ATE330224T1 - Funktionelles protein array - Google Patents
Funktionelles protein arrayInfo
- Publication number
- ATE330224T1 ATE330224T1 AT01956692T AT01956692T ATE330224T1 AT E330224 T1 ATE330224 T1 AT E330224T1 AT 01956692 T AT01956692 T AT 01956692T AT 01956692 T AT01956692 T AT 01956692T AT E330224 T1 ATE330224 T1 AT E330224T1
- Authority
- AT
- Austria
- Prior art keywords
- protein array
- functional protein
- proteins
- immobilised
- mrna
- Prior art date
Links
- 238000003498 protein array Methods 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 210000004671 cell-free system Anatomy 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 108020004999 messenger RNA Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 238000013518 transcription Methods 0.000 abstract 1
- 230000035897 transcription Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Wood Science & Technology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Light Receiving Elements (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0020016A GB0020016D0 (en) | 2000-08-15 | 2000-08-15 | Functional protein arrays |
GB0029309A GB0029309D0 (en) | 2000-12-01 | 2000-12-01 | Functional protein arrays |
GB0106610A GB0106610D0 (en) | 2001-03-16 | 2001-03-16 | Functional protein arrays |
GB0113883A GB0113883D0 (en) | 2001-06-07 | 2001-06-07 | Functional protein arrays |
GB0117232A GB0117232D0 (en) | 2001-07-14 | 2001-07-14 | Functional protein arrays |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE330224T1 true ATE330224T1 (de) | 2006-07-15 |
Family
ID=27515975
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01956692T ATE330224T1 (de) | 2000-08-15 | 2001-08-15 | Funktionelles protein array |
Country Status (12)
Country | Link |
---|---|
US (2) | US7674752B2 (de) |
EP (1) | EP1309861B1 (de) |
JP (1) | JP4719403B2 (de) |
AT (1) | ATE330224T1 (de) |
AU (2) | AU7861301A (de) |
CA (1) | CA2419490C (de) |
CY (1) | CY1105271T1 (de) |
DE (1) | DE60120713T2 (de) |
DK (1) | DK1309861T3 (de) |
ES (1) | ES2266224T3 (de) |
PT (1) | PT1309861E (de) |
WO (1) | WO2002014860A1 (de) |
Families Citing this family (82)
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---|---|---|---|---|
EP1360490B1 (de) * | 2001-01-23 | 2011-12-21 | President and Fellows of Harvard College | Nukleinsäure-programmierbare protein-arrays |
AU2002259137A1 (en) * | 2001-05-02 | 2002-11-11 | Sigma-Genosys, Ltd. | Methods for determining secondary modifications of molecules using arrays |
US7687437B2 (en) | 2001-07-13 | 2010-03-30 | Nanosphere, Inc. | Method for immobilizing molecules onto surfaces |
DE10145226A1 (de) * | 2001-09-13 | 2003-04-10 | Lifebits Ag | Herstellung von trägergebundenen Molekülen |
US7105347B2 (en) | 2002-07-30 | 2006-09-12 | Corning Incorporated | Method and device for protein delivery into cells |
JP2004105070A (ja) * | 2002-09-18 | 2004-04-08 | Inst Of Physical & Chemical Res | 無細胞タンパク質合成系を用いたリガンド結合タンパク質の製造方法及びその使用 |
US7691580B2 (en) | 2003-01-29 | 2010-04-06 | Corning Incorporated | Reverse protein delivery into cells on coded microparticles |
EP1660885B1 (de) * | 2003-08-07 | 2012-10-03 | CellFree Sciences Co., Ltd. | Reagens zur herstellung eines protein-chips |
EP1737982A4 (de) * | 2004-04-14 | 2009-09-23 | Harvard College | Nukleinsäureprogrammierbare proteinanordnungen |
EP1763589A1 (de) * | 2004-06-30 | 2007-03-21 | RiNA Netzwerk RNA-Technologien GmbH | Biochip-pausen |
US20090054255A1 (en) | 2004-07-01 | 2009-02-26 | The Regents Of The University Of California | Microfluidic devices and methods |
JPWO2006052016A1 (ja) * | 2004-11-12 | 2008-05-29 | 独立行政法人科学技術振興機構 | タンパク質合成法、固相固定化mRNA及びタンパク質合成装置 |
