DE69806747D1 - Verfahren zur veresterung von aminosäuren und proteinen - Google Patents

Verfahren zur veresterung von aminosäuren und proteinen

Info

Publication number
DE69806747D1
DE69806747D1 DE69806747T DE69806747T DE69806747D1 DE 69806747 D1 DE69806747 D1 DE 69806747D1 DE 69806747 T DE69806747 T DE 69806747T DE 69806747 T DE69806747 T DE 69806747T DE 69806747 D1 DE69806747 D1 DE 69806747D1
Authority
DE
Germany
Prior art keywords
esterification
proteins
amino acids
acids
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69806747T
Other languages
English (en)
Other versions
DE69806747T2 (de
Inventor
Hubertus Boesten
Jan Quaedflieg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
DSM NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM NV filed Critical DSM NV
Application granted granted Critical
Publication of DE69806747D1 publication Critical patent/DE69806747D1/de
Publication of DE69806747T2 publication Critical patent/DE69806747T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C305/00—Esters of sulfuric acids
    • C07C305/02—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C305/04—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton being acyclic and saturated
    • C07C305/06—Hydrogenosulfates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69806747T 1997-04-25 1998-04-23 Verfahren zur veresterung von aminosäuren und proteinen Expired - Fee Related DE69806747T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL1005901A NL1005901C2 (nl) 1997-04-25 1997-04-25 Werkwijze voor de verestering van aminozuren en peptiden.
PCT/NL1998/000227 WO1998049133A1 (en) 1997-04-25 1998-04-23 Process for esterification of amino acids and peptides

Publications (2)

Publication Number Publication Date
DE69806747D1 true DE69806747D1 (de) 2002-08-29
DE69806747T2 DE69806747T2 (de) 2003-03-06

Family

ID=19764855

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69806747T Expired - Fee Related DE69806747T2 (de) 1997-04-25 1998-04-23 Verfahren zur veresterung von aminosäuren und proteinen

Country Status (8)

Country Link
US (1) US6222013B1 (de)
EP (1) EP0977726B1 (de)
JP (1) JP2001524107A (de)
AU (1) AU7085398A (de)
DE (1) DE69806747T2 (de)
ES (1) ES2178204T3 (de)
NL (1) NL1005901C2 (de)
WO (1) WO1998049133A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602006006326D1 (de) * 2005-10-20 2009-05-28 Dsm Ip Assets Bv Enzymatische umsetzung von oligopeptidamiden zu oligopeptidalkylestern
JP2012509089A (ja) * 2008-11-19 2012-04-19 ディーエスエム アイピー アセッツ ビー．ブイ． 酵素的活性化およびカップリングを使用したペプチド合成
WO2011113486A1 (en) 2010-03-17 2011-09-22 Deretil, S.A. Process for the synthesis of hydroxyphenylglycine esters

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2501677A1 (fr) * 1981-03-11 1982-09-17 Flork Michel Nouveau procede d'esterification d'amino-acides
PL159729B1 (pl) * 1989-04-10 1993-01-29 Sposób wytwarzania estru metylowego kwasu 3-aminopirazynokarboksylowego-2 PL
JPH05148199A (ja) 1991-11-28 1993-06-15 Ajinomoto Co Inc アミノ酸エステルの製造法

Also Published As

Publication number Publication date
JP2001524107A (ja) 2001-11-27
EP0977726B1 (de) 2002-07-24
EP0977726A1 (de) 2000-02-09
DE69806747T2 (de) 2003-03-06
WO1998049133A1 (en) 1998-11-05
ES2178204T3 (es) 2002-12-16
US6222013B1 (en) 2001-04-24
AU7085398A (en) 1998-11-24
NL1005901C2 (nl) 1998-10-27

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: DSM IP ASSETS B.V., HEERLEN, NL

8339 Ceased/non-payment of the annual fee