IL136137A0 - Hydrophobically-modified protein compositions and methods - Google Patents
Hydrophobically-modified protein compositions and methodsInfo
- Publication number
- IL136137A0 IL136137A0 IL13613798A IL13613798A IL136137A0 IL 136137 A0 IL136137 A0 IL 136137A0 IL 13613798 A IL13613798 A IL 13613798A IL 13613798 A IL13613798 A IL 13613798A IL 136137 A0 IL136137 A0 IL 136137A0
- Authority
- IL
- Israel
- Prior art keywords
- protein
- hydrophobically
- methods
- hydrophobic moiety
- modified protein
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Marine Sciences & Fisheries (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Graft Or Block Polymers (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6742397P | 1997-12-03 | 1997-12-03 | |
US7893598P | 1998-03-20 | 1998-03-20 | |
US8968598P | 1998-06-17 | 1998-06-17 | |
US9980098P | 1998-09-10 | 1998-09-10 | |
PCT/US1998/025676 WO1999028343A2 (en) | 1997-12-03 | 1998-12-03 | Hydrophobically-modified protein compositions and methods |
Publications (1)
Publication Number | Publication Date |
---|---|
IL136137A0 true IL136137A0 (en) | 2001-05-20 |
Family
ID=27490628
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL13613798A IL136137A0 (en) | 1997-12-03 | 1998-12-03 | Hydrophobically-modified protein compositions and methods |
IL136137A IL136137A (en) | 1997-12-03 | 2000-05-14 | Isolated hedgehog proteins and methods for their preparation |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL136137A IL136137A (en) | 1997-12-03 | 2000-05-14 | Isolated hedgehog proteins and methods for their preparation |
Country Status (26)
Country | Link |
---|---|
US (1) | US6444793B1 (da) |
EP (1) | EP1036092B1 (da) |
JP (1) | JP4289788B2 (da) |
KR (1) | KR20010032753A (da) |
CN (1) | CN1294595A (da) |
AT (1) | ATE295372T1 (da) |
AU (1) | AU757497B2 (da) |
BR (1) | BR9815142A (da) |
CA (1) | CA2309806A1 (da) |
CZ (1) | CZ20002008A3 (da) |
DE (1) | DE69830192T2 (da) |
DK (1) | DK1036092T3 (da) |
EA (1) | EA003739B1 (da) |
EE (1) | EE200000308A (da) |
ES (1) | ES2243018T3 (da) |
HK (1) | HK1030953A1 (da) |
HU (1) | HUP0100535A3 (da) |
IL (2) | IL136137A0 (da) |
IS (1) | IS2163B (da) |
MX (1) | MXPA00005494A (da) |
NO (1) | NO20002789L (da) |
NZ (1) | NZ504752A (da) |
PL (1) | PL197833B1 (da) |
PT (1) | PT1036092E (da) |
TR (1) | TR200001612T2 (da) |
WO (1) | WO1999028343A2 (da) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001525341A (ja) * | 1997-11-28 | 2001-12-11 | ロッシュ ディアグノスティクス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 活性ヘッジホッグタンパク質変異体、その調製方法及び医薬への適用 |
PT1036092E (pt) | 1997-12-03 | 2005-09-30 | Biogen Inc | Compos~icoes e metodos de proteinas hidrofobicamente modificadas |
US6897297B1 (en) * | 1997-12-03 | 2005-05-24 | Curis, Inc. | Hydrophobically-modified protein compositions and methods |
ES2252886T3 (es) * | 1998-04-30 | 2006-05-16 | Curis, Inc. | Conjugado de proteinas de erizo activo, proceso para su produccion y uso. |
TW570805B (en) | 1998-09-01 | 2004-01-11 | Hoffmann La Roche | Water-soluble pharmaceutical composition in an ionic complex |
DE69939327D1 (de) * | 1998-11-02 | 2008-09-25 | Curis Inc | Funktionelle antagonisten von hedgehog-aktivität |
DE69931390T2 (de) * | 1998-12-03 | 2007-06-06 | Curis, Inc., Cambridge | Verfahren und Zusammensetzungen zur Behandlung von Krankheiten bei denen Excitotoxizität beteiligt ist |
EP1025861A1 (de) * | 1999-02-04 | 2000-08-09 | Roche Diagnostics GmbH | Pharmazeutische Zusammensetzung von hydrophob modifizierten Hedgehog-Proteinen und deren Verwendung |
AU782493B2 (en) * | 1999-06-01 | 2005-08-04 | Curis, Inc. | Polymer conjugates of hedgehog proteins and uses |
IL149202A0 (en) * | 1999-11-05 | 2002-11-10 | Biogen Inc | Hedgehog fusion proteins and uses |
AU2005203058C1 (en) * | 1999-11-05 | 2009-07-02 | Curis, Inc. | Hedgehog fusion proteins and uses |
US7052514B2 (en) * | 2000-04-28 | 2006-05-30 | Curis, Inc. | Methods and reagents for tissue engineering of cartilage in vitro |
US20030235851A1 (en) * | 2002-04-19 | 2003-12-25 | Roberts Richard W. | Methods of using sense and/or nonsense suppression to make nucleic acid-peptide display libraries containing peptides with unnatural amino acid residues |
JP2008506703A (ja) | 2004-07-14 | 2008-03-06 | ユニバーシティ オブ ユタ リサーチ ファウンデーション | ネトリン関連化合物および用途 |
WO2006101273A1 (ja) * | 2005-03-25 | 2006-09-28 | Takeda Pharmaceutical Company Limited | 癌の予防・治療剤 |