US20060234265A1 (en) * | 2005-03-21 | 2006-10-19 | Jim Richey | Microarrays having multi-functional, compartmentalized analysis areas and methods of use |
US20070003954A1 (en) * | 2005-05-12 | 2007-01-04 | The Board Of Regents Of The University Of Texas System | Protein and antibody profiling using small molecule microarrays |
GB0511717D0 (en) * | 2005-06-09 | 2005-07-13 | Babraham Inst | Repeatable protein arrays |
EP1757942A1 (de) * | 2005-08-26 | 2007-02-28 | Max-Delbrück-Centrum | Array für den Nachweis von Protein-Protein Interaktionen und Methode zu dessen Herstellung |
US8148302B2 (en) | 2005-10-19 | 2012-04-03 | The United States Of America As Represented By The Department Of Health And Human Services | In situ assembling of protein microarrays |
US7889347B2 (en) | 2005-11-21 | 2011-02-15 | Plexera Llc | Surface plasmon resonance spectrometer with an actuator driven angle scanning mechanism |
US7463358B2 (en) | 2005-12-06 | 2008-12-09 | Lumera Corporation | Highly stable surface plasmon resonance plates, microarrays, and methods |
US8178316B2 (en) | 2006-06-29 | 2012-05-15 | President And Fellows Of Harvard College | Evaluating proteins |
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WO2010127186A1 (en) | 2009-04-30 | 2010-11-04 | Prognosys Biosciences, Inc. | Nucleic acid constructs and methods of use |
CA2763685A1 (en) * | 2009-05-29 | 2010-12-02 | The Board Of Regents Of The University Of Texas System | Peptoid ligands for isolation and treatment of autoimmune t-cells |
CN102439451B (zh) * | 2009-06-02 | 2014-12-03 | 德克萨斯大学系统董事会 | 患神经退行性疾病的对象中抗体所识别的小分子的鉴定 |
WO2011047257A1 (en) * | 2009-10-16 | 2011-04-21 | The Board Of Regents Of The University Of Texas System | Compositions and methods for producing cyclic peptoid libraries |
US20190300945A1 (en) | 2010-04-05 | 2019-10-03 | Prognosys Biosciences, Inc. | Spatially Encoded Biological Assays |
US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
AU2011237729B2 (en) | 2010-04-05 | 2014-04-03 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
CN103221539A (zh) | 2010-08-27 | 2013-07-24 | 国立大学法人东京大学 | 蛋白质或胜肽的印刷方法、及蛋白质阵列或胜肽阵列、以及功能性蛋白质或功能性胜肽的鉴定方法 |
DE102011010307A1 (de) | 2011-02-03 | 2012-08-09 | Albert-Ludwigs-Universität Freiburg | Vorrichtung und Verfahren zur Erzeugung von Protein-Mikroarrays |
EP3150750B1 (de) | 2011-04-08 | 2018-12-26 | Prognosys Biosciences, Inc. | Peptidkonstrukte und testsysteme dafür |
GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
CN103765212A (zh) | 2011-06-27 | 2014-04-30 | 杰克逊实验室 | 治疗癌症和自体免疫性疾病的方法和组合物 |
CN104220877B (zh) * | 2011-08-26 | 2018-05-15 | 阿兰·马克·克莱费尔德 | 非结合胆红素的荧光探针的开发和应用 |
US8987174B2 (en) | 2011-10-28 | 2015-03-24 | Prognosys Biosciences, Inc. | Methods for manufacturing molecular arrays |
US9701959B2 (en) | 2012-02-02 | 2017-07-11 | Invenra Inc. | High throughput screen for biologically active polypeptides |
JP6015894B2 (ja) * | 2012-03-19 | 2016-10-26 | 国立大学法人埼玉大学 | タンパク質アレイの製造方法及びタンパク質アレイ |
EP3901280A1 (de) | 2012-10-17 | 2021-10-27 | Spatial Transcriptomics AB | Verfahren und produkt zur optimierung einer lokalisierten oder räumlichen detektion einer genexpression in einer gewebeprobe |
EP4036579A1 (de) * | 2013-03-15 | 2022-08-03 | Arizona Board of Regents on behalf of Arizona State University | Biosensor-mikroarrayzusammensetzungen und verfahren |
CN105358984B (zh) | 2013-03-15 | 2020-02-18 | 普罗格诺西斯生物科学公司 | 用于检测肽/mhc/tcr结合的方法 |
EP4234716A3 (de) | 2013-06-25 | 2023-12-06 | Prognosys Biosciences, Inc. | Verfahren zur bestimmung der räumlichen muster biologischer ziele in einer probe |
WO2015029714A1 (ja) | 2013-08-30 | 2015-03-05 | 国立大学法人東京大学 | タンパク質アレイ又はペプチドアレイの製造方法、機能性タンパク質又は機能性ペプチドの同定方法、タンパク質アレイ又はペプチドアレイ、及び、機能性タンパク質又は機能性ペプチド同定キット |
