IL132809A0 - 4"-Substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives - Google Patents

4"-Substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives

Info

Publication number
IL132809A0
IL132809A0 IL13280998A IL13280998A IL132809A0 IL 132809 A0 IL132809 A0 IL 132809A0 IL 13280998 A IL13280998 A IL 13280998A IL 13280998 A IL13280998 A IL 13280998A IL 132809 A0 IL132809 A0 IL 132809A0
Authority
IL
Israel
Prior art keywords
homoerythromycin
deoxo
aza
derivatives
substituted
Prior art date
Application number
IL13280998A
Other languages
English (en)
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21959336&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL132809(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of IL132809A0 publication Critical patent/IL132809A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL13280998A 1997-06-11 1998-05-29 4"-Substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives IL132809A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4934897P 1997-06-11 1997-06-11
PCT/IB1998/000839 WO1998056802A1 (en) 1997-06-11 1998-05-29 4'-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives

Publications (1)

Publication Number Publication Date
IL132809A0 true IL132809A0 (en) 2001-03-19

Family

ID=21959336

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13280998A IL132809A0 (en) 1997-06-11 1998-05-29 4"-Substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives

Country Status (50)

Country Link
US (4) US6420536B1 (bg)
EP (1) EP0988310B9 (bg)
JP (2) JP3315704B2 (bg)
KR (1) KR100396168B1 (bg)
CN (4) CN1243766C (bg)
AP (1) AP1231A (bg)
AR (1) AR013086A1 (bg)
AT (1) ATE251173T1 (bg)
AU (1) AU749816B2 (bg)
BG (1) BG64391B1 (bg)
BR (1) BRPI9810519B8 (bg)
CA (1) CA2293823C (bg)
CO (1) CO4950611A1 (bg)
CZ (1) CZ298556B6 (bg)
DE (2) DE69818665T2 (bg)
DK (1) DK0988310T3 (bg)
DZ (1) DZ2514A1 (bg)
EA (1) EA002441B1 (bg)
EG (1) EG24081A (bg)
ES (1) ES2205487T3 (bg)
FR (1) FR04C0013I2 (bg)
GT (1) GT199800077A (bg)
HK (3) HK1028048A1 (bg)
HN (1) HN1998000086A (bg)
HR (1) HRP980314B1 (bg)
HU (2) HU228005B1 (bg)
ID (1) ID22992A (bg)
IL (1) IL132809A0 (bg)
IS (1) IS1998B (bg)
LU (1) LU91076I9 (bg)
MA (1) MA24564A1 (bg)
ME (1) ME00876B (bg)
MY (1) MY123354A (bg)
NL (1) NL300150I2 (bg)
NO (1) NO316911B1 (bg)
NZ (2) NZ514871A (bg)
OA (1) OA11224A (bg)
PA (1) PA8452201A1 (bg)
PE (1) PE79699A1 (bg)
PL (1) PL191601B1 (bg)
PT (1) PT988310E (bg)
RS (1) RS49675B (bg)
SI (1) SI0988310T1 (bg)
SK (1) SK284171B6 (bg)
TN (1) TNSN98082A1 (bg)
TW (1) TW472060B (bg)
UA (1) UA67744C2 (bg)
UY (1) UY25040A1 (bg)
WO (1) WO1998056802A1 (bg)
ZA (1) ZA985017B (bg)