RU2420580C2 (ru) * | 2005-11-11 | 2011-06-10 | Протеоджен Био С.Р.Л. | Способ преобразования водорастворимых активных белков в гидрофобные активные белки, их применение для получения мономолекулярных слоев ориентированных активных белков и устройства, включающие водорастворимые активные белки, преобразованные в гидрофобные активные белки |
WO2008057468A1 (en) | 2006-11-02 | 2008-05-15 | Curis, Inc. | Small organic molecule regulators of cell proliferation |
KR100876657B1 (ko) * | 2007-10-15 | 2009-01-07 | 한국기계연구원 | 표면개질된 마이크로비드와 마이크로비드 어레이칩의제조방법과 마이크로비드 어레이칩을 이용한 질병특이항원의 확인방법 |
WO2009105783A1 (en) * | 2008-02-21 | 2009-08-27 | Dermacare Neuroscience Institute | Cosmetic and dermatological formulations of mntf peptides |
WO2009108868A2 (en) * | 2008-02-27 | 2009-09-03 | Radiomedix Inc. | Radiolabeled hedgehog derivatives for imaging and therapy |
UA107571C2 (xx) * | 2009-04-03 | 2015-01-26 | Фармацевтична композиція | |
CN103665095A (zh) * | 2012-09-11 | 2014-03-26 | 中国人民解放军军事医学科学院卫生学环境医学研究所 | 一种疏水性多肽修饰抗体的合成方法 |
CN106924754B (zh) * | 2015-12-30 | 2021-11-09 | 北京大学 | 聚氨基酸偶联物 |
CN108147990B (zh) * | 2016-12-02 | 2023-01-24 | 上海中医药大学 | 一种膜锚定元件及其应用 |
MX2020004338A (es) | 2017-10-25 | 2020-10-14 | Janssen Pharmaceuticals Inc | Composiciones de peptidos tau fosforilados y sus usos. |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5374548A (en) * | 1986-05-02 | 1994-12-20 | Genentech, Inc. | Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor |
US5399347A (en) | 1987-06-24 | 1995-03-21 | Autoimmune, Inc. | Method of treating rheumatoid arthritis with type II collagen |
US5409611A (en) * | 1988-03-24 | 1995-04-25 | Terrapin Technoogies, Inc. | Method to identify analyte-binding ligands |
US5130297A (en) | 1988-06-23 | 1992-07-14 | Anergen, Inc. | Conjugates useful in ameliorating autoimmunity MHC-II-peptide |
US5824315A (en) * | 1993-10-25 | 1998-10-20 | Anergen, Inc. | Binding affinity of antigenic peptides for MHC molecules |
US6281332B1 (en) * | 1994-12-02 | 2001-08-28 | The Johns Hopkins University School Of Medicine | Hedgehog-derived polypeptides |
US5869602A (en) * | 1995-03-17 | 1999-02-09 | Novo Nordisk A/S | Peptide derivatives |
JP2002503088A (ja) * | 1996-10-07 | 2002-01-29 | ザ ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン | 新規ヘッジホッグ由来ポリペプチド |
PT1036092E (pt) | 1997-12-03 | 2005-09-30 | Biogen Inc | Compos~icoes e metodos de proteinas hidrofobicamente modificadas |
-
1998
- 1998-12-03 PT PT98964702T patent/PT1036092E/pt unknown
- 1998-12-03 DK DK98964702T patent/DK1036092T3/da active
- 1998-12-03 CZ CZ20002008A patent/CZ20002008A3/cs unknown
- 1998-12-03 EA EA200000605A patent/EA003739B1/ru not_active IP Right Cessation
- 1998-12-03 AT AT98964702T patent/ATE295372T1/de not_active IP Right Cessation
- 1998-12-03 JP JP2000523234A patent/JP4289788B2/ja not_active Expired - Lifetime
- 1998-12-03 TR TR2000/01612T patent/TR200001612T2/xx unknown
- 1998-12-03 MX MXPA00005494A patent/MXPA00005494A/es active IP Right Grant
- 1998-12-03 EP EP98964702A patent/EP1036092B1/en not_active Expired - Lifetime
- 1998-12-03 DE DE69830192T patent/DE69830192T2/de not_active Expired - Lifetime
- 1998-12-03 HU HU0100535A patent/HUP0100535A3/hu unknown
- 1998-12-03 AU AU19966/99A patent/AU757497B2/en not_active Ceased
- 1998-12-03 BR BR9815142-8A patent/BR9815142A/pt not_active Application Discontinuation
- 1998-12-03 CA CA002309806A patent/CA2309806A1/en not_active Abandoned
- 1998-12-03 KR KR1020007006044A patent/KR20010032753A/ko not_active Application Discontinuation
- 1998-12-03 NZ NZ504752A patent/NZ504752A/xx not_active IP Right Cessation
- 1998-12-03 EE EEP200000308A patent/EE200000308A/xx unknown
- 1998-12-03 WO PCT/US1998/025676 patent/WO1999028343A2/en active IP Right Grant
- 1998-12-03 PL PL341430A patent/PL197833B1/pl not_active IP Right Cessation
- 1998-12-03 CN CN98813447A patent/CN1294595A/zh active Pending
- 1998-12-03 ES ES98964702T patent/ES2243018T3/es not_active Expired - Lifetime
- 1998-12-03 IL IL13613798A patent/IL136137A0/xx unknown
-
1999
- 1999-06-03 US US09/325,256 patent/US6444793B1/en not_active Expired - Lifetime
-
2000
- 2000-05-14 IL IL136137A patent/IL136137A/en active IP Right Grant
- 2000-05-15 IS IS5499A patent/IS2163B/is unknown
- 2000-05-31 NO NO20002789A patent/NO20002789L/no not_active Application Discontinuation
-
2001
- 2001-03-01 HK HK01101512A patent/HK1030953A1/xx not_active IP Right Cessation
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