IL125146A - History - 3phenyl - 2 (methyl converted) Tropan, their preparation and pharmaceutical preparations containing them - Google Patents
History - 3phenyl - 2 (methyl converted) Tropan, their preparation and pharmaceutical preparations containing themInfo
- Publication number
- IL125146A IL125146A IL12514697A IL12514697A IL125146A IL 125146 A IL125146 A IL 125146A IL 12514697 A IL12514697 A IL 12514697A IL 12514697 A IL12514697 A IL 12514697A IL 125146 A IL125146 A IL 125146A
- Authority
- IL
- Israel
- Prior art keywords
- tropane
- dichlorophenyl
- compound
- nortropane
- chlorophenyl
- Prior art date
Links
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 title claims abstract description 15
- 238000002360 preparation method Methods 0.000 title claims description 23
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 12
- 150000003813 tropane derivatives Chemical class 0.000 title description 6
- 239000000203 mixture Substances 0.000 claims abstract description 54
- 229930004006 tropane Natural products 0.000 claims abstract description 35
- -1 tropane compound Chemical class 0.000 claims abstract description 29
- 150000003839 salts Chemical class 0.000 claims abstract description 19
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims abstract description 10
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims abstract description 8
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 7
- 239000001257 hydrogen Substances 0.000 claims abstract description 7
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 5
- 150000002367 halogens Chemical group 0.000 claims abstract description 5
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 5
- 125000001424 substituent group Chemical group 0.000 claims abstract description 3
- 229910052717 sulfur Inorganic materials 0.000 claims abstract description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 4
- 150000001875 compounds Chemical class 0.000 claims description 85
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 28
- XLRPYZSEQKXZAA-OCAPTIKFSA-N tropane Chemical compound C1CC[C@H]2CC[C@@H]1N2C XLRPYZSEQKXZAA-OCAPTIKFSA-N 0.000 claims description 27
- 238000000034 method Methods 0.000 claims description 23
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- 239000003814 drug Substances 0.000 claims description 7
- 230000001561 neurotransmitter reuptake Effects 0.000 claims description 7
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 6
- 208000027089 Parkinsonian disease Diseases 0.000 claims description 6
- 206010034010 Parkinsonism Diseases 0.000 claims description 6
- 206010013663 drug dependence Diseases 0.000 claims description 6
- 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims description 5
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- 238000004519 manufacturing process Methods 0.000 claims description 3
- PGYDXVBZYKQYCS-VPWBDBDCSA-N (1s,3s,4r,5r)-3-(3,4-dichlorophenyl)-4-(methoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane Chemical compound C1([C@@H]2[C@@H](COC)[C@]3(CC[C@@](C2)(N3C)[H])[H])=CC=C(Cl)C(Cl)=C1 PGYDXVBZYKQYCS-VPWBDBDCSA-N 0.000 claims description 2
