HUP0100535A2 - Módosított hidrofóbitású proteinkészítmények és eljárások előállításukra - Google Patents

Módosított hidrofóbitású proteinkészítmények és eljárások előállításukra

Info

Publication number
HUP0100535A2
HUP0100535A2 HU0100535A HUP0100535A HUP0100535A2 HU P0100535 A2 HUP0100535 A2 HU P0100535A2 HU 0100535 A HU0100535 A HU 0100535A HU P0100535 A HUP0100535 A HU P0100535A HU P0100535 A2 HUP0100535 A2 HU P0100535A2
Authority
HU
Hungary
Prior art keywords
proteins
modified
methods
subject
hydrophobicity
Prior art date
Application number
HU0100535A
Other languages
English (en)
Inventor
Darren P. Baker
Alphonse Galdes
Ellen A. Garber
R. Blake Pepinsky
Russell C. Petter
Jeffrey Porter
Kathryn L. Strauch
Frederick R. Taylor
Paul H. Weinrub
Dingyi Wen
Kevin P. Williams
Chenhui Zeng
Original Assignee
Biogen, Inc.
Ontogeny, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen, Inc., Ontogeny, Inc. filed Critical Biogen, Inc.
Publication of HUP0100535A2 publication Critical patent/HUP0100535A2/hu
Publication of HUP0100535A3 publication Critical patent/HUP0100535A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Graft Or Block Polymers (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

A találmány tárgyát - adott esetben hozzájuk kapcsolt vezikulákkal -módosított hidrofóbitású izolált proteinek képezik. A találmánytárgyát képezik továbbá eljárások multivalens proteinkomplexekelőállítására, proteinek fizikai-kémiai tulajdonságainak módosításáraés biológiai aktivitású proteinek módosítására. Szintén a találmánytárgyához tartoznak a találmány szerinti eljárásokkal létrehozottproteinkomplexek, illetve módosított proteinek, a módosítotthidrofóbitású proteinek gyógyászati alkalmazásai, valamint az egy vagytöbb lipofil gyökkel módosított hedgehog-polipeptidek. A találmányszerinti eljárás alkalmas proteinek hidrofóbitási sajátságainakmódosítására (pl. egy létező aminosavhoz hidrofób molekularésztkapcsolva vagy egy aminosavat hidrofób molekularésszel helyettesítve),miáltal növelhető a protein biológiai aktivitása és/vagy stabilitása. Ó
HU0100535A 1997-12-03 1998-12-03 Hydrophobically-modified protein compositions and methods HUP0100535A3 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6742397P 1997-12-03 1997-12-03
US7893598P 1998-03-20 1998-03-20
US8968598P 1998-06-17 1998-06-17
US9980098P 1998-09-10 1998-09-10
PCT/US1998/025676 WO1999028343A2 (en) 1997-12-03 1998-12-03 Hydrophobically-modified protein compositions and methods

Publications (2)

Publication Number Publication Date
HUP0100535A2 true HUP0100535A2 (hu) 2001-06-28
HUP0100535A3 HUP0100535A3 (en) 2003-09-29

Family

ID=27490628

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0100535A HUP0100535A3 (en) 1997-12-03 1998-12-03 Hydrophobically-modified protein compositions and methods

Country Status (26)