WO2015070037A2 (en) | 2013-11-08 | 2015-05-14 | Prognosys Biosciences, Inc. | Polynucleotide conjugates and methods for analyte detection |
US10584390B2 (en) | 2014-08-06 | 2020-03-10 | The Texas A&M University System | Tritrichomonas foetus nucleic acid detection methods |
CA2982146A1 (en) | 2015-04-10 | 2016-10-13 | Spatial Transcriptomics Ab | Spatially distinguished, multiplex nucleic acid analysis of biological specimens |
US11519033B2 (en) | 2018-08-28 | 2022-12-06 | 10X Genomics, Inc. | Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample |
US11926867B2 (en) | 2019-01-06 | 2024-03-12 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
US11649485B2 (en) | 2019-01-06 | 2023-05-16 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
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WO2021030268A2 (en) | 2019-08-09 | 2021-02-18 | Nutcracker Therapeutics, Inc. | Microfluidic apparatus and methods of use thereof |
WO2021092433A2 (en) | 2019-11-08 | 2021-05-14 | 10X Genomics, Inc. | Enhancing specificity of analyte binding |
WO2021091611A1 (en) | 2019-11-08 | 2021-05-14 | 10X Genomics, Inc. | Spatially-tagged analyte capture agents for analyte multiplexing |
ES2946357T3 (es) | 2019-12-23 | 2023-07-17 | 10X Genomics Inc | Métodos para el análisis espacial usando ligación con molde de ARN |
US11702693B2 (en) | 2020-01-21 | 2023-07-18 | 10X Genomics, Inc. | Methods for printing cells and generating arrays of barcoded cells |
US11732299B2 (en) | 2020-01-21 | 2023-08-22 | 10X Genomics, Inc. | Spatial assays with perturbed cells |
US11821035B1 (en) | 2020-01-29 | 2023-11-21 | 10X Genomics, Inc. | Compositions and methods of making gene expression libraries |
US12076701B2 (en) | 2020-01-31 | 2024-09-03 | 10X Genomics, Inc. | Capturing oligonucleotides in spatial transcriptomics |
US11898205B2 (en) | 2020-02-03 | 2024-02-13 | 10X Genomics, Inc. | Increasing capture efficiency of spatial assays |
US11732300B2 (en) | 2020-02-05 | 2023-08-22 | 10X Genomics, Inc. | Increasing efficiency of spatial analysis in a biological sample |
US11835462B2 (en) | 2020-02-11 | 2023-12-05 | 10X Genomics, Inc. | Methods and compositions for partitioning a biological sample |
US11891654B2 (en) | 2020-02-24 | 2024-02-06 | 10X Genomics, Inc. | Methods of making gene expression libraries |
US11926863B1 (en) | 2020-02-27 | 2024-03-12 | 10X Genomics, Inc. | Solid state single cell method for analyzing fixed biological cells |
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WO2021242834A1 (en) | 2020-05-26 | 2021-12-02 | 10X Genomics, Inc. | Method for resetting an array |
AU2021283184A1 (en) | 2020-06-02 | 2023-01-05 | 10X Genomics, Inc. | Spatial transcriptomics for antigen-receptors |
AU2021283174A1 (en) | 2020-06-02 | 2023-01-05 | 10X Genomics, Inc. | Nucleic acid library methods |
US12031177B1 (en) | 2020-06-04 | 2024-07-09 | 10X Genomics, Inc. | Methods of enhancing spatial resolution of transcripts |
EP4162074B1 (de) | 2020-06-08 | 2024-04-24 | 10X Genomics, Inc. | Verfahren zur bestimmung eines chirurgischen randes und verfahren zur verwendung davon |
EP4165207B1 (de) | 2020-06-10 | 2024-09-25 | 10X Genomics, Inc. | Verfahren zur bestimmung der position eines analyten in einer biologischen probe |
EP4172362B1 (de) | 2020-06-25 | 2024-09-18 | 10X Genomics, Inc. | Räumliche analyse der dna-methylierung |
US11761038B1 (en) | 2020-07-06 | 2023-09-19 | 10X Genomics, Inc. | Methods for identifying a location of an RNA in a biological sample |
US11981960B1 (en) | 2020-07-06 | 2024-05-14 | 10X Genomics, Inc. | Spatial analysis utilizing degradable hydrogels |
US11981958B1 (en) | 2020-08-20 | 2024-05-14 | 10X Genomics, Inc. | Methods for spatial analysis using DNA capture |