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HN1998000086A (es) 1997-06-11 1999-03-08 Pfizer Prod Inc Derivados de 9 - desofo - 9 aza - 9a - homoeritromicina a - c - 4 sustituidos.
EP1779853A3 (en) * 1997-09-10 2010-01-27 Merial Ltd. 9a-azalides as veterinary antimicrobial agents
US6339063B1 (en) 1997-09-10 2002-01-15 Merck & Co., Inc. 9a-azalides as veterinary antimicrobial agents
JP2001515865A (ja) * 1997-09-10 2001-09-25 メルク エンド カムパニー インコーポレーテッド 家畜抗菌剤としての９ａ−アザライド
AP9801420A0 (en) * 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.
US6043227A (en) * 1998-08-19 2000-03-28 Pfizer Inc. C11 carbamates of macrolide antibacterials
EP1437360A3 (en) * 1998-08-19 2005-04-06 Pfizer Products Inc. C11 Carbamates of macrolide antibacterials
US6100240A (en) * 1998-10-09 2000-08-08 Pfizer Inc Macrolide derivatives
CA2411293A1 (en) * 1999-01-28 2000-07-28 Pfizer Products Inc. Novel azalides and methods of making same
PT1189912E (pt) * 1999-05-18 2008-05-16 Pfizer Prod Inc Novas formas cristalinas de um antibiótico macrólido
AP2001002302A0 (en) * 1999-05-24 2001-10-25 Pfizer Prod Inc 13-Methyl erythromycin derivatives.
US6465437B1 (en) 1999-06-30 2002-10-15 Pfizer Inc. Diphosphate salt of a 4″-substituted-9-deoxo-9A-AZA-9A- homoerythromycin derivative and its pharmaceutical composition
US6764996B1 (en) 1999-08-24 2004-07-20 Abbott Laboratories 9a-azalides with antibacterial activity
EP1206476B1 (en) * 1999-08-24 2006-01-04 Abbott Laboratories 9a-azalides with antibacterial activity
US6608033B1 (en) 1999-08-27 2003-08-19 Pfizer Inc. Treatment or prevention of coccidiosis
CA2398485C (en) * 2000-01-27 2008-01-29 Pfizer Products Inc. Azalide antibiotic compositions
OA12257A (en) * 2000-04-27 2003-11-06 Pfizer Prod Inc the use of azalide antibiotic compositions for treating or preventing a bacterial or protozoal infection in mammals.
WO2002088158A1 (en) * 2001-04-27 2002-11-07 Pfizer Products Inc. Process for preparing 4'-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives
AU2002317415A1 (en) * 2001-08-01 2003-02-17 Pfizer Products Inc. Azalide antibiotic compositions
ES2552682T3 (es) 2003-03-10 2015-12-01 Merck Sharp & Dohme Corp. Agentes antibacterianos novedosos
WO2005030227A1 (en) 2003-09-23 2005-04-07 Enanta Pharmaceuticals, Inc. 9a, 11-3C-BICYCLIC 9a-AZALIDE DERIVATIVES
CN1882360A (zh) * 2003-11-21 2006-12-20 辉瑞产品公司 抗生素作为疫苗佐剂的用途
BRPI0508830B8 (pt) * 2004-03-16 2021-05-25 Boehringer Ingelheim Int derivados de benzeno substituídos por glucopiranosila, medicamentos contendo esses compostos, seu uso e processo para sua fabricação
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US7402568B2 (en) 2004-09-29 2008-07-22 Enanta Pharmaceuticals, Inc. Bicyclic 9a-azalide derivatives