Country Link
US (1) US6444793B1 (hu)
EP (1) EP1036092B1 (hu)
JP (1) JP4289788B2 (hu)
KR (1) KR20010032753A (hu)
CN (1) CN1294595A (hu)
AT (1) ATE295372T1 (hu)
AU (1) AU757497B2 (hu)
BR (1) BR9815142A (hu)
CA (1) CA2309806A1 (hu)
CZ (1) CZ20002008A3 (hu)
DE (1) DE69830192T2 (hu)
DK (1) DK1036092T3 (hu)
EA (1) EA003739B1 (hu)
EE (1) EE200000308A (hu)
ES (1) ES2243018T3 (hu)
HK (1) HK1030953A1 (hu)
HU (1) HUP0100535A3 (hu)
IL (2) IL136137A0 (hu)
IS (1) IS2163B (hu)
MX (1) MXPA00005494A (hu)
NO (1) NO20002789L (hu)
NZ (1) NZ504752A (hu)
PL (1) PL197833B1 (hu)
PT (1) PT1036092E (hu)
TR (1) TR200001612T2 (hu)
WO (1) WO1999028343A2 (hu)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL136230A0 (en) * 1997-11-28 2001-05-20 Roche Diagnostics Gmbh An active hedgehog-protein-mutant, a process for its preparation and its use for pharmaceutical purposes
EP1036092B1 (en) 1997-12-03 2005-05-11 Biogen, Inc. Hydrophobically-modified hedgehog protein compositions and methods
US6897297B1 (en) * 1997-12-03 2005-05-24 Curis, Inc. Hydrophobically-modified protein compositions and methods
EP0953576B1 (en) * 1998-04-30 2005-11-02 Curis, Inc. Active hedgehog protein conjugate, process for its production and use
TW570805B (en) 1998-09-01 2004-01-11 Hoffmann La Roche Water-soluble pharmaceutical composition in an ionic complex
WO2000025725A2 (en) * 1998-11-02 2000-05-11 Biogen, Inc. Functional antagonists of hedgehog activity
IL143403A0 (en) * 1998-12-03 2002-04-21 Biogen Inc Methods and compositions for treating disorders involving excitotoxicity
EP1025861A1 (de) * 1999-02-04 2000-08-09 Roche Diagnostics GmbH Pharmazeutische Zusammensetzung von hydrophob modifizierten Hedgehog-Proteinen und deren Verwendung
AU782493B2 (en) * 1999-06-01 2005-08-04 Curis, Inc. Polymer conjugates of hedgehog proteins and uses
EP1230271A1 (en) 1999-11-05 2002-08-14 Biogen, Inc. Hedgehog fusion proteins and uses
AU2005203058C1 (en) * 1999-11-05 2009-07-02 Curis, Inc. Hedgehog fusion proteins and uses
WO2001082994A1 (en) * 2000-04-28 2001-11-08 Curis, Inc. Methods and reagents for tissue engineering of cartilage in vitro
US20030235852A1 (en) * 2002-04-19 2003-12-25 Roberts Richard W. Nucleic acid-peptide display libraries containing peptides with unnatural amino acid residues, and methods of making same using peptide modifying agents
US7456151B2 (en) 2004-07-14 2008-11-25 University Of Utah Research Foundation Promoting angiogenesis with netrin1 polypeptides
JPWO2006101273A1 (ja) * 2005-03-25 2008-09-04 武田薬品工業株式会社 癌の予防・治療剤
RU2420580C2 (ru) * 2005-11-11 2011-06-10 Протеоджен Био С.Р.Л. Способ преобразования водорастворимых активных белков в гидрофобные активные белки, их применение для получения мономолекулярных слоев ориентированных активных белков и устройства, включающие водорастворимые активные белки, преобразованные в гидрофобные активные белки
WO2008057468A1 (en) 2006-11-02 2008-05-15 Curis, Inc. Small organic molecule regulators of cell proliferation
KR100876657B1 (ko) * 2007-10-15 2009-01-07 한국기계연구원 표면개질된 마이크로비드와 마이크로비드 어레이칩의제조방법과 마이크로비드 어레이칩을 이용한 질병특이항원의 확인방법
EP2247613B1 (en) * 2008-02-21 2018-05-30 Dermacare Neuroscience Institute Cosmetic and dermatological formulations of mntf peptides
US20100316566A1 (en) * 2008-02-27 2010-12-16 Radiomedix Inc. Radiolabeled hedgehog derivatives for imaging and therapy
UA107571C2 (xx) * 2009-04-03 2015-01-26 Фармацевтична композиція
CN103665095A (zh) * 2012-09-11 2014-03-26 中国人民解放军军事医学科学院卫生学环境医学研究所 一种疏水性多肽修饰抗体的合成方法
CN106924753B (zh) * 2015-12-30 2021-11-09 北京大学 制备蛋白质-聚氨基酸环状偶联物的方法
CN108147990B (zh) * 2016-12-02 2023-01-24 上海中医药大学 一种膜锚定元件及其应用
MA50465A (fr) 2017-10-25 2020-09-02 Ac Immune Sa Compositions de peptides tau phosphorylés et leurs utilisations

