BR9815142A - "proteìna isolada e modificada; vesicula; método de geração de um complexo proteìco multivalente; de modificação de uma proteìna; de tratamento de um disturbio neurológico; de alteração do estado de crescimento de uma célula; complexo proteìco; polipeptideo de ouriço; polipeptideo de ouriço modificado; proteìna sintética recombinante e uso terapêutico da proteìna" - Google Patents

"proteìna isolada e modificada; vesicula; método de geração de um complexo proteìco multivalente; de modificação de uma proteìna; de tratamento de um disturbio neurológico; de alteração do estado de crescimento de uma célula; complexo proteìco; polipeptideo de ouriço; polipeptideo de ouriço modificado; proteìna sintética recombinante e uso terapêutico da proteìna"

Info

Publication number
BR9815142A
BR9815142A BR9815142-8A BR9815142A BR9815142A BR 9815142 A BR9815142 A BR 9815142A BR 9815142 A BR9815142 A BR 9815142A BR 9815142 A BR9815142 A BR 9815142A
Authority
BR
Brazil
Prior art keywords
protein
modified
hedgehog polypeptide
complex
vesicle
Prior art date
Application number
BR9815142-8A
Other languages
English (en)
Inventor
Blake R Pepinsky
Darren P Baker
Dingyi Wen
Kevin P Williams
Ellen A Garber
Frederick R Taylor
Alphonse Galdes
Jeffrey Porter
Original Assignee
Biogen Inc
Ontogeny Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Inc, Ontogeny Inc filed Critical Biogen Inc
Publication of BR9815142A publication Critical patent/BR9815142A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Graft Or Block Polymers (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

<B>"PROTEìNA ISOLADA E MODIFICADA; VESICULA; METODO DE GERAçãO DE UM COMPLEXO PROTEICO MULTIVALENTE; DE MODIFICAçãO DE UMA PROTEìNA; DE TRATAMENTO DE UM DISTURBIO NEUROLóGICO; DE ALTERAçãO DO ESTADO DE CRESCIMENTO DE UMA CéLULA; COMPLEXO PROTEICO; POLIPEPTIDEO DE OURIçO; POLIPEPTIDEO DE OURIçO MODIFICADO; PROTEINA SINTéTICA RECOMBINANTE E USO TERAPEUTICO DA PROTEìNA"<D> Proteínas modificadas hidrofobicamente e métodos para produzi-las são descritas. Uma porção hidrofóbica é anexada à uma superfície de resíduo de amino-ácido. A porção hidrofóbica pode ser um lipídio ou um peptídeo. Alternativamente a proteína pode ser derivatizada por uma larga variedade de reações quimicas que depende de uma estrutura hidrofóbica para as proteínas. A proteína preferidfa é a de origem mamífera e, é selecionada a partir de um grupo consistido em ouriço (hedgehog) Sonic, Indian e Desert. A porção hidrofóbica é usada como um conveniente teste no local pode ser anexada uma vesícula tal como membrana celular, lipossoma ou micela.
BR9815142-8A 1997-12-03 1998-12-03 "proteìna isolada e modificada; vesicula; método de geração de um complexo proteìco multivalente; de modificação de uma proteìna; de tratamento de um disturbio neurológico; de alteração do estado de crescimento de uma célula; complexo proteìco; polipeptideo de ouriço; polipeptideo de ouriço modificado; proteìna sintética recombinante e uso terapêutico da proteìna" BR9815142A (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6742397P 1997-12-03 1997-12-03
US7893598P 1998-03-20 1998-03-20
US8968598P 1998-06-17 1998-06-17
US9980098P 1998-09-10 1998-09-10
PCT/US1998/025676 WO1999028343A2 (en) 1997-12-03 1998-12-03 Hydrophobically-modified protein compositions and methods

Publications (1)

Publication Number Publication Date
BR9815142A true BR9815142A (pt) 2000-10-10

Family

ID=27490628

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9815142-8A BR9815142A (pt) 1997-12-03 1998-12-03 "proteìna isolada e modificada; vesicula; método de geração de um complexo proteìco multivalente; de modificação de uma proteìna; de tratamento de um disturbio neurológico; de alteração do estado de crescimento de uma célula; complexo proteìco; polipeptideo de ouriço; polipeptideo de ouriço modificado; proteìna sintética recombinante e uso terapêutico da proteìna"

Country Status (26)

Country Link
US (1) US6444793B1 (pt)
EP (1) EP1036092B1 (pt)
JP (1) JP4289788B2 (pt)
KR (1) KR20010032753A (pt)
CN (1) CN1294595A (pt)
AT (1) ATE295372T1 (pt)
AU (1) AU757497B2 (pt)
BR (1) BR9815142A (pt)
CA (1) CA2309806A1 (pt)
CZ (1) CZ20002008A3 (pt)
DE (1) DE69830192T2 (pt)
DK (1) DK1036092T3 (pt)
EA (1) EA003739B1 (pt)
EE (1) EE200000308A (pt)
ES (1) ES2243018T3 (pt)
HK (1) HK1030953A1 (pt)
HU (1) HUP0100535A3 (pt)
IL (2) IL136137A0 (pt)
IS (1) IS2163B (pt)
MX (1) MXPA00005494A (pt)
NO (1) NO20002789L (pt)
NZ (1) NZ504752A (pt)
PL (1) PL197833B1 (pt)
PT (1) PT1036092E (pt)
TR (1) TR200001612T2 (pt)
WO (1) WO1999028343A2 (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU752816B2 (en) * 1997-11-28 2002-10-03 Curis, Inc. An active hedgehog-protein-mutant, a process for its preparation and its use for pharmaceutical purposes
US6897297B1 (en) 1997-12-03 2005-05-24 Curis, Inc. Hydrophobically-modified protein compositions and methods
NZ504752A (en) 1997-12-03 2002-10-25 Biogen Inc Hydrophobically-modified protein compositions (particularly hedgehog proteins)
EP1557427A3 (en) * 1998-04-30 2005-10-19 Curis, Inc. Hedgehog protein conjugate
TW570805B (en) 1998-09-01 2004-01-11 Hoffmann La Roche Water-soluble pharmaceutical composition in an ionic complex
AU765485B2 (en) * 1998-11-02 2003-09-18 Curis, Inc. Functional antagonists of hedgehog activity
CA2352570A1 (en) * 1998-12-03 2000-06-22 Biogen, Inc. Methods and compositions for treating disorders involving excitotoxicity
EP1025861A1 (de) * 1999-02-04 2000-08-09 Roche Diagnostics GmbH Pharmazeutische Zusammensetzung von hydrophob modifizierten Hedgehog-Proteinen und deren Verwendung
CA2375700A1 (en) * 1999-06-01 2000-12-07 Biogen, Inc. Polymer conjugates of hedgehog proteins and uses
AU2005203058C1 (en) * 1999-11-05 2009-07-02 Curis, Inc. Hedgehog fusion proteins and uses
IL149202A0 (en) * 1999-11-05 2002-11-10 Biogen Inc Hedgehog fusion proteins and uses
WO2001082994A1 (en) * 2000-04-28 2001-11-08 Curis, Inc. Methods and reagents for tissue engineering of cartilage in vitro
US20030235852A1 (en) * 2002-04-19 2003-12-25 Roberts Richard W. Nucleic acid-peptide display libraries containing peptides with unnatural amino acid residues, and methods of making same using peptide modifying agents
WO2006019904A1 (en) 2004-07-14 2006-02-23 University Of Utha Research Foundation Netrin-related compositions and uses
JPWO2006101273A1 (ja) * 2005-03-25 2008-09-04 武田薬品工業株式会社 癌の予防・治療剤
AU2006313464B2 (en) * 2005-11-11 2012-07-12 Proteogen Bio S.R.L. Method of converting water-soluble active proteins into hydrophobic active proteins, the use of the same for the preparation of monomolecular layers of oriented active proteins, and devices comprising the same
WO2008057468A1 (en) 2006-11-02 2008-05-15 Curis, Inc. Small organic molecule regulators of cell proliferation
KR100876657B1 (ko) * 2007-10-15 2009-01-07 한국기계연구원 표면개질된 마이크로비드와 마이크로비드 어레이칩의제조방법과 마이크로비드 어레이칩을 이용한 질병특이항원의 확인방법
EP2247613B1 (en) * 2008-02-21 2018-05-30 Dermacare Neuroscience Institute Cosmetic and dermatological formulations of mntf peptides
WO2009108868A2 (en) * 2008-02-27 2009-09-03 Radiomedix Inc. Radiolabeled hedgehog derivatives for imaging and therapy
UA107571C2 (xx) * 2009-04-03 2015-01-26 Фармацевтична композиція
CN103665095A (zh) * 2012-09-11 2014-03-26 中国人民解放军军事医学科学院卫生学环境医学研究所 一种疏水性多肽修饰抗体的合成方法
CN106924754B (zh) * 2015-12-30 2021-11-09 北京大学 聚氨基酸偶联物
CN108147990B (zh) * 2016-12-02 2023-01-24 上海中医药大学 一种膜锚定元件及其应用
IL302108A (en) 2017-10-25 2023-06-01 Ac Immune Sa Preparations of phosphorylated tau peptides and uses thereof