US7767797B1 (en) * 2004-09-30 2010-08-03 Synovo Gmbh Macrocyclic compounds and methods of use thereof
US7271155B2 (en) 2005-01-07 2007-09-18 Enanta Pharmaceuticals, Inc. 9A, 11-2C-bicyclic 9a-azalide derivatives
ATE429921T1 (de) * 2005-01-14 2009-05-15 Glaxosmithkline Zagreb 9a-carbamoyl- und thiocarbamoylazalide mit antimalariawirkung
EP2214484A4 (en) 2007-10-25 2013-01-02 Cempra Pharmaceuticals Inc PROCESS FOR PREPARING ANTIBACTERIAL MAKROLIDE AGENTS
EP2358379B1 (en) * 2008-10-24 2015-12-16 Cempra Pharmaceuticals, Inc. Biodefenses using triazole-containing macrolides
US9937194B1 (en) * 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
US9480679B2 (en) 2009-09-10 2016-11-01 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and MAC diseases
DK2550286T3 (en) 2010-03-22 2016-02-29 Cempra Pharmaceuticals Inc CRYSTALLINE FORMS OF A MACROLID AND APPLICATIONS THEREOF
EP2571506B1 (en) 2010-05-20 2017-05-10 Cempra Pharmaceuticals, Inc. Processes for preparing macrolides and ketolides and intermediates therefor
EP2613630A4 (en) 2010-09-10 2014-01-15 Cempra Pharmaceuticals Inc FLUOROCETOLIDES FORMING HYDROGEN LINKS TO TREAT DISEASES
US8940880B2 (en) * 2010-09-20 2015-01-27 Novartis Ag Process for the preparation of 9-deoxo-9a-homoerythromycin A, modified in the C-4″ of the cladinose ring by an epoxide group
EP2625185A4 (en) * 2010-10-10 2014-03-26 Synovo Gmbh INFLAMMATORY MAKROLIDE
CN102993250B (zh) * 2011-07-06 2016-02-10 洛阳惠中兽药有限公司 C-3取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物
CN102260306B (zh) * 2011-07-22 2012-07-18 山东鲁抗舍里乐药业有限公司 一种制备泰拉霉素的方法
EP2736915A1 (en) 2011-07-27 2014-06-04 Farma GRS, d.o.o. New crystalline forms of tulathromycin
KR20140139083A (ko) 2012-03-27 2014-12-04 셈프라 파마슈티컬스, 인크. 마크롤라이드계 항생제를 투여하기 위한 비경구 제제
CN102786569B (zh) * 2012-09-07 2016-12-07 安徽中升药业有限公司 泰拉霉素中间体及其制备方法与泰拉霉素的制备方法
JP6426696B2 (ja) 2013-03-14 2018-11-21 センプラ ファーマシューティカルズ，インコーポレイテッド 呼吸器疾患の治療のための方法および製剤
EP2968384A4 (en) 2013-03-15 2017-02-15 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
WO2015014907A1 (en) * 2013-07-31 2015-02-05 Farma Grs, D.O.O. Process for preparation of tulathromycin
CN103497227B (zh) * 2013-09-13 2015-09-30 青岛科技大学 一种泰拉菌素中间体的制备方法
CN104725446B (zh) * 2015-03-26 2017-10-27 宁夏泰瑞制药股份有限公司 一种从泰拉霉素粗品中分离泰拉霉素a和泰拉霉素b的方法
CN104861018A (zh) * 2015-06-17 2015-08-26 瑞普（天津）生物药业有限公司 一种泰拉菌素的制备方法
CN105646617A (zh) * 2016-01-21 2016-06-08 杭州海尔希畜牧科技有限公司 一种制备泰拉霉素的方法
FR3048612B1 (fr) * 2016-03-14 2020-10-02 Septeos Tulathromycine potentialisee
CN106046077B (zh) * 2016-08-04 2019-07-26 湖北美天生物科技股份有限公司 一种泰拉霉素a的合成方法
CN108003207B (zh) * 2017-12-19 2019-05-10 海门慧聚药业有限公司 制备泰拉霉素的方法
CN111087433B (zh) * 2018-10-23 2023-03-21 湖北美天生物科技股份有限公司 一种泰拉霉素中间体的制备方法