US11926822B1 (en) | 2020-09-23 | 2024-03-12 | 10X Genomics, Inc. | Three-dimensional spatial analysis |
US11827935B1 (en) | 2020-11-19 | 2023-11-28 | 10X Genomics, Inc. | Methods for spatial analysis using rolling circle amplification and detection probes |
EP4121555A1 (de) | 2020-12-21 | 2023-01-25 | 10X Genomics, Inc. | Verfahren, zusammensetzungen und systeme zur erfassung von sonden und/oder barcodes |
EP4301870A1 (de) | 2021-03-18 | 2024-01-10 | 10X Genomics, Inc. | Multiplex-erfassung von gen- und proteinexpression aus einer biologischen probe |
WO2022256503A1 (en) | 2021-06-03 | 2022-12-08 | 10X Genomics, Inc. | Methods, compositions, kits, and systems for enhancing analyte capture for spatial analysis |
WO2023034489A1 (en) | 2021-09-01 | 2023-03-09 | 10X Genomics, Inc. | Methods, compositions, and kits for blocking a capture probe on a spatial array |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5843701A (en) * | 1990-08-02 | 1998-12-01 | Nexstar Pharmaceticals, Inc. | Systematic polypeptide evolution by reverse translation |
JPH1025299A (ja) | 1996-07-12 | 1998-01-27 | Nec Corp | 整列ペプチド、及びそれを用いたタンパク質の結合・相互作用部位検出方法 |
CN1238366C (zh) | 1997-01-21 | 2006-01-25 | 综合医院公司 | 利用rna-蛋白融合体筛选蛋白 |
US6207370B1 (en) * | 1997-09-02 | 2001-03-27 | Sequenom, Inc. | Diagnostics based on mass spectrometric detection of translated target polypeptides |
US6087102A (en) | 1998-01-07 | 2000-07-11 | Clontech Laboratories, Inc. | Polymeric arrays and methods for their use in binding assays |
US6406921B1 (en) * | 1998-07-14 | 2002-06-18 | Zyomyx, Incorporated | Protein arrays for high-throughput screening |
AU775997B2 (en) | 1998-12-02 | 2004-08-19 | Bristol-Myers Squibb Company | DNA-protein fusions and uses thereof |
JP2003519495A (ja) | 2000-01-11 | 2003-06-24 | マキシジェン, インコーポレイテッド | 多様性生成およびスクリーニングのための一体化されたシステムおよび方法 |
EP1360490B1 (de) | 2001-01-23 | 2011-12-21 | President and Fellows of Harvard College | Nukleinsäure-programmierbare protein-arrays |
-
2001
- 2001-08-15 ES ES01956692T patent/ES2266224T3/es not_active Expired - Lifetime
- 2001-08-15 DE DE60120713T patent/DE60120713T2/de not_active Expired - Lifetime
- 2001-08-15 WO PCT/GB2001/003657 patent/WO2002014860A1/en active IP Right Grant
- 2001-08-15 PT PT01956692T patent/PT1309861E/pt unknown
- 2001-08-15 AU AU7861301A patent/AU7861301A/xx active Pending
- 2001-08-15 JP JP2002519938A patent/JP4719403B2/ja not_active Expired - Fee Related
- 2001-08-15 CA CA2419490A patent/CA2419490C/en not_active Expired - Fee Related
- 2001-08-15 AU AU2001278613A patent/AU2001278613B2/en not_active Ceased
- 2001-08-15 US US10/344,607 patent/US7674752B2/en not_active Expired - Fee Related
- 2001-08-15 EP EP01956692A patent/EP1309861B1/de not_active Expired - Lifetime
- 2001-08-15 DK DK01956692T patent/DK1309861T3/da active
- 2001-08-15 AT AT01956692T patent/ATE330224T1/de not_active IP Right Cessation
-
2006
- 2006-08-30 CY CY20061101233T patent/CY1105271T1/el unknown
-
2009
- 2009-01-09 US US12/351,465 patent/US20110245093A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20040161748A1 (en) | 2004-08-19 |
US7674752B2 (en) | 2010-03-09 |
US20110245093A1 (en) | 2011-10-06 |
PT1309861E (pt) | 2006-10-31 |
CY1105271T1 (el) | 2010-03-03 |
EP1309861A1 (de) | 2003-05-14 |
JP2004506898A (ja) | 2004-03-04 |
DK1309861T3 (da) | 2006-10-23 |
CA2419490C (en) | 2010-01-26 |
AU7861301A (en) | 2002-02-25 |
DE60120713D1 (de) | 2006-07-27 |
WO2002014860A1 (en) | 2002-02-21 |
WO2002014860A8 (en) | 2002-06-06 |
JP4719403B2 (ja) | 2011-07-06 |
CA2419490A1 (en) | 2002-02-21 |
ES2266224T3 (es) | 2007-03-01 |
DE60120713T2 (de) | 2007-06-06 |
AU2001278613B2 (en) | 2006-09-07 |
EP1309861B1 (de) | 2006-06-14 |
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