IL127861A - Crystals of vitamin d derivatives and process for the preparation thereof - Google Patents

Crystals of vitamin d derivatives and process for the preparation thereof

Info

Publication number
IL127861A
IL127861A IL12786197A IL12786197A IL127861A IL 127861 A IL127861 A IL 127861A IL 12786197 A IL12786197 A IL 12786197A IL 12786197 A IL12786197 A IL 12786197A IL 127861 A IL127861 A IL 127861A
Authority
IL
Israel
Prior art keywords
compound
formula
crystals
organic solvent
crude
Prior art date
Application number
IL12786197A
Other languages
English (en)
Other versions
IL127861A0 (en
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Priority to IL16073597A priority Critical patent/IL160735A/xx
Publication of IL127861A0 publication Critical patent/IL127861A0/xx
Publication of IL127861A publication Critical patent/IL127861A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J9/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005Oxygen-containing hetero ring
    • C07J71/001Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Liquid Crystal Substances (AREA)
IL12786197A 1996-07-01 1997-06-16 Crystals of vitamin d derivatives and process for the preparation thereof IL127861A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL16073597A IL160735A (en) 1996-07-01 1997-06-16 Pre form of vitamin d derivative

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP17132196 1996-07-01
PCT/JP1997/002060 WO1998000397A1 (fr) 1996-07-01 1997-06-16 Cristaux de derives de vitamine d et leur procede de preparation

Publications (2)

Publication Number Publication Date
IL127861A0 IL127861A0 (en) 1999-10-28
IL127861A true IL127861A (en) 2004-06-01

Family

ID=15921084

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12786197A IL127861A (en) 1996-07-01 1997-06-16 Crystals of vitamin d derivatives and process for the preparation thereof

Country Status (13)

