12-13 Genentech, Inc. Nucleic acid encoding PRO211 polypeptides
US6030831A (en) * 1997-09-19 2000-02-29 Genetech, Inc. Tie ligand homologues
WO1999032515A2 (en) * 1997-12-19 1999-07-01 Zymogenetics, Inc. Angiopoietin homolog, dna encoding it, and method of making it
US6706869B1 (en) * 1998-02-11 2004-03-16 Wyeth Map kinase phosphatases and polynucleotides encoding them
US20030099994A1 (en) * 1998-03-02 2003-05-29 Millennium Pharamceuticals, Inc. Novel FDRG protein and nucleic acid molecules and uses therefor
CA2322425A1 (en) * 1998-03-02 1999-09-10 Millennium Pharmaceuticals, Inc. Novel fdrg protein and nucleic acid molecules and uses therefor
WO1999055869A1 (en) * 1998-04-27 1999-11-04 Zymogenetics, Inc. Novel polypeptide growth factors and materials and methods for making them
SV1999000069A (es) * 1998-06-02 2000-04-11 Lilly Co Eli Angiopoyetina relacionada con secuencia del gen 3 en la cicatrizacion de la cara ref. x-12261
WO1999067382A2 (en) * 1998-06-24 1999-12-29 Compugen Ltd. Angiopoietin-like growth factor sequences
US7488590B2 (en) * 1998-10-23 2009-02-10 Amgen Inc. Modified peptides as therapeutic agents
IL143031A0 (en) * 1998-12-22 2002-04-21 Genentech Inc Methods and compositions for inhibiting neoplastic cell growth
KR100553300B1 (ko) * 1999-03-08 2006-02-20 제넨테크, 인크. 혈관신생 및 심혈관형성의 촉진 또는 억제 방법
ES2321954T3 (es) * 1999-03-08 2009-06-15 Genentech, Inc. Composiciones y procedimientos para el diagnostico de tumores.
US6703020B1 (en) 1999-04-28 2004-03-09 Board Of Regents, The University Of Texas System Antibody conjugate methods for selectively inhibiting VEGF
JP4926320B2 (ja) 1999-04-28 2012-05-09 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム Ｖｅｇｆの選択的阻害による癌処置のための組成物および方法
AU5979300A (en) * 1999-07-02 2001-01-22 Bayer Aktiengesellschaft Angiopoietin-6 and uses thereof
EP1210363A2 (de) * 1999-07-16 2002-06-05 Hyseq, Inc. Nukleinsäuresequenzen, die für putative angiopoietine codieren
JP2003505350A (ja) * 1999-07-20 2003-02-12 ジェネンテック・インコーポレーテッド 免疫関連疾患の治療のための組成物と方法
EP1484401A1 (de) * 1999-07-20 2004-12-08 Curagen Corporation Sekretionspolypeptiden und übereinstimmende Polynukleotiden
AU6229100A (en) * 1999-07-20 2001-02-05 Curagen Corporation Polypeptides and polynucleotides encoding same
US7001766B2 (en) * 1999-07-20 2006-02-21 Curagen Corporation Nucleic acid sequences encoding human angiopoietin-like polypeptides
KR20020062652A (ko) * 1999-12-09 2002-07-26 상꾜 가부시키가이샤 고지혈증의 치료 또는 예방제의 시험방법
AU2001244509A1 (en) * 2000-03-30 2001-10-08 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of treatment of conditions involving obstruction of blood flow
US20030096364A1 (en) * 2000-09-05 2003-05-22 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
AU2002232439A1 (en) * 2000-11-29 2002-06-11 Glaxo Group Limited Benzimidazole derivatives useful as tie-2 and/or vegfr-2 inhibitors
US7658924B2 (en) * 2001-10-11 2010-02-09 Amgen Inc. Angiopoietin-2 specific binding agents
US7205275B2 (en) * 2001-10-11 2007-04-17 Amgen Inc. Methods of treatment using specific binding agents of human angiopoietin-2
