TR200001612T2 - Hidrofobik olarak değişikliğe uğratılmış protein bileşimleri ve ilgili yöntemler. - Google Patents

Hidrofobik olarak değişikliğe uğratılmış protein bileşimleri ve ilgili yöntemler.

Info

Publication number
TR200001612T2
TR200001612T2 TR2000/01612T TR200001612T TR200001612T2 TR 200001612 T2 TR200001612 T2 TR 200001612T2 TR 2000/01612 T TR2000/01612 T TR 2000/01612T TR 200001612 T TR200001612 T TR 200001612T TR 200001612 T2 TR200001612 T2 TR 200001612T2
Authority
TR
Turkey
Prior art keywords
protein
hydrophobically modified
hydrophobic
related methods
modified protein
Prior art date
Application number
TR2000/01612T
Other languages
English (en)
Inventor
R. Pepinsky Blake
P. Baker Darren
Wen Dingyi
P. Williams Kevin
A. Garber Ellen
R. Taylor Frederick
Galdes Alphonse
Porter Jeffrey
Original Assignee
Biogen, Inc
Ontogeny, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen, Inc, Ontogeny, Inc. filed Critical Biogen, Inc
Publication of TR200001612T2 publication Critical patent/TR200001612T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Graft Or Block Polymers (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

Hidrofobik olarak degisiklige ugratilmis proteinler ve bunlarin olusturulmasina yönelik yöntemler anlatilmistir. Proteinin bir yüzey amino asit artigina bir hidrofobik yari parça baglanmistir. Hidrofobik yari parça bir lipit veya bir peptit olabilir. Seçenek olarak, protein, kendisine hidrofobik bir yapi ekleyen çok çesitli kimyasal tepkimeler araciligiyla da türetilebilir. Tercih edilen protein, memeli kökenli olan bir proteindir ve Sonic, Indian ve Desert dikenli proteinlerden olusan gruptan seçilmistir. Hidrofobik yari parça, kendisine bir hücre zari, lipozom veya misel gibi bir kesecigin baglanabilecegi, uygun bir bag(lanma noktasi) olarak kullanilmistir.
TR2000/01612T 1997-12-03 1998-12-03 Hidrofobik olarak değişikliğe uğratılmış protein bileşimleri ve ilgili yöntemler. TR200001612T2 (tr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US6742397P 1997-12-03 1997-12-03
US7893598P 1998-03-20 1998-03-20
US8968598P 1998-06-17 1998-06-17
US9980098P 1998-09-10 1998-09-10

Publications (1)

Publication Number Publication Date
TR200001612T2 true TR200001612T2 (tr) 2001-01-22

Family

ID=27490628

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/01612T TR200001612T2 (tr) 1997-12-03 1998-12-03 Hidrofobik olarak değişikliğe uğratılmış protein bileşimleri ve ilgili yöntemler.

Country Status (26)

Country Link
US (1) US6444793B1 (tr)
EP (1) EP1036092B1 (tr)
JP (1) JP4289788B2 (tr)
KR (1) KR20010032753A (tr)
CN (1) CN1294595A (tr)
AT (1) ATE295372T1 (tr)
AU (1) AU757497B2 (tr)
BR (1) BR9815142A (tr)
CA (1) CA2309806A1 (tr)
CZ (1) CZ20002008A3 (tr)
DE (1) DE69830192T2 (tr)
DK (1) DK1036092T3 (tr)
EA (1) EA003739B1 (tr)
EE (1) EE200000308A (tr)
ES (1) ES2243018T3 (tr)
HK (1) HK1030953A1 (tr)
HU (1) HUP0100535A3 (tr)
IL (2) IL136137A0 (tr)
IS (1) IS2163B (tr)
MX (1) MXPA00005494A (tr)
NO (1) NO20002789L (tr)
NZ (1) NZ504752A (tr)
PL (1) PL197833B1 (tr)
PT (1) PT1036092E (tr)
TR (1) TR200001612T2 (tr)
WO (1) WO1999028343A2 (tr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2312009A1 (en) * 1997-11-28 1999-06-10 Roche Diagnostics Gmbh An active hedgehog-protein-mutant, a process for its preparation and its use for pharmaceutical purposes
MXPA00005494A (es) 1997-12-03 2003-05-19 Curis Inc Composiciones de proteina hidrofobicamente modificada y metodos.
US6897297B1 (en) * 1997-12-03 2005-05-24 Curis, Inc. Hydrophobically-modified protein compositions and methods
ATE308563T1 (de) * 1998-04-30 2005-11-15 Curis Inc Aktives hedgehog-protein-konjugat, verfahren zur herstellung und verwendung
TW570805B (en) 1998-09-01 2004-01-11 Hoffmann La Roche Water-soluble pharmaceutical composition in an ionic complex
ATE404583T1 (de) * 1998-11-02 2008-08-15 Curis Inc Funktionelle antagonisten von hedgehog-aktivität
AU763032B2 (en) * 1998-12-03 2003-07-10 Curis, Inc. Methods and compositions for treating disorders involving excitotoxicity
EP1025861A1 (de) * 1999-02-04 2000-08-09 Roche Diagnostics GmbH Pharmazeutische Zusammensetzung von hydrophob modifizierten Hedgehog-Proteinen und deren Verwendung
JP2003502292A (ja) * 1999-06-01 2003-01-21 バイオジェン インコーポレイテッド ヘッジホッグタンパク質のポリマー結合体及び利用
AU2005203058C1 (en) * 1999-11-05 2009-07-02 Curis, Inc. Hedgehog fusion proteins and uses
JP2003513660A (ja) * 1999-11-05 2003-04-15 バイオジェン インコーポレイテッド ヘッジホッグ融合タンパク質及び利用
US7052514B2 (en) * 2000-04-28 2006-05-30 Curis, Inc. Methods and reagents for tissue engineering of cartilage in vitro
EP1504111A4 (en) * 2002-04-19 2005-11-23 California Inst Of Techn PEPTIDES NUCLEIC ACID PEPTIDE DISPLAY LIBRARS CONTAINING UNNATURELY AMINO-ACID-RESISTANT AND METHOD FOR THE PRODUCTION THEREOF
CA2573720A1 (en) 2004-07-14 2006-02-23 University Of Utah Research Foundation Netrin-related compositions and uses
WO2006101273A1 (ja) * 2005-03-25 2006-09-28 Takeda Pharmaceutical Company Limited 癌の予防・治療剤
AU2006313464B2 (en) * 2005-11-11 2012-07-12 Proteogen Bio S.R.L. Method of converting water-soluble active proteins into hydrophobic active proteins, the use of the same for the preparation of monomolecular layers of oriented active proteins, and devices comprising the same
WO2008057468A1 (en) 2006-11-02 2008-05-15 Curis, Inc. Small organic molecule regulators of cell proliferation
KR100876657B1 (ko) * 2007-10-15 2009-01-07 한국기계연구원 표면개질된 마이크로비드와 마이크로비드 어레이칩의제조방법과 마이크로비드 어레이칩을 이용한 질병특이항원의 확인방법
EP2247613B1 (en) * 2008-02-21 2018-05-30 Dermacare Neuroscience Institute Cosmetic and dermatological formulations of mntf peptides
US20100316566A1 (en) * 2008-02-27 2010-12-16 Radiomedix Inc. Radiolabeled hedgehog derivatives for imaging and therapy
UA107571C2 (xx) * 2009-04-03 2015-01-26 Фармацевтична композиція
CN103665095A (zh) * 2012-09-11 2014-03-26 中国人民解放军军事医学科学院卫生学环境医学研究所 一种疏水性多肽修饰抗体的合成方法
CN106924753B (zh) * 2015-12-30 2021-11-09 北京大学 制备蛋白质-聚氨基酸环状偶联物的方法
CN108147990B (zh) * 2016-12-02 2023-01-24 上海中医药大学 一种膜锚定元件及其应用
AU2018355325A1 (en) 2017-10-25 2020-05-07 Ac Immune S.A. Compositions of phosphorylated tau peptides and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5374548A (en) * 1986-05-02 1994-12-20 Genentech, Inc. Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor
US5399347A (en) 1987-06-24 1995-03-21 Autoimmune, Inc. Method of treating rheumatoid arthritis with type II collagen
US5409611A (en) * 1988-03-24 1995-04-25 Terrapin Technoogies, Inc. Method to identify analyte-binding ligands
US5130297A (en) 1988-06-23 1992-07-14 Anergen, Inc. Conjugates useful in ameliorating autoimmunity MHC-II-peptide
US5824315A (en) * 1993-10-25 1998-10-20 Anergen, Inc. Binding affinity of antigenic peptides for MHC molecules
US6281332B1 (en) * 1994-12-02 2001-08-28 The Johns Hopkins University School Of Medicine Hedgehog-derived polypeptides
US5869602A (en) * 1995-03-17 1999-02-09 Novo Nordisk A/S Peptide derivatives
IL129295A0 (en) * 1996-10-07 2000-02-17 Univ Johns Hopkins Med Novel hedgehog-derived polypeptides
MXPA00005494A (es) 1997-12-03 2003-05-19 Curis Inc Composiciones de proteina hidrofobicamente modificada y metodos.

Also Published As

Publication number Publication date
NO20002789D0 (no) 2000-05-31
ES2243018T3 (es) 2005-11-16
AU757497B2 (en) 2003-02-20
IL136137A (en) 2009-09-22
IL136137A0 (en) 2001-05-20
EP1036092B1 (en) 2005-05-11
DE69830192D1 (de) 2005-06-16
PT1036092E (pt) 2005-09-30
NO20002789L (no) 2000-08-02
KR20010032753A (ko) 2001-04-25
EE200000308A (et) 2001-10-15
EA200000605A1 (ru) 2000-12-25
JP4289788B2 (ja) 2009-07-01
WO1999028343A2 (en) 1999-06-10
AU1996699A (en) 1999-06-16
EA003739B1 (ru) 2003-08-28
HK1030953A1 (en) 2001-05-25
IS2163B (is) 2006-11-15
WO1999028343A9 (en) 1999-10-14
US6444793B1 (en) 2002-09-03
CZ20002008A3 (cs) 2001-11-14
WO1999028343A3 (en) 1999-08-12
HUP0100535A3 (en) 2003-09-29
PL341430A1 (en) 2001-04-09
NZ504752A (en) 2002-10-25
JP2001525336A (ja) 2001-12-11
BR9815142A (pt) 2000-10-10
PL197833B1 (pl) 2008-04-30
DE69830192T2 (de) 2006-01-12
HUP0100535A2 (hu) 2001-06-28
EP1036092A2 (en) 2000-09-20
CA2309806A1 (en) 1999-06-10
MXPA00005494A (es) 2003-05-19
ATE295372T1 (de) 2005-05-15
CN1294595A (zh) 2001-05-09
DK1036092T3 (da) 2005-08-15
IS5499A (is) 2000-05-15

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