DE69528128T2 - Rekombinante Chimäre Proteine und Verfahren zur deren Verwendung - Google Patents

Rekombinante Chimäre Proteine und Verfahren zur deren Verwendung

Info

Publication number
DE69528128T2
DE69528128T2 DE1995628128 DE69528128T DE69528128T2 DE 69528128 T2 DE69528128 T2 DE 69528128T2 DE 1995628128 DE1995628128 DE 1995628128 DE 69528128 T DE69528128 T DE 69528128T DE 69528128 T2 DE69528128 T2 DE 69528128T2
Authority
DE
Germany
Prior art keywords
methods
chimeric proteins
recombinant chimeric
recombinant
proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE1995628128
Other languages
English (en)
Other versions
DE69528128D1 (de
Inventor
Elliott A Gruskin
Pearl Espino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
United States Surgical Corp
Original Assignee
United States Surgical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by United States Surgical Corp filed Critical United States Surgical Corp
Application granted granted Critical
Publication of DE69528128D1 publication Critical patent/DE69528128D1/de
Publication of DE69528128T2 publication Critical patent/DE69528128T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4725—Proteoglycans, e.g. aggreccan
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE1995628128 1994-06-10 1995-06-12 Rekombinante Chimäre Proteine und Verfahren zur deren Verwendung Expired - Lifetime DE69528128T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25926394A 1994-06-10 1994-06-10

Publications (2)

Publication Number Publication Date
DE69528128D1 DE69528128D1 (de) 2002-10-17
DE69528128T2 true DE69528128T2 (de) 2003-03-13

Family

ID=22984241

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1995628128 Expired - Lifetime DE69528128T2 (de) 1994-06-10 1995-06-12 Rekombinante Chimäre Proteine und Verfahren zur deren Verwendung

Country Status (3)

Country Link
EP (1) EP0704532B1 (de)
CA (2) CA2712304C (de)
DE (1) DE69528128T2 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6352972B1 (en) * 1995-06-06 2002-03-05 Marcel E. Nimni Bone morphogenetic proteins and their use in bone growth
US5800811A (en) * 1995-06-06 1998-09-01 Hall; Frederick L. Artificial skin prepared from coclagen matrix containing transforming growth factor-β having a collagen binding site
DE19548476A1 (de) * 1995-12-22 1997-06-26 Bioph Biotech Entw Pharm Gmbh Zielgerichtete Verbindungen mit knorpel- und/oder knocheninduzierender Aktivität
US6492508B1 (en) * 1996-06-03 2002-12-10 United States Surgical Corp. A Division Of Tyco Healthcare Group Nucleic acids encoding extracellular matrix proteins
AU3668897A (en) * 1996-07-17 1998-02-09 University Of Medicine And Dentistry Of New Jersey Chimeric receptors for jak-stat signal transduction
WO1999012558A1 (en) * 1997-09-10 1999-03-18 Allegheny University Of The Health Sciences Inhibitors of collagen assembly
JP2000125872A (ja) * 1998-09-07 2000-05-09 Terumo Corp 三量体キメラタンパク質およびキメラタンパク質を含有するコラーゲンマトリックス
EP1177291A2 (de) 1999-04-30 2002-02-06 Biostratum, Inc. Laminin 8 und methoden zur verwendung
DE10020125A1 (de) * 2000-04-18 2001-10-25 Friedrich Schiller Uni Jena Bu Agens für den postoperativen Einsatz nach Entfernung von Knochentumoren
US7141392B2 (en) 2001-01-09 2006-11-28 Queen Mary And Westfield College Latent fusion protein
GB0100551D0 (en) * 2001-01-09 2001-02-21 Queen Mary & Westfield College Protein
WO2003035692A2 (en) * 2001-10-23 2003-05-01 The Victoria University Of Manchester Modified peptides and their uses
ATE500842T1 (de) 2002-05-04 2011-03-15 Acorda Therapeutics Inc Zusammensetzungen und verfahren zur förderung des neuronalen wachstums
ES2366333T3 (es) * 2002-08-15 2011-10-19 Acorda Therapeutics, Inc. Proteína quimérica.
GB0309064D0 (en) 2003-04-22 2003-05-28 Univ Manchester Modified peptides and their uses
US7959914B2 (en) 2003-05-16 2011-06-14 Acorda Therapeutics, Inc. Methods of reducing extravasation of inflammatory cells
MX348062B (es) 2003-05-16 2017-05-26 Acorda Therapeutics Inc Mutantes que degradan proteoglicanos para tratamiento del snc.
EP1571159A1 (de) 2004-03-04 2005-09-07 Bayerische Julius-Maximilians-Universität Würzburg Mutein von Knochenmorphogenetisches Protein und seine Verwendung
MXPA06013345A (es) 2004-05-18 2008-10-31 Acorda Therapeutics Inc Metodos para purificar condrointinasa y sus formulaciones estables.
WO2005113585A2 (en) * 2004-05-20 2005-12-01 Acceleron Pharma Inc. Modified tgf-beta superfamily polypeptides
EP1928490B8 (de) 2005-09-26 2012-10-03 Acorda Therapeutics, Inc. Zusammensetzungen und verfahren zur verwendung von chondroitinase-abci-mutanten
AU2007307736C1 (en) 2006-10-10 2014-04-10 Acorda Therapeutics, Inc. Compositions and methods of using chondroitinase ABCI mutants
CA2815267C (en) 2010-10-27 2019-06-25 Spiber Technologies Ab Spider silk fusion protein structures for binding to an organic target
EP2695894B1 (de) * 2011-04-08 2017-11-01 Osaka University Modifiziertes laminin und verwendung davon
CN104470607B (zh) 2012-05-02 2017-04-05 思百博技术股份公司 作为亲和配体的掺入有免疫球蛋白片段的蜘蛛丝融合蛋白结构
EP2844360B1 (de) 2012-05-02 2018-12-19 Spiber Technologies AB Spinnenseidenfusionsproteinstrukturen ohne repetitives fragment zur bindung an ein organisches target
US8969290B2 (en) 2012-06-26 2015-03-03 Worcester Polytechnic Institute Matrix scaffold with antimicrobial activity
WO2023200996A1 (en) * 2022-04-14 2023-10-19 Geltor, Inc. Compositions and methods for enhancing protein expression, solubility, and purification