US7138370B2 (en) * 2001-10-11 2006-11-21 Amgen Inc. Specific binding agents of human angiopoietin-2
US7521053B2 (en) * 2001-10-11 2009-04-21 Amgen Inc. Angiopoietin-2 specific binding agents
WO2003062373A2 (en) * 2001-10-18 2003-07-31 The Children's Hospital Of Philadelphia Methods and materials for the recruitment of endothelial cells
US20050123925A1 (en) 2002-11-15 2005-06-09 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
US20040067882A1 (en) * 2001-10-22 2004-04-08 Alsobrook John P. Therapeutic polypeptides, nucleic acids encoding same, and methods of use
CN1615440A (zh) * 2001-11-16 2005-05-11 杰南技术公司 含有血管生成素－样蛋白质3angptl3的组合物及其使用方法
WO2003048185A2 (en) * 2001-11-30 2003-06-12 Genvec, Inc. Angiopioetin related factors
US20090181092A1 (en) * 2004-07-16 2009-07-16 Spinal Restoration, Inc. Methods for Treating Joints and Discs with a Carrier Matrix and Cells
US8604185B2 (en) 2004-07-20 2013-12-10 Genentech, Inc. Inhibitors of angiopoietin-like 4 protein, combinations, and their use
GB0423554D0 (en) * 2004-10-22 2004-11-24 Cancer Rec Tech Ltd Therapeutic compounds
US20080119367A1 (en) * 2004-12-17 2008-05-22 Mayo Foundation For Medical Education And Research Prognosis of Renal Cell Carcinoma
GB0428082D0 (en) * 2004-12-22 2005-01-26 Welcome Trust The Ltd Therapeutic compounds
CA2649994A1 (en) 2006-04-26 2007-11-08 Cancer Research Technology Limited Imidazo[4,5-b]pyridin-2-one and oxazolo[4,5-b]pyridin-2-one compounds and analogs thereof as cancer therapeutic compounds
KR101503937B1 (ko) * 2006-12-08 2015-03-18 렉시컨 파마슈티컬스 인코퍼레이티드 Ａｎｇｐｔｌ３ 에 대한 단일클론 항체
CA2709257C (en) 2007-12-19 2016-12-13 Cancer Research Technology Limited Pyrido[2,3-b]pyrazine-8-substituted compounds and their use
JO2913B1 (en) 2008-02-20 2015-09-15 امجين إنك, Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses
GB0807609D0 (en) * 2008-04-25 2008-06-04 Cancer Rec Tech Ltd Therapeutic compounds and their use
DK2531502T3 (da) 2010-02-01 2014-05-19 Cancer Rec Tech Ltd 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea og associerede forbindelser og ders anvendelse i terapi
JO3412B1 (ar) 2011-06-17 2019-10-20 Regeneron Pharma أجسام مضادة ل angptl3 واستخداماتها
US9301971B2 (en) 2013-03-08 2016-04-05 Novartis Ag Peptides and compositions for treatment of joint damage
JO3564B1 (ar) 2013-03-08 2020-07-05 Novartis Ag ببتيدات وتركيبات لعلاج ضرر المفاصل
GB201320732D0 (en) 2013-11-25 2014-01-08 Cancer Rec Tech Ltd Methods of chemical synthesis
GB201320729D0 (en) 2013-11-25 2014-01-08 Cancer Rec Tech Ltd Therapeutic compounds and their use
NZ728425A (en) 2014-08-07 2022-05-27 Novartis Ag Angiopoietin-like 4 antibodies and methods of use
US9988443B2 (en) 2014-08-07 2018-06-05 Novartis Ag Angiopoetin-like 4 (ANGPTL4) antibodies and methods of use
AR116566A1 (es) 2018-10-03 2021-05-19 Novartis Ag Administración sostenida de polipéptidos similares a la angiopoyetina 3

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US5229495A (en) * 1991-06-18 1993-07-20 Ludwig Institute For Cancer Research Substantially pure receptor like TGF-β 1 binding molecules and uses thereof
