WO1990007000A3 - Nucleotides encoding human b1, 4-galactosyltransferase and uses thereof - Google Patents

Nucleotides encoding human b1, 4-galactosyltransferase and uses thereof Download PDF

Info

Publication number
WO1990007000A3
WO1990007000A3 PCT/US1989/005128 US8905128W WO9007000A3 WO 1990007000 A3 WO1990007000 A3 WO 1990007000A3 US 8905128 W US8905128 W US 8905128W WO 9007000 A3 WO9007000 A3 WO 9007000A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
galactosyltransferase
provides
encodes
acid sequence
Prior art date
Application number
PCT/US1989/005128
Other languages
French (fr)
Other versions
WO1990007000A2 (en
Inventor
Michiko N Fukuda
Hubert A Appert
Original Assignee
Jolla Cancer Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jolla Cancer Res Found filed Critical Jolla Cancer Res Found
Publication of WO1990007000A2 publication Critical patent/WO1990007000A2/en
Publication of WO1990007000A3 publication Critical patent/WO1990007000A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention provides an isolated nucleic acid sequence which encodes purified membrane-bound human β-1,4-galactosyltransferase, or a functional equivalent thereof. This invention also provides an isolated nucleic acid sequence which encodes purified soluble human β-1,4-galactosyltransferase or a functional equivalent thereof. The invention further provides vectors comprising these nucleic acid sequences and the expression of recombinant proteins by use of a host vector system. The invention still further provides antibodies reactive with the proteins and probes reactive with the nucleic acid sequences. Finally, the invention provides a method of diagnosing congenital dyserthropoietic anemia type II in a subject.
PCT/US1989/005128 1988-12-13 1989-11-16 Nucleotides encoding human b1, 4-galactosyltransferase and uses thereof WO1990007000A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28373288A 1988-12-13 1988-12-13
US283,732 1988-12-13

Publications (2)

Publication Number Publication Date
WO1990007000A2 WO1990007000A2 (en) 1990-06-28
WO1990007000A3 true WO1990007000A3 (en) 1990-08-09

Family

ID=23087318

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1989/005128 WO1990007000A2 (en) 1988-12-13 1989-11-16 Nucleotides encoding human b1, 4-galactosyltransferase and uses thereof

Country Status (3)

Country Link
AU (1) AU4751990A (en)
CA (1) CA2003797A1 (en)
WO (1) WO1990007000A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5032519A (en) * 1989-10-24 1991-07-16 The Regents Of The Univ. Of California Method for producing secretable glycosyltransferases and other Golgi processing enzymes
SE9201544L (en) * 1991-05-31 1992-12-01 Ciba Geigy Ag MAKE SUBSTANTIAL GYCOSYL TRANSFER PHASES
GB2256197B (en) * 1991-05-31 1995-11-22 Ciba Geigy Ag Yeast as host for expression of heterologous glycosyl transferase enzymes
WO1994012646A1 (en) * 1992-11-27 1994-06-09 Ciba-Geigy Ag Proteins having glycosyltransferase activity
GB9603256D0 (en) * 1996-02-16 1996-04-17 Wellcome Found Antibodies
US6558934B1 (en) * 1998-07-17 2003-05-06 Glycozm Aps UDP-galactose: β-N-acetyl-glucosamine β-1,4-galactosyl-transferase, β4Gal-T2
WO2001014535A2 (en) 1999-08-24 2001-03-01 Glycozym Aps UDP-N-ACETYLGLUCOSAMINE: GALACTOSE-β1,3-N-ACETYLGALACTOSAMINE-α-R/(GlcNAc to GalNAc) β1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE, C2GnT3
CN1331292A (en) * 2000-06-26 2002-01-16 上海博德基因开发有限公司 Polypeptide-human beta-1,4 galactosyltransferase 13.2 and polynucleotide for coding it

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Biochemical and Biophysical Research Communications, vol. 139, no. 1, 29 August 1986, Academic Press, Inc., (Duluth, MN, US), H.E. Appert et al.: "Isolation of a cDNA coding for human galactosyl transferase", pages 163-168, see the whole article (cited in the application) *
Biochemical and Biophysical Research Communications, vol. 187, no. 2, 15 December 1988, Academic Press, Inc., (Duluth, MN, US), K.A. Masri et al.: "Identification of the full-lenght coding sequence for human galactosyltransferase (beta-N-acetylglucosaminide: betal, 4-galactosyltransferase)", see pages 657-663 *
The Journal of Biological Chemistry, vol. 263, no. 21, 25 July 1988, (Baltimore, ND, US), N.L. Shaper et al.: "Characterization of the full lenght cDNA for murine beta-1,4-Galactosyltransferase", pages 10420-10428, see "Discussion" (cited in the application) *

Also Published As

Publication number Publication date
WO1990007000A2 (en) 1990-06-28
AU4751990A (en) 1990-07-10
CA2003797A1 (en) 1990-06-13

Similar Documents

Publication Publication Date Title
WO1999055868A3 (en) Fizz proteins
EP0784059A4 (en) Antigenic polypeptide of chlamydia pneumoniae
EP1559776A3 (en) Non-toxic, non-toxigenic, non-pathogenic Fusarium expression system and promoters and terminators for use therein
HK1013847A1 (en) Gdf-1 and uog-1 proteins
WO1996034107A3 (en) Antiviral proteins, dna coding sequences therefor, and uses thereof
EP0749442A4 (en) ISOLATED p27 PROTEIN AND ITS ENCODING NUCLEIC ACID MOLECULES
WO1999063088A3 (en) Membrane-bound proteins and nucleic acids encoding the same
WO1999028462A3 (en) Polypeptides and nucleic acids encoding the same
EP0360257A3 (en) Rna catalyst for cleaving specific rna sequences
WO1998018930A3 (en) Streptococcus pneumoniae antigens and vaccines
ES8602119A1 (en) Recombinant immunoglobulin preparations, methods for their preparation, DNA sequences, expression vectors and recombinant host cells therefor.
WO1999061469A3 (en) Prostate growth-associated membrane proteins
WO1998056927A3 (en) Nucleic acids encoding polypeptide having protease activity
NZ502391A (en) Mammalian cytokine: interleukin-B30 and related reagents
IL133056A0 (en) A polypeptide containing an immunogenic portion of a m tuberculosis antigen a variant thereof pharmaceutical compositions vaccines and kits containing same
EP0346710A3 (en) Cdnas coding for members of the carcinoembryonic antigen family
WO1997043409A3 (en) Method of providing novel dna sequences
EP0821064A3 (en) Recombinant fructosyl amino acid oxidase
WO1995006735A3 (en) Nucleotide sequences for novel protein tyrosine phosphatases
AU3230797A (en) Dna encoding dp. 75 and a process for its use
WO1990007000A3 (en) Nucleotides encoding human b1, 4-galactosyltransferase and uses thereof
WO1995008628A3 (en) Nucleic acids encoding merosin, merosin fragments and uses thereof
WO2002074960A3 (en) 38650, 28472, 5495, 65507, 81588 and 14354 methods and compositions of human proteins and uses thereof
WO2000043419A3 (en) Exocytosis pathway proteins and methods of use
WO2002002771A3 (en) Human sparc-homologous (hsparc-h1) gene and methods and uses thereof

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AU JP

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE ES FR GB IT LU NL SE

AK Designated states

Kind code of ref document: A3

Designated state(s): AU JP

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH DE ES FR GB IT LU NL SE