CY1105248T1 - Ομολογα συνδετη υποδοχεα κινασης τυροσινης νl3 τιε - Google Patents

Ομολογα συνδετη υποδοχεα κινασης τυροσινης νl3 τιε

Info

Publication number
CY1105248T1
CY1105248T1 CY20061101260T CY061101260T CY1105248T1 CY 1105248 T1 CY1105248 T1 CY 1105248T1 CY 20061101260 T CY20061101260 T CY 20061101260T CY 061101260 T CY061101260 T CY 061101260T CY 1105248 T1 CY1105248 T1 CY 1105248T1
Authority
CY
Cyprus
Prior art keywords
holm
tyrosine kinase
kinase receptor
receptor binder
nucleic acid
Prior art date
Application number
CY20061101260T
Other languages
English (en)
Inventor
Sherman Fong
Napoleone Ferrara
Audrey Goddard
Paul J. Godowski
Austin L. Gurney
Kenneth Hillan
P. Mickey Williams
Original Assignee
Genentech, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech, Inc. filed Critical Genentech, Inc.
Publication of CY1105248T1 publication Critical patent/CY1105248T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Plant Pathology (AREA)
  • Dermatology (AREA)
  • Microbiology (AREA)
  • Vascular Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Η παρούσα εφεύρεση αφορά απομονωμένα μόρια νουκλεϊκών οξέων που κωδικοποιούν τα πρωτότυπα ομόλογα συνδέτη (ligand) TIE, NL-2, NL-3 και NL-6 (FLS139), πρωτεΐνες που κωδικοποιούνται από αυτά τα μόρια νουκλεϊκών οξέων, όπως επίσης και μεθόδους και μέσα κατασκευής και χρήσης αυτών των μορίων νουκλεϊκών οξέων και πρωτεϊνών.
CY20061101260T 1997-09-19 2006-09-05 Ομολογα συνδετη υποδοχεα κινασης τυροσινης νl3 τιε CY1105248T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/934,494 US6030831A (en) 1997-09-19 1997-09-19 Tie ligand homologues
EP98946988A EP1015586B1 (en) 1997-09-19 1998-09-14 Tie receptor tyrosine kinase ligand homologues

Publications (1)

Publication Number Publication Date
CY1105248T1 true CY1105248T1 (el) 2010-03-03

Family

ID=25465645

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20061101260T CY1105248T1 (el) 1997-09-19 2006-09-05 Ομολογα συνδετη υποδοχεα κινασης τυροσινης νl3 τιε

Country Status (16)

Country Link
US (3) US6030831A (el)
EP (3) EP1482041B1 (el)
JP (3) JP3668795B2 (el)
KR (3) KR100467185B1 (el)
AT (3) ATE435912T1 (el)
AU (1) AU744285B2 (el)
CA (1) CA2304810C (el)
CY (1) CY1105248T1 (el)
DE (3) DE69840966D1 (el)
DK (3) DK1482040T3 (el)
ES (2) ES2260848T3 (el)
IL (3) IL134647A0 (el)
NZ (1) NZ502945A (el)
PT (2) PT1015586E (el)
WO (1) WO1999015654A2 (el)
ZA (1) ZA988392B (el)