- HTKSGXUNQZSQKB-VBRUCIBASA-N (1s,5r)-3-(3,4-dichlorophenyl)-4-(ethylsulfanylmethyl)-8-methyl-8-azabicyclo[3.2.1]octane Chemical compound CCSCC([C@]1(CC[C@@](C2)(N1C)[H])[H])C2C1=CC=C(Cl)C(Cl)=C1 HTKSGXUNQZSQKB-VBRUCIBASA-N 0.000 claims description 2
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- IIUOULDVNOMXAP-ZJIFWQFVSA-N (1s,3s,4r,5r)-3-(4-chlorophenyl)-4-(methoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane Chemical compound C1([C@@H]2[C@@H](COC)[C@]3(CC[C@@](C2)(N3C)[H])[H])=CC=C(Cl)C=C1 IIUOULDVNOMXAP-ZJIFWQFVSA-N 0.000 claims 1
- VCVWXKKWDOJNIT-VBRUCIBASA-N (1s,5r)-3-(3,4-dichlorophenyl)-4-(ethoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane Chemical compound CCOCC([C@]1(CC[C@@](C2)(N1C)[H])[H])C2C1=CC=C(Cl)C(Cl)=C1 VCVWXKKWDOJNIT-VBRUCIBASA-N 0.000 claims 1
- PGYDXVBZYKQYCS-PIISCBOPSA-N (1s,5r)-3-(3,4-dichlorophenyl)-4-(methoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane Chemical compound COCC([C@]1(CC[C@@](C2)(N1C)[H])[H])C2C1=CC=C(Cl)C(Cl)=C1 PGYDXVBZYKQYCS-PIISCBOPSA-N 0.000 claims 1
- IJIHFJXJGNXNBL-FAYHIZQSSA-N (1s,5r)-3-(3,4-dichlorophenyl)-8-methyl-4-(propan-2-yloxymethyl)-8-azabicyclo[3.2.1]octane Chemical compound CC(C)OCC([C@]1(CC[C@@](C2)(N1C)[H])[H])C2C1=CC=C(Cl)C(Cl)=C1 IJIHFJXJGNXNBL-FAYHIZQSSA-N 0.000 claims 1
- IIUOULDVNOMXAP-SLTXQBBLSA-N (1s,5r)-3-(4-chlorophenyl)-4-(methoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane Chemical compound COCC([C@]1(CC[C@@](C2)(N1C)[H])[H])C2C1=CC=C(Cl)C=C1 IIUOULDVNOMXAP-SLTXQBBLSA-N 0.000 claims 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK19496 | 1996-02-22 | ||
| PCT/EP1997/000850 WO1997030997A1 (en) | 1996-02-22 | 1997-02-21 | Tropane-derivatives, their preparation and use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL125146A0 IL125146A0 (en) | 1999-01-26 |
| IL125146A true IL125146A (en) | 2002-03-10 |
Family
ID=8090830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12514697A IL125146A (en) | 1996-02-22 | 1997-02-21 | History - 3phenyl - 2 (methyl converted) Tropan, their preparation and pharmaceutical preparations containing them |
Country Status (32)
| Country | Link |
|---|---|
| US (3) | US6288079B1 (bg) |
| EP (2) | EP0885220B1 (bg) |
| JP (1) | JP3238414B2 (bg) |
| KR (1) | KR100446571B1 (bg) |
| CN (1) | CN1077574C (bg) |
| AT (1) | ATE203023T1 (bg) |
| AU (1) | AU720358B2 (bg) |
| BG (1) | BG63945B1 (bg) |
| BR (1) | BR9707636A (bg) |
| CA (1) | CA2244773C (bg) |
| CZ (1) | CZ287007B6 (bg) |
| DE (1) | DE69705608T2 (bg) |
| DK (1) | DK0885220T3 (bg) |
| EE (1) | EE04751B1 (bg) |
| ES (1) | ES2159839T3 (bg) |
| GR (1) | GR3036829T3 (bg) |
| HK (1) | HK1018957A1 (bg) |
| HU (1) | HU228356B1 (bg) |
| IL (1) | IL125146A (bg) |
| IS (1) | IS1824B (bg) |
| NO (1) | NO318731B1 (bg) |
| NZ (1) | NZ330886A (bg) |
| PL (1) | PL185132B1 (bg) |
| PT (1) | PT885220E (bg) |
| RU (1) | RU2167876C2 (bg) |
| SG (1) | SG99853A1 (bg) |
| SI (1) | SI0885220T1 (bg) |
| SK (1) | SK281813B6 (bg) |
| TR (1) | TR199801641T2 (bg) |
| UA (1) | UA49872C2 (bg) |
| WO (1) | WO1997030997A1 (bg) |
| ZA (1) | ZA971525B (bg) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100615867B1 (ko) * | 1998-09-30 | 2006-08-25 | 니혼 메디피직스 가부시키가이샤 | 광학 활성 트로피논 모노카르복실산 유도체의 제조 방법 |
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