US5955291A (en) * 1992-01-09 1999-09-21 Alitalo; Kari Antibodies recognizing tie receptor tyrosine kinase and uses thereof
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AU4651893A (en) * 1992-06-26 1994-01-24 Immunex Corporation Novel tyrosine kinase
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DE69534180T2 (de) * 1994-09-22 2006-03-02 Licentia Ltd. Promotor der tie rezeptor protein kinase
US5650490A (en) * 1994-10-07 1997-07-22 Regeneron Pharmaceuticals, Inc. Tie-2 ligand 2
US5814464A (en) * 1994-10-07 1998-09-29 Regeneron Pharma Nucleic acids encoding TIE-2 ligand-2
EP0821728B1 (de) * 1995-04-06 2004-08-11 Regeneron Pharmaceuticals, Inc. Tie-2 liganden, herstellungsverfahren und verwendung
EP0939809B1 (de) * 1996-06-19 2003-03-26 Regeneron Pharmaceuticals, Inc. Ligand (tie ligand-4) vom tie-2 rezeptor und dessen verwendungen
US6265564B1 (en) * 1996-08-02 2001-07-24 Regeneron Pharmaceuticals, Inc. Expressed ligand-vascular intercellular signalling molecule
US5972338A (en) * 1997-09-19 1999-10-26 Genentech, Inc. Tie ligands homologues
US6030831A (en) * 1997-09-19 2000-02-29 Genetech, Inc. Tie ligand homologues
WO1999055869A1 (en) * 1998-04-27 1999-11-04 Zymogenetics, Inc. Novel polypeptide growth factors and materials and methods for making them
SV1999000069A (es) * 1998-06-02 2000-04-11 Lilly Co Eli Angiopoyetina relacionada con secuencia del gen 3 en la cicatrizacion de la cara ref. x-12261
WO1999067382A2 (en) * 1998-06-24 1999-12-29 Compugen Ltd. Angiopoietin-like growth factor sequences

Also Published As

Publication number Publication date
EP1015586B1 (de) 2006-03-01
CA2304810A1 (en) 1999-04-01
US6074873A (en) 2000-06-13
JP2001517438A (ja) 2001-10-09
EP1482041B1 (de) 2009-07-08
ES2260848T3 (es) 2006-11-01
US6348351B1 (en) 2002-02-19
IL134647A0 (en) 2001-04-30
DK1015586T3 (da) 2006-07-03
PT1482040E (pt) 2006-10-31
JP2005176848A (ja) 2005-07-07
IL187847A0 (en) 2008-03-20
ES2268538T3 (es) 2007-03-16
CA2304810C (en) 2011-05-10
JP3668795B2 (ja) 2005-07-06
KR100467185B1 (ko) 2005-01-24
EP1482040A2 (de) 2004-12-01
EP1015586A2 (de) 2000-07-05
NZ502945A (en) 2001-11-30
WO1999015654A2 (en) 1999-04-01
KR100467186B1 (ko) 2005-01-24
IL187847A (en) 2011-06-30
PT1015586E (pt) 2006-07-31
JP2005185284A (ja) 2005-07-14
DK1482040T3 (da) 2006-10-02
KR20010024143A (ko) 2001-03-26
AU9388198A (en) 1999-04-12
US6030831A (en) 2000-02-29
IL177638A0 (en) 2006-12-31
KR100472262B1 (ko) 2005-03-07
CY1105248T1 (el) 2010-03-03
AU744285B2 (en) 2002-02-21
ATE435912T1 (de) 2009-07-15
KR20040097230A (ko) 2004-11-17
DK1482041T3 (da) 2009-11-02
EP1482040B1 (de) 2006-06-07
KR20040097229A (ko) 2004-11-17
WO1999015654A3 (en) 1999-10-21
ATE329028T1 (de) 2006-06-15
DE69833670T2 (de) 2006-09-21
EP1482040A3 (de) 2004-12-08
DE69840966D1 (de) 2009-08-20
DE69833670D1 (de) 2006-04-27
JP4239018B2 (ja) 2009-03-18
ZA988392B (en) 2000-03-22
EP1482041A1 (de) 2004-12-01
DE69834852T2 (de) 2007-05-24
ATE318905T1 (de) 2006-03-15

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