Country Link
US (5) US6448421B1 (zh)
EP (2) EP1693363A3 (zh)
KR (1) KR100487269B1 (zh)
CN (2) CN1276927C (zh)
AT (1) ATE325788T1 (zh)
AU (1) AU717568B2 (zh)
CA (1) CA2259339C (zh)
DE (1) DE69735845T2 (zh)
ES (1) ES2264164T3 (zh)
HK (1) HK1018438A1 (zh)
IL (1) IL127861A (zh)
TW (2) TWI247001B (zh)
WO (1) WO1998000397A1 (zh)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2004012743A1 (ja) * 2002-08-01 2006-09-21 中外製薬株式会社 乾癬治療剤
WO2004046097A1 (en) * 2002-11-18 2004-06-03 Teva Pharmaceutical Industries Ltd. A crystallization method for purification of calcipotriene
ES2638836T3 (es) * 2004-02-06 2017-10-24 Chugai Seiyaku Kabushiki Kaisha Preparación de ED-71
CN101223135A (zh) * 2005-07-18 2008-07-16 特瓦制药工业有限公司 帕立骨化醇的制备
KR20110113664A (ko) * 2006-08-29 2011-10-17 테바 파마슈티컬 인더스트리즈 리미티드 비타민 d 및 코르티코스테로이드를 포함하는 약학 조성물
US9481646B2 (en) * 2007-04-18 2016-11-01 The Johns Hopkins University Low calcemic, highly antiproliferative, analogs of calcitriol
WO2009111873A1 (en) 2008-03-12 2009-09-17 Cytochroma, Inc. Stabilized 1,25-dihydroxyvitamin d2 and method of making same
US20090275768A1 (en) * 2008-04-30 2009-11-05 Formosa Laboratories, Inc. Preparation of Paricalcitol
LT2558577T (lt) 2010-04-16 2019-03-12 Nuevolution A/S Bifunkciniai kompleksai ir tokių kompleksų gamybos ir naudojimo būdai
CN106336369A (zh) * 2016-08-18 2017-01-18 上海皓元医药股份有限公司 一种艾地骨化醇(Eldecalcitol)晶型及其制备方法
KR102346516B1 (ko) 2016-11-21 2022-01-03 연성정밀화학(주) 엘더칼시톨 결정의 제조방법
CN107540589B (zh) * 2017-09-14 2022-05-03 上海彩迩文生化科技有限公司 一种艾尔骨化醇晶型、药物组合物及制备方法和应用
CN110204470A (zh) * 2019-06-11 2019-09-06 南京海融医药科技股份有限公司 一种艾地骨化醇的新的结晶形式及其制备方法和应用
CN110527700B (zh) * 2019-08-30 2021-07-16 厦门金达威维生素有限公司 一种维生素d3的提纯方法
CN111830158B (zh) * 2020-07-17 2022-04-01 大连美创药业有限公司 一种合成艾地骨化醇中间体的液相色谱检测方法
CN111855851B (zh) * 2020-07-17 2022-04-01 大连美创药业有限公司 一种合成艾地骨化醇中间体的液相色谱检测方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3334116A (en) 1964-06-08 1967-08-01 Martin Marietta Corp Phthalocyanine dyestuffs
US3334118A (en) * 1965-07-28 1967-08-01 Nopco Chem Co Process for obtaining purified crystalline vitamin d
JPS5115609A (en) * 1974-07-27 1976-02-07 Eisai Co Ltd 5 66 toransuubitamin d noketsushokaho
US4297289A (en) * 1980-07-17 1981-10-27 Wisconsin Alumni Research Foundation Vitamin D compounds isotopically substituted at carbon 6 and process for their preparation
US4307025A (en) * 1981-02-17 1981-12-22 Wisconsin Alumni Research Foundation 1α, 25-dihydroxy-2β-fluorovitamin D3
US4502991A (en) * 1983-08-18 1985-03-05 Wisconsin Alumni Research Foundation 23,23-Difluoro-1α,25-dihydroxy-vitamin D3
US4689180A (en) 1984-01-30 1987-08-25 Wisconsin Alumni Research Foundation 1α,25-dihydroxy-22Z-dehydroxyvitamin D compound
US4719204A (en) * 1984-03-05 1988-01-12 Wisconsin Alumni Research Foundation Fowl bone mineralization with 28-NOR 1α-hydroxyvitamin D2 analogs
US4666634A (en) * 1984-12-05 1987-05-19 Chugai Seiyaku Kabushiki Kaisha vitamin D3 derivatives having a substituent at 2-position
US4892821A (en) * 1987-07-08 1990-01-09 Taisho Pharmaceutical Co., Ltd. Method for preparing vitamin D compounds
EP0536311A4 (en) 1990-06-21 1993-05-19 Trustees Of Boston University Compositions comprising vitamin d precursors, analogs thereof and their use
JP3030157B2 (ja) * 1991-03-13 2000-04-10 株式会社クラレ シクロヘキサントリオール誘導体
JPH05115609A (ja) * 1991-10-31 1993-05-14 Olympic Co Ltd 遊技場の管理装置
ATE181062T1 (de) * 1992-08-28 1999-06-15 Bone Care Int Inc 1alpha,24(s)-dihydroxy vitamin d2, seine synthese und verwendung
IL107748A (en) * 1992-11-27 1998-08-16 Chugai Pharmaceutical Co Ltd A method for producing a history of vitamin D.
JP3429341B2 (ja) * 1993-10-14 2003-07-22 株式会社日清製粉グループ本社 活性型ビタミンd中間体
JP3589685B2 (ja) * 1993-11-02 2004-11-17 中外製薬株式会社 ステロイド類の25位水酸化物の生物学的製造法
JP3678446B2 (ja) * 1993-11-02 2005-08-03 中外製薬株式会社 1β−ヒドロキシビタミン▲D3▼誘導体
CA2122431C (en) * 1994-04-28 2006-10-10 Reinhold W. Vieth Topical administration of vitamin d to mammals and compositions therefor
JP3579094B2 (ja) 1994-07-26 2004-10-20 中外製薬株式会社 2位に置換基を有するビタミンd誘導体
AU710931B2 (en) * 1996-02-28 1999-09-30 Sumitomo Pharmaceuticals Company, Limited Crystalline vitamin D derivative