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US4512982A (en) * 1984-04-13 1985-04-23 Pfizer Inc. 9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method
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UA70972C2 (uk) 1998-11-20 2004-11-15 Пфайзер Продактс Інк. 13-членні азаліди і їх застосування як антибіотиків

Also Published As

Publication number Publication date
AU749816B2 (en) 2002-07-04
US6936592B2 (en) 2005-08-30
AP9801255A0 (en) 1998-06-30
HK1068893A1 (en) 2005-07-29
PL191601B1 (pl) 2006-06-30
LU91076I9 (en) 2018-07-02
PT988310E (pt) 2003-12-31
MA24564A1 (fr) 1998-12-31
ME00876B (me) 2012-06-20
DE69818665T2 (de) 2004-04-29
UY25040A1 (es) 2000-09-29
FR04C0013I2 (bg) 2005-10-21
NL300150I1 (nl) 2004-08-02
ES2205487T3 (es) 2004-05-01
US20020061858A1 (en) 2002-05-23
CA2293823A1 (en) 1998-12-17
SK168399A3 (en) 2000-11-07
CN1243766C (zh) 2006-03-01
JP2002316933A (ja) 2002-10-31
EP0988310B1 (en) 2003-10-01
BRPI9810519B1 (pt) 2012-02-22
HU228005B1 (en) 2012-08-28
CN1172947C (zh) 2004-10-27
BRPI9810519B8 (pt) 2022-11-16
UA67744C2 (uk) 2004-07-15
DE69818665D1 (de) 2003-11-06
ID22992A (id) 1999-12-23
GT199800077A (es) 1999-12-02
DK0988310T3 (da) 2003-12-15
JP3315704B2 (ja) 2002-08-19
SK284171B6 (sk) 2004-10-05
HRP980314A2 (en) 1999-04-30
HRP980314B1 (en) 2004-04-30
OA11224A (en) 2003-07-16
CZ298556B6 (cs) 2007-11-07
DZ2514A1 (fr) 2003-02-01
CN101691390A (zh) 2010-04-07
MY123354A (en) 2006-05-31
HUP0002209A3 (en) 2003-05-28
HK1028048A1 (en) 2001-02-02
NO316911B1 (no) 2004-06-21
DE122004000018I1 (de) 2004-09-30
JP2000514098A (ja) 2000-10-24
LU91076I2 (fr) 2004-07-05
HUS1200028I1 (hu) 2016-08-29
PA8452201A1 (es) 2000-05-24
HK1088014A1 (en) 2006-10-27
PE79699A1 (es) 1999-08-25
NO996106L (no) 2000-02-10
IS5252A (is) 1999-11-16
NZ514871A (en) 2003-08-29
WO1998056802A1 (en) 1998-12-17
HN1998000086A (es) 1999-03-08
CA2293823C (en) 2004-02-17
KR100396168B1 (ko) 2003-08-27
EA002441B1 (ru) 2002-04-25
TW472060B (en) 2002-01-11
CO4950611A1 (es) 2000-09-01
NZ500660A (en) 2002-03-01
DE122004000018I2 (de) 2011-01-13
CN1259136A (zh) 2000-07-05
EA199901015A1 (ru) 2000-06-26
EP0988310A1 (en) 2000-03-29
PL337505A1 (en) 2000-08-28
CN1793155A (zh) 2006-06-28
FR04C0013I1 (bg) 2004-06-11
AU7347598A (en) 1998-12-30
ATE251173T1 (de) 2003-10-15
AR013086A1 (es) 2000-12-13
EP0988310B9 (en) 2006-03-08
AP1231A (en) 2003-12-11
TNSN98082A1 (fr) 2005-03-15
US6420536B1 (en) 2002-07-16
ZA985017B (en) 1999-12-17
RS49675B (sr) 2007-11-15
BG103945A (bg) 2000-07-31
YU58699A (bg) 2002-08-12
EG24081A (en) 2008-05-11
SI0988310T1 (en) 2004-02-29
US20040180842A1 (en) 2004-09-16
IS1998B (is) 2005-03-15
BG64391B1 (bg) 2004-12-30
US20040023896A1 (en) 2004-02-05
KR20010013632A (ko) 2001-02-26
CN1793155B (zh) 2010-05-12
US6777393B2 (en) 2004-08-17
NL300150I2 (nl) 2004-09-01
BRPI9810519A (pt) 2000-09-19
HUP0002209A2 (hu) 2000-12-28
CZ442199A3 (cs) 2000-07-12
CN1566129A (zh) 2005-01-19
NO996106D0 (no) 1999-12-10

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