BR0207325A - Métodos terapêuticos para doenças associadas com expressão diminuìda de gene de aop-1 ou aop-1 - Google Patents

Métodos terapêuticos para doenças associadas com expressão diminuìda de gene de aop-1 ou aop-1

Info

Publication number
BR0207325A
BR0207325A BR0207325-0A BR0207325A BR0207325A BR 0207325 A BR0207325 A BR 0207325A BR 0207325 A BR0207325 A BR 0207325A BR 0207325 A BR0207325 A BR 0207325A
Authority
BR
Brazil
Prior art keywords
aop
gene expression
diseases associated
therapeutic methods
decreased
Prior art date
Application number
BR0207325-0A
Other languages
English (en)
Inventor
Fumiyuki Hattori
Keijiro Sugimura
Mayumi Furuya
Original Assignee
Daiichi Suntory Pharma Co Ltd
Daiichi Suntory Biomedical Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Suntory Pharma Co Ltd, Daiichi Suntory Biomedical Res filed Critical Daiichi Suntory Pharma Co Ltd
Publication of BR0207325A publication Critical patent/BR0207325A/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C12N9/0004—Oxidoreductases (1.)
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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    • A—HUMAN NECESSITIES
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    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
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    • C12N2799/04—Uses of viruses as vector in vivo
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N2800/00—Detection or diagnosis of diseases
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    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/34—Genitourinary disorders
    • G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy

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Abstract

"MéTODOS TERAPêUTICOS PARA DOENçAS ASSOCIADAS COM EXPRESSãO DIMINUìDA DE GENE DE AOP-1 OU AOP-1". Revela-se um método profilático ou terapêutico para uma doença associada com expressão diminuída de gene de AOP-1 ou AOP-1, compreendendo (1) transfecção de um ácido nucléico codificando AOP-1 ou um ácido nucléico codificando um polipeptídeo tendo uma adição, extinção ou substituição de um ou mais aminoácidos quando comparado com a seq³ência de aminoácido de AOP-1 enquanto se retém a função de AOP-1, ou (2) administração de um material acentuando a expressão de gene de AOP-1, um material acentuando a produção de AOP-1 ou um material acentuando a função de AOP-1.
BR0207325-0A 2001-02-16 2002-02-18 Métodos terapêuticos para doenças associadas com expressão diminuìda de gene de aop-1 ou aop-1 BR0207325A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001041003 2001-02-16
PCT/JP2002/001358 WO2002064169A1 (fr) 2001-02-16 2002-02-18 Procedes de traitement de maladies en association avec la diminution de l'expression du gene aop-1 ou de aop-1 et remedes conçus pour ces maladies

Publications (1)

Publication Number Publication Date
BR0207325A true BR0207325A (pt) 2004-02-10

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BR0207325-0A BR0207325A (pt) 2001-02-16 2002-02-18 Métodos terapêuticos para doenças associadas com expressão diminuìda de gene de aop-1 ou aop-1

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Country Link
US (1) US7598228B2 (pt)
EP (1) EP1360965A4 (pt)
JP (1) JP4271445B2 (pt)
KR (1) KR100986225B1 (pt)
CN (1) CN1496271B (pt)
AU (1) AU2002233643B2 (pt)
BR (1) BR0207325A (pt)
CA (1) CA2438590A1 (pt)
IL (1) IL157364A0 (pt)
WO (1) WO2002064169A1 (pt)

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US7598228B2 (en) 2009-10-06
JPWO2002064169A1 (ja) 2004-06-10
EP1360965A1 (en) 2003-11-12
CN1496271B (zh) 2010-04-28
CN1496271A (zh) 2004-05-12
IL157364A0 (en) 2004-02-19
JP4271445B2 (ja) 2009-06-03
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AU2002233643B2 (en) 2007-07-26

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