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US20030099994A1 (en) * 1998-03-02 2003-05-29 Millennium Pharamceuticals, Inc. Novel FDRG protein and nucleic acid molecules and uses therefor
JP2002516067A (ja) * 1998-03-02 2002-06-04 ミレニアム・フアーマシユーチカルズ・インコーポレーテツド 新規ｆｄｒｇタンパク質および核酸分子、ならびにそのための用途
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US6342221B1 (en) 1999-04-28 2002-01-29 Board Of Regents, The University Of Texas System Antibody conjugate compositions for selectively inhibiting VEGF
US6703020B1 (en) 1999-04-28 2004-03-09 Board Of Regents, The University Of Texas System Antibody conjugate methods for selectively inhibiting VEGF
AU5979300A (en) * 1999-07-02 2001-01-22 Bayer Aktiengesellschaft Angiopoietin-6 and uses thereof
WO2001005825A2 (en) * 1999-07-16 2001-01-25 Hyseq, Inc. Nucleic acid sequences encoding putative angiopoietin proteins
AU4011300A (en) * 1999-07-20 2001-02-05 Genentech Inc. Compositions and methods for the treatment of immune related diseases
EP1484401A1 (en) * 1999-07-20 2004-12-08 Curagen Corporation Secreted polypeptides and corresponding polynucleotides
CA2379925A1 (en) * 1999-07-20 2001-01-25 Curagen Corporation Polypeptides and polynucleotides encoding same
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AU2001244509A1 (en) * 2000-03-30 2001-10-08 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of treatment of conditions involving obstruction of blood flow
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US7238813B2 (en) * 2000-11-29 2007-07-03 Smithkline Beecham Corporation Chemical compounds
US7658924B2 (en) * 2001-10-11 2010-02-09 Amgen Inc. Angiopoietin-2 specific binding agents
US7138370B2 (en) * 2001-10-11 2006-11-21 Amgen Inc. Specific binding agents of human angiopoietin-2
US7521053B2 (en) * 2001-10-11 2009-04-21 Amgen Inc. Angiopoietin-2 specific binding agents
US7205275B2 (en) * 2001-10-11 2007-04-17 Amgen Inc. Methods of treatment using specific binding agents of human angiopoietin-2
AU2002365261A1 (en) * 2001-10-18 2003-09-02 The Children's Hospital Of Philadelphia Methods and materials for the recruitment of endothelial cells
US20050123925A1 (en) * 2002-11-15 2005-06-09 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
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Also Published As

Publication number Publication date
NZ502945A (en) 2001-11-30
ES2260848T3 (es) 2006-11-01
US6074873A (en) 2000-06-13
EP1482040A2 (en) 2004-12-01
EP1482040B1 (en) 2006-06-07
KR20010024143A (ko) 2001-03-26
JP2001517438A (ja) 2001-10-09
DE69834852D1 (de) 2006-07-20
JP2005185284A (ja) 2005-07-14
PT1482040E (pt) 2006-10-31
DK1015586T3 (da) 2006-07-03
DK1482040T3 (da) 2006-10-02
DE69833670D1 (de) 2006-04-27
ATE435912T1 (de) 2009-07-15
EP1482041A1 (en) 2004-12-01
KR20040097230A (ko) 2004-11-17
KR20040097229A (ko) 2004-11-17
AU9388198A (en) 1999-04-12
CA2304810C (en) 2011-05-10
IL177638A0 (en) 2006-12-31
IL134647A0 (en) 2001-04-30
JP4239018B2 (ja) 2009-03-18
AU744285B2 (en) 2002-02-21
EP1015586A2 (en) 2000-07-05
KR100467186B1 (ko) 2005-01-24
JP3668795B2 (ja) 2005-07-06
PT1015586E (pt) 2006-07-31
KR100467185B1 (ko) 2005-01-24
ATE318905T1 (de) 2006-03-15
US6348351B1 (en) 2002-02-19
EP1482041B1 (en) 2009-07-08
CA2304810A1 (en) 1999-04-01
DE69833670T2 (de) 2006-09-21
EP1482040A3 (en) 2004-12-08
ZA988392B (en) 2000-03-22
WO1999015654A2 (en) 1999-04-01
DK1482041T3 (da) 2009-11-02
DE69840966D1 (de) 2009-08-20
US6030831A (en) 2000-02-29
EP1015586B1 (en) 2006-03-01
IL187847A0 (en) 2008-03-20
IL187847A (en) 2011-06-30
DE69834852T2 (de) 2007-05-24
JP2005176848A (ja) 2005-07-07
WO1999015654A3 (en) 1999-10-21
KR100472262B1 (ko) 2005-03-07
ES2268538T3 (es) 2007-03-16
ATE329028T1 (de) 2006-06-15

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