ATE236984T1 - Verfahren zur herstellung von hydrophoben polypeptiden, proteinen und peptiden - Google Patents
Verfahren zur herstellung von hydrophoben polypeptiden, proteinen und peptidenInfo
- Publication number
- ATE236984T1 ATE236984T1 AT94109676T AT94109676T ATE236984T1 AT E236984 T1 ATE236984 T1 AT E236984T1 AT 94109676 T AT94109676 T AT 94109676T AT 94109676 T AT94109676 T AT 94109676T AT E236984 T1 ATE236984 T1 AT E236984T1
- Authority
- AT
- Austria
- Prior art keywords
- proteins
- peptides
- hydrophobic polypeptides
- producing hydrophobic
- purification
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Hospice & Palliative Care (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP93110755 | 1993-07-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE236984T1 true ATE236984T1 (de) | 2003-04-15 |
Family
ID=8213046
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT94109676T ATE236984T1 (de) | 1993-07-06 | 1994-06-23 | Verfahren zur herstellung von hydrophoben polypeptiden, proteinen und peptiden |
Country Status (14)
Country | Link |
---|---|
US (1) | US5750374A (de) |
EP (2) | EP0641861B1 (de) |
JP (2) | JP2947401B2 (de) |
CN (3) | CN1916017A (de) |
AT (1) | ATE236984T1 (de) |
AU (1) | AU666274B2 (de) |
CA (1) | CA2125467C (de) |
DE (1) | DE69432449T2 (de) |
DK (1) | DK0641861T3 (de) |
ES (1) | ES2194017T3 (de) |
NZ (1) | NZ260907A (de) |
PT (1) | PT641861E (de) |
RU (1) | RU94023251A (de) |
ZA (1) | ZA944686B (de) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6303567B1 (en) | 1995-03-14 | 2001-10-16 | Praecis Pharmaceuticals, Inc . | Modulators of β-amyloid peptide aggregation comprising D-amino acids |
US5854204A (en) * | 1995-03-14 | 1998-12-29 | Praecis Pharmaceuticals, Inc. | Aβ peptides that modulate β-amyloid aggregation |
US5817626A (en) * | 1995-03-14 | 1998-10-06 | Praecis Pharmaceuticals Incorporated | Modulators of beta-amyloid peptide aggregation |
US5854215A (en) * | 1995-03-14 | 1998-12-29 | Praecis Pharmaceuticals Incorporated | Modulators of β-amyloid peptide aggregation |
GB9618952D0 (en) | 1996-09-11 | 1996-10-23 | Sandoz Ltd | Process |
US5985242A (en) * | 1995-10-27 | 1999-11-16 | Praecis Pharmaceuticals, Inc. | Modulators of β-amyloid peptide aggregation comprising D-amino acids |
US6277826B1 (en) | 1996-08-27 | 2001-08-21 | Praecis Pharmaceuticals, Inc. | Modulators of β-amyloid peptide aggregation comprising D-amino acids |
NZ514414A (en) | 1999-03-04 | 2004-02-27 | Praecis Pharm Inc | Modulators of beta-amyloid peptide aggregation comprising D-amino acids |
EP1187920A2 (de) | 1999-06-09 | 2002-03-20 | Arch Development Corporation | Rekombinante prionänhliche gene, proteine, materialien und verfahren davon |
CA2387646A1 (en) * | 1999-10-21 | 2001-04-26 | Kalobios, Inc. | A general method for optimizing the expression of heterologous proteins |
US7799561B2 (en) * | 2002-06-12 | 2010-09-21 | Sigma-Aldrich, Co. | Affinity peptides and method for purification of recombinant proteins |
FR2859221B1 (fr) * | 2003-08-28 | 2005-10-14 | Centre Nat Rech Scient | Vecteur de co-expression de domaines membranaires de proteines d'enveloppe d'un virus et utilisations |
US7741053B2 (en) * | 2005-05-13 | 2010-06-22 | Sigma-Aldrich Co. | Processes for purification of recombinant proteins |
KR100621354B1 (ko) * | 2005-06-14 | 2006-09-08 | 광주과학기술원 | 유비퀴틴을 이용한 아밀로이드-베타 펩티드의 제조방법 |
WO2010063460A1 (en) * | 2008-12-02 | 2010-06-10 | Universität Zürich | Recombinant production of hydrophobic peptides and fusion proteins for use in producing same |
EP3199540A4 (de) * | 2014-09-26 | 2018-05-09 | Kaneka Corporation | Verfahren zur herstellung von hydrophoben peptiden |