Also Published As

Publication number Publication date
US20050009794A1 (en) 2005-01-13
CN1637017A (zh) 2005-07-13
ATE325788T1 (de) 2006-06-15
CN1216861C (zh) 2005-08-31
AU3107397A (en) 1998-01-21
US6831183B2 (en) 2004-12-14
US20070225513A1 (en) 2007-09-27
CA2259339C (en) 2009-04-21
ES2264164T3 (es) 2006-12-16
US7235679B2 (en) 2007-06-26
US7323580B2 (en) 2008-01-29
WO1998000397A1 (fr) 1998-01-08
CA2259339A1 (en) 1998-01-08
US20030018206A1 (en) 2003-01-23
AU717568B2 (en) 2000-03-30
CN1276927C (zh) 2006-09-27
US6448421B1 (en) 2002-09-10
CN1223639A (zh) 1999-07-21
KR100487269B1 (ko) 2005-05-03
EP0924199A4 (zh) 1999-07-28
IL127861A0 (en) 1999-10-28
US20060217354A1 (en) 2006-09-28
DE69735845T2 (de) 2006-12-28
US20020111503A1 (en) 2002-08-15
EP0924199A1 (en) 1999-06-23
TW200502205A (en) 2005-01-16
KR20050008861A (ko) 2005-01-21
TW584627B (en) 2004-04-21
EP1693363A3 (en) 2012-05-16
EP0924199B1 (en) 2006-05-10
HK1018438A1 (en) 1999-12-24
DE69735845D1 (de) 2006-06-14
TWI247001B (en) 2006-01-11
EP1693363A2 (en) 2006-08-23

Similar Documents

Publication Publication Date Title
US7323580B2 (en) Crystals of a vitamin D derivative and a method for the preparation thereof
KR100400941B1 (ko) 축합6환화합물및그의제조방법
US3907843A (en) 1{60 -Hydroxyergocalciferol and processes for preparing same
CN104781272A (zh) 奥贝胆酸的制备、用途和固体形式
LU82613A1 (fr) Amides antihypertensives
MX2010014060A (es) Proceso para preparar un agonista de receptor de adenosina a2a y sus polimorfas.
JPS63500661A (ja) 新規ビタミンd類似体
KR20220161368A (ko) 물의 존재 하에 메틸화에 의한 mcl-1 저해 화합물의 제조
ITMI20011726A1 (it) Forme polimorfe della lercanidipina cloridrato
FR2463122A1 (fr) Amides polyprenylcarboxyliques, procede de preparation de ceux-ci et composition pharmaceutique a base desdits amides
JP3429432B2 (ja) ビタミンd誘導体結晶およびその製造方法
Godfroid et al. Structure-activity relationship in PAF-acether. 3. Hydrophobic contribution to agonistic activity
KR100554560B1 (ko) 비타민d유도체결정및그의제조방법
SU1240362A3 (ru) Способ получени производных гидантоина
JP2020189856A (ja) ソフピロニウム臭化物の結晶形態及びその製造方法
EP3604284A1 (en) Crystalline eltrombopag monoethanolamine salt form d
JP2663105B2 (ja) 14α−ヒドロキシ−4−アンドロステン−3,6,17−トリオン水和物結晶及びその製造法
EP4360660A1 (en) Process for the preparation of a gadolinium contrast agent
WO2023131017A1 (zh) 一种稠环衍生物的晶型、其制备方法及其应用
CN114478679A (zh) 双氢青蒿素-熊去氧胆酸缀合物的多晶型物及其制备方法和应用
SU1409122A3 (ru) Способ получени винкубина
JPH07206789A (ja) コンブレタスタチン類縁化合物
CN112321420A (zh) 一种萘普生杂质及其制备方法
WO2013055244A1 (en) Preparation of protoescigenin from escin
NO139436B (no) Cykloheksandiolderivat for anvendelse som mellomprodukt ved fremstilling av syntetiske antibiotika av hybrimycinserien

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
EXP Patent expired