DK1036092T3 - Hydrofobisk modificeret hedgehog proteinsammensætning og fremgangsmåder - Google Patents
Hydrofobisk modificeret hedgehog proteinsammensætning og fremgangsmåderInfo
- Publication number
- DK1036092T3 DK1036092T3 DK98964702T DK98964702T DK1036092T3 DK 1036092 T3 DK1036092 T3 DK 1036092T3 DK 98964702 T DK98964702 T DK 98964702T DK 98964702 T DK98964702 T DK 98964702T DK 1036092 T3 DK1036092 T3 DK 1036092T3
- Authority
- DK
- Denmark
- Prior art keywords
- protein
- methods
- hydrophobically modified
- protein composition
- hedgehog protein
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Analytical Chemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Marine Sciences & Fisheries (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Graft Or Block Polymers (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6742397P | 1997-12-03 | 1997-12-03 | |
US7893598P | 1998-03-20 | 1998-03-20 | |
US8968598P | 1998-06-17 | 1998-06-17 | |
US9980098P | 1998-09-10 | 1998-09-10 | |
PCT/US1998/025676 WO1999028343A2 (en) | 1997-12-03 | 1998-12-03 | Hydrophobically-modified protein compositions and methods |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1036092T3 true DK1036092T3 (da) | 2005-08-15 |
Family
ID=27490628
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK98964702T DK1036092T3 (da) | 1997-12-03 | 1998-12-03 | Hydrofobisk modificeret hedgehog proteinsammensætning og fremgangsmåder |
Country Status (26)
Country | Link |
---|---|
US (1) | US6444793B1 (da) |
EP (1) | EP1036092B1 (da) |
JP (1) | JP4289788B2 (da) |
KR (1) | KR20010032753A (da) |
CN (1) | CN1294595A (da) |
AT (1) | ATE295372T1 (da) |
AU (1) | AU757497B2 (da) |
BR (1) | BR9815142A (da) |
CA (1) | CA2309806A1 (da) |
CZ (1) | CZ20002008A3 (da) |
DE (1) | DE69830192T2 (da) |
DK (1) | DK1036092T3 (da) |
EA (1) | EA003739B1 (da) |
EE (1) | EE200000308A (da) |
ES (1) | ES2243018T3 (da) |
HK (1) | HK1030953A1 (da) |
HU (1) | HUP0100535A3 (da) |
IL (2) | IL136137A0 (da) |
IS (1) | IS2163B (da) |
MX (1) | MXPA00005494A (da) |
NO (1) | NO20002789L (da) |
NZ (1) | NZ504752A (da) |
PL (1) | PL197833B1 (da) |
PT (1) | PT1036092E (da) |
TR (1) | TR200001612T2 (da) |
WO (1) | WO1999028343A2 (da) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2312009A1 (en) * | 1997-11-28 | 1999-06-10 | Roche Diagnostics Gmbh | An active hedgehog-protein-mutant, a process for its preparation and its use for pharmaceutical purposes |
US6897297B1 (en) * | 1997-12-03 | 2005-05-24 | Curis, Inc. | Hydrophobically-modified protein compositions and methods |
WO1999028343A2 (en) | 1997-12-03 | 1999-06-10 | Biogen, Inc. | Hydrophobically-modified protein compositions and methods |
DK0953576T3 (da) * | 1998-04-30 | 2006-03-20 | Curis Inc | Aktivt hedgehog-proteinkonjugat, fremgangsmåde til fremstilling heraf og anvendelse |
TW570805B (en) | 1998-09-01 | 2004-01-11 | Hoffmann La Roche | Water-soluble pharmaceutical composition in an ionic complex |
AU765485B2 (en) * | 1998-11-02 | 2003-09-18 | Curis, Inc. | Functional antagonists of hedgehog activity |
WO2000035948A1 (en) * | 1998-12-03 | 2000-06-22 | Biogen, Inc. | Methods and compositions for treating disorders involving excitotoxicity |
EP1025861A1 (de) * | 1999-02-04 | 2000-08-09 | Roche Diagnostics GmbH | Pharmazeutische Zusammensetzung von hydrophob modifizierten Hedgehog-Proteinen und deren Verwendung |
WO2000073337A1 (en) * | 1999-06-01 | 2000-12-07 | Biogen, Inc. | Polymer conjugates of hedgehog proteins and uses |
WO2001034654A1 (en) * | 1999-11-05 | 2001-05-17 | Biogen, Inc. | Hedgehog fusion proteins and uses |
AU2005203058C1 (en) * | 1999-11-05 | 2009-07-02 | Curis, Inc. | Hedgehog fusion proteins and uses |
AU2001255767A1 (en) * | 2000-04-28 | 2001-11-12 | Curis, Inc. | Methods and reagents for tissue engineering of cartilage in vitro |
WO2003089454A2 (en) * | 2002-04-19 | 2003-10-30 | California Institute Of Technology | Unnatural amino acid containing display libraries |
US7456151B2 (en) | 2004-07-14 | 2008-11-25 | University Of Utah Research Foundation | Promoting angiogenesis with netrin1 polypeptides |
WO2006101273A1 (ja) * | 2005-03-25 | 2006-09-28 | Takeda Pharmaceutical Company Limited | 癌の予防・治療剤 |
BRPI0618528A2 (pt) * | 2005-11-11 | 2012-04-17 | Proteogen Bio S R L | método de conversão de proteìnas ativas solúveis em água em proteìnas ativas hidrofóbicas, uso das mesmas para a preparação de camadas monomoleculares de proteìnas ativas orientadas e dispositivos compreendendo as ditas proteìnas |
WO2008057468A1 (en) | 2006-11-02 | 2008-05-15 | Curis, Inc. | Small organic molecule regulators of cell proliferation |
KR100876657B1 (ko) * | 2007-10-15 | 2009-01-07 | 한국기계연구원 | 표면개질된 마이크로비드와 마이크로비드 어레이칩의제조방법과 마이크로비드 어레이칩을 이용한 질병특이항원의 확인방법 |
US8334253B2 (en) * | 2008-02-21 | 2012-12-18 | Dermacare Neuroscience Institute | Cosmetic and dermatological formulations of MNTF peptides |
US20100316566A1 (en) * | 2008-02-27 | 2010-12-16 | Radiomedix Inc. | Radiolabeled hedgehog derivatives for imaging and therapy |
UA107571C2 (xx) * | 2009-04-03 | 2015-01-26 | Фармацевтична композиція | |
CN103665095A (zh) * | 2012-09-11 | 2014-03-26 | 中国人民解放军军事医学科学院卫生学环境医学研究所 | 一种疏水性多肽修饰抗体的合成方法 |
CN106924754B (zh) * | 2015-12-30 | 2021-11-09 | 北京大学 | 聚氨基酸偶联物 |
CN108147990B (zh) * | 2016-12-02 | 2023-01-24 | 上海中医药大学 | 一种膜锚定元件及其应用 |
EA202091012A1 (ru) | 2017-10-25 | 2020-08-27 | Янссен Фармасьютикалз, Инк. | Композиции фосфорилированных тау-пептидов и их применения |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5374548A (en) * | 1986-05-02 | 1994-12-20 | Genentech, Inc. | Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor |
US5399347A (en) | 1987-06-24 | 1995-03-21 | Autoimmune, Inc. | Method of treating rheumatoid arthritis with type II collagen |
US5409611A (en) * | 1988-03-24 | 1995-04-25 | Terrapin Technoogies, Inc. | Method to identify analyte-binding ligands |
US5130297A (en) | 1988-06-23 | 1992-07-14 | Anergen, Inc. | Conjugates useful in ameliorating autoimmunity MHC-II-peptide |
US5824315A (en) * | 1993-10-25 | 1998-10-20 | Anergen, Inc. | Binding affinity of antigenic peptides for MHC molecules |
US6281332B1 (en) * | 1994-12-02 | 2001-08-28 | The Johns Hopkins University School Of Medicine | Hedgehog-derived polypeptides |
US5869602A (en) * | 1995-03-17 | 1999-02-09 | Novo Nordisk A/S | Peptide derivatives |
JP2002503088A (ja) * | 1996-10-07 | 2002-01-29 | ザ ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン | 新規ヘッジホッグ由来ポリペプチド |
WO1999028343A2 (en) | 1997-12-03 | 1999-06-10 | Biogen, Inc. | Hydrophobically-modified protein compositions and methods |
-
1998
- 1998-12-03 WO PCT/US1998/025676 patent/WO1999028343A2/en active IP Right Grant
- 1998-12-03 HU HU0100535A patent/HUP0100535A3/hu unknown
- 1998-12-03 CN CN98813447A patent/CN1294595A/zh active Pending
- 1998-12-03 BR BR9815142-8A patent/BR9815142A/pt not_active Application Discontinuation
- 1998-12-03 JP JP2000523234A patent/JP4289788B2/ja not_active Expired - Lifetime
- 1998-12-03 DK DK98964702T patent/DK1036092T3/da active
- 1998-12-03 IL IL13613798A patent/IL136137A0/xx unknown
- 1998-12-03 KR KR1020007006044A patent/KR20010032753A/ko not_active Application Discontinuation
- 1998-12-03 PL PL341430A patent/PL197833B1/pl not_active IP Right Cessation
- 1998-12-03 AU AU19966/99A patent/AU757497B2/en not_active Ceased
- 1998-12-03 EP EP98964702A patent/EP1036092B1/en not_active Expired - Lifetime
- 1998-12-03 CZ CZ20002008A patent/CZ20002008A3/cs unknown
- 1998-12-03 EA EA200000605A patent/EA003739B1/ru not_active IP Right Cessation
- 1998-12-03 ES ES98964702T patent/ES2243018T3/es not_active Expired - Lifetime
- 1998-12-03 NZ NZ504752A patent/NZ504752A/xx not_active IP Right Cessation
- 1998-12-03 MX MXPA00005494A patent/MXPA00005494A/es active IP Right Grant
- 1998-12-03 TR TR2000/01612T patent/TR200001612T2/xx unknown
- 1998-12-03 AT AT98964702T patent/ATE295372T1/de not_active IP Right Cessation
- 1998-12-03 CA CA002309806A patent/CA2309806A1/en not_active Abandoned
- 1998-12-03 DE DE69830192T patent/DE69830192T2/de not_active Expired - Lifetime
- 1998-12-03 EE EEP200000308A patent/EE200000308A/xx unknown
- 1998-12-03 PT PT98964702T patent/PT1036092E/pt unknown
-
1999
- 1999-06-03 US US09/325,256 patent/US6444793B1/en not_active Expired - Lifetime
-
2000
- 2000-05-14 IL IL136137A patent/IL136137A/en active IP Right Grant
- 2000-05-15 IS IS5499A patent/IS2163B/is unknown
- 2000-05-31 NO NO20002789A patent/NO20002789L/no not_active Application Discontinuation
-
2001
- 2001-03-01 HK HK01101512A patent/HK1030953A1/xx not_active IP Right Cessation
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