IL124563A - 5-phenyl-3-(substituted oximino) pyrrolo [3, 2-h] isoquinoline-2-one derivatives pharmaceutical compositions containing them and their preparation - Google Patents

5-phenyl-3-(substituted oximino) pyrrolo [3, 2-h] isoquinoline-2-one derivatives pharmaceutical compositions containing them and their preparation

Info

Publication number
IL124563A
IL124563A IL12456397A IL12456397A IL124563A IL 124563 A IL124563 A IL 124563A IL 12456397 A IL12456397 A IL 12456397A IL 12456397 A IL12456397 A IL 12456397A IL 124563 A IL124563 A IL 124563A
Authority
IL
Israel
Prior art keywords
het
phenyl
pyrrolo
isoquinoline
preparation
Prior art date
Application number
IL12456397A
Other languages
English (en)
Other versions
IL124563A0 (en
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Publication of IL124563A0 publication Critical patent/IL124563A0/xx
Publication of IL124563A publication Critical patent/IL124563A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL12456397A 1996-10-01 1997-10-01 5-phenyl-3-(substituted oximino) pyrrolo [3, 2-h] isoquinoline-2-one derivatives pharmaceutical compositions containing them and their preparation IL124563A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK106996 1996-10-01
DK127796 1996-11-13
PCT/DK1997/000418 WO1998014447A1 (en) 1996-10-01 1997-10-01 Novel indole-2,3-dione-3-oxime derivatives

Publications (2)

Publication Number Publication Date
IL124563A0 IL124563A0 (en) 1998-12-06
IL124563A true IL124563A (en) 2005-05-17

Family

ID=26065167

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12456397A IL124563A (en) 1996-10-01 1997-10-01 5-phenyl-3-(substituted oximino) pyrrolo [3, 2-h] isoquinoline-2-one derivatives pharmaceutical compositions containing them and their preparation

Country Status (29)

Country Link
US (3) USRE38200E1 (bg)
EP (1) EP0869958B1 (bg)
JP (1) JP3319762B2 (bg)
KR (1) KR100492052B1 (bg)
CN (1) CN1093859C (bg)
AT (1) ATE286052T1 (bg)
AU (1) AU716435B2 (bg)
BG (1) BG63874B1 (bg)
BR (1) BR9706765A (bg)
CA (1) CA2238410C (bg)
CZ (1) CZ297938B6 (bg)
DE (1) DE69732090T2 (bg)
DK (1) DK0869958T3 (bg)
EE (1) EE9800144A (bg)
ES (1) ES2235253T3 (bg)
HK (1) HK1017682A1 (bg)
HU (1) HU225145B1 (bg)
IL (1) IL124563A (bg)
IS (1) IS2123B (bg)
NO (1) NO310722B1 (bg)
NZ (1) NZ330456A (bg)
PL (1) PL193041B1 (bg)
PT (1) PT869958E (bg)
RU (1) RU2190612C2 (bg)
SI (1) SI0869958T1 (bg)
SK (1) SK282729B6 (bg)
TR (1) TR199800956T1 (bg)
UA (1) UA54403C2 (bg)
WO (1) WO1998014447A1 (bg)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA54403C2 (uk) * 1996-10-01 2003-03-17 Н'Юросерч А/С Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму
AU751414B2 (en) 1998-03-31 2002-08-15 Neurosearch A/S Indole-2,3-dione-3-oxime derivatives for therapeutic use
AU4910500A (en) * 1999-05-19 2000-12-12 Neurosearch A/S Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders
US7282511B2 (en) * 2000-01-24 2007-10-16 Neurosearch A/S Isatine derivatives with neurotrophic activity
IT1318636B1 (it) * 2000-07-21 2003-08-27 Roberto Pellicciari Derivati dell'acido 2- o 3- tenoico ad attivita' antagonista deirecettori del glutammato.
EP1361878A1 (en) * 2001-02-15 2003-11-19 Neurosearch A/S Treatment of parkinson's disease by the combined action of a compound with neurotrophic activity and a compound enhancing the dopamine activity
BR0211140A (pt) 2001-07-13 2005-10-25 Upjohn Co Compostos e composições de indóis de hexaidroazepina (4, 5-g) e indolinas como ligantes de receptores 5-ht
NZ537810A (en) 2002-08-22 2006-10-27 Neurosearch As A method of preparing enantiomers of indole-2,3-dione-3-oxime derivatives
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds
WO2007059608A1 (en) * 2005-11-23 2007-05-31 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
WO2007115403A1 (en) * 2006-04-10 2007-10-18 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
EP2010529A1 (en) * 2006-04-10 2009-01-07 PainCeptor Pharma Corp. Compositions and methods for modulating gated ion channels
US20100041691A1 (en) * 2006-09-12 2010-02-18 Neurosearch A/S Pharmaceutical compositions comprising combinations of an ampa/kainate antagonistic compound and an inhibitor of a multidrug resistance protein
US20080108603A1 (en) * 2006-10-19 2008-05-08 Eisenach James C Combination therapy for the treatment of pain
US20080108622A1 (en) * 2006-10-19 2008-05-08 Eisenach James C Combination therapy for the treatment of pain
WO2010104324A2 (ko) * 2009-03-10 2010-09-16 한국과학기술연구원 베타-아밀로이드 집적체 및 피브릴에 우수한 결합 친화도를 가지는 할로겐화 이소인돌론 화합물, 및 이의 제조 방법 및 용도
CN102653538A (zh) * 2011-03-04 2012-09-05 爱斯医药科技(南京)有限公司 Spd-502的制备方法
MX2017013877A (es) 2015-04-29 2018-08-15 Janssen Pharmaceutica Nv Compuestos de benzimidazolona y benzotiazolona y su uso como moduladores del receptor ampa.
US10604484B2 (en) 2015-04-29 2020-03-31 Janssen Pharmaceutica Nv Indolone compounds and their use as AMPA receptor modulators
MA41988B1 (fr) 2015-04-29 2021-03-31 Janssen Pharmaceutica Nv Azabenzimidazoles et leur utilisation comme modulateurs du recepteur ampa
BR112017023038A2 (pt) 2015-04-29 2018-07-03 Janssen Pharmaceutica Nv imidazopirazinas e pirazolopirimidinas e seu uso como moduladores do receptor ampa

