NL1005901C2 - Werkwijze voor de verestering van aminozuren en peptiden. - Google Patents

Werkwijze voor de verestering van aminozuren en peptiden. Download PDF

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Publication number
NL1005901C2
NL1005901C2 NL1005901A NL1005901A NL1005901C2 NL 1005901 C2 NL1005901 C2 NL 1005901C2 NL 1005901 A NL1005901 A NL 1005901A NL 1005901 A NL1005901 A NL 1005901A NL 1005901 C2 NL1005901 C2 NL 1005901C2
Authority
NL
Netherlands
Prior art keywords
amino acid
peptide
esterification
alcohol
acid
Prior art date
Application number
NL1005901A
Other languages
English (en)
Dutch (nl)
Inventor
Peter Jan Leonard M Quaedflieg
Wilhelmus Hubertus Jos Boesten
Original Assignee
Dsm Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Nv filed Critical Dsm Nv
Priority to NL1005901A priority Critical patent/NL1005901C2/nl
Priority to ES98917795T priority patent/ES2178204T3/es
Priority to PCT/NL1998/000227 priority patent/WO1998049133A1/en
Priority to AU70853/98A priority patent/AU7085398A/en
Priority to JP54684798A priority patent/JP2001524107A/ja
Priority to EP98917795A priority patent/EP0977726B1/de
Priority to DE69806747T priority patent/DE69806747T2/de
Application granted granted Critical
Publication of NL1005901C2 publication Critical patent/NL1005901C2/nl
Priority to US09/425,023 priority patent/US6222013B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C305/00—Esters of sulfuric acids
    • C07C305/02—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C305/04—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton being acyclic and saturated
    • C07C305/06—Hydrogenosulfates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NL1005901A 1997-04-25 1997-04-25 Werkwijze voor de verestering van aminozuren en peptiden. NL1005901C2 (nl)

Priority Applications (8)

Application Number Priority Date Filing Date Title
NL1005901A NL1005901C2 (nl) 1997-04-25 1997-04-25 Werkwijze voor de verestering van aminozuren en peptiden.
ES98917795T ES2178204T3 (es) 1997-04-25 1998-04-23 Procedimiento para la esterificacion de aminoacidos y peptidos.
PCT/NL1998/000227 WO1998049133A1 (en) 1997-04-25 1998-04-23 Process for esterification of amino acids and peptides
AU70853/98A AU7085398A (en) 1997-04-25 1998-04-23 Process for esterification of amino acids and peptides
JP54684798A JP2001524107A (ja) 1997-04-25 1998-04-23 アミノ酸およびペプチドのエステル化法
EP98917795A EP0977726B1 (de) 1997-04-25 1998-04-23 Verfahren zur veresterung von aminosäuren und proteinen
DE69806747T DE69806747T2 (de) 1997-04-25 1998-04-23 Verfahren zur veresterung von aminosäuren und proteinen
US09/425,023 US6222013B1 (en) 1997-04-25 1999-10-25 Process for esterification of amino

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL1005901 1997-04-25
NL1005901A NL1005901C2 (nl) 1997-04-25 1997-04-25 Werkwijze voor de verestering van aminozuren en peptiden.

Publications (1)

Publication Number Publication Date
NL1005901C2 true NL1005901C2 (nl) 1998-10-27

Family

ID=19764855

Family Applications (1)

Application Number Title Priority Date Filing Date
NL1005901A NL1005901C2 (nl) 1997-04-25 1997-04-25 Werkwijze voor de verestering van aminozuren en peptiden.

Country Status (8)

Country Link
US (1) US6222013B1 (de)
EP (1) EP0977726B1 (de)
JP (1) JP2001524107A (de)
AU (1) AU7085398A (de)
DE (1) DE69806747T2 (de)
ES (1) ES2178204T3 (de)
NL (1) NL1005901C2 (de)
WO (1) WO1998049133A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602006006326D1 (de) * 2005-10-20 2009-05-28 Dsm Ip Assets Bv Enzymatische umsetzung von oligopeptidamiden zu oligopeptidalkylestern
JP2012509089A (ja) * 2008-11-19 2012-04-19 ディーエスエム アイピー アセッツ ビー．ブイ． 酵素的活性化およびカップリングを使用したペプチド合成
WO2011113486A1 (en) 2010-03-17 2011-09-22 Deretil, S.A. Process for the synthesis of hydroxyphenylglycine esters

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2501677A1 (fr) * 1981-03-11 1982-09-17 Flork Michel Nouveau procede d'esterification d'amino-acides
PL159729B1 (pl) * 1989-04-10 1993-01-29 Sposób wytwarzania estru metylowego kwasu 3-aminopirazynokarboksylowego-2 PL
EP0544205A2 (de) * 1991-11-28 1993-06-02 Ajinomoto Co., Inc. Verfahren zur Herstellung von Estern aus Aminosäuren

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2501677A1 (fr) * 1981-03-11 1982-09-17 Flork Michel Nouveau procede d'esterification d'amino-acides
PL159729B1 (pl) * 1989-04-10 1993-01-29 Sposób wytwarzania estru metylowego kwasu 3-aminopirazynokarboksylowego-2 PL
EP0544205A2 (de) * 1991-11-28 1993-06-02 Ajinomoto Co., Inc. Verfahren zur Herstellung von Estern aus Aminosäuren

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 107, no. 13, 28 September 1987, Columbus, Ohio, US; abstract no. 115953h, I. RUSEV ET AL: "Esterification of alpha-amino carboxylic acids with monomethyl sulfate" page 665; XP002050388 *
CHEMICAL ABSTRACTS, vol. 119, no. 11, 13 September 1993, Columbus, Ohio, US; abstract no. 117812h, R. A. EL-SAYED ET AL: "Some new reactions of cinnamoylmorpholine derivatives with amino acids" page 999; XP002050390 *
CHEMICAL ABSTRACTS, vol. 122, no. 7, 13 February 1995, Columbus, Ohio, US; abstract no. 81410w, A. WOLKSI ET AL: "Method for preparation of the methyl ester of 3-aminopyrazine-2-carboxylic acid" page 1097; XP002050389 *
DATABASE WPI Derwent World Patents Index; *
KHIM. IND., vol. 58, no. 10, 1986, pages 445 - 447 *
PAK. J. SCI. IND. RES., vol. 35, no. 11, 1992, pages 434 - 437 *

Also Published As

Publication number Publication date
JP2001524107A (ja) 2001-11-27
EP0977726B1 (de) 2002-07-24
EP0977726A1 (de) 2000-02-09
DE69806747T2 (de) 2003-03-06
WO1998049133A1 (en) 1998-11-05
ES2178204T3 (es) 2002-12-16
US6222013B1 (en) 2001-04-24
AU7085398A (en) 1998-11-24
DE69806747D1 (de) 2002-08-29

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Effective date: 20011101