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4761471A (en) 1980-08-04 1988-08-02 The Regents Of The University Of California Bone morphogenetic protein composition
US4294753A (en) 1980-08-04 1981-10-13 The Regents Of The University Of California Bone morphogenetic protein process
US4472840A (en) 1981-09-21 1984-09-25 Jefferies Steven R Method of inducing osseous formation by implanting bone graft material
US4563489A (en) 1984-02-10 1986-01-07 University Of California Biodegradable organic polymer delivery system for bone morphogenetic protein
JPH0662679B2 (ja) 1985-06-21 1994-08-17 新田ゼラチン株式会社 組織親和性コラ−ゲンとその製法
US5187076A (en) 1986-07-01 1993-02-16 Genetics Institute, Inc. DNA sequences encoding BMP-6 proteins
US5106748A (en) 1986-07-01 1992-04-21 Genetics Institute, Inc. Dna sequences encoding 5 proteins
US5013649A (en) 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
US5108922A (en) 1986-07-01 1992-04-28 Genetics Institute, Inc. DNA sequences encoding BMP-1 products
ZA874681B (en) 1986-07-01 1988-04-27 Genetics Inst Novel osteoinductive factors
EP0286239B1 (de) 1987-03-10 1996-03-13 New England Biolabs, Inc. Herstellung und Reinigung eines Proteins, das mit einem Bindungsprotein fusioniert ist
US5250302A (en) 1988-04-08 1993-10-05 Stryker Corporation Osteogenic devices
US5011691A (en) 1988-08-15 1991-04-30 Stryker Corporation Osteogenic devices
US5106626A (en) * 1988-10-11 1992-04-21 International Genetic Engineering, Inc. Osteogenic factors
US5168050A (en) 1990-05-24 1992-12-01 Genentech, Inc. Mammalian expression of the bone morphogenetic protein-2b using bmp2a/bmp2b fusion
WO1993000050A1 (en) 1991-06-21 1993-01-07 Genetics Institute, Inc. Pharmaceutical formulations of osteogenic proteins
US5171579A (en) 1991-10-11 1992-12-15 Genetics Institute, Inc. Formulations of blood clot-polymer matrix for delivery of osteogenic proteins
JP2829405B2 (ja) * 1991-10-14 1998-11-25 寳酒造株式会社 機能性ポリペプチド
EP0648239A4 (de) * 1992-07-02 1995-09-27 Collagen Corp Biovertragliches polymerkonjugat.

Also Published As

Publication number Publication date
CA2712304A1 (en) 1995-12-11
CA2151547A1 (en) 1995-12-11
EP0704532A2 (de) 1996-04-03
EP0704532B1 (de) 2002-09-11
EP0704532A3 (de) 1996-07-03
CA2151547C (en) 2010-10-12
CA2712304C (en) 2011-10-25
DE69528128D1 (de) 2002-10-17

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