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2076948C (en) * 1991-08-28 2002-04-16 Frank Watjen Isatineoxime derivatives, their preparation and use
US5721230A (en) 1993-05-10 1998-02-24 Hoffmann-La Roche Inc. Substituted pyrroles
ES2111930T3 (es) * 1993-05-13 1998-03-16 Neurosearch As Antagonistas del acido amp y procedimientos de tratamiento con la ayuda de estos.
DK81593D0 (da) * 1993-07-07 1993-07-07 Neurosearch As Nye isatinoximderivater, deres fremstilling og anvendelse
JP3164371B2 (ja) * 1994-09-14 2001-05-08 ノイロサーチ アクティーゼルスカブ インドール−２，３−ジオン−３−オキシム誘導体、その製造および使用
CA2199614C (en) * 1994-09-14 2000-02-22 Peter Moldt Fused indole and quinoxaline derivatives, their preparation and use
UA54403C2 (uk) * 1996-10-01 2003-03-17 Н'Юросерч А/С Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму

Also Published As

Publication number Publication date
HUP9901630A2 (hu) 1999-08-30
PL193041B1 (pl) 2007-01-31
IL124563A0 (en) 1998-12-06
US6124285A (en) 2000-09-26
NO310722B1 (no) 2001-08-20
NZ330456A (en) 1998-11-25
AU716435B2 (en) 2000-02-24
WO1998014447A1 (en) 1998-04-09
JP3319762B2 (ja) 2002-09-03
USRE38200E1 (en) 2003-07-22
BG102489A (bg) 1999-04-30
SI0869958T1 (en) 2005-06-30
KR100492052B1 (ko) 2005-09-30
UA54403C2 (uk) 2003-03-17
NO982466L (no) 1998-07-31
BR9706765A (pt) 1999-09-14
HK1017682A1 (en) 1999-11-26
IS4748A (is) 1998-05-18
CZ297938B6 (cs) 2007-05-02
CZ160698A3 (cs) 1998-10-14
PL327073A1 (en) 1998-11-23
IS2123B (is) 2006-07-14
MX9804365A (es) 1998-10-31
EP0869958A1 (en) 1998-10-14
ES2235253T3 (es) 2005-07-01
NO982466D0 (no) 1998-05-29
ATE286052T1 (de) 2005-01-15
RU2190612C2 (ru) 2002-10-10
SK67698A3 (en) 1998-11-04
KR19990071823A (ko) 1999-09-27
US6693111B1 (en) 2004-02-17
AU4376897A (en) 1998-04-24
CN1207100A (zh) 1999-02-03
TR199800956T1 (xx) 1998-12-21
DE69732090T2 (de) 2005-12-29
EE9800144A (et) 1998-10-15
DE69732090D1 (de) 2005-02-03
HUP9901630A3 (en) 2001-11-28
HU225145B1 (en) 2006-07-28
JP2000501432A (ja) 2000-02-08
PT869958E (pt) 2005-05-31
DK0869958T3 (da) 2005-04-18
EP0869958B1 (en) 2004-12-29
BG63874B1 (bg) 2003-04-30
CA2238410A1 (en) 1998-04-09
CN1093859C (zh) 2002-11-06
CA2238410C (en) 2007-06-12
SK282729B6 (sk) 2002-11-06