Family Cites Families (9)

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US5374548A (en) * 1986-05-02 1994-12-20 Genentech, Inc. Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor
US5399347A (en) 1987-06-24 1995-03-21 Autoimmune, Inc. Method of treating rheumatoid arthritis with type II collagen
US5409611A (en) * 1988-03-24 1995-04-25 Terrapin Technoogies, Inc. Method to identify analyte-binding ligands
US5130297A (en) 1988-06-23 1992-07-14 Anergen, Inc. Conjugates useful in ameliorating autoimmunity MHC-II-peptide
US5824315A (en) * 1993-10-25 1998-10-20 Anergen, Inc. Binding affinity of antigenic peptides for MHC molecules
US6281332B1 (en) * 1994-12-02 2001-08-28 The Johns Hopkins University School Of Medicine Hedgehog-derived polypeptides
US5869602A (en) * 1995-03-17 1999-02-09 Novo Nordisk A/S Peptide derivatives
JP2002503088A (ja) * 1996-10-07 2002-01-29 ザ ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン 新規ヘッジホッグ由来ポリペプチド
NZ504752A (en) 1997-12-03 2002-10-25 Biogen Inc Hydrophobically-modified protein compositions (particularly hedgehog proteins)

Also Published As

Publication number Publication date
JP4289788B2 (ja) 2009-07-01
JP2001525336A (ja) 2001-12-11
PL341430A1 (en) 2001-04-09
TR200001612T2 (tr) 2001-01-22
IL136137A0 (en) 2001-05-20
EA200000605A1 (ru) 2000-12-25
WO1999028343A2 (en) 1999-06-10
IL136137A (en) 2009-09-22
DE69830192D1 (de) 2005-06-16
EP1036092A2 (en) 2000-09-20
MXPA00005494A (es) 2003-05-19
NZ504752A (en) 2002-10-25
CZ20002008A3 (cs) 2001-11-14
EE200000308A (et) 2001-10-15
ES2243018T3 (es) 2005-11-16
AU757497B2 (en) 2003-02-20
IS5499A (is) 2000-05-15
DE69830192T2 (de) 2006-01-12
NO20002789D0 (no) 2000-05-31
EP1036092B1 (en) 2005-05-11
ATE295372T1 (de) 2005-05-15
NO20002789L (no) 2000-08-02
DK1036092T3 (da) 2005-08-15
IS2163B (is) 2006-11-15
HK1030953A1 (en) 2001-05-25
PL197833B1 (pl) 2008-04-30
WO1999028343A9 (en) 1999-10-14
WO1999028343A3 (en) 1999-08-12
CA2309806A1 (en) 1999-06-10
US6444793B1 (en) 2002-09-03
AU1996699A (en) 1999-06-16
CN1294595A (zh) 2001-05-09
HUP0100535A3 (en) 2003-09-29
PT1036092E (pt) 2005-09-30
HUP0100535A2 (hu) 2001-06-28
EA003739B1 (ru) 2003-08-28
KR20010032753A (ko) 2001-04-25

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