US10118956B2 (en) | 2014-12-01 | 2018-11-06 | Pfenex Inc. | Fusion partners for peptide production |
CN105001307B (zh) * | 2015-07-31 | 2016-08-24 | 南京斯拜科生化实业有限公司 | 一种溶解难溶多肽的偶联肽链及其在液相色谱中分离纯化的应用 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0207044A1 (de) * | 1985-06-20 | 1986-12-30 | Monsanto Company | Freisetzung von Peptiden aus Polypeptiden |
ES2000859A6 (es) * | 1985-08-12 | 1988-03-16 | Syntex Inc | Un metodo para producir un vector de expresion bacteriana para la expresion de proteinas de fusion |
WO1987006005A1 (en) * | 1986-03-24 | 1987-10-08 | Ortho Pharmaceutical Corporation | Synthetic htlv-iii peptides, compositions and uses thereof |
CA1304886C (en) * | 1986-07-10 | 1992-07-07 | Heinz Dobeli | Metal chelate resins |
US5047513A (en) * | 1986-07-10 | 1991-09-10 | Hoffmann-La Roche Inc. | Metal chelate resins |
EP0289110A3 (de) * | 1987-02-02 | 1990-01-24 | Swiss Serum and Vaccine Institute Berne | Konjugierter Malaria-Impfstoff |
CA1340522C (en) * | 1987-03-10 | 1999-05-04 | Heinz Dobeli | Fusion proteins containing neighbouring histidines for improved purification |
US5416007A (en) * | 1987-03-20 | 1995-05-16 | Creative Biomolecules, Inc. | Enhanced proteolytic cleavage of recombinant fusion proteins |
US5124255A (en) * | 1988-03-11 | 1992-06-23 | Abbott Laboratories | CKS method of protein synthesis |
IT1226728B (it) * | 1988-08-05 | 1991-02-05 | Eniricerche Spa | Coniugato peptidico immunologicamente attivo utile come vaccino antimalaria e metodo di immunizzazione impiegante lo stesso |
US5045190A (en) * | 1988-11-08 | 1991-09-03 | Carbonell Ruben G | Chromatography apparatus |
US5387742A (en) * | 1990-06-15 | 1995-02-07 | Scios Nova Inc. | Transgenic mice displaying the amyloid-forming pathology of alzheimer's disease |
WO1992003474A1 (en) * | 1990-08-24 | 1992-03-05 | President And Fellows Of Harvard College | METHOD OF INTERFERING WITH FORMATION OF α-ANTICHYMOTRYPSIN-β-PROTEIN COMPLEX AND SYNTHETIC PEPTIDES FOR USE THEREIN |
EP0484787B1 (de) * | 1990-11-03 | 2001-10-10 | Dade Behring Marburg GmbH | HCV-spezifische Peptide, Mittel dazu und ihre Verwendung |
NZ243636A (en) * | 1991-07-29 | 1993-06-25 | Iaf Biochem Int | Immunoassay and kit for simultaneously detecting antibodies to hiv-1, hiv-2, htlv-1 and htlv-11 |
US5434050A (en) * | 1991-08-13 | 1995-07-18 | Regents Of The University Of Minnesota | Labelled β-amyloid peptide and methods of screening for Alzheimer's disease |
-
1994
- 1994-06-08 CA CA002125467A patent/CA2125467C/en not_active Expired - Fee Related
- 1994-06-23 EP EP94109676A patent/EP0641861B1/de not_active Expired - Lifetime
- 1994-06-23 ES ES94109676T patent/ES2194017T3/es not_active Expired - Lifetime
- 1994-06-23 PT PT94109676T patent/PT641861E/pt unknown
- 1994-06-23 AT AT94109676T patent/ATE236984T1/de not_active IP Right Cessation
- 1994-06-23 DE DE69432449T patent/DE69432449T2/de not_active Expired - Fee Related
- 1994-06-23 DK DK94109676T patent/DK0641861T3/da active
- 1994-06-23 EP EP03000052A patent/EP1304381A3/de not_active Withdrawn
- 1994-06-29 US US08/268,348 patent/US5750374A/en not_active Expired - Fee Related
- 1994-06-29 ZA ZA944686A patent/ZA944686B/xx unknown
- 1994-07-01 NZ NZ260907A patent/NZ260907A/en not_active IP Right Cessation
- 1994-07-01 AU AU66122/94A patent/AU666274B2/en not_active Ceased
- 1994-07-04 RU RU94023251/13A patent/RU94023251A/ru unknown
- 1994-07-04 CN CNA2006101006833A patent/CN1916017A/zh active Pending
- 1994-07-04 CN CNB99101393XA patent/CN100439391C/zh not_active Expired - Fee Related
- 1994-07-04 CN CN94108110A patent/CN1057535C/zh not_active Expired - Fee Related
- 1994-07-05 JP JP6153161A patent/JP2947401B2/ja not_active Expired - Fee Related