Similar Documents

Publication Publication Date Title
IL124563A (en) 5-phenyl-3-(substituted oximino) pyrrolo [3, 2-h] isoquinoline-2-one derivatives pharmaceutical compositions containing them and their preparation
UY25679A1 (es) Derivados de quinolin-2-ona inhibidores de la farnesil proteína transferasa útiles como agentes contra el cáncer
FI954609A (fi) 1-amidinofenyyli-pyrrolidoneja, -piperidinoneja ja -atsetinoneja verihiutaleiden kasaantumisen inhibiittoreina
TW349098B (en) Naphthalene derivatives, process for the preparation thereof, and intermediates therefor
ES2162466T3 (es) Derivados de 1,2,4-triazolo(4,3-b)pirido(3,2-d)piridazina y composiciones farmaceuticas que los contienen.
MY132073A (en) Thienopyrimidine and thienopyridine derivatives useful as anticancer agents
BG103947A (bg) Производни на 9-оксимеритромицин
HUP0003826A2 (hu) Új triazolo [4,5-d] pirimidin-származékok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények
FR2639349B1 (fr) Nouveaux derives du chromane actifs sur le systeme nerveux central, leur procede de preparation et les compositions pharmaceutiques en contenant
IL94768A0 (en) Pharmaceutical compositions containing aryl-substituted amine derivatives,certain such novel compounds and their preparation
EP1140900A4 (en) PYRAZOLE COMPOUNDS AND USE OF SUCH COMPOUNDS
AP9801377A0 (en) Tricyclic erythromycin derivatives.
IL112102A0 (en) Annelated dihydropyridinoacetic acid derivatives, their preparation and pharmaceutical compositions containing them
FR2671349B1 (fr) Nouveaux derives de 1,4-dihydropyridine, leur procede de preparation et composition therapeutique les contenant.
IL91648A (en) Amino acid quinoline and naphthyridine derivatives, their preparation and pharmaceutical compositions containing them
TW367328B (en) Benzofuro[3,2-b]pyridine derivatives, process for the preparation thereof and pharmaceutical composition containing the same
HUP0105406A2 (hu) Imidazo[1,2-a]kinolinszármazékok, eljárás előállításukra, ezeket tartalmazó gyógyszerkészítmények, valamint intermedierek
HUP0003475A2 (hu) Neutrofil-elasztáz gátló hatású pirrolo-pirrolon-származékok, eljárás előállításukra, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények
AP9901559A0 (en) Tricyclic 3-keto derivatives of 6-0-methylerythromycin.
AR019390A1 (es) Derivados de acidos sulfonilaminofosfinicos y sulfonilaminofosfonicos, procedimiento para su preparacion, compuestos intermediarios, medicamentos, procedimiento para su preparacion y empleo de dichos derivados para la preparacion de un medicamento.
HUP9904526A2 (hu) Piperidinszármazékok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények
HUP9801810A2 (hu) Imidazo[1,5-a]piridin-csoporttal helyettesített szerin-proteáz inhibitorok, ezek előállítása és ezeket tartalmazó gyógyszerkészítmények
HUP0002659A2 (hu) Benzo-5,6-ciklohepta[1,2-b]piridin-származékok, e vegyületeket tartalmazó gyógyszerkészítmények és alkalmazásuk
AR036554A1 (es) Coniosulfuros y sus derivados, procedimiento para su preparacion y su utilizacion como medicamentos
ES455436A1 (es) Procedimiento de preparacion de acidos tienotienilcarbonife-nilalcanoicos.

Legal Events

Date Code Title Description
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees