DE69830192D1 - Hydrophobisch-modifizierte Hedgehog Protein Zusammensetzungen und Verfahren - Google Patents
Hydrophobisch-modifizierte Hedgehog Protein Zusammensetzungen und VerfahrenInfo
- Publication number
- DE69830192D1 DE69830192D1 DE69830192T DE69830192T DE69830192D1 DE 69830192 D1 DE69830192 D1 DE 69830192D1 DE 69830192 T DE69830192 T DE 69830192T DE 69830192 T DE69830192 T DE 69830192T DE 69830192 D1 DE69830192 D1 DE 69830192D1
- Authority
- DE
- Germany
- Prior art keywords
- hydrophobic
- protein
- methods
- hydrophobic moiety
- protein compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Marine Sciences & Fisheries (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Graft Or Block Polymers (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6742397P | 1997-12-03 | 1997-12-03 | |
US67423P | 1997-12-03 | ||
US7893598P | 1998-03-20 | 1998-03-20 | |
US78935P | 1998-03-20 | ||
US8968598P | 1998-06-17 | 1998-06-17 | |
US89685P | 1998-06-17 | ||
US9980098P | 1998-09-10 | 1998-09-10 | |
US99800P | 1998-09-10 | ||
PCT/US1998/025676 WO1999028343A2 (en) | 1997-12-03 | 1998-12-03 | Hydrophobically-modified protein compositions and methods |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69830192D1 true DE69830192D1 (de) | 2005-06-16 |
DE69830192T2 DE69830192T2 (de) | 2006-01-12 |
Family
ID=27490628
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69830192T Expired - Lifetime DE69830192T2 (de) | 1997-12-03 | 1998-12-03 | Hydrophobisch-modifizierte Hedgehog Protein Zusammensetzungen und Verfahren |
Country Status (26)
Country | Link |
---|---|
US (1) | US6444793B1 (de) |
EP (1) | EP1036092B1 (de) |
JP (1) | JP4289788B2 (de) |
KR (1) | KR20010032753A (de) |
CN (1) | CN1294595A (de) |
AT (1) | ATE295372T1 (de) |
AU (1) | AU757497B2 (de) |
BR (1) | BR9815142A (de) |
CA (1) | CA2309806A1 (de) |
CZ (1) | CZ20002008A3 (de) |
DE (1) | DE69830192T2 (de) |
DK (1) | DK1036092T3 (de) |
EA (1) | EA003739B1 (de) |
EE (1) | EE200000308A (de) |
ES (1) | ES2243018T3 (de) |
HK (1) | HK1030953A1 (de) |
HU (1) | HUP0100535A3 (de) |
IL (2) | IL136137A0 (de) |
IS (1) | IS2163B (de) |
MX (1) | MXPA00005494A (de) |
NO (1) | NO20002789L (de) |
NZ (1) | NZ504752A (de) |
PL (1) | PL197833B1 (de) |
PT (1) | PT1036092E (de) |
TR (1) | TR200001612T2 (de) |
WO (1) | WO1999028343A2 (de) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2312009A1 (en) * | 1997-11-28 | 1999-06-10 | Roche Diagnostics Gmbh | An active hedgehog-protein-mutant, a process for its preparation and its use for pharmaceutical purposes |
MXPA00005494A (es) | 1997-12-03 | 2003-05-19 | Curis Inc | Composiciones de proteina hidrofobicamente modificada y metodos. |
US6897297B1 (en) * | 1997-12-03 | 2005-05-24 | Curis, Inc. | Hydrophobically-modified protein compositions and methods |
ATE308563T1 (de) * | 1998-04-30 | 2005-11-15 | Curis Inc | Aktives hedgehog-protein-konjugat, verfahren zur herstellung und verwendung |
TW570805B (en) | 1998-09-01 | 2004-01-11 | Hoffmann La Roche | Water-soluble pharmaceutical composition in an ionic complex |
ATE404583T1 (de) * | 1998-11-02 | 2008-08-15 | Curis Inc | Funktionelle antagonisten von hedgehog-aktivität |
AU763032B2 (en) * | 1998-12-03 | 2003-07-10 | Curis, Inc. | Methods and compositions for treating disorders involving excitotoxicity |
EP1025861A1 (de) * | 1999-02-04 | 2000-08-09 | Roche Diagnostics GmbH | Pharmazeutische Zusammensetzung von hydrophob modifizierten Hedgehog-Proteinen und deren Verwendung |
JP2003502292A (ja) * | 1999-06-01 | 2003-01-21 | バイオジェン インコーポレイテッド | ヘッジホッグタンパク質のポリマー結合体及び利用 |
AU2005203058C1 (en) * | 1999-11-05 | 2009-07-02 | Curis, Inc. | Hedgehog fusion proteins and uses |
JP2003513660A (ja) * | 1999-11-05 | 2003-04-15 | バイオジェン インコーポレイテッド | ヘッジホッグ融合タンパク質及び利用 |
US7052514B2 (en) * | 2000-04-28 | 2006-05-30 | Curis, Inc. | Methods and reagents for tissue engineering of cartilage in vitro |
EP1504111A4 (de) * | 2002-04-19 | 2005-11-23 | California Inst Of Techn | Peptide mit unnatürlichen aminosäureresten enthaltende nukleinsäure-peptid-display-bibliotheken und verfahren zur herstellung davon |
CA2573720A1 (en) | 2004-07-14 | 2006-02-23 | University Of Utah Research Foundation | Netrin-related compositions and uses |
WO2006101273A1 (ja) * | 2005-03-25 | 2006-09-28 | Takeda Pharmaceutical Company Limited | 癌の予防・治療剤 |