-
1998
- 1998-02-12 JP JP10030205A patent/JPH1143500A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
ES2194017T3 (es) | 2003-11-16 |
RU94023251A (ru) | 1996-05-10 |
ZA944686B (en) | 1995-01-06 |
AU6612294A (en) | 1995-01-27 |
CN1916017A (zh) | 2007-02-21 |
EP0641861A2 (de) | 1995-03-08 |
JP2947401B2 (ja) | 1999-09-13 |
CN1098416A (zh) | 1995-02-08 |
US5750374A (en) | 1998-05-12 |
EP0641861A3 (de) | 1997-07-30 |
CA2125467A1 (en) | 1995-01-07 |
DE69432449T2 (de) | 2004-04-08 |
JPH1143500A (ja) | 1999-02-16 |
EP1304381A3 (de) | 2003-05-02 |
EP0641861B1 (de) | 2003-04-09 |
NZ260907A (en) | 1996-06-25 |
CA2125467C (en) | 2001-02-06 |
PT641861E (pt) | 2003-07-31 |
DK0641861T3 (da) | 2003-07-28 |
AU666274B2 (en) | 1996-02-01 |
CN100439391C (zh) | 2008-12-03 |
CN1057535C (zh) | 2000-10-18 |
JPH07102000A (ja) | 1995-04-18 |
CN1227846A (zh) | 1999-09-08 |
DE69432449D1 (de) | 2003-05-15 |
EP1304381A2 (de) | 2003-04-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE236984T1 (de) | Verfahren zur herstellung von hydrophoben polypeptiden, proteinen und peptiden | |
DE69020143D1 (de) | Verfahren zur verwendung und herstellung von peptiden. | |
DE69433934D1 (de) | Verfahren und Zusammensetzungen zur erhöhten Proteinproduktion von rekombinanter DNA | |
DE60041119D1 (de) | Verfahren zur präsentation von (poly)peptiden/proteinen auf bakteriophagenpartikeln via disulfidbindungen | |
DE69122494D1 (de) | Vorrichtung zur transdermalen Applikation von Protein- oder Peptid-Medikamenten | |
DE69019074D1 (de) | Verfahren zur Fraktionierung von Plasmaproteinen. | |
NZ224057A (en) | A polypeptide of a vascular anticoagulant protein and method of preparation | |
ES550943A0 (es) | Un procedimiento para preparar una proteina de fusion derivada de la secuencia de aminoacidos de la preprorrelaxina humana. | |
DE68925275D1 (de) | Endotoxin-bindeprotein und dessen verwendung | |
ES2079621T3 (es) | Procedimiento de identificacion o de titulacion de proteinas y aplicaciones. | |
ES2123582T3 (es) | Proteina con capacidad de formacion de huesos y procedimiento para su produccion. | |
DE69010155D1 (de) | Verfahren zur Trennung von Aminosäuren. | |
ATE189232T1 (de) | Protein-s polypeptide und deren verwendungen | |
ATE139572T1 (de) | Verfahren zur reinigung von rekombinanten proteinen und dafür nützliche produkte | |
DE59702207D1 (de) | Verfahren zur eignungsprüfung von faktor viii-haltigen proteinfraktionen | |
DE59004279D1 (de) | Verfahren zur C-terminalen Modifizierung von Proteinen. | |
DE69328488D1 (de) | Peptide, analoge und ihre mischungen zur detektion und erzeugung von antikörpern gegen die e1 und e2 proteine des rubella virus | |
DE69531955D1 (de) | PROGRESSIVE ANDERUNG VON SIGNAL-PROTEINEN UND PEPTIDEn UND DIE HERGESTELLTEN SUPERAGONISTEN UND ANTAGONISTEN | |
DE69806747D1 (de) | Verfahren zur veresterung von aminosäuren und proteinen | |
DE3485883D1 (de) | Rekombinante materialien und verfahren zur herstellung von menschliche konnektive gewebe aktivierende peptide iii und deren analoge. | |
DE3888078D1 (de) | Veränderungsverfahren für Peptide und Proteine. | |
DE59407615D1 (de) | Verfahren zur Herstellung von Peptiden und Verwendung | |
DE69631054D1 (de) | Verfahren zur charakterisierung der feinstruktur von proteinbindungsstellen | |
ATE79651T1 (de) | Rekombinante materialien und verfahren zur herstellung von menschliche konnektive gewebe aktivierende peptide iii und deren analoge. | |
ATA37288A (de) | Verfahren zur auftrennung und reinigung von proteinfraktionen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 0641861 Country of ref document: EP |
|
REN | Ceased due to non-payment of the annual fee |