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5374548A (en) * 1986-05-02 1994-12-20 Genentech, Inc. Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor
US5399347A (en) 1987-06-24 1995-03-21 Autoimmune, Inc. Method of treating rheumatoid arthritis with type II collagen
US5409611A (en) * 1988-03-24 1995-04-25 Terrapin Technoogies, Inc. Method to identify analyte-binding ligands
US5130297A (en) 1988-06-23 1992-07-14 Anergen, Inc. Conjugates useful in ameliorating autoimmunity MHC-II-peptide
US5824315A (en) * 1993-10-25 1998-10-20 Anergen, Inc. Binding affinity of antigenic peptides for MHC molecules
US6281332B1 (en) * 1994-12-02 2001-08-28 The Johns Hopkins University School Of Medicine Hedgehog-derived polypeptides
US5869602A (en) * 1995-03-17 1999-02-09 Novo Nordisk A/S Peptide derivatives
EP0966478A4 (en) * 1996-10-07 2002-08-21 Univ Johns Hopkins Med NOVEL POLYPEPTIDES DERIVED FROM A HERISSON PROTEIN
EP1036092B1 (en) 1997-12-03 2005-05-11 Biogen, Inc. Hydrophobically-modified hedgehog protein compositions and methods

Also Published As

Publication number Publication date
EA200000605A1 (ru) 2000-12-25
PT1036092E (pt) 2005-09-30
WO1999028343A3 (en) 1999-08-12
KR20010032753A (ko) 2001-04-25
EE200000308A (et) 2001-10-15
IS5499A (is) 2000-05-15
WO1999028343A9 (en) 1999-10-14
JP2001525336A (ja) 2001-12-11
TR200001612T2 (tr) 2001-01-22
NZ504752A (en) 2002-10-25
PL341430A1 (en) 2001-04-09
EA003739B1 (ru) 2003-08-28
NO20002789D0 (no) 2000-05-31
MXPA00005494A (es) 2003-05-19
IS2163B (is) 2006-11-15
HUP0100535A3 (en) 2003-09-29
AU757497B2 (en) 2003-02-20
PL197833B1 (pl) 2008-04-30
ATE295372T1 (de) 2005-05-15
DE69830192T2 (de) 2006-01-12
WO1999028343A2 (en) 1999-06-10
BR9815142A (pt) 2000-10-10
IL136137A0 (en) 2001-05-20
AU1996699A (en) 1999-06-16
CA2309806A1 (en) 1999-06-10
DK1036092T3 (da) 2005-08-15
EP1036092B1 (en) 2005-05-11
CN1294595A (zh) 2001-05-09
JP4289788B2 (ja) 2009-07-01
NO20002789L (no) 2000-08-02
IL136137A (en) 2009-09-22
US6444793B1 (en) 2002-09-03
HK1030953A1 (en) 2001-05-25
DE69830192D1 (de) 2005-06-16
EP1036092A2 (en) 2000-09-20
ES2243018T3 (es) 2005-11-16
CZ20002008A3 (cs) 2001-11-14

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Legal Events

Date Code Title Description
GB9A Succession in title

Owner name: CURIS, INC., US

Free format text: FORMER OWNER(S): BIOGEN, INC., US; ONTOGENY, INC., US

Owner name: BIOGEN IDEC MA INC., US

Free format text: FORMER OWNER(S): BIOGEN, INC., US; ONTOGENY, INC., US

FD9A Lapse of provisional protection due to non-payment of fees