AU2006313464B2 (en) * | 2005-11-11 | 2012-07-12 | Proteogen Bio S.R.L. | Method of converting water-soluble active proteins into hydrophobic active proteins, the use of the same for the preparation of monomolecular layers of oriented active proteins, and devices comprising the same |
WO2008057468A1 (en) | 2006-11-02 | 2008-05-15 | Curis, Inc. | Small organic molecule regulators of cell proliferation |
KR100876657B1 (ko) * | 2007-10-15 | 2009-01-07 | 한국기계연구원 | 표면개질된 마이크로비드와 마이크로비드 어레이칩의제조방법과 마이크로비드 어레이칩을 이용한 질병특이항원의 확인방법 |
EP2247613B1 (de) * | 2008-02-21 | 2018-05-30 | Dermacare Neuroscience Institute | Mntf enthaltende kosmetische und dermatologische zusammensetzungen |
US20100316566A1 (en) * | 2008-02-27 | 2010-12-16 | Radiomedix Inc. | Radiolabeled hedgehog derivatives for imaging and therapy |
UA107571C2 (xx) * | 2009-04-03 | 2015-01-26 | Фармацевтична композиція | |
CN103665095A (zh) * | 2012-09-11 | 2014-03-26 | 中国人民解放军军事医学科学院卫生学环境医学研究所 | 一种疏水性多肽修饰抗体的合成方法 |
CN106924753B (zh) * | 2015-12-30 | 2021-11-09 | 北京大学 | 制备蛋白质-聚氨基酸环状偶联物的方法 |
CN108147990B (zh) * | 2016-12-02 | 2023-01-24 | 上海中医药大学 | 一种膜锚定元件及其应用 |
AU2018355325A1 (en) | 2017-10-25 | 2020-05-07 | Ac Immune S.A. | Compositions of phosphorylated tau peptides and uses thereof |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5374548A (en) * | 1986-05-02 | 1994-12-20 | Genentech, Inc. | Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor |
US5399347A (en) | 1987-06-24 | 1995-03-21 | Autoimmune, Inc. | Method of treating rheumatoid arthritis with type II collagen |
US5409611A (en) * | 1988-03-24 | 1995-04-25 | Terrapin Technoogies, Inc. | Method to identify analyte-binding ligands |
US5130297A (en) | 1988-06-23 | 1992-07-14 | Anergen, Inc. | Conjugates useful in ameliorating autoimmunity MHC-II-peptide |
US5824315A (en) * | 1993-10-25 | 1998-10-20 | Anergen, Inc. | Binding affinity of antigenic peptides for MHC molecules |
US6281332B1 (en) * | 1994-12-02 | 2001-08-28 | The Johns Hopkins University School Of Medicine | Hedgehog-derived polypeptides |
US5869602A (en) * | 1995-03-17 | 1999-02-09 | Novo Nordisk A/S | Peptide derivatives |
IL129295A0 (en) * | 1996-10-07 | 2000-02-17 | Univ Johns Hopkins Med | Novel hedgehog-derived polypeptides |
MXPA00005494A (es) | 1997-12-03 | 2003-05-19 | Curis Inc | Composiciones de proteina hidrofobicamente modificada y metodos. |
-
1998
- 1998-12-03 MX MXPA00005494A patent/MXPA00005494A/es active IP Right Grant
- 1998-12-03 HU HU0100535A patent/HUP0100535A3/hu unknown
- 1998-12-03 AU AU19966/99A patent/AU757497B2/en not_active Ceased
- 1998-12-03 EA EA200000605A patent/EA003739B1/ru not_active IP Right Cessation
- 1998-12-03 BR BR9815142-8A patent/BR9815142A/pt not_active Application Discontinuation
- 1998-12-03 DE DE69830192T patent/DE69830192T2/de not_active Expired - Lifetime
- 1998-12-03 CN CN98813447A patent/CN1294595A/zh active Pending
- 1998-12-03 DK DK98964702T patent/DK1036092T3/da active
- 1998-12-03 AT AT98964702T patent/ATE295372T1/de not_active IP Right Cessation
- 1998-12-03 JP JP2000523234A patent/JP4289788B2/ja not_active Expired - Lifetime
- 1998-12-03 EE EEP200000308A patent/EE200000308A/xx unknown
- 1998-12-03 TR TR2000/01612T patent/TR200001612T2/xx unknown
- 1998-12-03 CA CA002309806A patent/CA2309806A1/en not_active Abandoned
- 1998-12-03 WO PCT/US1998/025676 patent/WO1999028343A2/en active IP Right Grant
- 1998-12-03 CZ CZ20002008A patent/CZ20002008A3/cs unknown
- 1998-12-03 EP EP98964702A patent/EP1036092B1/de not_active Expired - Lifetime
- 1998-12-03 ES ES98964702T patent/ES2243018T3/es not_active Expired - Lifetime
- 1998-12-03 PL PL341430A patent/PL197833B1/pl not_active IP Right Cessation
- 1998-12-03 NZ NZ504752A patent/NZ504752A/xx not_active IP Right Cessation
- 1998-12-03 IL IL13613798A patent/IL136137A0/xx unknown
- 1998-12-03 KR KR1020007006044A patent/KR20010032753A/ko not_active Application Discontinuation
- 1998-12-03 PT PT98964702T patent/PT1036092E/pt unknown
-
1999
- 1999-06-03 US US09/325,256 patent/US6444793B1/en not_active Expired - Lifetime
-
2000
- 2000-05-14 IL IL136137A patent/IL136137A/en active IP Right Grant
- 2000-05-15 IS IS5499A patent/IS2163B/is unknown
- 2000-05-31 NO NO20002789A patent/NO20002789L/no not_active Application Discontinuation
-
2001
- 2001-03-01 HK HK01101512A patent/HK1030953A1/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |